KEGG 04066 HIF-1 signaling pathway
[list]

Species hsa(Human) mmu(Mouse) rno(Rat) mcc(Monkey) cfa(Dog) fca(Domestic cat)
UMAP
Representative coexpressed gene network LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04066 HIF-1 signaling pathway 35
hsa00010 Glycolysis / Gluconeogenesis 18
hsa05200 Pathways in cancer 16
hsa05230 Central carbon metabolism in cancer 15
hsa01200 Carbon metabolism 15
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04066 HIF-1 signaling pathway 44
mmu05200 Pathways in cancer 24
mmu05415 Diabetic cardiomyopathy 19
mmu04151 PI3K-Akt signaling pathway 18
mmu05230 Central carbon metabolism in cancer 18
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno04066 HIF-1 signaling pathway 35
rno00010 Glycolysis / Gluconeogenesis 20
rno01200 Carbon metabolism 16
rno05230 Central carbon metabolism in cancer 16
rno01230 Biosynthesis of amino acids 13
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mcc04066 HIF-1 signaling pathway 36
mcc05200 Pathways in cancer 18
mcc00010 Glycolysis / Gluconeogenesis 16
mcc05230 Central carbon metabolism in cancer 15
mcc04151 PI3K-Akt signaling pathway 14
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
cfa04066 HIF-1 signaling pathway 38
cfa05200 Pathways in cancer 18
cfa00010 Glycolysis / Gluconeogenesis 15
cfa05230 Central carbon metabolism in cancer 15
cfa04010 MAPK signaling pathway 13
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
fca04066 HIF-1 signaling pathway 37
fca05200 Pathways in cancer 16
fca05230 Central carbon metabolism in cancer 16
fca00010 Glycolysis / Gluconeogenesis 15
fca01200 Carbon metabolism 14
Gene list in the network
Symbol Function*
AKT2 AKT serine/threonine kinase 2
ALDOC aldolase, fructose-bisphosphate C
ANGPT2 angiopoietin 2
ATP5F1A ATP synthase F1 subunit alpha
ATP5F1B ATP synthase F1 subunit beta
BNIP3 BCL2 interacting protein 3
CREBBP CREB binding protein
CCN2 cellular communication network factor 2
EDN1 endothelin 1
ENO1 enolase 1
ENO2 enolase 2
EP300 E1A binding protein p300
FLT1 fms related receptor tyrosine kinase 1
FLT4 fms related receptor tyrosine kinase 4
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GPI glucose-6-phosphate isomerase
HK1 hexokinase 1
HK2 hexokinase 2
IFNG interferon gamma
IGF1R insulin like growth factor 1 receptor
CCN1 cellular communication network factor 1
IL6 interleukin 6
LDHA lactate dehydrogenase A
LDHB lactate dehydrogenase B
NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1
NOS2 nitric oxide synthase 2
NOS3 nitric oxide synthase 3
SERPINE1 serpin family E member 1
PDHA1 pyruvate dehydrogenase E1 subunit alpha 1
PDHB pyruvate dehydrogenase E1 subunit beta
PDK1 pyruvate dehydrogenase kinase 1
PDK3 pyruvate dehydrogenase kinase 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PFKM phosphofructokinase, muscle
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PKM pyruvate kinase M1/2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
RELA RELA proto-oncogene, NF-kB subunit
SLC2A1 solute carrier family 2 member 1
TEK TEK receptor tyrosine kinase
TPI1 triosephosphate isomerase 1
USF2 upstream transcription factor 2, c-fos interacting
VEGFA vascular endothelial growth factor A
KDM2A lysine demethylase 2A
MED13L mediator complex subunit 13L
HILPDA hypoxia inducible lipid droplet associated
ERO1A endoplasmic reticulum oxidoreductase 1 alpha
EGLN1 egl-9 family hypoxia inducible factor 1
ADGRL4 adhesion G protein-coupled receptor L4
TNIP3 TNFAIP3 interacting protein 3
EGLN3 egl-9 family hypoxia inducible factor 3
MIR210HG MIR210 host gene
Symbol Function*
Angpt2 angiopoietin 2
Akt1 thymoma viral proto-oncogene 1
Akt2 thymoma viral proto-oncogene 2
Aldoa aldolase A, fructose-bisphosphate
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1
Bnip3 BCL2/adenovirus E1B interacting protein 3
Bsg basigin
Coro1a coronin, actin binding protein 1A
