KEGG 05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
[list]

Species hsa(Human) mmu(Mouse) rno(Rat) mcc(Monkey) cfa(Dog) fca(Domestic cat)
UMAP
Representative coexpressed gene network LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 35
hsa04660 T cell receptor signaling pathway 29
hsa04659 Th17 cell differentiation 24
hsa04658 Th1 and Th2 cell differentiation 23
hsa05170 Human immunodeficiency virus 1 infection 22
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 43
mmu04660 T cell receptor signaling pathway 37
mmu05170 Human immunodeficiency virus 1 infection 30
mmu04659 Th17 cell differentiation 28
mmu05135 Yersinia infection 27
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 42
rno04660 T cell receptor signaling pathway 34
rno05170 Human immunodeficiency virus 1 infection 30
rno04659 Th17 cell differentiation 29
rno04658 Th1 and Th2 cell differentiation 27
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mcc05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 45
mcc04660 T cell receptor signaling pathway 37
mcc04659 Th17 cell differentiation 31
mcc04658 Th1 and Th2 cell differentiation 30
mcc05170 Human immunodeficiency virus 1 infection 27
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
cfa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 37
cfa04660 T cell receptor signaling pathway 24
cfa05169 Epstein-Barr virus infection 22
cfa05161 Hepatitis B 21
cfa05162 Measles 21
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
fca05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 35
fca04660 T cell receptor signaling pathway 23
fca05170 Human immunodeficiency virus 1 infection 22
fca04658 Th1 and Th2 cell differentiation 20
fca04659 Th17 cell differentiation 20
Gene list in the network
Symbol Function*
AKT2 AKT serine/threonine kinase 2
CD2 CD2 molecule
CD3D CD3d molecule
CD3E CD3e molecule
CD3G CD3g molecule
CD247 CD247 molecule
CD5 CD5 molecule
CD28 CD28 molecule
MAPK14 mitogen-activated protein kinase 14
DUSP1 dual specificity phosphatase 1
FOS Fos proto-oncogene, AP-1 transcription factor subunit
FOSB FosB proto-oncogene, AP-1 transcription factor subunit
MTOR mechanistic target of rapamycin kinase
IL2RG interleukin 2 receptor subunit gamma
ITPR3 inositol 1,4,5-trisphosphate receptor type 3
JAK1 Janus kinase 1
JUN Jun proto-oncogene, AP-1 transcription factor subunit
LCK LCK proto-oncogene, Src family tyrosine kinase
SH2D1A SH2 domain containing 1A
MAP3K3 mitogen-activated protein kinase kinase kinase 3
NFATC1 nuclear factor of activated T cells 1
NFATC2 nuclear factor of activated T cells 2
NFKB1 nuclear factor kappa B subunit 1
NFKB2 nuclear factor kappa B subunit 2
NFKBIA NFKB inhibitor alpha
NFKBIB NFKB inhibitor beta
NFKBIE NFKB inhibitor epsilon
PDCD1 programmed cell death 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
PLCG1 phospholipase C gamma 1
PRKCQ protein kinase C theta
MAPK11 mitogen-activated protein kinase 11
MAPK13 mitogen-activated protein kinase 13
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
PTPN6 protein tyrosine phosphatase non-receptor type 6
PTPN7 protein tyrosine phosphatase non-receptor type 7
PTPN11 protein tyrosine phosphatase non-receptor type 11
RELA RELA proto-oncogene, NF-kB subunit
RELB RELB proto-oncogene, NF-kB subunit
RPS6KA1 ribosomal protein S6 kinase A1
MAPK12 mitogen-activated protein kinase 12
USF2 upstream transcription factor 2, c-fos interacting
ZAP70 zeta chain of T cell receptor associated protein kinase 70
CD83 CD83 molecule
GRAP2 GRB2 related adaptor protein 2
KIAA0100 KIAA0100
