[←][→] fca  SOS2 Gene
functional annotation
Function   SOS Ras/Rho guanine nucleotide exchange factor 2  
GO BP
GO CC
GO MF
KEGG fca01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (80 genes)
fca01522 [list] [network] Endocrine resistance (96 genes)
fca04010 [list] [network] MAPK signaling pathway (289 genes)
fca04012 [list] [network] ErbB signaling pathway (84 genes)
fca04014 [list] [network] Ras signaling pathway (231 genes)
fca04062 [list] [network] Chemokine signaling pathway (183 genes)
fca04068 [list] [network] FoxO signaling pathway (129 genes)
fca04072 [list] [network] Phospholipase D signaling pathway (151 genes)
fca04150 [list] [network] mTOR signaling pathway (155 genes)
fca04151 [list] [network] PI3K-Akt signaling pathway (344 genes)
fca04510 [list] [network] Focal adhesion (201 genes)
fca04540 [list] [network] Gap junction (86 genes)
fca04630 [list] [network] JAK-STAT signaling pathway (159 genes)
fca04650 [list] [network] Natural killer cell mediated cytotoxicity (98 genes)
fca04660 [list] [network] T cell receptor signaling pathway (103 genes)
fca04662 [list] [network] B cell receptor signaling pathway (74 genes)
fca04664 [list] [network] Fc epsilon RI signaling pathway (69 genes)
fca04714 [list] [network] Thermogenesis (234 genes)
fca04722 [list] [network] Neurotrophin signaling pathway (121 genes)
fca04810 [list] [network] Regulation of actin cytoskeleton (219 genes)
fca04910 [list] [network] Insulin signaling pathway (140 genes)
fca04912 [list] [network] GnRH signaling pathway (93 genes)
fca04915 [list] [network] Estrogen signaling pathway (139 genes)
fca04917 [list] [network] Prolactin signaling pathway (71 genes)
fca04926 [list] [network] Relaxin signaling pathway (129 genes)
fca04935 [list] [network] Growth hormone synthesis, secretion and action (117 genes)
fca05034 [list] [network] Alcoholism (189 genes)
fca05160 [list] [network] Hepatitis C (153 genes)
fca05161 [list] [network] Hepatitis B (157 genes)
fca05163 [list] [network] Human cytomegalovirus infection (225 genes)
fca05165 [list] [network] Human papillomavirus infection (328 genes)
fca05200 [list] [network] Pathways in cancer (531 genes)
fca05205 [list] [network] Proteoglycans in cancer (212 genes)
fca05206 [list] [network] MicroRNAs in cancer (161 genes)
fca05207 [list] [network] Chemical carcinogenesis - receptor activation (181 genes)
fca05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (224 genes)
fca05210 [list] [network] Colorectal cancer (89 genes)
fca05211 [list] [network] Renal cell carcinoma (70 genes)
fca05213 [list] [network] Endometrial cancer (57 genes)
fca05214 [list] [network] Glioma (76 genes)
fca05215 [list] [network] Prostate cancer (95 genes)
fca05220 [list] [network] Chronic myeloid leukemia (75 genes)
fca05221 [list] [network] Acute myeloid leukemia (67 genes)
fca05223 [list] [network] Non-small cell lung cancer (72 genes)
fca05224 [list] [network] Breast cancer (146 genes)
fca05225 [list] [network] Hepatocellular carcinoma (163 genes)
fca05226 [list] [network] Gastric cancer (147 genes)
fca05231 [list] [network] Choline metabolism in cancer (97 genes)
Protein XP_023111443.1 
BLAST XP_023111443.1 
Orthologous [Ortholog page] SOS1 (hsa)  SOS2 (hsa)  Sos1 (mmu)  Sos2 (mmu)  Sos (dme)  Sos2 (rno)  sos-1 (cel)  Sos1 (rno)  SOS2 (gga)  SOS1 (gga)  SOS1 (cfa)  SOS2 (cfa)  sos1 (dre)  sos2 (dre)  SOS2 (mcc)  SOS1 (mcc)  CDC25 (sce)  SOS1 (fca) 
Subcellular
localization
wolf
nucl 5,  cyto 3,  pero 1,  cysk 1  (predict for XP_023111443.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
fca04068 FoxO signaling pathway 2
fca04110 Cell cycle 2
fca04151 PI3K-Akt signaling pathway 2
fca05165 Human papillomavirus infection 2
fca04150 mTOR signaling pathway 2
Genes directly connected with SOS2 on the network
coex z* Locus Function* Coexpression
detail		 Entrez Gene ID*
7.8 MARCHF7 membrane associated ring-CH-type finger 7 [detail] 101093628
7.1 PHF3 PHD finger protein 3 [detail] 101082655
6.7 SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 [detail] 101087430
6.7 ERCC6L2 ERCC excision repair 6 like 2 [detail] 101088625
6.5 ZMYM1 zinc finger MYM-type containing 1 [detail] 101085056
6.0 RBL2 RB transcriptional corepressor like 2 [detail] 101097858
5.9 ABRAXAS1 abraxas 1, BRCA1 A complex subunit [detail] 101083929
Coexpressed
gene list		 [Coexpressed gene list for SOS2]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity*
Link to other DBs
Entrez Gene ID 101088847      
Refseq ID (protein) XP_023111443.1 


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