[←][→] mmu  Src Gene
functional annotation
Function   Rous sarcoma oncogene  
GO BP
GO:0086098 [list] [network] angiotensin-activated signaling pathway involved in heart process  (2 genes)  IGI  
GO:0001545 [list] [network] primary ovarian follicle growth  (3 genes)  ISO  
GO:0071393 [list] [network] cellular response to progesterone stimulus  (3 genes)  ISO  
GO:2000588 [list] [network] positive regulation of platelet-derived growth factor receptor-beta signaling pathway  (3 genes)  IMP  
GO:0051902 [list] [network] negative regulation of mitochondrial depolarization  (5 genes)  ISO  
GO:2000386 [list] [network] positive regulation of ovarian follicle development  (5 genes)  ISO  
GO:2000394 [list] [network] positive regulation of lamellipodium morphogenesis  (6 genes)  ISO  
GO:2001286 [list] [network] regulation of caveolin-mediated endocytosis  (6 genes)  ISO  
GO:0036035 [list] [network] osteoclast development  (7 genes)  IBA IGI  
GO:0050847 [list] [network] progesterone receptor signaling pathway  (10 genes)  IBA ISO  
GO:0051974 [list] [network] negative regulation of telomerase activity  (13 genes)  ISO  
GO:0071803 [list] [network] positive regulation of podosome assembly  (13 genes)  IDA IGI  
GO:0070102 [list] [network] interleukin-6-mediated signaling pathway  (14 genes)  IDA ISO  
GO:0048011 [list] [network] neurotrophin TRK receptor signaling pathway  (15 genes)  ISO  
GO:2000811 [list] [network] negative regulation of anoikis  (15 genes)  ISO  
GO:0036120 [list] [network] cellular response to platelet-derived growth factor stimulus  (17 genes)  IDA  
GO:0051895 [list] [network] negative regulation of focal adhesion assembly  (17 genes)  ISO  
GO:0071498 [list] [network] cellular response to fluid shear stress  (17 genes)  IMP  
GO:0060576 [list] [network] intestinal epithelial cell development  (18 genes)  IDA ISO  
GO:2000641 [list] [network] regulation of early endosome to late endosome transport  (18 genes)  ISO  
GO:0032211 [list] [network] negative regulation of telomere maintenance via telomerase  (19 genes)  ISO  
GO:0043149 [list] [network] stress fiber assembly  (19 genes)  ISO  
GO:0038083 [list] [network] peptidyl-tyrosine autophosphorylation  (20 genes)  ISO  
GO:0098962 [list] [network] regulation of postsynaptic neurotransmitter receptor activity  (21 genes)  ISO  
GO:0045056 [list] [network] transcytosis  (23 genes)  ISO  
GO:0046628 [list] [network] positive regulation of insulin receptor signaling pathway  (25 genes)  ISO  
GO:0045737 [list] [network] positive regulation of cyclin-dependent protein serine/threonine kinase activity  (26 genes)  ISO  
GO:0060065 [list] [network] uterus development  (26 genes)  IMP  
GO:0010954 [list] [network] positive regulation of protein processing  (27 genes)  IGI  
GO:0031954 [list] [network] positive regulation of protein autophosphorylation  (27 genes)  ISO  
GO:0045453 [list] [network] bone resorption  (27 genes)  IBA IMP  
GO:0060444 [list] [network] branching involved in mammary gland duct morphogenesis  (27 genes)  IMP  
GO:0032148 [list] [network] activation of protein kinase B activity  (28 genes)  ISO  
GO:0048041 [list] [network] focal adhesion assembly  (30 genes)  ISO  
GO:0043552 [list] [network] positive regulation of phosphatidylinositol 3-kinase activity  (31 genes)  ISO  
GO:0033146 [list] [network] regulation of intracellular estrogen receptor signaling pathway  (37 genes)  IMP  
GO:0007173 [list] [network] epidermal growth factor receptor signaling pathway  (43 genes)  IBA  
GO:0045747 [list] [network] positive regulation of Notch signaling pathway  (44 genes)  IDA ISO  
GO:0010907 [list] [network] positive regulation of glucose metabolic process  (45 genes)  ISO  
GO:0031648 [list] [network] protein destabilization  (56 genes)  IMP  