RASGRP1 RAS guanyl releasing protein 1
BATF basic leucine zipper ATF-like transcription factor
EHD1 EH domain containing 1
TBC1D2B TBC1 domain family member 2B
TRAT1 T cell receptor associated transmembrane adaptor 1
VPS13D vacuolar protein sorting 13 homolog D
SIRPG signal regulatory protein gamma
TICAM1 toll like receptor adaptor molecule 1
THEMIS thymocyte selection associated
LINC00861 long intergenic non-protein coding RNA 861
Symbol Function*
Akt1 thymoma viral proto-oncogene 1
Akt2 thymoma viral proto-oncogene 2
Atf3 activating transcription factor 3
Bcl3 B cell leukemia/lymphoma 3
Cd2 CD2 antigen
Cd28 CD28 antigen
Cd3d CD3 antigen, delta polypeptide
Cd3e CD3 antigen, epsilon polypeptide
Cd3g CD3 antigen, gamma polypeptide
Cd247 CD247 antigen
Cd4 CD4 antigen
Cd5 CD5 antigen
Cd6 CD6 antigen
Cd8a CD8 antigen, alpha chain
Cd8b1 CD8 antigen, beta chain 1
Fos FBJ osteosarcoma oncogene
Ptpn6 protein tyrosine phosphatase, non-receptor type 6
Hras Harvey rat sarcoma virus oncogene
Icam1 intercellular adhesion molecule 1
Ikbkg inhibitor of kappaB kinase gamma
Itk IL2 inducible T cell kinase
Jak2 Janus kinase 2
Jun jun proto-oncogene
Lat linker for activation of T cells
Lck lymphocyte protein tyrosine kinase
Sh2b3 SH2B adaptor protein 3
Mbd3 methyl-CpG binding domain protein 3
Myd88 myeloid differentiation primary response gene 88
Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
Nfkbie nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
Pdcd1 programmed cell death 1
Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Prkcq protein kinase C, theta
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Mapk11 mitogen-activated protein kinase 11
Ptpn1 protein tyrosine phosphatase, non-receptor type 1
Dusp1 dual specificity phosphatase 1
Rac2 Rac family small GTPase 2
Rasgrp1 RAS guanyl releasing protein 1
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B
Sh2d1a SH2 domain containing 1A
Stat3 signal transducer and activator of transcription 3
Stat5a signal transducer and activator of transcription 5A
Thy1 thymus cell antigen 1, theta
Tnfaip3 tumor necrosis factor, alpha-induced protein 3
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a
Cd27 CD27 antigen
Traf6 TNF receptor-associated factor 6
Zap70 zeta-chain (TCR) associated protein kinase
Tlr2 toll-like receptor 2
Map2k2 mitogen-activated protein kinase kinase 2
Map3k3 mitogen-activated protein kinase kinase kinase 3
Mapk1 mitogen-activated protein kinase 1
Mapk14 mitogen-activated protein kinase 14
Sh2d2a SH2 domain containing 2A
Mapk12 mitogen-activated protein kinase 12
Batf basic leucine zipper transcription factor, ATF-like
Mtch1 mitochondrial carrier 1
Bcl11b B cell leukemia/lymphoma 11B
Gpalpp1 GPALPP motifs containing 1
Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
Cxcr6 chemokine (C-X-C motif) receptor 6
Tlr9 toll-like receptor 9
Cd96 CD96 antigen
Csnk1g2 casein kinase 1, gamma 2
Pld4 phospholipase D family, member 4
Hdac10 histone deacetylase 10
Ticam2 toll-like receptor adaptor molecule 2
Gstp3 glutathione S-transferase pi 3
Arhgap30 Rho GTPase activating protein 30
Ubash3a ubiquitin associated and SH3 domain containing, A
Symbol Function*
Jak2 Janus kinase 2
Jun Jun proto-oncogene, AP-1 transcription factor subunit
Nras NRAS proto-oncogene, GTPase
Ppp3ca protein phosphatase 3 catalytic subunit alpha
Ppp3cb protein phosphatase 3 catalytic subunit beta
Cd8b CD8b molecule
Cd4 Cd4 molecule
Camk4 calcium/calmodulin-dependent protein kinase IV
Stat3 signal transducer and activator of transcription 3
Cd247 Cd247 molecule
