[←][→] hsa  PDGFRA Gene
functional annotation
Function   platelet derived growth factor receptor alpha  
GO BP
GO:0035790 [list] [network] platelet-derived growth factor receptor-alpha signaling pathway  (1 genes)  IMP  
GO:0038091 [list] [network] positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  (3 genes)  IDA  
GO:0072277 [list] [network] metanephric glomerular capillary formation  (3 genes)  ISS  
GO:2000739 [list] [network] regulation of mesenchymal stem cell differentiation  (7 genes)  IMP  
GO:0001553 [list] [network] luteinization  (8 genes)  ISS  
GO:0033327 [list] [network] Leydig cell differentiation  (11 genes)  IEA  
GO:0050872 [list] [network] white fat cell differentiation  (14 genes)  IEA  
GO:0048557 [list] [network] embryonic digestive tract morphogenesis  (16 genes)  ISS  
GO:0055003 [list] [network] cardiac myofibril assembly  (16 genes)  ISS  
GO:0061298 [list] [network] retina vasculature development in camera-type eye  (17 genes)  ISS  
GO:0010544 [list] [network] negative regulation of platelet activation  (19 genes)  IDA  
GO:0023019 [list] [network] signal transduction involved in regulation of gene expression  (21 genes)  IEA  
GO:0030325 [list] [network] adrenal gland development  (23 genes)  IEA  
GO:0030539 [list] [network] male genitalia development  (23 genes)  IEA  
GO:0060325 [list] [network] face morphogenesis  (29 genes)  IEA  
GO:0043552 [list] [network] positive regulation of phosphatidylinositol 3-kinase activity  (33 genes)  IMP  
GO:0048008 [list] [network] platelet-derived growth factor receptor signaling pathway  (35 genes)  IDA  
GO:0008210 [list] [network] estrogen metabolic process  (39 genes)  IEA  
GO:2000249 [list] [network] regulation of actin cytoskeleton reorganization  (39 genes)  TAS  
GO:0070527 [list] [network] platelet aggregation  (45 genes)  IMP  
GO:0010863 [list] [network] positive regulation of phospholipase C activity  (46 genes)  IMP  
GO:0048701 [list] [network] embryonic cranial skeleton morphogenesis  (46 genes)  IBA ISS  
GO:0048146 [list] [network] positive regulation of fibroblast proliferation  (48 genes)  IDA  
GO:0071230 [list] [network] cellular response to amino acid stimulus  (71 genes)  IEA  
GO:0048015 [list] [network] phosphatidylinositol-mediated signaling  (79 genes)  IMP  
GO:0042475 [list] [network] odontogenesis of dentin-containing tooth  (80 genes)  IEA  
GO:0002244 [list] [network] hematopoietic progenitor cell differentiation  (84 genes)  IEA  
GO:0060021 [list] [network] roof of mouth development  (86 genes)  IEA  
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling  (91 genes)  TAS  
GO:0048704 [list] [network] embryonic skeletal system morphogenesis  (94 genes)  ISS  
GO:0034614 [list] [network] cellular response to reactive oxygen species  (125 genes)  IDA  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (149 genes)  IDA  
GO:0030324 [list] [network] lung development  (172 genes)  IEA  
GO:0051897 [list] [network] positive regulation of protein kinase B signaling  (186 genes)  TAS  
GO:0046777 [list] [network] protein autophosphorylation  (187 genes)  IDA  
GO:0060326 [list] [network] cell chemotaxis  (205 genes)  IMP  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (217 genes)  IMP  
GO:0050920 [list] [network] regulation of chemotaxis  (223 genes)  IMP  
GO:0007204 [list] [network] positive regulation of cytosolic calcium ion concentration  (280 genes)  IMP  
GO:0001701 [list] [network] in utero embryonic development  (362 genes)  IEA  
GO:0000165 [list] [network] MAPK cascade  (376 genes)  TAS  
GO:0030198 [list] [network] extracellular matrix organization  (379 genes)  IEA  
GO:0042060 [list] [network] wound healing  (455 genes)  ISS  
GO:0033674 [list] [network] positive regulation of kinase activity  (477 genes)  IBA  
GO:0007169 [list] [network] transmembrane receptor protein tyrosine kinase signaling pathway  (525 genes)  IBA  
GO:0030335 [list] [network] positive regulation of cell migration  (554 genes)  IDA IMP  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (976 genes)  IDA IMP  
GO:0001775 [list] [network] cell activation  (1087 genes)  TAS  
GO:0007275 [list] [network] multicellular organism development  (4941 genes)  IBA  
GO CC
GO:0005902 [list] [network] microvillus  (91 genes)  IEA  
GO:0009897 [list] [network] external side of plasma membrane  (415 genes)  IEA  
GO:0043235 [list] [network] receptor complex  (530 genes)  IBA  
GO:0005929 [list] [network] cilium  (678 genes)  ISS  
GO:0005789 [list] [network] endoplasmic reticulum membrane  (1133 genes)  TAS  
GO:0005794 [list] [network] Golgi apparatus  (1594 genes)  ISS  
GO:0005887 [list] [network] integral component of plasma membrane  (1649 genes)  IBA IDA  
GO:0031226 [list] [network] intrinsic component of plasma membrane  (1731 genes)  IDA  
