COXPRESdb : GeneID search result

[←][→] mcc MAP2K1 Gene

functional annotation

Function

mitogen-activated protein kinase kinase 1

GO BP

GO CC

GO MF

KEGG

mcc01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)

mcc01522 [list] [network] Endocrine resistance (98 genes)

mcc04010 [list] [network] MAPK signaling pathway (301 genes)

mcc04012 [list] [network] ErbB signaling pathway (85 genes)

mcc04014 [list] [network] Ras signaling pathway (250 genes)

mcc04015 [list] [network] Rap1 signaling pathway (229 genes)

mcc04022 [list] [network] cGMP-PKG signaling pathway (169 genes)

mcc04024 [list] [network] cAMP signaling pathway (226 genes)

mcc04062 [list] [network] Chemokine signaling pathway (200 genes)

mcc04066 [list] [network] HIF-1 signaling pathway (119 genes)

mcc04068 [list] [network] FoxO signaling pathway (131 genes)

mcc04071 [list] [network] Sphingolipid signaling pathway (120 genes)

mcc04072 [list] [network] Phospholipase D signaling pathway (168 genes)

mcc04114 [list] [network] Oocyte meiosis (126 genes)

mcc04140 [list] [network] Autophagy - animal (147 genes)

mcc04150 [list] [network] mTOR signaling pathway (155 genes)

mcc04151 [list] [network] PI3K-Akt signaling pathway (381 genes)

mcc04210 [list] [network] Apoptosis (150 genes)

mcc04218 [list] [network] Cellular senescence (174 genes)

mcc04270 [list] [network] Vascular smooth muscle contraction (142 genes)

mcc04370 [list] [network] VEGF signaling pathway (58 genes)

mcc04371 [list] [network] Apelin signaling pathway (142 genes)

mcc04380 [list] [network] Osteoclast differentiation (131 genes)

mcc04510 [list] [network] Focal adhesion (205 genes)

mcc04540 [list] [network] Gap junction (94 genes)

mcc04550 [list] [network] Signaling pathways regulating pluripotency of stem cells (144 genes)

mcc04613 [list] [network] Neutrophil extracellular trap formation (214 genes)

mcc04620 [list] [network] Toll-like receptor signaling pathway (108 genes)

mcc04650 [list] [network] Natural killer cell mediated cytotoxicity (142 genes)

mcc04660 [list] [network] T cell receptor signaling pathway (107 genes)

mcc04662 [list] [network] B cell receptor signaling pathway (96 genes)

mcc04664 [list] [network] Fc epsilon RI signaling pathway (78 genes)

mcc04666 [list] [network] Fc gamma R-mediated phagocytosis (106 genes)

mcc04668 [list] [network] TNF signaling pathway (115 genes)

mcc04720 [list] [network] Long-term potentiation (70 genes)

mcc04722 [list] [network] Neurotrophin signaling pathway (122 genes)

mcc04725 [list] [network] Cholinergic synapse (114 genes)

mcc04726 [list] [network] Serotonergic synapse (118 genes)

mcc04730 [list] [network] Long-term depression (61 genes)

mcc04810 [list] [network] Regulation of actin cytoskeleton (221 genes)

mcc04910 [list] [network] Insulin signaling pathway (141 genes)

mcc04912 [list] [network] GnRH signaling pathway (97 genes)

mcc04914 [list] [network] Progesterone-mediated oocyte maturation (93 genes)

mcc04915 [list] [network] Estrogen signaling pathway (144 genes)

mcc04916 [list] [network] Melanogenesis (103 genes)

mcc04917 [list] [network] Prolactin signaling pathway (70 genes)

mcc04919 [list] [network] Thyroid hormone signaling pathway (124 genes)

mcc04921 [list] [network] Oxytocin signaling pathway (163 genes)

mcc04926 [list] [network] Relaxin signaling pathway (133 genes)

mcc04928 [list] [network] Parathyroid hormone synthesis, secretion and action (109 genes)

mcc04929 [list] [network] GnRH secretion (64 genes)

mcc04934 [list] [network] Cushing syndrome (161 genes)

mcc04935 [list] [network] Growth hormone synthesis, secretion and action (128 genes)

mcc05010 [list] [network] Alzheimer disease (441 genes)

mcc05022 [list] [network] Pathways of neurodegeneration - multiple diseases (540 genes)

mcc05034 [list] [network] Alcoholism (204 genes)

mcc05132 [list] [network] Salmonella infection (264 genes)