Crebbp CREB binding protein
Edn1 endothelin 1
Eno1 enolase 1, alpha non-neuron
Akr1b8 aldo-keto reductase family 1, member B8
Ccn2 cellular communication network factor 2
Flt1 FMS-like tyrosine kinase 1
Gapdh glyceraldehyde-3-phosphate dehydrogenase
Gpi1 glucose-6-phosphate isomerase 1
Gys1 glycogen synthase 1, muscle
Hk1 hexokinase 1
Hk2 hexokinase 2
Hmox1 heme oxygenase 1
Ccn1 cellular communication network factor 1
Ins1 insulin I
Ins2 insulin II
Insr insulin receptor
Ldha lactate dehydrogenase A
Ltbr lymphotoxin B receptor
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Nos3 nitric oxide synthase 3, endothelial cell
P4ha1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
Pdha1 pyruvate dehydrogenase E1 alpha 1
Pfkl phosphofructokinase, liver, B-type
Pgam1 phosphoglycerate mutase 1
Pgk1 phosphoglycerate kinase 1
Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Pkm pyruvate kinase, muscle
Prkcb protein kinase C, beta
Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1
Ptprb protein tyrosine phosphatase, receptor type, B
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1
Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2
Stat3 signal transducer and activator of transcription 3
Stat5a signal transducer and activator of transcription 5A
Stxbp1 syntaxin binding protein 1
Tek TEK receptor tyrosine kinase
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Timp1 tissue inhibitor of metalloproteinase 1
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a
Tpi1 triosephosphate isomerase 1
Try4 trypsin 4
Vegfa vascular endothelial growth factor A
Akt3 thymoma viral proto-oncogene 3
Map2k1 mitogen-activated protein kinase kinase 1
Ero1a endoplasmic reticulum oxidoreductase 1 alpha
Higd1a HIG1 domain family, member 1A
Pfkp phosphofructokinase, platelet
Rbx1 ring-box 1
Nampt nicotinamide phosphoribosyltransferase
Prelid1 PRELI domain containing 1
Eloc elongin C
Pdhb pyruvate dehydrogenase (lipoamide) beta
Slc16a3 solute carrier family 16 (monocarboxylic acid transporters), member 3
Snx25 sorting nexin 25
Csnk1g2 casein kinase 1, gamma 2
Mmrn2 multimerin 2
Egln1 egl-9 family hypoxia-inducible factor 1
Egln2 egl-9 family hypoxia-inducible factor 2
Egln3 egl-9 family hypoxia-inducible factor 3
Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Tnrc6b trinucleotide repeat containing 6b
Eny2 ENY2 transcription and export complex 2 subunit
Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1
Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1
Kat6a K(lysine) acetyltransferase 6A
Gm5069 glyceraldehyde-3-phosphate dehydrogenase pseudogene
Ep300 E1A binding protein p300
Symbol Function*
Aldoa aldolase, fructose-bisphosphate A
Aldoc aldolase, fructose-bisphosphate C
Edn1 endothelin 1
Eno1 enolase 1
Eno2 enolase 2
Gapdh glyceraldehyde-3-phosphate dehydrogenase
Ldha lactate dehydrogenase A
Ldhb lactate dehydrogenase B
Serpine1 serpin family E member 1
Pgam1 phosphoglycerate mutase 1
Pgk1 phosphoglycerate kinase 1
Slc2a1 solute carrier family 2 member 1
Tpi1 triosephosphate isomerase 1
Hk1 hexokinase 1
Hk2 hexokinase 2
Pfkl phosphofructokinase, liver type
Ldhc lactate dehydrogenase C
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha
Flt1 Fms related receptor tyrosine kinase 1
Stk39 serine threonine kinase 39
Egln3 egl-9 family hypoxia-inducible factor 3
Mtor mechanistic target of rapamycin kinase
Pfkp phosphofructokinase, platelet
Cabs1 calcium binding protein, spermatid associated 1
Ccn2 cellular communication network factor 2
Adgrl4 adhesion G protein-coupled receptor L4
Pi4ka phosphatidylinositol 4-kinase alpha
Pfkm phosphofructokinase, muscle
Slc16a3 solute carrier family 16 member 3
Nfkb1 nuclear factor kappa B subunit 1
Vegfa vascular endothelial growth factor A
Tek TEK receptor tyrosine kinase
Angpt2 angiopoietin 2
Pdk1 pyruvate dehydrogenase kinase 1
Mapk1 mitogen activated protein kinase 1
