[←][→] hsa  GRB2 Gene
functional annotation
Function   growth factor receptor bound protein 2  
GO BP
GO:0035635 [list] [network] entry of bacterium into host cell  (8 genes)  TAS  
GO:0060670 [list] [network] branching involved in labyrinthine layer morphogenesis  (12 genes)  IEA  
GO:0035723 [list] [network] interleukin-15-mediated signaling pathway  (13 genes)  TAS  
GO:0048011 [list] [network] neurotrophin TRK receptor signaling pathway  (20 genes)  TAS  
GO:0038128 [list] [network] ERBB2 signaling pathway  (32 genes)  TAS  
GO:0042059 [list] [network] negative regulation of epidermal growth factor receptor signaling pathway  (48 genes)  TAS  
GO:0007173 [list] [network] epidermal growth factor receptor signaling pathway  (51 genes)  IMP TAS  
GO:0031295 [list] [network] T cell costimulation  (53 genes)  TAS  
GO:0031623 [list] [network] receptor internalization  (64 genes)  IMP  
GO:0031532 [list] [network] actin cytoskeleton reorganization  (67 genes)  IMP  
GO:0071479 [list] [network] cellular response to ionizing radiation  (70 genes)  IMP  
GO:0046579 [list] [network] positive regulation of Ras protein signal transduction  (73 genes)  TAS  
GO:2000379 [list] [network] positive regulation of reactive oxygen species metabolic process  (75 genes)  IMP  
GO:0008543 [list] [network] fibroblast growth factor receptor signaling pathway  (80 genes)  TAS  
GO:0030838 [list] [network] positive regulation of actin filament polymerization  (85 genes)  IEA  
GO:0008286 [list] [network] insulin receptor signaling pathway  (87 genes)  IPI TAS  
GO:0038096 [list] [network] Fc-gamma receptor signaling pathway involved in phagocytosis  (132 genes)  TAS  
GO:0042770 [list] [network] signal transduction in response to DNA damage  (163 genes)  IMP  
GO:0038095 [list] [network] Fc-epsilon receptor signaling pathway  (169 genes)  TAS  
GO:0007265 [list] [network] Ras protein signal transduction  (176 genes)  TAS  
GO:0051897 [list] [network] positive regulation of protein kinase B signaling  (186 genes)  TAS  
GO:0007411 [list] [network] axon guidance  (270 genes)  TAS  
GO:0007568 [list] [network] aging  (279 genes)  IEA  
GO:0050900 [list] [network] leukocyte migration  (375 genes)  TAS  
GO:0000165 [list] [network] MAPK cascade  (376 genes)  TAS  
GO:0043408 [list] [network] regulation of MAPK cascade  (628 genes)  IEA  
GO:0019221 [list] [network] cytokine-mediated signaling pathway  (709 genes)  TAS  
GO:0048646 [list] [network] anatomical structure formation involved in morphogenesis  (875 genes)  IEA  
GO:0061024 [list] [network] membrane organization  (952 genes)  TAS  
GO CC
GO:0070436 [list] [network] Grb2-EGFR complex  (2 genes)  IDA  
GO:0008180 [list] [network] COP9 signalosome  (15 genes)  IDA  
GO:0005911 [list] [network] cell-cell junction  (492 genes)  IEA  
GO:0005768 [list] [network] endosome  (991 genes)  IDA  
GO:0012506 [list] [network] vesicle membrane  (1184 genes)  IEA  
GO:0005730 [list] [network] nucleolus  (1457 genes)  IDA  
GO:0005794 [list] [network] Golgi apparatus  (1594 genes)  IEA  
GO:0070062 [list] [network] extracellular exosome  (2212 genes)  HDA  
GO:0005654 [list] [network] nucleoplasm  (4086 genes)  IDA  
GO:0005829 [list] [network] cytosol  (5345 genes)  TAS  
GO:0005886 [list] [network] plasma membrane  (5772 genes)  TAS  
GO:0005634 [list] [network] nucleus  (8115 genes)  IDA  
GO:0005737 [list] [network] cytoplasm  (11897 genes)  IDA  
GO MF
GO:0005168 [list] [network] neurotrophin TRKA receptor binding  (6 genes)  IPI  
GO:0043560 [list] [network] insulin receptor substrate binding  (11 genes)  IPI  
GO:0046875 [list] [network] ephrin receptor binding  (28 genes)  IPI  
GO:0005154 [list] [network] epidermal growth factor receptor binding  (33 genes)  IPI  
GO:0001784 [list] [network] phosphotyrosine residue binding  (44 genes)  IPI  
GO:0017124 [list] [network] SH3 domain binding  (130 genes)  IDA  
GO:0019903 [list] [network] protein phosphatase binding  (150 genes)  IEA  