Atf3 activating transcription factor 3
Nfkbia NFKB inhibitor alpha
Cd28 Cd28 molecule
Cd3d CD3d molecule
Cd6 Cd6 molecule
Cd69 Cd69 molecule
Rasgrp1 RAS guanyl releasing protein 1
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha
Cd5 Cd5 molecule
Map2k2 mitogen activated protein kinase kinase 2
Mapk12 mitogen-activated protein kinase 12
Batf3 basic leucine zipper ATF-like transcription factor 3
Mtpn myotrophin
Zfp36 zinc finger protein 36
Lat linker for activation of T cells
Nfkb1 nuclear factor kappa B subunit 1
Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta
Cxcr3 C-X-C motif chemokine receptor 3
Map2k6 mitogen-activated protein kinase kinase 6
Mllt3 MLLT3, super elongation complex subunit
Ifngr1 interferon gamma receptor 1
Csnk2a1 casein kinase 2 alpha 1
Mapk1 mitogen activated protein kinase 1
Ptpn6 protein tyrosine phosphatase, non-receptor type 6
Map2k1 mitogen activated protein kinase kinase 1
Skap1 src kinase associated phosphoprotein 1
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Mapkapk2 MAPK activated protein kinase 2
Hras HRas proto-oncogene, GTPase
Ctsw cathepsin W
Calhm6 calcium homeostasis modulator family member 6
Abhd17a abhydrolase domain containing 17A, depalmitoylase
Cd3g CD3g molecule
Myd88 MYD88, innate immune signal transduction adaptor
Zap70 zeta chain of T cell receptor associated protein kinase 70
Aff1 AF4/FMR2 family, member 1
Ripk1 receptor interacting serine/threonine kinase 1
Rela RELA proto-oncogene, NF-kB subunit
Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Nfkb2 nuclear factor kappa B subunit 2
Tlr2 toll-like receptor 2
Sh2d2a SH2 domain containing 2A
Traf6 TNF receptor associated factor 6
Dusp2 dual specificity phosphatase 2
Lck LCK proto-oncogene, Src family tyrosine kinase
Fos Fos proto-oncogene, AP-1 transcription factor subunit
Rin3 Ras and Rab interactor 3
Cd3e CD3e molecule
Nfkbie NFKB inhibitor epsilon
Ifngr2 interferon gamma receptor 2
Nfatc3 nuclear factor of activated T-cells 3
Itk IL2-inducible T-cell kinase
Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Capza2 capping actin protein of muscle Z-line subunit alpha 2
Ier2 immediate early response 2
Cd2 Cd2 molecule
Lax1 lymphocyte transmembrane adaptor 1
Arhgap30 Rho GTPase activating protein 30
Ptprcap protein tyrosine phosphatase, receptor type, C-associated protein
Gimap7 GTPase, IMAP family member 7
Cd27 CD27 molecule
Sit1 signaling threshold regulating transmembrane adaptor 1
Ddx6 DEAD-box helicase 6
Ebi3 Epstein-Barr virus induced 3
Mapk11 mitogen-activated protein kinase 11
Relb RELB proto-oncogene, NF-kB subunit
Nfatc1 nuclear factor of activated T-cells 1
LOC102554317 uncharacterized LOC102554317
Symbol Function*
FYN FYN proto-oncogene, Src family tyrosine kinase
GTF2I general transcription factor IIi
TLR2 toll like receptor 2
TICAM1 toll like receptor adaptor molecule 1
TLR4 toll like receptor 4
JAK1 Janus kinase 1
CD2 CD2 molecule
STAT1 signal transducer and activator of transcription 1
HIPK3 homeodomain interacting protein kinase 3
LOC694538 guanylate-binding protein 1
NFKBIB NFKB inhibitor beta
CD6 CD6 molecule
NFKBIA NFKB inhibitor alpha
LOC696306 T cell receptor beta variable 3-1
SKAP1 src kinase associated phosphoprotein 1
CD247 CD247 molecule
NFATC1 nuclear factor of activated T cells 1
MAPK1 mitogen-activated protein kinase 1
SCML4 Scm polycomb group protein like 4
LOC698785 uncharacterized LOC698785
CD3E CD3e molecule
IFNGR2 interferon gamma receptor 2
CD3D CD3d molecule
AKT2 AKT serine/threonine kinase 2
PSD4 pleckstrin and Sec7 domain containing 4
