[←][→] mcc  MAP2K2 Gene
functional annotation
Function   mitogen-activated protein kinase kinase 2  
GO BP
GO CC
GO MF
KEGG mcc01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
mcc01522 [list] [network] Endocrine resistance (98 genes)
mcc04010 [list] [network] MAPK signaling pathway (301 genes)
mcc04012 [list] [network] ErbB signaling pathway (85 genes)
mcc04014 [list] [network] Ras signaling pathway (250 genes)
mcc04015 [list] [network] Rap1 signaling pathway (229 genes)
mcc04022 [list] [network] cGMP-PKG signaling pathway (169 genes)
mcc04024 [list] [network] cAMP signaling pathway (226 genes)
mcc04066 [list] [network] HIF-1 signaling pathway (119 genes)
mcc04068 [list] [network] FoxO signaling pathway (131 genes)
mcc04071 [list] [network] Sphingolipid signaling pathway (120 genes)
mcc04072 [list] [network] Phospholipase D signaling pathway (168 genes)
mcc04140 [list] [network] Autophagy - animal (147 genes)
mcc04150 [list] [network] mTOR signaling pathway (155 genes)
mcc04151 [list] [network] PI3K-Akt signaling pathway (381 genes)
mcc04210 [list] [network] Apoptosis (150 genes)
mcc04218 [list] [network] Cellular senescence (174 genes)
mcc04270 [list] [network] Vascular smooth muscle contraction (142 genes)
mcc04370 [list] [network] VEGF signaling pathway (58 genes)
mcc04371 [list] [network] Apelin signaling pathway (142 genes)
mcc04540 [list] [network] Gap junction (94 genes)
mcc04550 [list] [network] Signaling pathways regulating pluripotency of stem cells (144 genes)
mcc04613 [list] [network] Neutrophil extracellular trap formation (214 genes)
mcc04620 [list] [network] Toll-like receptor signaling pathway (108 genes)
mcc04650 [list] [network] Natural killer cell mediated cytotoxicity (142 genes)
mcc04660 [list] [network] T cell receptor signaling pathway (107 genes)
mcc04662 [list] [network] B cell receptor signaling pathway (96 genes)
mcc04664 [list] [network] Fc epsilon RI signaling pathway (78 genes)
mcc04720 [list] [network] Long-term potentiation (70 genes)
mcc04722 [list] [network] Neurotrophin signaling pathway (122 genes)
mcc04730 [list] [network] Long-term depression (61 genes)
mcc04810 [list] [network] Regulation of actin cytoskeleton (221 genes)
mcc04910 [list] [network] Insulin signaling pathway (141 genes)
mcc04912 [list] [network] GnRH signaling pathway (97 genes)
mcc04915 [list] [network] Estrogen signaling pathway (144 genes)
mcc04916 [list] [network] Melanogenesis (103 genes)
mcc04917 [list] [network] Prolactin signaling pathway (70 genes)
mcc04919 [list] [network] Thyroid hormone signaling pathway (124 genes)
mcc04921 [list] [network] Oxytocin signaling pathway (163 genes)
mcc04926 [list] [network] Relaxin signaling pathway (133 genes)
mcc04929 [list] [network] GnRH secretion (64 genes)
mcc04934 [list] [network] Cushing syndrome (161 genes)
mcc04935 [list] [network] Growth hormone synthesis, secretion and action (128 genes)
mcc05010 [list] [network] Alzheimer disease (441 genes)
mcc05022 [list] [network] Pathways of neurodegeneration - multiple diseases (540 genes)
mcc05132 [list] [network] Salmonella infection (264 genes)
mcc05135 [list] [network] Yersinia infection (153 genes)
mcc05160 [list] [network] Hepatitis C (173 genes)
mcc05161 [list] [network] Hepatitis B (180 genes)
mcc05163 [list] [network] Human cytomegalovirus infection (257 genes)
mcc05164 [list] [network] Influenza A (191 genes)
mcc05165 [list] [network] Human papillomavirus infection (352 genes)
