KEGG 01521 EGFR tyrosine kinase inhibitor resistance
[list]

Species hsa(Human) mmu(Mouse) rno(Rat) mcc(Monkey) cfa(Dog) fca(Domestic cat)
UMAP
Representative coexpressed gene network LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa01521 EGFR tyrosine kinase inhibitor resistance 18
hsa04151 PI3K-Akt signaling pathway 17
hsa05200 Pathways in cancer 16
hsa04010 MAPK signaling pathway 13
hsa05215 Prostate cancer 12
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu01521 EGFR tyrosine kinase inhibitor resistance 28
mmu05200 Pathways in cancer 24
mmu04151 PI3K-Akt signaling pathway 23
mmu04014 Ras signaling pathway 21
mmu04510 Focal adhesion 21
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno01521 EGFR tyrosine kinase inhibitor resistance 22
rno04151 PI3K-Akt signaling pathway 18
rno05200 Pathways in cancer 18
rno04722 Neurotrophin signaling pathway 14
rno05206 MicroRNAs in cancer 14
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mcc01521 EGFR tyrosine kinase inhibitor resistance 18
mcc04151 PI3K-Akt signaling pathway 16
mcc05200 Pathways in cancer 16
mcc05165 Human papillomavirus infection 15
mcc05224 Breast cancer 14
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
cfa04151 PI3K-Akt signaling pathway 13
cfa01521 EGFR tyrosine kinase inhibitor resistance 12
cfa05205 Proteoglycans in cancer 10
cfa04010 MAPK signaling pathway 9
cfa05200 Pathways in cancer 9
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
fca01521 EGFR tyrosine kinase inhibitor resistance 22
fca04151 PI3K-Akt signaling pathway 21
fca05200 Pathways in cancer 21
fca04014 Ras signaling pathway 16
fca05226 Gastric cancer 16
Gene list in the network
Symbol Function*
AKT2 AKT serine/threonine kinase 2
ARAF A-Raf proto-oncogene, serine/threonine kinase
COL6A3 collagen type VI alpha 3 chain
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FGFR3 fibroblast growth factor receptor 3
FGFR2 fibroblast growth factor receptor 2
MTOR mechanistic target of rapamycin kinase
GSK3B glycogen synthase kinase 3 beta
HGF hepatocyte growth factor
IL6R interleukin 6 receptor
JAK1 Janus kinase 1
NF1 neurofibromin 1
PDGFRA platelet derived growth factor receptor alpha
PDGFRB platelet derived growth factor receptor beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
MAP2K2 mitogen-activated protein kinase kinase 2
SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2
TGFA transforming growth factor alpha
USF2 upstream transcription factor 2, c-fos interacting
ATP11B ATPase phospholipid transporting 11B (putative)
VPS13D vacuolar protein sorting 13 homolog D
GPAT3 glycerol-3-phosphate acyltransferase 3
Symbol Function*
Akt1 thymoma viral proto-oncogene 1
Akt2 thymoma viral proto-oncogene 2
Coro1a coronin, actin binding protein 1A
Ednra endothelin receptor type A
Eef2k eukaryotic elongation factor-2 kinase
Egfr epidermal growth factor receptor
Erbb2 erb-b2 receptor tyrosine kinase 2
Erbb3 erb-b2 receptor tyrosine kinase 3
Fgfr2 fibroblast growth factor receptor 2
Fgfr3 fibroblast growth factor receptor 3
Gab1 growth factor receptor bound protein 2-associated protein 1
Gpc4 glypican 4
Hgf hepatocyte growth factor
Hras Harvey rat sarcoma virus oncogene
Mbd3 methyl-CpG binding domain protein 3
Pdgfa platelet derived growth factor, alpha
Pdgfra platelet derived growth factor receptor, alpha polypeptide
Pdgfrb platelet derived growth factor receptor, beta polypeptide
Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Pik3r1 phosphoinositide-3-kinase regulatory subunit 1
Prkca protein kinase C, alpha
Prkcb protein kinase C, beta
Pten phosphatase and tensin homolog
Ptpn13 protein tyrosine phosphatase, non-receptor type 13
Atxn1 ataxin 1
Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1
Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2
Sox10 SRY (sex determining region Y)-box 10
Src Rous sarcoma oncogene
Stat3 signal transducer and activator of transcription 3
Stat5a signal transducer and activator of transcription 5A
Map2k2 mitogen-activated protein kinase kinase 2
Pdgfc platelet-derived growth factor, C polypeptide
Mtch1 mitochondrial carrier 1
Foxo3 forkhead box O3
Gsk3b glycogen synthase kinase 3 beta
Jmy junction-mediating and regulatory protein
Slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Csnk1g2 casein kinase 1, gamma 2
Pdzd8 PDZ domain containing 8
Shc4 SHC (Src homology 2 domain containing) family, member 4
Tns3 tensin 3
Symbol Function*
Bcl2 BCL2, apoptosis regulator
