[←][→] mmu  Pdgfrb Gene
functional annotation
Function   platelet derived growth factor receptor, beta polypeptide  
GO BP
GO:0035789 [list] [network] metanephric mesenchymal cell migration  (1 genes)  ISO  
GO:0060981 [list] [network] cell migration involved in coronary angiogenesis  (1 genes)  IMP  
GO:0106096 [list] [network] response to ceramide  (1 genes)  IMP  
GO:0071670 [list] [network] smooth muscle cell chemotaxis  (2 genes)  IGI  
GO:0072223 [list] [network] metanephric glomerular mesangium development  (2 genes)  IEP  
GO:0072262 [list] [network] metanephric glomerular mesangial cell proliferation involved in metanephros development  (2 genes)  IMP  
GO:0035793 [list] [network] positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (3 genes)  IMP  
GO:0038091 [list] [network] positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  (3 genes)  ISO  
GO:0072277 [list] [network] metanephric glomerular capillary formation  (3 genes)  IGI  
GO:0035441 [list] [network] cell migration involved in vasculogenesis  (4 genes)  IMP  
GO:0035791 [list] [network] platelet-derived growth factor receptor-beta signaling pathway  (7 genes)  ISO  
GO:0060437 [list] [network] lung growth  (7 genes)  ISO  
GO:2000491 [list] [network] positive regulation of hepatic stellate cell activation  (7 genes)  ISO  
GO:0060947 [list] [network] cardiac vascular smooth muscle cell differentiation  (15 genes)  TAS  
GO:0097178 [list] [network] ruffle assembly  (16 genes)  IDA  
GO:0055003 [list] [network] cardiac myofibril assembly  (18 genes)  IGI  
GO:0032516 [list] [network] positive regulation of phosphoprotein phosphatase activity  (21 genes)  ISO  
GO:0030325 [list] [network] adrenal gland development  (26 genes)  IGI  
GO:0048745 [list] [network] smooth muscle tissue development  (27 genes)  IMP  
GO:0061298 [list] [network] retina vasculature development in camera-type eye  (27 genes)  IGI IMP  
GO:0032967 [list] [network] positive regulation of collagen biosynthetic process  (29 genes)  ISO  
GO:0090280 [list] [network] positive regulation of calcium ion import  (29 genes)  IMP  
GO:0043552 [list] [network] positive regulation of phosphatidylinositol 3-kinase activity  (31 genes)  ISO  
GO:0035909 [list] [network] aorta morphogenesis  (33 genes)  IGI  
GO:0010863 [list] [network] positive regulation of phospholipase C activity  (34 genes)  ISO  
GO:0035025 [list] [network] positive regulation of Rho protein signal transduction  (35 genes)  ISO  
GO:0006024 [list] [network] glycosaminoglycan biosynthetic process  (36 genes)  ISO  
GO:0048008 [list] [network] platelet-derived growth factor receptor signaling pathway  (41 genes)  IMP ISO  
GO:0045840 [list] [network] positive regulation of mitotic nuclear division  (45 genes)  IDA  
GO:0070301 [list] [network] cellular response to hydrogen peroxide  (59 genes)  IMP  
GO:0014911 [list] [network] positive regulation of smooth muscle cell migration  (62 genes)  IBA IGI IMP ISO  
GO:0048146 [list] [network] positive regulation of fibroblast proliferation  (70 genes)  ISO  
GO:0048015 [list] [network] phosphatidylinositol-mediated signaling  (73 genes)  ISO  
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling  (75 genes)  IDA  
GO:2000573 [list] [network] positive regulation of DNA biosynthetic process  (76 genes)  IMP  
GO:2000379 [list] [network] positive regulation of reactive oxygen species metabolic process  (77 genes)  IMP  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (89 genes)  IDA ISO  
GO:0048661 [list] [network] positive regulation of smooth muscle cell proliferation  (103 genes)  IMP ISO  
GO:0043406 [list] [network] positive regulation of MAP kinase activity  (109 genes)  IDA  