GO:0034446 [list] [network] substrate adhesion-dependent cell spreading  (56 genes)  IDA  
GO:0070301 [list] [network] cellular response to hydrogen peroxide  (59 genes)  IMP  
GO:0035306 [list] [network] positive regulation of dephosphorylation  (61 genes)  ISO  
GO:0014911 [list] [network] positive regulation of smooth muscle cell migration  (62 genes)  ISO  
GO:2000573 [list] [network] positive regulation of DNA biosynthetic process  (76 genes)  ISO  
GO:0051057 [list] [network] positive regulation of small GTPase mediated signal transduction  (79 genes)  ISO  
GO:0007229 [list] [network] integrin-mediated signaling pathway  (80 genes)  ISO  
GO:0043154 [list] [network] negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (82 genes)  ISO  
GO:0007179 [list] [network] transforming growth factor beta receptor signaling pathway  (87 genes)  ISO  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (89 genes)  IDA ISO  
GO:1900182 [list] [network] positive regulation of protein localization to nucleus  (92 genes)  IGI  
GO:0070555 [list] [network] response to interleukin-1  (93 genes)  ISO  
GO:0048477 [list] [network] oogenesis  (94 genes)  IMP  
GO:2001243 [list] [network] negative regulation of intrinsic apoptotic signaling pathway  (101 genes)  IBA ISO  
GO:2001237 [list] [network] negative regulation of extrinsic apoptotic signaling pathway  (103 genes)  IBA ISO  
GO:0042476 [list] [network] odontogenesis  (104 genes)  IMP  
GO:0034614 [list] [network] cellular response to reactive oxygen species  (105 genes)  IDA  
GO:0090263 [list] [network] positive regulation of canonical Wnt signaling pathway  (107 genes)  IGI  
GO:0043406 [list] [network] positive regulation of MAP kinase activity  (109 genes)  ISO  
GO:0051897 [list] [network] positive regulation of protein kinase B signaling  (116 genes)  ISO  
GO:0071560 [list] [network] cellular response to transforming growth factor beta stimulus  (128 genes)  IGI  
GO:0031333 [list] [network] negative regulation of protein-containing complex assembly  (146 genes)  ISO  
GO:0010634 [list] [network] positive regulation of epithelial cell migration  (155 genes)  ISO  
GO:0071902 [list] [network] positive regulation of protein serine/threonine kinase activity  (186 genes)  ISO  
GO:0018105 [list] [network] peptidyl-serine phosphorylation  (187 genes)  ISO  
GO:0071375 [list] [network] cellular response to peptide hormone stimulus  (188 genes)  IGI  
GO:0050731 [list] [network] positive regulation of peptidyl-tyrosine phosphorylation  (191 genes)  IGI ISO  
GO:0046777 [list] [network] protein autophosphorylation  (194 genes)  ISO  
GO:0060491 [list] [network] regulation of cell projection assembly  (202 genes)  IGI  
GO:0043393 [list] [network] regulation of protein binding  (217 genes)  IDA  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (228 genes)  IMP ISO  
GO:0010632 [list] [network] regulation of epithelial cell migration  (240 genes)  ISO  
GO:0051222 [list] [network] positive regulation of protein transport  (317 genes)  ISO  
GO:0007169 [list] [network] transmembrane receptor protein tyrosine kinase signaling pathway  (365 genes)  IBA  
GO:0030900 [list] [network] forebrain development  (397 genes)  IGI  
GO:0022407 [list] [network] regulation of cell-cell adhesion  (458 genes)  ISO  
GO:0045785 [list] [network] positive regulation of cell adhesion  (472 genes)  ISO  
GO:0001819 [list] [network] positive regulation of cytokine production  (501 genes)  ISO  
GO:0008283 [list] [network] cell population proliferation  (578 genes)  ISO  
GO:0043065 [list] [network] positive regulation of apoptotic process  (598 genes)  ISO  
GO:0006468 [list] [network] protein phosphorylation  (665 genes)  IDA  
GO:0045087 [list] [network] innate immune response  (814 genes)  IBA  
