[←][→] fca  SOS1 Gene
functional annotation
Function   SOS Ras/Rac guanine nucleotide exchange factor 1  
GO BP
GO CC
GO MF
KEGG fca01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (80 genes)
fca01522 [list] [network] Endocrine resistance (96 genes)
fca04010 [list] [network] MAPK signaling pathway (289 genes)
fca04012 [list] [network] ErbB signaling pathway (84 genes)
fca04014 [list] [network] Ras signaling pathway (231 genes)
fca04062 [list] [network] Chemokine signaling pathway (183 genes)
fca04068 [list] [network] FoxO signaling pathway (129 genes)
fca04072 [list] [network] Phospholipase D signaling pathway (151 genes)
fca04150 [list] [network] mTOR signaling pathway (155 genes)
fca04151 [list] [network] PI3K-Akt signaling pathway (344 genes)
fca04510 [list] [network] Focal adhesion (201 genes)
fca04540 [list] [network] Gap junction (86 genes)
fca04630 [list] [network] JAK-STAT signaling pathway (159 genes)
fca04650 [list] [network] Natural killer cell mediated cytotoxicity (98 genes)
fca04660 [list] [network] T cell receptor signaling pathway (103 genes)
fca04662 [list] [network] B cell receptor signaling pathway (74 genes)
fca04664 [list] [network] Fc epsilon RI signaling pathway (69 genes)
fca04714 [list] [network] Thermogenesis (234 genes)
fca04722 [list] [network] Neurotrophin signaling pathway (121 genes)
fca04810 [list] [network] Regulation of actin cytoskeleton (219 genes)
fca04910 [list] [network] Insulin signaling pathway (140 genes)
fca04912 [list] [network] GnRH signaling pathway (93 genes)
fca04915 [list] [network] Estrogen signaling pathway (139 genes)
fca04917 [list] [network] Prolactin signaling pathway (71 genes)
fca04926 [list] [network] Relaxin signaling pathway (129 genes)
fca04935 [list] [network] Growth hormone synthesis, secretion and action (117 genes)
fca05034 [list] [network] Alcoholism (189 genes)
fca05160 [list] [network] Hepatitis C (153 genes)
fca05161 [list] [network] Hepatitis B (157 genes)
fca05163 [list] [network] Human cytomegalovirus infection (225 genes)
fca05165 [list] [network] Human papillomavirus infection (328 genes)
fca05200 [list] [network] Pathways in cancer (531 genes)
fca05205 [list] [network] Proteoglycans in cancer (212 genes)
fca05206 [list] [network] MicroRNAs in cancer (161 genes)
fca05207 [list] [network] Chemical carcinogenesis - receptor activation (181 genes)
fca05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (224 genes)
fca05210 [list] [network] Colorectal cancer (89 genes)
fca05211 [list] [network] Renal cell carcinoma (70 genes)
fca05213 [list] [network] Endometrial cancer (57 genes)
fca05214 [list] [network] Glioma (76 genes)
fca05215 [list] [network] Prostate cancer (95 genes)
fca05220 [list] [network] Chronic myeloid leukemia (75 genes)
fca05221 [list] [network] Acute myeloid leukemia (67 genes)
fca05223 [list] [network] Non-small cell lung cancer (72 genes)
fca05224 [list] [network] Breast cancer (146 genes)
fca05225 [list] [network] Hepatocellular carcinoma (163 genes)
fca05226 [list] [network] Gastric cancer (147 genes)
fca05231 [list] [network] Choline metabolism in cancer (97 genes)
Protein XP_011279463.1  XP_011279464.1  XP_011279465.1 
BLAST XP_011279463.1  XP_011279464.1  XP_011279465.1 
Orthologous [Ortholog page] SOS1 (hsa)  SOS2 (hsa)  Sos1 (mmu)  Sos2 (mmu)  Sos (dme)  Sos2 (rno)  sos-1 (cel)  Sos1 (rno)  SOS2 (gga)  SOS1 (gga)  SOS1 (cfa)  SOS2 (cfa)  sos1 (dre)  sos2 (dre)  SOS2 (mcc)  SOS1 (mcc)  CDC25 (sce)  SOS2 (fca) 
Subcellular
localization
wolf
nucl 5,  cyto_nucl 4,  cyto 3  (predict for XP_011279463.1)
nucl 5,  cyto_nucl 4,  cyto 3  (predict for XP_011279464.1)
nucl 5,  cyto_nucl 4,  cyto 3  (predict for XP_011279465.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
fca04714 Thermogenesis 3
fca05225 Hepatocellular carcinoma 3
fca04068 FoxO signaling pathway 3
fca04630 JAK-STAT signaling pathway 3
fca04935 Growth hormone synthesis, secretion and action 3
Genes directly connected with SOS1 on the network
coex z* Locus Function* Coexpression
detail		 Entrez Gene ID*
7.2 EP300 E1A binding protein p300 [detail] 101088344
6.6 EXOC1 exocyst complex component 1 [detail] 101088235
6.5 GPATCH8 G-patch domain containing 8 [detail] 101101177
6.1 LOC105260984 uncharacterized LOC105260984 [detail] 105260984
6.1 ZNF445 zinc finger protein 445 [detail] 101099145
5.7 LOC109493877 uncharacterized LOC109493877 [detail] 109493877
4.1 LOC111556919 uncharacterized LOC111556919 [detail] 111556919
Coexpressed
gene list		 [Coexpressed gene list for SOS1]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity*
Link to other DBs
Entrez Gene ID 101098862      
Refseq ID (protein) XP_011279463.1 
XP_011279464.1 
XP_011279465.1 


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