GO:0046488 [list] [network] phosphatidylinositol metabolic process  (138 genes)  ISO  
GO:0050921 [list] [network] positive regulation of chemotaxis  (150 genes)  IDA  
GO:0046777 [list] [network] protein autophosphorylation  (194 genes)  IDA ISO  
GO:0060326 [list] [network] cell chemotaxis  (208 genes)  ISO  
GO:0001894 [list] [network] tissue homeostasis  (224 genes)  IMP  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (228 genes)  IDA IMP ISO  
GO:0048705 [list] [network] skeletal system morphogenesis  (255 genes)  IMP  
GO:0050730 [list] [network] regulation of peptidyl-tyrosine phosphorylation  (262 genes)  IMP  
GO:0001822 [list] [network] kidney development  (309 genes)  IMP  
GO:0007169 [list] [network] transmembrane receptor protein tyrosine kinase signaling pathway  (365 genes)  IBA  
GO:0032956 [list] [network] regulation of actin cytoskeleton organization  (369 genes)  IGI  
GO:0033674 [list] [network] positive regulation of kinase activity  (435 genes)  IBA  
GO:0006935 [list] [network] chemotaxis  (502 genes)  IEA  
GO:0048568 [list] [network] embryonic organ development  (518 genes)  IEP  
GO:0001568 [list] [network] blood vessel development  (547 genes)  IEP  
GO:0001701 [list] [network] in utero embryonic development  (547 genes)  IMP  
GO:0030335 [list] [network] positive regulation of cell migration  (567 genes)  ISO  
GO:0043065 [list] [network] positive regulation of apoptotic process  (598 genes)  ISO  
GO:0006468 [list] [network] protein phosphorylation  (665 genes)  IEA  
GO:0030097 [list] [network] hemopoiesis  (728 genes)  IMP  
GO:0016310 [list] [network] phosphorylation  (836 genes)  IEA  
GO:0016477 [list] [network] cell migration  (896 genes)  ISO  
GO:0043066 [list] [network] negative regulation of apoptotic process  (968 genes)  ISO  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (1011 genes)  ISO  
GO:0035556 [list] [network] intracellular signal transduction  (1356 genes)  ISO  
GO:0007165 [list] [network] signal transduction  (4968 genes)  IDA ISO  
GO:0007275 [list] [network] multicellular organism development  (5017 genes)  IBA  
GO:0006807 [list] [network] nitrogen compound metabolic process  (5914 genes)  IMP  
GO CC
GO:0001726 [list] [network] ruffle  (153 genes)  IDA  
GO:0016324 [list] [network] apical plasma membrane  (366 genes)  ISO  
GO:0043235 [list] [network] receptor complex  (412 genes)  IBA  
GO:0005764 [list] [network] lysosome  (520 genes)  IEA  
GO:0009986 [list] [network] cell surface  (1142 genes)  IDA ISO  
GO:0005794 [list] [network] Golgi apparatus  (1525 genes)  ISO  
GO:0005887 [list] [network] integral component of plasma membrane  (1555 genes)  IBA  
GO:0031226 [list] [network] intrinsic component of plasma membrane  (1644 genes)  ISO  
GO:0031410 [list] [network] cytoplasmic vesicle  (2033 genes)  IEA  
GO:0005886 [list] [network] plasma membrane  (5442 genes)  ISO  
GO:0016021 [list] [network] integral component of membrane  (5954 genes)  IEA  
GO:0005634 [list] [network] nucleus  (7226 genes)  ISO  
GO:0016020 [list] [network] membrane  (9571 genes)  ISO  
GO:0005737 [list] [network] cytoplasm  (11434 genes)  IDA ISO  
GO:0043231 [list] [network] intracellular membrane-bounded organelle  (11551 genes)  ISO  
GO MF
GO:0005019 [list] [network] platelet-derived growth factor beta-receptor activity  (1 genes)  IBA ISO  
GO:0005017 [list] [network] platelet-derived growth factor-activated receptor activity  (2 genes)  IDA ISO  
GO:0038085 [list] [network] vascular endothelial growth factor binding  (6 genes)  ISO  
GO:0048407 [list] [network] platelet-derived growth factor binding  (12 genes)  IBA ISO TAS  
GO:0005161 [list] [network] platelet-derived growth factor receptor binding  (14 genes)  ISO  