mcc05135 [list] [network] Yersinia infection (153 genes)

mcc05160 [list] [network] Hepatitis C (173 genes)

mcc05161 [list] [network] Hepatitis B (180 genes)

mcc05163 [list] [network] Human cytomegalovirus infection (257 genes)

mcc05164 [list] [network] Influenza A (191 genes)

mcc05165 [list] [network] Human papillomavirus infection (352 genes)

mcc05166 [list] [network] Human T-cell leukemia virus 1 infection (247 genes)

mcc05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (227 genes)

mcc05170 [list] [network] Human immunodeficiency virus 1 infection (247 genes)

mcc05200 [list] [network] Pathways in cancer (573 genes)

mcc05205 [list] [network] Proteoglycans in cancer (211 genes)

mcc05206 [list] [network] MicroRNAs in cancer (293 genes)

mcc05207 [list] [network] Chemical carcinogenesis - receptor activation (215 genes)

mcc05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (272 genes)

mcc05210 [list] [network] Colorectal cancer (107 genes)

mcc05211 [list] [network] Renal cell carcinoma (72 genes)

mcc05212 [list] [network] Pancreatic cancer (88 genes)

mcc05213 [list] [network] Endometrial cancer (61 genes)

mcc05214 [list] [network] Glioma (79 genes)

mcc05215 [list] [network] Prostate cancer (97 genes)

mcc05216 [list] [network] Thyroid cancer (39 genes)

mcc05218 [list] [network] Melanoma (74 genes)

mcc05219 [list] [network] Bladder cancer (41 genes)

mcc05220 [list] [network] Chronic myeloid leukemia (80 genes)

mcc05221 [list] [network] Acute myeloid leukemia (69 genes)

mcc05223 [list] [network] Non-small cell lung cancer (75 genes)

mcc05224 [list] [network] Breast cancer (150 genes)

mcc05225 [list] [network] Hepatocellular carcinoma (177 genes)

mcc05226 [list] [network] Gastric cancer (153 genes)

mcc05230 [list] [network] Central carbon metabolism in cancer (76 genes)

mcc05231 [list] [network] Choline metabolism in cancer (107 genes)

mcc05235 [list] [network] PD-L1 expression and PD-1 checkpoint pathway in cancer (93 genes)

Protein

NP_001244478.1 XP_014997969.1

BLAST

NP_001244478.1 XP_014997969.1

Orthologous

[Ortholog page] MAP2K1 (hsa) MAP2K2 (hsa) Map2k1 (mmu) Map2k2 (mmu) Dsor1 (dme) Map2k2 (rno) Map2k1 (rno) mek-2 (cel) MAP2K2 (gga) map2k1 (dre) MAP2K1 (gga) MAP2K1 (cfa) map2k2a (dre) MAP2K2 (cfa) MAP2K2 (mcc) PBS2 (sce) pab2 (spo) map2k2b (dre) MAP2K1 (fca) MAP2K2 (fca)

Subcellular
localization
wolf

cyto 5, nucl 5	(predict for NP_001244478.1)
cyto 6, cyto_nucl 5, nucl 3	(predict for XP_014997969.1)

Gene coexpression

Network^*for
coexpressed
genes

[Cytoscape]

KEGG^* ID	Title	#genes	Link to the KEGG^* map (Multiple genes)
mcc04114	Oocyte meiosis	2
mcc04914	Progesterone-mediated oocyte maturation	2
mcc04014	Ras signaling pathway	2
mcc04015	Rap1 signaling pathway	2
mcc04022	cGMP-PKG signaling pathway	2

Genes directly connected with MAP2K1 on the network
coex z^*	Locus	Function^*	Coexpression detail	Entrez Gene ID^*
5.5	NPEPPS	aminopeptidase puromycin sensitive	[detail]	693995
5.4	NPTN	neuroplastin	[detail]	699627
5.2	PCBP1	poly(rC) binding protein 1	[detail]	709520
4.8	WRNIP1	WRN helicase interacting protein 1	[detail]	707250
4.4	UBE2E2	ubiquitin conjugating enzyme E2 E2	[detail]	699101

Coexpressed
gene list

[Coexpressed gene list for MAP2K1]

Gene expression

All samples

[Expression pattern for all samples]

Tissue specificity^*

Link to other DBs
Entrez Gene ID	710415
Refseq ID (protein)	NP_001244478.1
Refseq ID (protein)	XP_014997969.1

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