COXPRESdb : GeneID search result

[←][→] fca MAP2K2 Gene

functional annotation

Function

mitogen-activated protein kinase kinase 2

GO BP

GO CC

GO MF

KEGG

fca01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (80 genes)

fca01522 [list] [network] Endocrine resistance (96 genes)

fca04010 [list] [network] MAPK signaling pathway (289 genes)

fca04012 [list] [network] ErbB signaling pathway (84 genes)

fca04014 [list] [network] Ras signaling pathway (231 genes)

fca04015 [list] [network] Rap1 signaling pathway (215 genes)

fca04022 [list] [network] cGMP-PKG signaling pathway (169 genes)

fca04024 [list] [network] cAMP signaling pathway (222 genes)

fca04066 [list] [network] HIF-1 signaling pathway (116 genes)

fca04068 [list] [network] FoxO signaling pathway (129 genes)

fca04071 [list] [network] Sphingolipid signaling pathway (122 genes)

fca04072 [list] [network] Phospholipase D signaling pathway (151 genes)

fca04140 [list] [network] Autophagy - animal (151 genes)

fca04150 [list] [network] mTOR signaling pathway (155 genes)

fca04151 [list] [network] PI3K-Akt signaling pathway (344 genes)

fca04210 [list] [network] Apoptosis (145 genes)

fca04218 [list] [network] Cellular senescence (159 genes)

fca04270 [list] [network] Vascular smooth muscle contraction (134 genes)

fca04370 [list] [network] VEGF signaling pathway (57 genes)

fca04371 [list] [network] Apelin signaling pathway (142 genes)

fca04540 [list] [network] Gap junction (86 genes)

fca04550 [list] [network] Signaling pathways regulating pluripotency of stem cells (143 genes)

fca04613 [list] [network] Neutrophil extracellular trap formation (182 genes)

fca04620 [list] [network] Toll-like receptor signaling pathway (95 genes)

fca04650 [list] [network] Natural killer cell mediated cytotoxicity (98 genes)

fca04660 [list] [network] T cell receptor signaling pathway (103 genes)

fca04662 [list] [network] B cell receptor signaling pathway (74 genes)

fca04664 [list] [network] Fc epsilon RI signaling pathway (69 genes)

fca04720 [list] [network] Long-term potentiation (68 genes)

fca04722 [list] [network] Neurotrophin signaling pathway (121 genes)

fca04730 [list] [network] Long-term depression (59 genes)

fca04810 [list] [network] Regulation of actin cytoskeleton (219 genes)

fca04910 [list] [network] Insulin signaling pathway (140 genes)

fca04912 [list] [network] GnRH signaling pathway (93 genes)

fca04915 [list] [network] Estrogen signaling pathway (139 genes)

fca04916 [list] [network] Melanogenesis (102 genes)

fca04917 [list] [network] Prolactin signaling pathway (71 genes)

fca04919 [list] [network] Thyroid hormone signaling pathway (123 genes)

fca04921 [list] [network] Oxytocin signaling pathway (152 genes)

fca04926 [list] [network] Relaxin signaling pathway (129 genes)

fca04929 [list] [network] GnRH secretion (64 genes)

fca04934 [list] [network] Cushing syndrome (154 genes)

fca04935 [list] [network] Growth hormone synthesis, secretion and action (117 genes)

fca05010 [list] [network] Alzheimer disease (390 genes)

fca05022 [list] [network] Pathways of neurodegeneration - multiple diseases (480 genes)

fca05132 [list] [network] Salmonella infection (253 genes)

fca05135 [list] [network] Yersinia infection (136 genes)

fca05160 [list] [network] Hepatitis C (153 genes)

fca05161 [list] [network] Hepatitis B (157 genes)

fca05163 [list] [network] Human cytomegalovirus infection (225 genes)

fca05164 [list] [network] Influenza A (169 genes)

fca05165 [list] [network] Human papillomavirus infection (328 genes)

fca05166 [list] [network] Human T-cell leukemia virus 1 infection (233 genes)

fca05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (195 genes)

fca05170 [list] [network] Human immunodeficiency virus 1 infection (211 genes)

fca05200 [list] [network] Pathways in cancer (531 genes)

fca05205 [list] [network] Proteoglycans in cancer (212 genes)

fca05206 [list] [network] MicroRNAs in cancer (161 genes)

fca05207 [list] [network] Chemical carcinogenesis - receptor activation (181 genes)