GO:0016310 [list] [network] phosphorylation  (836 genes)  IMP  
GO:0007155 [list] [network] cell adhesion  (870 genes)  IBA  
GO:0016477 [list] [network] cell migration  (896 genes)  IMP  
GO:1902533 [list] [network] positive regulation of intracellular signal transduction  (940 genes)  ISO  
GO:0043066 [list] [network] negative regulation of apoptotic process  (968 genes)  ISO  
GO:0007049 [list] [network] cell cycle  (1198 genes)  IEA  
GO:0010628 [list] [network] positive regulation of gene expression  (1244 genes)  ISO  
GO:0045892 [list] [network] negative regulation of transcription, DNA-templated  (1298 genes)  ISO  
GO:0035556 [list] [network] intracellular signal transduction  (1356 genes)  IGI ISO  
GO:0045893 [list] [network] positive regulation of transcription, DNA-templated  (1550 genes)  ISO  
GO:0002376 [list] [network] immune system process  (2502 genes)  IEA  
GO:0030154 [list] [network] cell differentiation  (3713 genes)  IBA  
GO CC
GO:0002102 [list] [network] podosome  (26 genes)  IDA  
GO:0099091 [list] [network] postsynaptic specialization, intracellular component  (38 genes)  ISO  
GO:0032587 [list] [network] ruffle membrane  (73 genes)  IDA  
GO:0005901 [list] [network] caveola  (97 genes)  IDA ISO  
GO:0031234 [list] [network] extrinsic component of cytoplasmic side of plasma membrane  (105 genes)  IBA  
GO:0005884 [list] [network] actin filament  (131 genes)  IDA  
GO:0005925 [list] [network] focal adhesion  (170 genes)  IMP  
GO:0005770 [list] [network] late endosome  (244 genes)  ISO  
GO:0014069 [list] [network] postsynaptic density  (401 genes)  ISO  
GO:0005743 [list] [network] mitochondrial inner membrane  (454 genes)  IDA ISO  
GO:0098978 [list] [network] glutamatergic synapse  (518 genes)  ISO  
GO:0005764 [list] [network] lysosome  (520 genes)  ISO  
GO:0048471 [list] [network] perinuclear region of cytoplasm  (687 genes)  IDA ISO  
GO:0043005 [list] [network] neuron projection  (1541 genes)  ISO  
GO:0005739 [list] [network] mitochondrion  (1890 genes)  IDA ISO  
GO:0030054 [list] [network] cell junction  (2071 genes)  ISO  
GO:0005856 [list] [network] cytoskeleton  (2248 genes)  IDA  
GO:0005654 [list] [network] nucleoplasm  (3580 genes)  ISO TAS  
GO:0005829 [list] [network] cytosol  (3785 genes)  ISO TAS  
GO:0005886 [list] [network] plasma membrane  (5442 genes)  IDA ISO TAS  
GO:0005634 [list] [network] nucleus  (7226 genes)  IDA  
GO:0016020 [list] [network] membrane  (9571 genes)  IMP ISO  
GO:0005737 [list] [network] cytoplasm  (11434 genes)  IDA ISO  
GO MF
GO:0071253 [list] [network] connexin binding  (7 genes)  IPI  
GO:0070700 [list] [network] BMP receptor binding  (14 genes)  ISO  
GO:0016004 [list] [network] phospholipase activator activity  (16 genes)  ISO  
GO:0043274 [list] [network] phospholipase binding  (27 genes)  ISO  
GO:0005158 [list] [network] insulin receptor binding  (28 genes)  ISO  
GO:0046875 [list] [network] ephrin receptor binding  (32 genes)  IPI ISO  
GO:0004715 [list] [network] non-membrane spanning protein tyrosine kinase activity  (45 genes)  IBA ISO  
GO:0042169 [list] [network] SH2 domain binding  (46 genes)  ISO  
GO:0030331 [list] [network] estrogen receptor binding  (50 genes)  ISO  
GO:0005080 [list] [network] protein kinase C binding  (64 genes)  ISO  
GO:0097110 [list] [network] scaffold protein binding  (77 genes)  IPI ISO  
GO:0051219 [list] [network] phosphoprotein binding  (110 genes)  ISO  
GO:0004713 [list] [network] protein tyrosine kinase activity  (134 genes)  EXP IBA IDA IMP ISO  
GO:0005178 [list] [network] integrin binding  (142 genes)  ISO  
GO:0044325 [list] [network] transmembrane transporter binding  (147 genes)  ISO  
GO:0070851 [list] [network] growth factor receptor binding  (156 genes)  IBA ISO  
