[←][→] hsa  PDGFRB Gene
functional annotation
Function   platelet derived growth factor receptor beta  
GO BP
GO:0035789 [list] [network] metanephric mesenchymal cell migration  (1 genes)  IEA  
GO:0060981 [list] [network] cell migration involved in coronary angiogenesis  (1 genes)  ISS  
GO:0072262 [list] [network] metanephric glomerular mesangial cell proliferation involved in metanephros development  (1 genes)  ISS  
GO:0071670 [list] [network] smooth muscle cell chemotaxis  (2 genes)  ISS  
GO:0035793 [list] [network] positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (3 genes)  ISS  
GO:0038091 [list] [network] positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  (3 genes)  IDA  
GO:0072277 [list] [network] metanephric glomerular capillary formation  (3 genes)  ISS  
GO:0072278 [list] [network] metanephric comma-shaped body morphogenesis  (3 genes)  IEA  
GO:0035441 [list] [network] cell migration involved in vasculogenesis  (4 genes)  ISS  
GO:2000491 [list] [network] positive regulation of hepatic stellate cell activation  (4 genes)  IEA  
GO:0072284 [list] [network] metanephric S-shaped body morphogenesis  (5 genes)  IEA  
GO:0035791 [list] [network] platelet-derived growth factor receptor-beta signaling pathway  (7 genes)  IMP  
GO:0060437 [list] [network] lung growth  (7 genes)  IEA  
GO:0072075 [list] [network] metanephric mesenchyme development  (14 genes)  IEA  
GO:0055003 [list] [network] cardiac myofibril assembly  (16 genes)  ISS  
GO:0061298 [list] [network] retina vasculature development in camera-type eye  (17 genes)  ISS  
GO:0032516 [list] [network] positive regulation of phosphoprotein phosphatase activity  (21 genes)  IDA  
GO:0036120 [list] [network] cellular response to platelet-derived growth factor stimulus  (21 genes)  IEA  
GO:0055093 [list] [network] response to hyperoxia  (22 genes)  IEA  
GO:0090280 [list] [network] positive regulation of calcium ion import  (22 genes)  ISS  
GO:0032967 [list] [network] positive regulation of collagen biosynthetic process  (27 genes)  IEA  
GO:0035909 [list] [network] aorta morphogenesis  (31 genes)  ISS  
GO:0035025 [list] [network] positive regulation of Rho protein signal transduction  (33 genes)  IEA  
GO:0043552 [list] [network] positive regulation of phosphatidylinositol 3-kinase activity  (33 genes)  IDA  
GO:0034405 [list] [network] response to fluid shear stress  (34 genes)  IEA  
GO:0048008 [list] [network] platelet-derived growth factor receptor signaling pathway  (35 genes)  IDA  
GO:0045840 [list] [network] positive regulation of mitotic nuclear division  (43 genes)  ISS  
GO:0010863 [list] [network] positive regulation of phospholipase C activity  (46 genes)  IDA  
GO:0014911 [list] [network] positive regulation of smooth muscle cell migration  (46 genes)  IBA IMP ISS  
GO:0048146 [list] [network] positive regulation of fibroblast proliferation  (48 genes)  IEA  
GO:2000573 [list] [network] positive regulation of DNA biosynthetic process  (66 genes)  ISS  
GO:0043627 [list] [network] response to estrogen  (75 genes)  IEA  
GO:2000379 [list] [network] positive regulation of reactive oxygen species metabolic process  (75 genes)  ISS  
GO:0048015 [list] [network] phosphatidylinositol-mediated signaling  (79 genes)  IMP  
GO:0043406 [list] [network] positive regulation of MAP kinase activity  (89 genes)  ISS  
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling  (91 genes)  ISS  
GO:0006024 [list] [network] glycosaminoglycan biosynthetic process  (100 genes)  IEA  