Eif4e eukaryotic translation initiation factor 4E
Map2k1 mitogen activated protein kinase kinase 1
Ero1a endoplasmic reticulum oxidoreductase 1 alpha
Adgrf5 adhesion G protein-coupled receptor F5
Mapkapk2 MAPK activated protein kinase 2
Gpi glucose-6-phosphate isomerase
Aldoart2 aldolase 1 A retrogene 2
Ubqln3 ubiquilin 3
Egln1 egl-9 family hypoxia-inducible factor 1
Rela RELA proto-oncogene, NF-kB subunit
Nfkb2 nuclear factor kappa B subunit 2
Ptprb protein tyrosine phosphatase, receptor type, B
Tln2 talin 2
Pgk2 phosphoglycerate kinase 2
Ifngr2 interferon gamma receptor 2
Fam162a family with sequence similarity 162, member A
Cul2 cullin 2
Ldhal6b lactate dehydrogenase A-like 6B
RGD1562690 similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M)
Mgarp mitochondria-localized glutamic acid-rich protein
Gys1 glycogen synthase 1
Relb RELB proto-oncogene, NF-kB subunit
Symbol Function*
FLT1 fms related receptor tyrosine kinase 1
PDHB pyruvate dehydrogenase E1 subunit beta
GAPDH glyceraldehyde-3-phosphate dehydrogenase
ATP6V0A1 ATPase H+ transporting V0 subunit a1
CDH5 cadherin 5
LDHC lactate dehydrogenase C
NPEPPS aminopeptidase puromycin sensitive
LDHA lactate dehydrogenase A
CYBB cytochrome b-245 beta chain
LOC696959 phosphoglycerate mutase 1
ANGPT1 angiopoietin 1
PKM pyruvate kinase M1/2
UQCRC2 ubiquinol-cytochrome c reductase core protein II
EGF epidermal growth factor
IFNGR2 interferon gamma receptor 2
C1H1orf159 chromosome 1 C1orf159 homolog
CAMK2D calcium/calmodulin dependent protein kinase II delta
EGLN2 egl-9 family hypoxia inducible factor 2
CREBBP CREB binding protein
COQ9 coenzyme Q9
HIF1A hypoxia inducible factor 1 subunit alpha
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
INSR insulin receptor
PGAM1 phosphoglycerate mutase 1
EP300 E1A binding protein p300
PGK1 phosphoglycerate kinase 1
TEK TEK receptor tyrosine kinase
PFKM phosphofructokinase, muscle
IGF1R insulin like growth factor 1 receptor
ALDOA aldolase, fructose-bisphosphate A
IL17RA interleukin 17 receptor A
RABL6 RAB, member RAS oncogene family like 6
ALDOC aldolase, fructose-bisphosphate C
ENO1 enolase 1
NFKB1 nuclear factor kappa B subunit 1
MAP2K1 mitogen-activated protein kinase kinase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
TPI1 triosephosphate isomerase 1
RELB RELB proto-oncogene, NF-kB subunit
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
LIMK2 LIM domain kinase 2
IL6R interleukin 6 receptor
KANSL1 KAT8 regulatory NSL complex subunit 1
TNRC18 trinucleotide repeat containing 18
CHMP6 charged multivesicular body protein 6
BRPF3 bromodomain and PHD finger containing 3
HMOX1 heme oxygenase 1
PIK3R2 phosphoinositide-3-kinase regulatory subunit 2
ZGPAT zinc finger CCCH-type and G-patch domain containing
ARID1A AT-rich interaction domain 1A
RPS6KB2 ribosomal protein S6 kinase B2
MAP2K2 mitogen-activated protein kinase kinase 2
PFKL phosphofructokinase, liver type
PFKP phosphofructokinase, platelet
IFNGR1 interferon gamma receptor 1
PDHA1 pyruvate dehydrogenase E1 subunit alpha 1
C12H2orf88 chromosome 12 C2orf88 homolog
EGLN2 egl-9 family hypoxia inducible factor 2
Symbol Function*
EDN1 endothelin 1
SERPINE1 serpin family E member 1
TNFRSF1A TNF receptor superfamily member 1A
TEK TEK receptor tyrosine kinase
GAPDH glyceraldehyde-3-phosphate dehydrogenase
VEGFA vascular endothelial growth factor A
PKM pyruvate kinase M1/2
EGFR epidermal growth factor receptor
IGF1R insulin like growth factor 1 receptor
RBX1 ring-box 1
BICRAL BRD4 interacting chromatin remodeling complex associated protein like
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ANKRD37 ankyrin repeat domain 37
CCN2 cellular communication network factor 2
PDK1 pyruvate dehydrogenase kinase 1
LDHA lactate dehydrogenase A
TAF4 TATA-box binding protein associated factor 4
LDHB lactate dehydrogenase B
TPI1 triosephosphate isomerase 1