FOS Fos proto-oncogene, AP-1 transcription factor subunit
NFATC3 nuclear factor of activated T cells 3
NFKBIE NFKB inhibitor epsilon
DUSP1 dual specificity phosphatase 1
LOC703029 immunoglobulin lambda-1 light chain-like
PCBP2 poly(rC) binding protein 2
RASGRP1 RAS guanyl releasing protein 1
LAT linker for activation of T cells
HIF1A hypoxia inducible factor 1 subunit alpha
IKBKB inhibitor of nuclear factor kappa B kinase subunit beta
PTEN phosphatase and tensin homolog
CD3G CD3g molecule
CD28 CD28 molecule
ICOS inducible T cell costimulator
ZAP70 zeta chain of T cell receptor associated protein kinase 70
ITM2A integral membrane protein 2A
PPP3CA protein phosphatase 3 catalytic subunit alpha
NFKB1 nuclear factor kappa B subunit 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
NFATC2 nuclear factor of activated T cells 2
KLF6 Kruppel like factor 6
CSNK2A2 casein kinase 2 alpha 2
PTPN6 protein tyrosine phosphatase non-receptor type 6
RELB RELB proto-oncogene, NF-kB subunit
LOC714689 nuclear factor NF-kappa-B p100 subunit
ITK IL2 inducible T cell kinase
MAPK12 mitogen-activated protein kinase 12
MAPK11 mitogen-activated protein kinase 11
FOSB FosB proto-oncogene, AP-1 transcription factor subunit
RELA RELA proto-oncogene, NF-kB subunit
LOC716034 signal-regulatory protein gamma
MAP3K11 mitogen-activated protein kinase kinase kinase 11
CD274 CD274 molecule
JUN Jun proto-oncogene, AP-1 transcription factor subunit
CLEC2D C-type lectin domain family 2 member D
LCK LCK proto-oncogene, Src family tyrosine kinase
IRAK3 interleukin 1 receptor associated kinase 3
PPP1R15A protein phosphatase 1 regulatory subunit 15A
CHMP6 charged multivesicular body protein 6
RAB6A RAB6A, member RAS oncogene family
MAPK14 mitogen-activated protein kinase 14
FLT3LG fms related receptor tyrosine kinase 3 ligand
CD7 CD7 molecule
RPS6KB2 ribosomal protein S6 kinase B2
MAP2K2 mitogen-activated protein kinase kinase 2
UBASH3A ubiquitin associated and SH3 domain containing A
PRKCQ protein kinase C theta
PDCD1 programmed cell death 1
LOC100424766 uncharacterized LOC100424766
LOC106999340 immunoglobulin kappa light chain
LOC106999345 T cell receptor alpha variable 26-1-like
LOC107000845 uncharacterized LOC107000845
LOC114677059 uncharacterized LOC114677059
Symbol Function*
TLR4 toll like receptor 4
CD28 CD28 molecule
EGFR epidermal growth factor receptor
NFKB1 nuclear factor kappa B subunit 1
JAK1 Janus kinase 1
CD3E CD3e molecule
TLR2 toll like receptor 2
MYD88 MYD88 innate immune signal transduction adaptor
PRKCQ protein kinase C theta
RBL2 RB transcriptional corepressor like 2
LCK LCK proto-oncogene, Src family tyrosine kinase
TRAT1 T cell receptor associated transmembrane adaptor 1
CD3D CD3d molecule
NFKBIA NFKB inhibitor alpha
MAP3K3 mitogen-activated protein kinase kinase kinase 3
SKAP1 src kinase associated phosphoprotein 1
RELA RELA proto-oncogene, NF-kB subunit
DPF2 double PHD fingers 2
NFATC1 nuclear factor of activated T cells 1
JAK2 Janus kinase 2
CD274 CD274 molecule
RIC1 RIC1 homolog, RAB6A GEF complex partner 1
SYK spleen associated tyrosine kinase
CD37 CD37 molecule
RELB RELB proto-oncogene, NF-kB subunit
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
FKBP8 FKBP prolyl isomerase 8
NCLN nicalin
RHOG ras homolog family member G
GPR171 G protein-coupled receptor 171
PTPN6 protein tyrosine phosphatase non-receptor type 6
NFKB2 nuclear factor kappa B subunit 2
PIK3R1 phosphoinositide-3-kinase regulatory subunit 1
UBASH3A ubiquitin associated and SH3 domain containing A
STAT1 signal transducer and activator of transcription 1
