[←][→] mmu  Pdgfa Gene
functional annotation
Function   platelet derived growth factor, alpha  
GO BP
GO:0060683 [list] [network] regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling  (1 genes)  IMP  
GO:0010512 [list] [network] negative regulation of phosphatidylinositol biosynthetic process  (2 genes)  ISO  
GO:0035793 [list] [network] positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (3 genes)  ISO  
GO:1990401 [list] [network] embryonic lung development  (3 genes)  IMP  
GO:0010544 [list] [network] negative regulation of platelet activation  (19 genes)  ISO  
GO:0031954 [list] [network] positive regulation of protein autophosphorylation  (27 genes)  IBA ISO  
GO:0002053 [list] [network] positive regulation of mesenchymal cell proliferation  (36 genes)  IMP  
GO:0048008 [list] [network] platelet-derived growth factor receptor signaling pathway  (41 genes)  IBA ISO  
GO:0050919 [list] [network] negative chemotaxis  (43 genes)  ISO  
GO:0048286 [list] [network] lung alveolus development  (64 genes)  IMP  
GO:0048146 [list] [network] positive regulation of fibroblast proliferation  (70 genes)  ISO  
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling  (75 genes)  IBA ISO  
GO:0014910 [list] [network] regulation of smooth muscle cell migration  (92 genes)  ISO  
GO:0051781 [list] [network] positive regulation of cell division  (97 genes)  IEA  
GO:0001942 [list] [network] hair follicle development  (103 genes)  IMP  
GO:0043406 [list] [network] positive regulation of MAP kinase activity  (109 genes)  IBA ISO  
GO:0051897 [list] [network] positive regulation of protein kinase B signaling  (116 genes)  ISO  
GO:0048565 [list] [network] digestive tract development  (124 genes)  IGI IMP  
GO:0060348 [list] [network] bone development  (219 genes)  IGI  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (228 genes)  IBA ISO  
GO:0043588 [list] [network] skin development  (262 genes)  IMP  
GO:0050730 [list] [network] regulation of peptidyl-tyrosine phosphorylation  (262 genes)  IDA  
GO:0001525 [list] [network] angiogenesis  (326 genes)  IDA  
GO:0009611 [list] [network] response to wounding  (368 genes)  ISO  
GO:0030031 [list] [network] cell projection assembly  (414 genes)  IDA  
GO:0043410 [list] [network] positive regulation of MAPK cascade  (482 genes)  ISO  
GO:0030036 [list] [network] actin cytoskeleton organization  (527 genes)  IDA  
GO:0030335 [list] [network] positive regulation of cell migration  (567 genes)  IBA ISO  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (1011 genes)  IBA IMP ISO  
GO:0009887 [list] [network] animal organ morphogenesis  (1068 genes)  IGI IMP  
GO:0007275 [list] [network] multicellular organism development  (5017 genes)  IEA  
GO CC
GO:0005902 [list] [network] microvillus  (103 genes)  IDA  
GO:0009986 [list] [network] cell surface  (1142 genes)  ISO  
GO:0005615 [list] [network] extracellular space  (2015 genes)  IBA IDA ISO  
GO:0005576 [list] [network] extracellular region  (2754 genes)  IEA  
GO:0016020 [list] [network] membrane  (9571 genes)  IEA  
GO MF
GO:0048407 [list] [network] platelet-derived growth factor binding  (12 genes)  ISO  
GO:0005161 [list] [network] platelet-derived growth factor receptor binding  (14 genes)  IBA ISO  
GO:0005518 [list] [network] collagen binding  (80 genes)  ISO  
GO:0008083 [list] [network] growth factor activity  (148 genes)  ISO  
GO:0070851 [list] [network] growth factor receptor binding  (156 genes)  IBA  
GO:0046982 [list] [network] protein heterodimerization activity  (305 genes)  ISO  
GO:0042803 [list] [network] protein homodimerization activity  (780 genes)  ISO  
GO:0042802 [list] [network] identical protein binding  (2357 genes)  ISO  
KEGG mmu01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
mmu04010 [list] [network] MAPK signaling pathway (294 genes)
mmu04014 [list] [network] Ras signaling pathway (232 genes)
mmu04015 [list] [network] Rap1 signaling pathway (214 genes)
mmu04020 [list] [network] Calcium signaling pathway (240 genes)
mmu04072 [list] [network] Phospholipase D signaling pathway (149 genes)
mmu04151 [list] [network] PI3K-Akt signaling pathway (359 genes)
mmu04510 [list] [network] Focal adhesion (201 genes)
mmu04540 [list] [network] Gap junction (86 genes)
mmu04630 [list] [network] JAK-STAT signaling pathway (168 genes)
mmu04810 [list] [network] Regulation of actin cytoskeleton (220 genes)
mmu05200 [list] [network] Pathways in cancer (543 genes)
mmu05202 [list] [network] Transcriptional misregulation in cancer (223 genes)
mmu05206 [list] [network] MicroRNAs in cancer (303 genes)
mmu05214 [list] [network] Glioma (74 genes)
mmu05215 [list] [network] Prostate cancer (99 genes)
mmu05218 [list] [network] Melanoma (72 genes)
mmu05231 [list] [network] Choline metabolism in cancer (98 genes)
mmu05418 [list] [network] Fluid shear stress and atherosclerosis (148 genes)
Protein NP_001350200.1  NP_032834.1  XP_006504722.1  XP_011239273.1  XP_030110058.1  XP_030110059.1  XP_036020763.1 
BLAST NP_001350200.1  NP_032834.1  XP_006504722.1  XP_011239273.1  XP_030110058.1  XP_030110059.1  XP_036020763.1 
Orthologous [Ortholog page] PDGFA (hsa)  PDGFB (hsa)  Pdgfb (mmu)  Pdgfb (rno)  Pdgfa (rno)  Pvf1 (dme)  PDGFB (gga)  PDGFA (gga)  pdgfaa (dre)  PDGFB (cfa)  PDGFA (cfa)  PDGFB (mcc)  PDGFA (mcc)  pdgfab (dre)  pdgfbb (dre)  si:ch211-79m20.1 (dre)  PDGFB (fca)  PDGFA (fca) 
Subcellular
localization
wolf
extr 9  (predict for NP_001350200.1)
extr 9,  cyto 1,  lyso 1  (predict for NP_032834.1)
extr 9  (predict for XP_006504722.1)
extr 9  (predict for XP_011239273.1)
extr 9,  cyto 1,  lyso 1  (predict for XP_030110058.1)
extr 9,  cyto 1,  lyso 1  (predict for XP_030110059.1)
extr 9  (predict for XP_036020763.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu01521 EGFR tyrosine kinase inhibitor resistance 3
mmu04014 Ras signaling pathway 3
mmu04015 Rap1 signaling pathway 3
mmu04072 Phospholipase D signaling pathway 3
mmu04810 Regulation of actin cytoskeleton 3
Genes directly connected with Pdgfa on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
5.2 Slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 [detail] 0 102857
5.1 Tns3 tensin 3 [detail] 0 319939
5.1 Mras muscle and microspikes RAS [detail] 0 17532
4.7 Cadm1 cell adhesion molecule 1 [detail] 0 54725
4.4 Fam20c FAM20C, golgi associated secretory pathway kinase [detail] 0 80752
Coexpressed
gene list		 [Coexpressed gene list for Pdgfa]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 18590      
Refseq ID (protein) NP_001350200.1 
NP_032834.1 
XP_006504722.1 
XP_011239273.1 
XP_030110058.1 
XP_030110059.1 
XP_036020763.1 


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