PGAM1 phosphoglycerate mutase 1
CUL2 cullin 2
PFKP phosphofructokinase, platelet
FAM162A family with sequence similarity 162 member A
HK1 hexokinase 1
POLR2A RNA polymerase II subunit A
ENO1 enolase 1
ALDOA aldolase, fructose-bisphosphate A
CREBBP CREB binding protein
ELOB elongin B
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
ENOSF1 enolase superfamily member 1
EGLN3 egl-9 family hypoxia inducible factor 3
ALDOC aldolase, fructose-bisphosphate C
PGK1 phosphoglycerate kinase 1
SLC2A1 solute carrier family 2 member 1
MKNK1 MAPK interacting serine/threonine kinase 1
SLC16A3 solute carrier family 16 member 3
RELA RELA proto-oncogene, NF-kB subunit
FKBP8 FKBP prolyl isomerase 8
INSR insulin receptor
RHOG ras homolog family member G
PXN paxillin
STRAP serine/threonine kinase receptor associated protein
LTBR lymphotoxin beta receptor
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
ARID1A AT-rich interaction domain 1A
PFKL phosphofructokinase, liver type
OSMR oncostatin M receptor
MAPKAPK2 MAPK activated protein kinase 2
AKT1 AKT serine/threonine kinase 1
STAT3 signal transducer and activator of transcription 3
BNIP3 BCL2 interacting protein 3
ANGPT2 angiopoietin 2
BNIP3L BCL2 interacting protein 3 like
EMCN endomucin
PIK3R2 phosphoinositide-3-kinase regulatory subunit 2
LONP1 lon peptidase 1, mitochondrial
MAP2K2 mitogen-activated protein kinase kinase 2
GPI glucose-6-phosphate isomerase
EP300 E1A binding protein p300
SPEN spen family transcriptional repressor
PRKCG protein kinase C gamma
IFNGR1 interferon gamma receptor 1
HK2 hexokinase 2
LOC102151128 nucleoside diphosphate kinase, mitochondrial-like
LOC119881520 phosphoglycolate phosphatase
Symbol Function*
TLR4 toll like receptor 4
GAPDH glyceraldehyde-3-phosphate dehydrogenase
BCL2 BCL2 apoptosis regulator
EDN1 endothelin 1
CS citrate synthase
SLC2A1 solute carrier family 2 member 1
SERPINE1 serpin family E member 1
INSR insulin receptor
AKT2 AKT serine/threonine kinase 2
ELOC elongin C
EIF4E eukaryotic translation initiation factor 4E
TMEM38A transmembrane protein 38A
LTBR lymphotoxin beta receptor
LOC101081229 pyruvate kinase PKM
MAP2K1 mitogen-activated protein kinase kinase 1
PITPNM1 phosphatidylinositol transfer protein membrane associated 1
GYG1 glycogenin 1
EGLN3 egl-9 family hypoxia inducible factor 3
RTN2 reticulon 2
ATP8B4 ATPase phospholipid transporting 8B4 (putative)
CAMK2A calcium/calmodulin dependent protein kinase II alpha
KMT2E lysine methyltransferase 2E (inactive)
LOC101085148 serotransferrin
TPI1 triosephosphate isomerase 1
CYBB cytochrome b-245 beta chain
PGK1 phosphoglycerate kinase 1
LOC101087599 inhibitor of carbonic anhydrase-like
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
DCP1A decapping mRNA 1A
EP300 E1A binding protein p300
PFKM phosphofructokinase, muscle
PFKL phosphofructokinase, liver type
STAT5A signal transducer and activator of transcription 5A
ARID1B AT-rich interaction domain 1B
ENO3 enolase 3
TEK TEK receptor tyrosine kinase
LDHB lactate dehydrogenase B
PDK1 pyruvate dehydrogenase kinase 1
ENO1 enolase 1
FZD4 frizzled class receptor 4
ITGA5 integrin subunit alpha 5
CREBBP CREB binding protein
ANK1 ankyrin 1
NRBP1 nuclear receptor binding protein 1
LOC101097072 ATP-dependent 6-phosphofructokinase, platelet type
MTOR mechanistic target of rapamycin kinase
MTMR1 myotubularin related protein 1
HK1 hexokinase 1
CAMK2B calcium/calmodulin dependent protein kinase II beta
PGAM1 phosphoglycerate mutase 1
EIF4E2 eukaryotic translation initiation factor 4E family member 2
POMP proteasome maturation protein
LDHA lactate dehydrogenase A
ALDOA aldolase, fructose-bisphosphate A
GPATCH8 G-patch domain containing 8
LOC102900930 uncharacterized LOC102900930
MAFF MAF bZIP transcription factor F
LOC111556765 uncharacterized LOC111556765
PFKP phosphofructokinase, platelet


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