GO:0043548 [list] [network] phosphatidylinositol 3-kinase binding  (41 genes)  ISO  
GO:0004714 [list] [network] transmembrane receptor protein tyrosine kinase activity  (62 genes)  IBA  
GO:0004713 [list] [network] protein tyrosine kinase activity  (134 genes)  ISO  
GO:0019838 [list] [network] growth factor binding  (151 genes)  IBA  
GO:0004672 [list] [network] protein kinase activity  (583 genes)  IEA  
GO:0016301 [list] [network] kinase activity  (740 genes)  IMP  
GO:0019901 [list] [network] protein kinase binding  (774 genes)  ISO  
GO:0005524 [list] [network] ATP binding  (1396 genes)  IEA  
GO:0005102 [list] [network] signaling receptor binding  (1742 genes)  IPI ISO  
GO:0000166 [list] [network] nucleotide binding  (2052 genes)  IEA  
GO:0016740 [list] [network] transferase activity  (2235 genes)  IEA  
GO:0019899 [list] [network] enzyme binding  (2298 genes)  ISO  
GO:0005515 [list] [network] protein binding  (9507 genes)  IPI  
KEGG mmu01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
mmu04010 [list] [network] MAPK signaling pathway (294 genes)
mmu04014 [list] [network] Ras signaling pathway (232 genes)
mmu04015 [list] [network] Rap1 signaling pathway (214 genes)
mmu04020 [list] [network] Calcium signaling pathway (240 genes)
mmu04072 [list] [network] Phospholipase D signaling pathway (149 genes)
mmu04151 [list] [network] PI3K-Akt signaling pathway (359 genes)
mmu04510 [list] [network] Focal adhesion (201 genes)
mmu04540 [list] [network] Gap junction (86 genes)
mmu04630 [list] [network] JAK-STAT signaling pathway (168 genes)
mmu04810 [list] [network] Regulation of actin cytoskeleton (220 genes)
mmu05165 [list] [network] Human papillomavirus infection (362 genes)
mmu05200 [list] [network] Pathways in cancer (543 genes)
mmu05206 [list] [network] MicroRNAs in cancer (303 genes)
mmu05214 [list] [network] Glioma (74 genes)
mmu05215 [list] [network] Prostate cancer (99 genes)
mmu05218 [list] [network] Melanoma (72 genes)
mmu05230 [list] [network] Central carbon metabolism in cancer (69 genes)
mmu05231 [list] [network] Choline metabolism in cancer (98 genes)
Protein NP_001139740.1  NP_032835.2  XP_011245158.1  XP_030106221.1 
BLAST NP_001139740.1  NP_032835.2  XP_011245158.1  XP_030106221.1 
Orthologous [Ortholog page] PDGFRB (hsa)  Pdgfrb (rno)  PDGFRB (cfa)  pdgfrb (dre)  PDGFRB (mcc)  PDGFRB (gga)  PDGFRB (fca) 
Subcellular
localization
wolf
plas 3,  extr_plas 3,  extr 2,  E.R. 1,  pero 1,  nucl 1,  cyto 1,  mito 1,  cyto_nucl 1,  cyto_mito 1,  E.R._golg 1,  mito_nucl 1  (predict for NP_001139740.1)
plas 3,  extr_plas 3,  extr 2,  E.R. 1,  pero 1,  nucl 1,  cyto 1,  mito 1,  cyto_nucl 1,  cyto_mito 1,  E.R._golg 1,  mito_nucl 1  (predict for NP_032835.2)
pero 4,  extr 3,  extr_plas 3,  plas 2,  E.R. 1  (predict for XP_011245158.1)
pero 4,  extr 3,  extr_plas 3,  plas 2,  E.R. 1  (predict for XP_030106221.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu05200 Pathways in cancer 6
mmu04015 Rap1 signaling pathway 4
mmu04020 Calcium signaling pathway 4
mmu04151 PI3K-Akt signaling pathway 4
mmu01521 EGFR tyrosine kinase inhibitor resistance 3
Genes directly connected with Pdgfrb on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
7.7 Pdgfra platelet derived growth factor receptor, alpha polypeptide [detail] 90 18595
7.1 Adgra2 adhesion G protein-coupled receptor A2 [detail] 3 78560
7.1 Fbn1 fibrillin 1 [detail] 1 14118
6.7 Ednra endothelin receptor type A [detail] 3 13617
6.3 S1pr3 sphingosine-1-phosphate receptor 3 [detail] 4 13610
Coexpressed
gene list		 [Coexpressed gene list for Pdgfrb]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 18596      
Refseq ID (protein) NP_001139740.1 
NP_032835.2 
XP_011245158.1 
XP_030106221.1 


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