GO:0030054 [list] [network] cell junction  (2092 genes)  IDA  
GO:0005654 [list] [network] nucleoplasm  (4086 genes)  IDA  
GO:0032991 [list] [network] protein-containing complex  (5444 genes)  IDA  
GO:0005886 [list] [network] plasma membrane  (5772 genes)  IDA TAS  
GO:0005634 [list] [network] nucleus  (8115 genes)  ISS  
GO:0016020 [list] [network] membrane  (9592 genes)  HDA  
GO:0005737 [list] [network] cytoplasm  (11897 genes)  ISS  
GO MF
GO:0005018 [list] [network] platelet-derived growth factor alpha-receptor activity  (1 genes)  IBA IDA IMP  
GO:0038085 [list] [network] vascular endothelial growth factor binding  (5 genes)  IPI  
GO:0005021 [list] [network] vascular endothelial growth factor-activated receptor activity  (7 genes)  IDA  
GO:0048407 [list] [network] platelet-derived growth factor binding  (11 genes)  IBA IDA IPI  
GO:0005161 [list] [network] platelet-derived growth factor receptor binding  (15 genes)  IPI  
GO:0004714 [list] [network] transmembrane receptor protein tyrosine kinase activity  (127 genes)  IBA IDA  
GO:0019838 [list] [network] growth factor binding  (142 genes)  IBA  
GO:0004672 [list] [network] protein kinase activity  (577 genes)  IDA  
GO:0042803 [list] [network] protein homodimerization activity  (680 genes)  IDA  
GO:0044877 [list] [network] protein-containing complex binding  (1303 genes)  IEA  
GO:0005524 [list] [network] ATP binding  (1474 genes)  IEA  
GO:0005515 [list] [network] protein binding  (13898 genes)  IPI  
KEGG hsa01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
hsa04010 [list] [network] MAPK signaling pathway (294 genes)
hsa04014 [list] [network] Ras signaling pathway (232 genes)
hsa04015 [list] [network] Rap1 signaling pathway (210 genes)
hsa04020 [list] [network] Calcium signaling pathway (240 genes)
hsa04072 [list] [network] Phospholipase D signaling pathway (148 genes)
hsa04144 [list] [network] Endocytosis (251 genes)
hsa04151 [list] [network] PI3K-Akt signaling pathway (354 genes)
hsa04510 [list] [network] Focal adhesion (201 genes)
hsa04540 [list] [network] Gap junction (88 genes)
hsa04630 [list] [network] JAK-STAT signaling pathway (162 genes)
hsa04810 [list] [network] Regulation of actin cytoskeleton (218 genes)
hsa05163 [list] [network] Human cytomegalovirus infection (225 genes)
hsa05200 [list] [network] Pathways in cancer (531 genes)
hsa05206 [list] [network] MicroRNAs in cancer (310 genes)
hsa05214 [list] [network] Glioma (75 genes)
hsa05215 [list] [network] Prostate cancer (97 genes)
hsa05218 [list] [network] Melanoma (72 genes)
hsa05230 [list] [network] Central carbon metabolism in cancer (70 genes)
hsa05231 [list] [network] Choline metabolism in cancer (98 genes)
Protein NP_001334756.1  NP_001334757.1  NP_001334758.1  NP_001334759.1  NP_006197.1  XP_005265800.1  XP_006714104.1  XP_016863770.1 
BLAST NP_001334756.1  NP_001334757.1  NP_001334758.1  NP_001334759.1  NP_006197.1  XP_005265800.1  XP_006714104.1  XP_016863770.1 
Orthologous [Ortholog page] Pdgfra (mmu)  Pdgfra (rno)  pdgfra (dre)  PDGFRA (gga)  PDGFRA (cfa)  PDGFRA (mcc)  PDGFRA (fca) 
Subcellular
localization
wolf
extr 3,  plas 2,  pero 2,  E.R. 2,  cyto_pero 1,  nucl 1  (predict for NP_001334756.1)
plas 8,  extr 1  (predict for NP_001334757.1)
extr 3,  plas 3,  E.R. 2,  pero 2,  nucl 1  (predict for NP_001334758.1)
plas 8,  pero 1  (predict for NP_001334759.1)
extr 3,  plas 3,  E.R. 2,  pero 2,  nucl 1  (predict for NP_006197.1)
extr 3,  plas 3,  E.R. 2,  pero 2,  nucl 1  (predict for XP_005265800.1)
plas 8,  extr 1,  mito 0,  pero 0,  lyso 0,  mito_pero 0,  E.R._golg 0  (predict for XP_006714104.1)
plas 8,  pero 2  (predict for XP_016863770.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04151 PI3K-Akt signaling pathway 9
hsa04510 Focal adhesion 7
hsa04974 Protein digestion and absorption 5
hsa04015 Rap1 signaling pathway 5
hsa05200 Pathways in cancer 5
Genes directly connected with PDGFRA on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
7.3 COL6A3 collagen type VI alpha 3 chain [detail] 2 1293
6.6 DCN decorin [detail] 12 1634
6.5 PCDH18 protocadherin 18 [detail] 0 54510
6.1 SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 [detail] 0 79987
6.1 PRRX1 paired related homeobox 1 [detail] 6 5396
5.5 COLEC12 collectin subfamily member 12 [detail] 0 81035
5.1 HGF hepatocyte growth factor [detail] 0 3082
4.8 HAS2 hyaluronan synthase 2 [detail] 0 3037
4.7 CLMP CXADR like membrane protein [detail] 0 79827
4.5 LPAR1 lysophosphatidic acid receptor 1 [detail] 0 1902
Coexpressed
gene list		 [Coexpressed gene list for PDGFRA]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 5156      
Refseq ID (protein) NP_001334756.1 
NP_001334757.1 
NP_001334758.1 
NP_001334759.1 
NP_006197.1 
XP_005265800.1 
XP_006714104.1 
XP_016863770.1 


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