GO:0020037 [list] [network] heme binding  (162 genes)  ISO  
GO:0008022 [list] [network] protein C-terminus binding  (232 genes)  ISO  
GO:0050839 [list] [network] cell adhesion molecule binding  (295 genes)  ISO  
GO:0031625 [list] [network] ubiquitin protein ligase binding  (316 genes)  ISO  
GO:0004672 [list] [network] protein kinase activity  (583 genes)  IDA IMP ISO  
GO:0016301 [list] [network] kinase activity  (740 genes)  IMP  
GO:0019901 [list] [network] protein kinase binding  (774 genes)  ISO  
GO:0019904 [list] [network] protein domain specific binding  (820 genes)  IPI  
GO:0019900 [list] [network] kinase binding  (865 genes)  ISO  
GO:0005524 [list] [network] ATP binding  (1396 genes)  IEA  
GO:0044877 [list] [network] protein-containing complex binding  (1549 genes)  ISO  
GO:0005102 [list] [network] signaling receptor binding  (1742 genes)  IBA ISO  
GO:0000166 [list] [network] nucleotide binding  (2052 genes)  IEA  
GO:0016740 [list] [network] transferase activity  (2235 genes)  IEA  
GO:0019899 [list] [network] enzyme binding  (2298 genes)  ISO  
GO:0005515 [list] [network] protein binding  (9507 genes)  IPI  
KEGG mmu01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
mmu01522 [list] [network] Endocrine resistance (93 genes)
mmu04012 [list] [network] ErbB signaling pathway (84 genes)
mmu04015 [list] [network] Rap1 signaling pathway (214 genes)
mmu04062 [list] [network] Chemokine signaling pathway (192 genes)
mmu04137 [list] [network] Mitophagy - animal (68 genes)
mmu04144 [list] [network] Endocytosis (272 genes)
mmu04360 [list] [network] Axon guidance (181 genes)
mmu04370 [list] [network] VEGF signaling pathway (58 genes)
mmu04510 [list] [network] Focal adhesion (201 genes)
mmu04520 [list] [network] Adherens junction (71 genes)
mmu04530 [list] [network] Tight junction (167 genes)
mmu04540 [list] [network] Gap junction (86 genes)
mmu04611 [list] [network] Platelet activation (124 genes)
mmu04613 [list] [network] Neutrophil extracellular trap formation (207 genes)
mmu04625 [list] [network] C-type lectin receptor signaling pathway (112 genes)
mmu04727 [list] [network] GABAergic synapse (89 genes)
mmu04750 [list] [network] Inflammatory mediator regulation of TRP channels (127 genes)
mmu04810 [list] [network] Regulation of actin cytoskeleton (220 genes)
mmu04912 [list] [network] GnRH signaling pathway (90 genes)
mmu04915 [list] [network] Estrogen signaling pathway (134 genes)
mmu04917 [list] [network] Prolactin signaling pathway (74 genes)
mmu04919 [list] [network] Thyroid hormone signaling pathway (120 genes)
mmu04921 [list] [network] Oxytocin signaling pathway (153 genes)
mmu04926 [list] [network] Relaxin signaling pathway (129 genes)
mmu05100 [list] [network] Bacterial invasion of epithelial cells (76 genes)
mmu05135 [list] [network] Yersinia infection (134 genes)
mmu05152 [list] [network] Tuberculosis (180 genes)
mmu05161 [list] [network] Hepatitis B (163 genes)
mmu05163 [list] [network] Human cytomegalovirus infection (256 genes)
mmu05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (224 genes)
mmu05168 [list] [network] Herpes simplex virus 1 infection (459 genes)
mmu05203 [list] [network] Viral carcinogenesis (229 genes)
mmu05205 [list] [network] Proteoglycans in cancer (205 genes)
mmu05207 [list] [network] Chemical carcinogenesis - receptor activation (225 genes)
mmu05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (222 genes)
mmu05219 [list] [network] Bladder cancer (41 genes)
mmu05417 [list] [network] Lipid and atherosclerosis (216 genes)
mmu05418 [list] [network] Fluid shear stress and atherosclerosis (148 genes)
Protein NP_001020566.1  NP_033297.2  XP_006499126.1  XP_006499128.1  XP_006499129.1  XP_011237704.1  XP_011237705.1  XP_011237706.1  XP_030104859.1  XP_030104861.1  XP_030104862.1  XP_036015972.1  XP_036015973.1  XP_036015974.1  XP_036015976.1  XP_036015977.1  XP_036015978.1 