mcc05166 [list] [network] Human T-cell leukemia virus 1 infection (247 genes)
mcc05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (227 genes)
mcc05170 [list] [network] Human immunodeficiency virus 1 infection (247 genes)
mcc05200 [list] [network] Pathways in cancer (573 genes)
mcc05205 [list] [network] Proteoglycans in cancer (211 genes)
mcc05206 [list] [network] MicroRNAs in cancer (293 genes)
mcc05207 [list] [network] Chemical carcinogenesis - receptor activation (215 genes)
mcc05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (272 genes)
mcc05210 [list] [network] Colorectal cancer (107 genes)
mcc05211 [list] [network] Renal cell carcinoma (72 genes)
mcc05213 [list] [network] Endometrial cancer (61 genes)
mcc05214 [list] [network] Glioma (79 genes)
mcc05215 [list] [network] Prostate cancer (97 genes)
mcc05216 [list] [network] Thyroid cancer (39 genes)
mcc05218 [list] [network] Melanoma (74 genes)
mcc05219 [list] [network] Bladder cancer (41 genes)
mcc05220 [list] [network] Chronic myeloid leukemia (80 genes)
mcc05221 [list] [network] Acute myeloid leukemia (69 genes)
mcc05223 [list] [network] Non-small cell lung cancer (75 genes)
mcc05224 [list] [network] Breast cancer (150 genes)
mcc05225 [list] [network] Hepatocellular carcinoma (177 genes)
mcc05226 [list] [network] Gastric cancer (153 genes)
mcc05230 [list] [network] Central carbon metabolism in cancer (76 genes)
mcc05231 [list] [network] Choline metabolism in cancer (107 genes)
mcc05235 [list] [network] PD-L1 expression and PD-1 checkpoint pathway in cancer (93 genes)
Protein XP_014977979.1  XP_014977980.1 
BLAST XP_014977979.1  XP_014977980.1 
Orthologous [Ortholog page] MAP2K1 (hsa)  MAP2K2 (hsa)  Map2k1 (mmu)  Map2k2 (mmu)  Dsor1 (dme)  Map2k2 (rno)  Map2k1 (rno)  mek-2 (cel)  MAP2K2 (gga)  map2k1 (dre)  MAP2K1 (gga)  MAP2K1 (cfa)  map2k2a (dre)  MAP2K2 (cfa)  MAP2K1 (mcc)  PBS2 (sce)  pab2 (spo)  map2k2b (dre)  MAP2K1 (fca)  MAP2K2 (fca) 
Subcellular
localization
wolf
mito 7,  cyto 2,  nucl 1,  cyto_pero 1,  cyto_plas 1,  cyto_golg 1  (predict for XP_014977979.1)
mito 6,  cyto 2,  cyto_nucl 2,  nucl 1  (predict for XP_014977980.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mcc05165 Human papillomavirus infection 4
mcc05010 Alzheimer disease 2
mcc05022 Pathways of neurodegeneration - multiple diseases 2
mcc05169 Epstein-Barr virus infection 2
mcc04024 cAMP signaling pathway 2
Genes directly connected with MAP2K2 on the network
coex z* Locus Function* Coexpression
detail		 Entrez Gene ID*
8.4 RABL6 RAB, member RAS oncogene family like 6 [detail] 709111
7.0 ABHD17A abhydrolase domain containing 17A, depalmitoylase [detail] 709119
6.9 RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [detail] 719330
6.5 NR1H2 nuclear receptor subfamily 1 group H member 2 [detail] 719210
6.2 IRF3 interferon regulatory factor 3 [detail] 718970
5.8 ORAI1 ORAI calcium release-activated calcium modulator 1 [detail] 700190
5.7 CHMP6 charged multivesicular body protein 6 [detail] 718353
5.5 TADA3 transcriptional adaptor 3 [detail] 700090
5.3 TLE5 TLE family member 5, transcriptional modulator [detail] 712353
Coexpressed
gene list		 [Coexpressed gene list for MAP2K2]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity*
Link to other DBs
Entrez Gene ID 721821      
Refseq ID (protein) XP_014977979.1 
XP_014977980.1 


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