Hgf hepatocyte growth factor
Nras NRAS proto-oncogene, GTPase
Pdgfrb platelet derived growth factor receptor beta
Tgfa transforming growth factor alpha
Stat3 signal transducer and activator of transcription 3
Pdgfra platelet derived growth factor receptor alpha
Agrn agrin
Plcg1 phospholipase C, gamma 1
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha
Gas6 growth arrest specific 6
Map2k2 mitogen activated protein kinase kinase 2
Bcl2l11 BCL2 like 11
Mtpn myotrophin
Pdpk1 3-phosphoinositide dependent protein kinase-1
Gsk3b glycogen synthase kinase 3 beta
Fgfr3 fibroblast growth factor receptor 3
Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2
Braf B-Raf proto-oncogene, serine/threonine kinase
Mapk1 mitogen activated protein kinase 1
Map2k1 mitogen activated protein kinase kinase 1
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Serinc5 serine incorporator 5
Ipmk inositol polyphosphate multikinase
Hras HRas proto-oncogene, GTPase
Foxo3 forkhead box O3
Abhd17a abhydrolase domain containing 17A, depalmitoylase
Fbxo11 F-box protein 11
S1pr3 sphingosine-1-phosphate receptor 3
Axl Axl receptor tyrosine kinase
Osmr oncostatin M receptor
Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1
Gab1 GRB2-associated binding protein 1
Symbol Function*
FGF2 fibroblast growth factor 2
JAK1 Janus kinase 1
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
STUB1 STIP1 homology and U-box containing protein 1
IGF1 insulin like growth factor 1
MAPK1 mitogen-activated protein kinase 1
EGF epidermal growth factor
HRAS HRas proto-oncogene, GTPase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
B4GALT2 beta-1,4-galactosyltransferase 2
ANKRD17 ankyrin repeat domain 17
SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2
CLMP CXADR like membrane protein
MAPK3 mitogen-activated protein kinase 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
NF1 neurofibromin 1
GSK3B glycogen synthase kinase 3 beta
SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1
ITGB3 integrin subunit beta 3
KIAA2026 KIAA2026
BAD BCL2 associated agonist of cell death
CHMP6 charged multivesicular body protein 6
BAX BCL2 associated X, apoptosis regulator
PIK3R2 phosphoinositide-3-kinase regulatory subunit 2
AP1S1 adaptor related protein complex 1 subunit sigma 1
RPS6KB2 ribosomal protein S6 kinase B2
MAP2K2 mitogen-activated protein kinase kinase 2
Symbol Function*
ERBB2 erb-b2 receptor tyrosine kinase 2
EGFR epidermal growth factor receptor
JAK1 Janus kinase 1
DDA1 DET1 and DDB1 associated 1
RBL2 RB transcriptional corepressor like 2
PDGFD platelet derived growth factor D
ERBB3 erb-b2 receptor tyrosine kinase 3
KDR kinase insert domain receptor
GRB2 growth factor receptor bound protein 2
FKBP8 FKBP prolyl isomerase 8
PIK3R1 phosphoinositide-3-kinase regulatory subunit 1
OSMR oncostatin M receptor
MAPKAPK2 MAPK activated protein kinase 2
AKT1 AKT serine/threonine kinase 1
STAT3 signal transducer and activator of transcription 3
PIK3R2 phosphoinositide-3-kinase regulatory subunit 2
MAP2K2 mitogen-activated protein kinase kinase 2
MYH14 myosin heavy chain 14
Symbol Function*
MET MET proto-oncogene, receptor tyrosine kinase
BCL2L1 BCL2 like 1
BCL2 BCL2 apoptosis regulator
KRAS KRAS proto-oncogene, GTPase
FGF2 fibroblast growth factor 2
AKT2 AKT serine/threonine kinase 2
EGFR epidermal growth factor receptor
MAP2K1 mitogen-activated protein kinase kinase 1
GSK3B glycogen synthase kinase 3 beta
PHF3 PHD finger protein 3
JAK1 Janus kinase 1
PDGFRB platelet derived growth factor receptor beta
MAPK1 mitogen-activated protein kinase 1
AKT1 AKT serine/threonine kinase 1
MAPK3 mitogen-activated protein kinase 3
SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2
ARAF A-Raf proto-oncogene, serine/threonine kinase
NUDT6 nudix hydrolase 6
PDGFRA platelet derived growth factor receptor alpha
STAT5A signal transducer and activator of transcription 5A
NRG2 neuregulin 2
LIMD1 LIM domain containing 1
PIK3R3 phosphoinositide-3-kinase regulatory subunit 3
NRBP1 nuclear receptor binding protein 1
RALGAPB Ral GTPase activating protein non-catalytic subunit beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
RBL2 RB transcriptional corepressor like 2
MTMR1 myotubularin related protein 1
EIF4E2 eukaryotic translation initiation factor 4E family member 2
FLII FLII actin remodeling protein
MAP2K2 mitogen-activated protein kinase kinase 2
LOC102902292 uncharacterized LOC102902292


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