TBC1D2B TBC1 domain family member 2B
ITK IL2 inducible T cell kinase
OSMR oncostatin M receptor
CD3G CD3g molecule
TNFRSF25 TNF receptor superfamily member 25
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
SEPTIN1 septin 1
KCNA3 potassium voltage-gated channel subfamily A member 3
MAPKAPK2 MAPK activated protein kinase 2
FOS Fos proto-oncogene, AP-1 transcription factor subunit
AKT1 AKT serine/threonine kinase 1
STAT3 signal transducer and activator of transcription 3
CCR7 C-C motif chemokine receptor 7
CD2 CD2 molecule
CD7 CD7 molecule
LOC607937 T cell receptor alpha variable 9-2
LAT linker for activation of T cells
JUN Jun proto-oncogene, AP-1 transcription factor subunit
PIK3R2 phosphoinositide-3-kinase regulatory subunit 2
CHERP calcium homeostasis endoplasmic reticulum protein
CD247 CD247 molecule
CD27 CD27 molecule
TICAM1 toll like receptor adaptor molecule 1
MAP2K2 mitogen-activated protein kinase kinase 2
BATF basic leucine zipper ATF-like transcription factor
IL7R interleukin 7 receptor
SH2D1A SH2 domain containing 1A
ZAP70 zeta chain of T cell receptor associated protein kinase 70
CAMK4 calcium/calmodulin dependent protein kinase IV
TRAF6 TNF receptor associated factor 6
ADAR adenosine deaminase RNA specific
IFNGR1 interferon gamma receptor 1
NFKBIE NFKB inhibitor epsilon
LOC111097892 uncharacterized LOC111097892
LOC119871549 uncharacterized LOC119871549
PLEKHM1 pleckstrin homology and RUN domain containing M1
Symbol Function*
TLR4 toll like receptor 4
CD4 CD4 molecule
TLR2 toll like receptor 2
FOS Fos proto-oncogene, AP-1 transcription factor subunit
HRAS HRas proto-oncogene, GTPase
CD274 CD274 molecule
PDCD1 programmed cell death 1
NFATC2 nuclear factor of activated T cells 2
CD247 CD247 molecule
MAP2K1 mitogen-activated protein kinase kinase 1
LOC101081599 cytokine SCM-1 beta
MAP2K3 mitogen-activated protein kinase kinase 3
TICAM1 toll like receptor adaptor molecule 1
CD3D CD3d molecule
MAP3K3 mitogen-activated protein kinase kinase kinase 3
NFATC3 nuclear factor of activated T cells 3
JAK1 Janus kinase 1
STAT1 signal transducer and activator of transcription 1
SEPTIN1 septin 1
IFNGR1 interferon gamma receptor 1
PPP3CB protein phosphatase 3 catalytic subunit beta
MAPK1 mitogen-activated protein kinase 1
CSNK2B casein kinase 2 beta
CD3G CD3g molecule
CARMIL2 capping protein regulator and myosin 1 linker 2
LOC101090324 TIR domain-containing adapter molecule 2
PPP3R1 protein phosphatase 3 regulatory subunit B, alpha
MAPKAPK2 MAPK activated protein kinase 2
RASGRP1 RAS guanyl releasing protein 1
IRAK3 interleukin 1 receptor associated kinase 3
LAT linker for activation of T cells
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
FOSB FosB proto-oncogene, AP-1 transcription factor subunit
PSMD8 proteasome 26S subunit, non-ATPase 8
LIME1 Lck interacting transmembrane adaptor 1
SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
ZAP70 zeta chain of T cell receptor associated protein kinase 70
PPP3CA protein phosphatase 3 catalytic subunit alpha
JUN Jun proto-oncogene, AP-1 transcription factor subunit
RBL2 RB transcriptional corepressor like 2
MTMR1 myotubularin related protein 1
STK10 serine/threonine kinase 10
LCK LCK proto-oncogene, Src family tyrosine kinase
STAT2 signal transducer and activator of transcription 2
NFKBIB NFKB inhibitor beta
TRAF6 TNF receptor associated factor 6
HLX H2.0 like homeobox
NFATC1 nuclear factor of activated T cells 1
LOC102899105 uncharacterized LOC102899105


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