BLAST NP_001020566.1  NP_033297.2  XP_006499126.1  XP_006499128.1  XP_006499129.1  XP_011237704.1  XP_011237705.1  XP_011237706.1  XP_030104859.1  XP_030104861.1  XP_030104862.1  XP_036015972.1  XP_036015973.1  XP_036015974.1  XP_036015976.1  XP_036015977.1  XP_036015978.1 
Orthologous [Ortholog page] BLK (hsa)  FGR (hsa)  FRK (hsa)  FYN (hsa)  HCK (hsa)  LCK (hsa)  LYN (hsa)  PTK6 (hsa)  SRC (hsa)  SRMS (hsa)  YES1 (hsa)  Blk (mmu)  Fgr (mmu)  Frk (mmu)  Fyn (mmu)  Hck (mmu)  Lck (mmu)  Lyn (mmu)  Ptk6 (mmu)  Srms (mmu)  Yes1 (mmu)  Yes1 (rno)  Fyn (rno)  Hck (rno)  Src42A (dme)  Src64B (dme)  Fgr (rno)  Frk (rno)  Lyn (rno)  Src (rno)  src-1 (cel)  F26E4.5 (cel)  src-2 (cel)  T25B9.4 (cel)  W01B6.5 (cel)  Srms (rno)  Lck (rno)  src (dre)  yrk (dre)  Blk (rno)  Ptk6 (rno)  fyna (dre)  YES1 (gga)  FYN (gga)  SRC (gga)  LCK (gga)  YES1 (cfa)  yes1 (dre)  lck (dre)  PTK6 (gga)  HCK (gga)  LYN (gga)  FRK (gga)  BLK (gga)  lyn (dre)  FYN (cfa)  SRMS (cfa)  LYN (cfa)  LCK (cfa)  FRK (cfa)  HCK (cfa)  SRC (cfa)  BLK (cfa)  FGR (cfa)  ptk6a (dre)  frk (dre)  blk (dre)  FYN (mcc)  fynb (dre)  BLK (mcc)  YES1 (mcc)  LYN (mcc)  SRC (mcc)  HCK (mcc)  FRK (mcc)  FGR (mcc)  LCK (mcc)  SRMS (mcc)  PTK6 (mcc)  ptk6b (dre)  FGR (gga)  nda2 (spo)  atb2 (spo)  srms (dre)  FGR (fca)  BLK (fca)  FYN (fca)  FRK (fca)  YES1 (fca)  LYN (fca)  LCK (fca)  SRMS (fca)  PTK6 (fca)  SRC (fca)  HCK (fca)  hck (dre)  LOC102156300 (cfa)  LOC119865729 (cfa) 
Subcellular
localization
wolf
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for NP_001020566.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for NP_033297.2)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_006499126.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_006499128.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_006499129.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_011237704.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_011237705.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_011237706.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_030104859.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_030104861.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_030104862.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_036015972.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_036015973.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_036015974.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_036015976.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_036015977.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_036015978.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04015 Rap1 signaling pathway 4
mmu04530 Tight junction 3
mmu04014 Ras signaling pathway 2
mmu04072 Phospholipase D signaling pathway 2
mmu05200 Pathways in cancer 2
Genes directly connected with Src on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
5.5 Dlg5 discs large MAGUK scaffold protein 5 [detail] 0 71228
5.3 Slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 [detail] 0 102857
5.2 Foxp4 forkhead box P4 [detail] 0 74123
4.8 Ralgds ral guanine nucleotide dissociation stimulator [detail] 0 19730
Coexpressed
gene list		 [Coexpressed gene list for Src]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity*
Link to other DBs
Entrez Gene ID 20779      
Refseq ID (protein) NP_001020566.1 
NP_033297.2 
XP_006499126.1 
XP_006499128.1 
XP_006499129.1 
XP_011237704.1 
XP_011237705.1 
XP_011237706.1 
XP_030104859.1 
XP_030104861.1 
XP_030104862.1 
XP_036015972.1 
XP_036015973.1 
XP_036015974.1 
XP_036015976.1 
XP_036015977.1 
XP_036015978.1 


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