COXPRESdb : GeneID search result

[←][→] fca MAP2K1 Gene

functional annotation

Function

mitogen-activated protein kinase kinase 1

GO BP

GO CC

GO MF

KEGG

fca01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (80 genes)

fca01522 [list] [network] Endocrine resistance (96 genes)

fca04010 [list] [network] MAPK signaling pathway (289 genes)

fca04012 [list] [network] ErbB signaling pathway (84 genes)

fca04014 [list] [network] Ras signaling pathway (231 genes)

fca04015 [list] [network] Rap1 signaling pathway (215 genes)

fca04022 [list] [network] cGMP-PKG signaling pathway (169 genes)

fca04024 [list] [network] cAMP signaling pathway (222 genes)

fca04062 [list] [network] Chemokine signaling pathway (183 genes)

fca04066 [list] [network] HIF-1 signaling pathway (116 genes)

fca04068 [list] [network] FoxO signaling pathway (129 genes)

fca04071 [list] [network] Sphingolipid signaling pathway (122 genes)

fca04072 [list] [network] Phospholipase D signaling pathway (151 genes)

fca04114 [list] [network] Oocyte meiosis (122 genes)

fca04140 [list] [network] Autophagy - animal (151 genes)

fca04150 [list] [network] mTOR signaling pathway (155 genes)

fca04151 [list] [network] PI3K-Akt signaling pathway (344 genes)

fca04210 [list] [network] Apoptosis (145 genes)

fca04218 [list] [network] Cellular senescence (159 genes)

fca04270 [list] [network] Vascular smooth muscle contraction (134 genes)

fca04370 [list] [network] VEGF signaling pathway (57 genes)

fca04371 [list] [network] Apelin signaling pathway (142 genes)

fca04380 [list] [network] Osteoclast differentiation (120 genes)

fca04510 [list] [network] Focal adhesion (201 genes)

fca04540 [list] [network] Gap junction (86 genes)

fca04550 [list] [network] Signaling pathways regulating pluripotency of stem cells (143 genes)

fca04613 [list] [network] Neutrophil extracellular trap formation (182 genes)

fca04620 [list] [network] Toll-like receptor signaling pathway (95 genes)

fca04650 [list] [network] Natural killer cell mediated cytotoxicity (98 genes)

fca04660 [list] [network] T cell receptor signaling pathway (103 genes)

fca04662 [list] [network] B cell receptor signaling pathway (74 genes)

fca04664 [list] [network] Fc epsilon RI signaling pathway (69 genes)

fca04666 [list] [network] Fc gamma R-mediated phagocytosis (91 genes)

fca04668 [list] [network] TNF signaling pathway (108 genes)

fca04720 [list] [network] Long-term potentiation (68 genes)

fca04722 [list] [network] Neurotrophin signaling pathway (121 genes)

fca04725 [list] [network] Cholinergic synapse (111 genes)

fca04726 [list] [network] Serotonergic synapse (110 genes)

fca04730 [list] [network] Long-term depression (59 genes)

fca04810 [list] [network] Regulation of actin cytoskeleton (219 genes)

fca04910 [list] [network] Insulin signaling pathway (140 genes)

fca04912 [list] [network] GnRH signaling pathway (93 genes)

fca04914 [list] [network] Progesterone-mediated oocyte maturation (91 genes)

fca04915 [list] [network] Estrogen signaling pathway (139 genes)

fca04916 [list] [network] Melanogenesis (102 genes)

fca04917 [list] [network] Prolactin signaling pathway (71 genes)

fca04919 [list] [network] Thyroid hormone signaling pathway (123 genes)

fca04921 [list] [network] Oxytocin signaling pathway (152 genes)

fca04926 [list] [network] Relaxin signaling pathway (129 genes)

fca04928 [list] [network] Parathyroid hormone synthesis, secretion and action (107 genes)

fca04929 [list] [network] GnRH secretion (64 genes)

fca04934 [list] [network] Cushing syndrome (154 genes)

fca04935 [list] [network] Growth hormone synthesis, secretion and action (117 genes)

fca05010 [list] [network] Alzheimer disease (390 genes)

fca05022 [list] [network] Pathways of neurodegeneration - multiple diseases (480 genes)

fca05034 [list] [network] Alcoholism (189 genes)