fca05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (224 genes)

fca05210 [list] [network] Colorectal cancer (89 genes)

fca05211 [list] [network] Renal cell carcinoma (70 genes)

fca05213 [list] [network] Endometrial cancer (57 genes)

fca05214 [list] [network] Glioma (76 genes)

fca05215 [list] [network] Prostate cancer (95 genes)

fca05216 [list] [network] Thyroid cancer (37 genes)

fca05218 [list] [network] Melanoma (71 genes)

fca05219 [list] [network] Bladder cancer (41 genes)

fca05220 [list] [network] Chronic myeloid leukemia (75 genes)

fca05221 [list] [network] Acute myeloid leukemia (67 genes)

fca05223 [list] [network] Non-small cell lung cancer (72 genes)

fca05224 [list] [network] Breast cancer (146 genes)

fca05225 [list] [network] Hepatocellular carcinoma (163 genes)

fca05226 [list] [network] Gastric cancer (147 genes)

fca05230 [list] [network] Central carbon metabolism in cancer (70 genes)

fca05231 [list] [network] Choline metabolism in cancer (97 genes)

fca05235 [list] [network] PD-L1 expression and PD-1 checkpoint pathway in cancer (89 genes)

Protein

XP_023099673.1 XP_023099675.1 XP_023099682.1 XP_023099685.1

BLAST

XP_023099673.1 XP_023099675.1 XP_023099682.1 XP_023099685.1

Orthologous

[Ortholog page] MAP2K1 (hsa) MAP2K2 (hsa) Map2k1 (mmu) Map2k2 (mmu) Dsor1 (dme) Map2k2 (rno) Map2k1 (rno) mek-2 (cel) MAP2K2 (gga) map2k1 (dre) MAP2K1 (gga) MAP2K1 (cfa) map2k2a (dre) MAP2K2 (cfa) MAP2K1 (mcc) MAP2K2 (mcc) PBS2 (sce) pab2 (spo) map2k2b (dre) MAP2K1 (fca)

Subcellular
localization
wolf

mito 5, cyto_mito 3, mito_pero 3, nucl 3, cyto_nucl 2, cyto 1	(predict for XP_023099673.1)
mito 7, cyto_mito 4, cyto 2, cyto_nucl 1	(predict for XP_023099675.1)
mito 5, cyto_mito 3, mito_pero 3, extr 2, nucl 2, cyto_nucl 2	(predict for XP_023099682.1)
mito 5, cyto_mito 4, cyto_nucl 2, cyto 2, extr 2	(predict for XP_023099685.1)

Gene coexpression

Network^*for
coexpressed
genes

[Cytoscape]

KEGG^* ID	Title	#genes	Link to the KEGG^* map (Multiple genes)
fca05010	Alzheimer disease	2
fca05022	Pathways of neurodegeneration - multiple diseases	2
fca04015	Rap1 signaling pathway	2
fca04722	Neurotrophin signaling pathway	2
fca04910	Insulin signaling pathway	2

Genes directly connected with MAP2K2 on the network
coex z^*	Locus	Function^*	Coexpression detail	Entrez Gene ID^*
6.9	SGTA	small glutamine rich tetratricopeptide repeat co-chaperone alpha	[detail]	101082292
6.8	GGA1	golgi associated, gamma adaptin ear containing, ARF binding protein 1	[detail]	101093371
6.5	FLII	FLII actin remodeling protein	[detail]	101099846
6.3	NUDCD3	NudC domain containing 3	[detail]	111559463
6.2	ZDHHC7	zinc finger DHHC-type palmitoyltransferase 7	[detail]	101083311
6.0	MRPL54	mitochondrial ribosomal protein L54	[detail]	101098520
6.0	DCAF11	DDB1 and CUL4 associated factor 11	[detail]	101099129
5.6	DPP9	dipeptidyl peptidase 9	[detail]	101091347
5.3	RAPGEF1	Rap guanine nucleotide exchange factor 1	[detail]	101099507
4.3	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	[detail]	101089330

Coexpressed
gene list

[Coexpressed gene list for MAP2K2]

Gene expression

All samples

[Expression pattern for all samples]

Tissue specificity^*

Link to other DBs
Entrez Gene ID	101100281
Refseq ID (protein)	XP_023099673.1
	XP_023099675.1
	XP_023099682.1
	XP_023099685.1

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