GO:0048661 [list] [network] positive regulation of smooth muscle cell proliferation  (102 genes)  IMP ISS  
GO:0032526 [list] [network] response to retinoic acid  (107 genes)  IEA  
GO:0042542 [list] [network] response to hydrogen peroxide  (124 genes)  IEA  
GO:0008584 [list] [network] male gonad development  (137 genes)  IEA  
GO:0032355 [list] [network] response to estradiol  (141 genes)  IEA  
GO:0050921 [list] [network] positive regulation of chemotaxis  (141 genes)  ISS  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (149 genes)  IDA  
GO:0046488 [list] [network] phosphatidylinositol metabolic process  (181 genes)  IMP  
GO:0048839 [list] [network] inner ear development  (185 genes)  IEA  
GO:0051897 [list] [network] positive regulation of protein kinase B signaling  (186 genes)  TAS  
GO:0046777 [list] [network] protein autophosphorylation  (187 genes)  IDA  
GO:0060326 [list] [network] cell chemotaxis  (205 genes)  IDA  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (217 genes)  IMP ISS  
GO:0009636 [list] [network] response to toxic substance  (242 genes)  IEA  
GO:0007568 [list] [network] aging  (279 genes)  IEA  
GO:0032956 [list] [network] regulation of actin cytoskeleton organization  (357 genes)  ISS  
GO:0000165 [list] [network] MAPK cascade  (376 genes)  TAS  
GO:0042060 [list] [network] wound healing  (455 genes)  IEA  
GO:0033674 [list] [network] positive regulation of kinase activity  (477 genes)  IBA  
GO:0007169 [list] [network] transmembrane receptor protein tyrosine kinase signaling pathway  (525 genes)  IBA  
GO:0030335 [list] [network] positive regulation of cell migration  (554 genes)  IDA  
GO:0043065 [list] [network] positive regulation of apoptotic process  (590 genes)  IEA  
GO:0043066 [list] [network] negative regulation of apoptotic process  (905 genes)  IEA  
GO:0016477 [list] [network] cell migration  (964 genes)  IMP  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (976 genes)  IMP  
GO:0007186 [list] [network] G protein-coupled receptor signaling pathway  (1290 genes)  IEA  
GO:0007275 [list] [network] multicellular organism development  (4941 genes)  IBA  
GO:0007165 [list] [network] signal transduction  (5169 genes)  IDA  
GO CC
GO:0043202 [list] [network] lysosomal lumen  (96 genes)  IEA  
GO:0016324 [list] [network] apical plasma membrane  (364 genes)  ISS  
GO:0005925 [list] [network] focal adhesion  (421 genes)  HDA  
GO:0043235 [list] [network] receptor complex  (530 genes)  IBA  
GO:0009986 [list] [network] cell surface  (898 genes)  IEA  
GO:0005794 [list] [network] Golgi apparatus  (1594 genes)  IDA  
GO:0005887 [list] [network] integral component of plasma membrane  (1649 genes)  IBA  
GO:0031226 [list] [network] intrinsic component of plasma membrane  (1731 genes)  IDA  
GO:0031410 [list] [network] cytoplasmic vesicle  (2431 genes)  IEA  
GO:0005886 [list] [network] plasma membrane  (5772 genes)  TAS  
GO:0005634 [list] [network] nucleus  (8115 genes)  ISS  
GO:0016020 [list] [network] membrane  (9592 genes)  HDA IDA  
GO:0005737 [list] [network] cytoplasm  (11897 genes)  ISS  
GO:0043231 [list] [network] intracellular membrane-bounded organelle  (12534 genes)  IDA  
GO MF
GO:0005019 [list] [network] platelet-derived growth factor beta-receptor activity  (2 genes)  IBA IDA IMP  
GO:0004992 [list] [network] platelet activating factor receptor activity  (3 genes)  TAS  
GO:0005017 [list] [network] platelet-derived growth factor-activated receptor activity  (3 genes)  TAS  