fca05132 [list] [network] Salmonella infection (253 genes)

fca05135 [list] [network] Yersinia infection (136 genes)

fca05160 [list] [network] Hepatitis C (153 genes)

fca05161 [list] [network] Hepatitis B (157 genes)

fca05163 [list] [network] Human cytomegalovirus infection (225 genes)

fca05164 [list] [network] Influenza A (169 genes)

fca05165 [list] [network] Human papillomavirus infection (328 genes)

fca05166 [list] [network] Human T-cell leukemia virus 1 infection (233 genes)

fca05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (195 genes)

fca05170 [list] [network] Human immunodeficiency virus 1 infection (211 genes)

fca05200 [list] [network] Pathways in cancer (531 genes)

fca05205 [list] [network] Proteoglycans in cancer (212 genes)

fca05206 [list] [network] MicroRNAs in cancer (161 genes)

fca05207 [list] [network] Chemical carcinogenesis - receptor activation (181 genes)

fca05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (224 genes)

fca05210 [list] [network] Colorectal cancer (89 genes)

fca05211 [list] [network] Renal cell carcinoma (70 genes)

fca05212 [list] [network] Pancreatic cancer (76 genes)

fca05213 [list] [network] Endometrial cancer (57 genes)

fca05214 [list] [network] Glioma (76 genes)

fca05215 [list] [network] Prostate cancer (95 genes)

fca05216 [list] [network] Thyroid cancer (37 genes)

fca05218 [list] [network] Melanoma (71 genes)

fca05219 [list] [network] Bladder cancer (41 genes)

fca05220 [list] [network] Chronic myeloid leukemia (75 genes)

fca05221 [list] [network] Acute myeloid leukemia (67 genes)

fca05223 [list] [network] Non-small cell lung cancer (72 genes)

fca05224 [list] [network] Breast cancer (146 genes)

fca05225 [list] [network] Hepatocellular carcinoma (163 genes)

fca05226 [list] [network] Gastric cancer (147 genes)

fca05230 [list] [network] Central carbon metabolism in cancer (70 genes)

fca05231 [list] [network] Choline metabolism in cancer (97 genes)

fca05235 [list] [network] PD-L1 expression and PD-1 checkpoint pathway in cancer (89 genes)

Protein

XP_003987067.1 XP_011281239.1

BLAST

XP_003987067.1 XP_011281239.1

Orthologous

[Ortholog page] MAP2K1 (hsa) MAP2K2 (hsa) Map2k1 (mmu) Map2k2 (mmu) Dsor1 (dme) Map2k2 (rno) Map2k1 (rno) mek-2 (cel) MAP2K2 (gga) map2k1 (dre) MAP2K1 (gga) MAP2K1 (cfa) map2k2a (dre) MAP2K2 (cfa) MAP2K1 (mcc) MAP2K2 (mcc) PBS2 (sce) pab2 (spo) map2k2b (dre) MAP2K2 (fca)

Subcellular
localization
wolf

cyto 6, cyto_nucl 5, nucl 3	(predict for XP_003987067.1)
cyto 5, nucl 5	(predict for XP_011281239.1)

Gene coexpression

Network^*for
coexpressed
genes

[Cytoscape]

KEGG^* ID	Title	#genes	Link to the KEGG^* map (Multiple genes)
fca04010	MAPK signaling pathway	3
fca04014	Ras signaling pathway	3
fca04015	Rap1 signaling pathway	3
fca04024	cAMP signaling pathway	3
fca04062	Chemokine signaling pathway	3

Genes directly connected with MAP2K1 on the network
coex z^*	Locus	Function^*	Coexpression detail	Entrez Gene ID^*
6.8	MAPK1	mitogen-activated protein kinase 1	[detail]	101087614
5.1	MTMR1	myotubularin related protein 1	[detail]	101098208
4.8	HPRT1	hypoxanthine phosphoribosyltransferase 1	[detail]	101095235
4.8	VPS26B	VPS26, retromer complex component B	[detail]	101096510

Coexpressed
gene list

[Coexpressed gene list for MAP2K1]

Gene expression

All samples

[Expression pattern for all samples]

Tissue specificity^*

Link to other DBs
Entrez Gene ID	101081387
Refseq ID (protein)	XP_003987067.1
Refseq ID (protein)	XP_011281239.1

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