| functional annotation |
| Function |
SOS Ras/Rho guanine nucleotide exchange factor 2 |
|
| GO BP |
|
GO:2000973 [list] [network] regulation of pro-B cell differentiation
|
(8 genes)
|
IEA
|
 |
|
GO:0033081 [list] [network] regulation of T cell differentiation in thymus
|
(23 genes)
|
IEA
|
|
|
GO:0001782 [list] [network] B cell homeostasis
|
(28 genes)
|
IEA
|
|
|
GO:0051057 [list] [network] positive regulation of small GTPase mediated signal transduction
|
(81 genes)
|
IEA
|
|
|
GO:0042129 [list] [network] regulation of T cell proliferation
|
(172 genes)
|
IEA
|
|
|
GO:0007264 [list] [network] small GTPase mediated signal transduction
|
(261 genes)
|
IEA
|
|
|
GO:0051056 [list] [network] regulation of small GTPase mediated signal transduction
|
(325 genes)
|
TAS
|
|
|
GO:0043065 [list] [network] positive regulation of apoptotic process
|
(590 genes)
|
TAS
|
|
|
GO:0007186 [list] [network] G protein-coupled receptor signaling pathway
|
(1290 genes)
|
TAS
|
|
|
GO:0050790 [list] [network] regulation of catalytic activity
|
(2362 genes)
|
IEA
|
|
|
| GO CC |
|
| GO MF |
|
GO:0005085 [list] [network] guanyl-nucleotide exchange factor activity
|
(211 genes)
|
IEA
|
|
|
GO:0046982 [list] [network] protein heterodimerization activity
|
(326 genes)
|
IEA
|
|
|
GO:0003677 [list] [network] DNA binding
|
(2502 genes)
|
IEA
|
|
|
GO:0005515 [list] [network] protein binding
|
(13898 genes)
|
IPI
|
|
|
| KEGG |
hsa01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes) |
 |
| hsa01522 [list] [network] Endocrine resistance (98 genes) |
|
| hsa04010 [list] [network] MAPK signaling pathway (294 genes) |
|
| hsa04012 [list] [network] ErbB signaling pathway (85 genes) |
|
| hsa04014 [list] [network] Ras signaling pathway (232 genes) |
|
| hsa04062 [list] [network] Chemokine signaling pathway (192 genes) |
|
| hsa04068 [list] [network] FoxO signaling pathway (131 genes) |
|
| hsa04072 [list] [network] Phospholipase D signaling pathway (148 genes) |
|
| hsa04150 [list] [network] mTOR signaling pathway (155 genes) |
|
| hsa04151 [list] [network] PI3K-Akt signaling pathway (354 genes) |
|
| hsa04510 [list] [network] Focal adhesion (201 genes) |
|
| hsa04540 [list] [network] Gap junction (88 genes) |
|
| hsa04630 [list] [network] JAK-STAT signaling pathway (162 genes) |
|
| hsa04650 [list] [network] Natural killer cell mediated cytotoxicity (131 genes) |
|
| hsa04660 [list] [network] T cell receptor signaling pathway (104 genes) |
|
| hsa04662 [list] [network] B cell receptor signaling pathway (82 genes) |
|
| hsa04664 [list] [network] Fc epsilon RI signaling pathway (68 genes) |
|
| hsa04714 [list] [network] Thermogenesis (232 genes) |
|
| hsa04722 [list] [network] Neurotrophin signaling pathway (119 genes) |
|
| hsa04810 [list] [network] Regulation of actin cytoskeleton (218 genes) |
|
| hsa04910 [list] [network] Insulin signaling pathway (137 genes) |
|
| hsa04912 [list] [network] GnRH signaling pathway (93 genes) |
|
| hsa04915 [list] [network] Estrogen signaling pathway (138 genes) |
|
| hsa04917 [list] [network] Prolactin signaling pathway (70 genes) |
|
| hsa04926 [list] [network] Relaxin signaling pathway (129 genes) |
|
| hsa04935 [list] [network] Growth hormone synthesis, secretion and action (119 genes) |
|
| hsa05034 [list] [network] Alcoholism (187 genes) |
|
| hsa05160 [list] [network] Hepatitis C (157 genes) |
|
| hsa05161 [list] [network] Hepatitis B (162 genes) |
|
| hsa05163 [list] [network] Human cytomegalovirus infection (225 genes) |
|
| hsa05165 [list] [network] Human papillomavirus infection (331 genes) |
|
| hsa05200 [list] [network] Pathways in cancer (531 genes) |
|
| hsa05205 [list] [network] Proteoglycans in cancer (205 genes) |
|
| hsa05206 [list] [network] MicroRNAs in cancer (310 genes) |
|
| hsa05207 [list] [network] Chemical carcinogenesis - receptor activation (212 genes) |
|
| hsa05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (223 genes) |
|
| hsa05210 [list] [network] Colorectal cancer (86 genes) |
|
| hsa05211 [list] [network] Renal cell carcinoma (69 genes) |
|
| hsa05213 [list] [network] Endometrial cancer (58 genes) |
|
| hsa05214 [list] [network] Glioma (75 genes) |
|
| hsa05215 [list] [network] Prostate cancer (97 genes) |
|
| hsa05220 [list] [network] Chronic myeloid leukemia (76 genes) |
|
| hsa05221 [list] [network] Acute myeloid leukemia (67 genes) |
|
| hsa05223 [list] [network] Non-small cell lung cancer (72 genes) |
|
| hsa05224 [list] [network] Breast cancer (147 genes) |
|
| hsa05225 [list] [network] Hepatocellular carcinoma (168 genes) |
|
| hsa05226 [list] [network] Gastric cancer (149 genes) |
|
| hsa05231 [list] [network] Choline metabolism in cancer (98 genes) |
|
| Protein |
NP_008870.2
|
| BLAST |
NP_008870.2
|
| Orthologous |
[Ortholog page]
SOS1 (hsa)
Sos1 (mmu)
Sos2 (mmu)
Sos (dme)
Sos2 (rno)
sos-1 (cel)
Sos1 (rno)
SOS2 (gga)
SOS1 (gga)
SOS1 (cfa)
SOS2 (cfa)
sos1 (dre)
sos2 (dre)
SOS2 (mcc)
SOS1 (mcc)
CDC25 (sce)
SOS2 (fca)
SOS1 (fca)
|
Subcellular
localization
wolf |
|
nucl 5,
cyto 3,
cysk 1
|
(predict for NP_008870.2)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| hsa05014 |
Amyotrophic lateral sclerosis |
3 |
 |
| hsa04910 |
Insulin signaling pathway |
3 |
 |
| hsa05010 |
Alzheimer disease |
3 |
 |
| hsa05160 |
Hepatitis C |
3 |
 |
| hsa05161 |
Hepatitis B |
3 |
 |
Genes directly connected with SOS2 on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
CoexPub |
Entrez Gene ID* |
| 6.8 |
DICER1 |
dicer 1, ribonuclease III |
[detail] |
0 |
23405 |
| 6.5 |
AGO4 |
argonaute RISC component 4 |
[detail] |
1 |
192670 |
| 6.2 |
ATP11B |
ATPase phospholipid transporting 11B (putative) |
[detail] |
0 |
23200 |
|
Coexpressed
gene list |
[Coexpressed gene list for SOS2]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
SOS2 Gene