GO:0038085 [list] [network] vascular endothelial growth factor binding  (5 genes)  IPI  
GO:0048407 [list] [network] platelet-derived growth factor binding  (11 genes)  IBA IDA IPI  
GO:0005161 [list] [network] platelet-derived growth factor receptor binding  (15 genes)  IPI  
GO:0043548 [list] [network] phosphatidylinositol 3-kinase binding  (32 genes)  IEA  
GO:0004714 [list] [network] transmembrane receptor protein tyrosine kinase activity  (127 genes)  IBA  
GO:0004713 [list] [network] protein tyrosine kinase activity  (140 genes)  IDA  
GO:0019838 [list] [network] growth factor binding  (142 genes)  IBA  
GO:0019901 [list] [network] protein kinase binding  (677 genes)  IPI  
GO:0005524 [list] [network] ATP binding  (1474 genes)  IEA  
GO:0005102 [list] [network] signaling receptor binding  (1550 genes)  IPI  
GO:0019899 [list] [network] enzyme binding  (2058 genes)  IPI  
GO:0005515 [list] [network] protein binding  (13898 genes)  IPI  
KEGG hsa01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
hsa04010 [list] [network] MAPK signaling pathway (294 genes)
hsa04014 [list] [network] Ras signaling pathway (232 genes)
hsa04015 [list] [network] Rap1 signaling pathway (210 genes)
hsa04020 [list] [network] Calcium signaling pathway (240 genes)
hsa04072 [list] [network] Phospholipase D signaling pathway (148 genes)
hsa04151 [list] [network] PI3K-Akt signaling pathway (354 genes)
hsa04510 [list] [network] Focal adhesion (201 genes)
hsa04540 [list] [network] Gap junction (88 genes)
hsa04630 [list] [network] JAK-STAT signaling pathway (162 genes)
hsa04810 [list] [network] Regulation of actin cytoskeleton (218 genes)
hsa05165 [list] [network] Human papillomavirus infection (331 genes)
hsa05200 [list] [network] Pathways in cancer (531 genes)
hsa05206 [list] [network] MicroRNAs in cancer (310 genes)
hsa05214 [list] [network] Glioma (75 genes)
hsa05215 [list] [network] Prostate cancer (97 genes)
hsa05218 [list] [network] Melanoma (72 genes)
hsa05230 [list] [network] Central carbon metabolism in cancer (70 genes)
hsa05231 [list] [network] Choline metabolism in cancer (98 genes)
Protein NP_001341945.1  NP_001341946.1  NP_002600.1 
BLAST NP_001341945.1  NP_001341946.1  NP_002600.1 
Orthologous [Ortholog page] Pdgfrb (mmu)  Pdgfrb (rno)  PDGFRB (cfa)  pdgfrb (dre)  PDGFRB (mcc)  PDGFRB (gga)  PDGFRB (fca) 
Subcellular
localization
wolf
plas 9,  E.R. 1  (predict for NP_001341945.1)
plas 8,  E.R. 1  (predict for NP_001341946.1)
plas 8,  E.R. 2  (predict for NP_002600.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04974 Protein digestion and absorption 7
hsa04151 PI3K-Akt signaling pathway 6
hsa04510 Focal adhesion 6
hsa05165 Human papillomavirus infection 6
hsa04512 ECM-receptor interaction 5
Genes directly connected with PDGFRB on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
8.4 CD248 CD248 molecule [detail] 27 57124
7.6 COL6A3 collagen type VI alpha 3 chain [detail] 5 1293
7.2 COL1A2 collagen type I alpha 2 chain [detail] 13 1278
7.2 PODN podocan [detail] 0 127435
6.1 ANGPTL2 angiopoietin like 2 [detail] 0 23452
5.2 DDR2 discoidin domain receptor tyrosine kinase 2 [detail] 16 4921
5.2 OLFML2B olfactomedin like 2B [detail] 4 25903
4.8 CLMAT3 colorectal liver metastasis associated transcript 3 [detail] 0 101927096
Coexpressed
gene list		 [Coexpressed gene list for PDGFRB]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 5159      
Refseq ID (protein) NP_001341945.1 
NP_001341946.1 
NP_002600.1 


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