GO:0030674 [list] [network] protein-macromolecule adaptor activity  (289 genes)  IEA  
GO:0019901 [list] [network] protein kinase binding  (677 genes)  IPI  
GO:0044877 [list] [network] protein-containing complex binding  (1303 genes)  IEA  
GO:0003723 [list] [network] RNA binding  (1968 genes)  HDA  
GO:0042802 [list] [network] identical protein binding  (1971 genes)  IPI  
GO:0005515 [list] [network] protein binding  (13898 genes)  IPI  
KEGG hsa01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
hsa01522 [list] [network] Endocrine resistance (98 genes)
hsa04010 [list] [network] MAPK signaling pathway (294 genes)
hsa04012 [list] [network] ErbB signaling pathway (85 genes)
hsa04014 [list] [network] Ras signaling pathway (232 genes)
hsa04062 [list] [network] Chemokine signaling pathway (192 genes)
hsa04068 [list] [network] FoxO signaling pathway (131 genes)
hsa04072 [list] [network] Phospholipase D signaling pathway (148 genes)
hsa04150 [list] [network] mTOR signaling pathway (155 genes)
hsa04151 [list] [network] PI3K-Akt signaling pathway (354 genes)
hsa04380 [list] [network] Osteoclast differentiation (128 genes)
hsa04510 [list] [network] Focal adhesion (201 genes)
hsa04540 [list] [network] Gap junction (88 genes)
hsa04550 [list] [network] Signaling pathways regulating pluripotency of stem cells (143 genes)
hsa04630 [list] [network] JAK-STAT signaling pathway (162 genes)
hsa04650 [list] [network] Natural killer cell mediated cytotoxicity (131 genes)
hsa04660 [list] [network] T cell receptor signaling pathway (104 genes)
hsa04662 [list] [network] B cell receptor signaling pathway (82 genes)
hsa04664 [list] [network] Fc epsilon RI signaling pathway (68 genes)
hsa04714 [list] [network] Thermogenesis (232 genes)
hsa04722 [list] [network] Neurotrophin signaling pathway (119 genes)
hsa04910 [list] [network] Insulin signaling pathway (137 genes)
hsa04912 [list] [network] GnRH signaling pathway (93 genes)
hsa04915 [list] [network] Estrogen signaling pathway (138 genes)
hsa04917 [list] [network] Prolactin signaling pathway (70 genes)
hsa04926 [list] [network] Relaxin signaling pathway (129 genes)
hsa04935 [list] [network] Growth hormone synthesis, secretion and action (119 genes)
hsa05034 [list] [network] Alcoholism (187 genes)
hsa05160 [list] [network] Hepatitis C (157 genes)
hsa05161 [list] [network] Hepatitis B (162 genes)
hsa05163 [list] [network] Human cytomegalovirus infection (225 genes)
hsa05165 [list] [network] Human papillomavirus infection (331 genes)
hsa05200 [list] [network] Pathways in cancer (531 genes)
hsa05203 [list] [network] Viral carcinogenesis (204 genes)
hsa05205 [list] [network] Proteoglycans in cancer (205 genes)
hsa05206 [list] [network] MicroRNAs in cancer (310 genes)
hsa05207 [list] [network] Chemical carcinogenesis - receptor activation (212 genes)
hsa05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (223 genes)
hsa05210 [list] [network] Colorectal cancer (86 genes)
hsa05211 [list] [network] Renal cell carcinoma (69 genes)
hsa05213 [list] [network] Endometrial cancer (58 genes)
hsa05214 [list] [network] Glioma (75 genes)
hsa05215 [list] [network] Prostate cancer (97 genes)
hsa05220 [list] [network] Chronic myeloid leukemia (76 genes)
hsa05221 [list] [network] Acute myeloid leukemia (67 genes)
hsa05223 [list] [network] Non-small cell lung cancer (72 genes)
hsa05224 [list] [network] Breast cancer (147 genes)
hsa05225 [list] [network] Hepatocellular carcinoma (168 genes)
hsa05226 [list] [network] Gastric cancer (149 genes)
hsa05231 [list] [network] Choline metabolism in cancer (98 genes)
Protein NP_002077.1  NP_987102.1 
BLAST NP_002077.1  NP_987102.1 
Orthologous [Ortholog page] GRAP2 (hsa)  GRAP (hsa)  Grb2 (mmu)  Grap2 (mmu)  drk (dme)  Grap (mmu)  Grb2 (rno)  sem-5 (cel)  Grap (rno)  Grap2 (rno)  GRB2 (gga)  grap2b (dre)  GRAPL (hsa)  grb2b (dre)  GRAPL (gga)  GRAP2 (cfa)  GRB2 (cfa)  LOC489534 (cfa)  grb2a (dre)  grap2a (dre)  grapa (dre)  grapb (dre)  GRB2 (mcc)  GRAP (mcc)  GRAP2 (mcc)  GRAP2 (gga)  LSB1 (sce)  PIN3 (sce)  sla2a (dre)  GRAP2 (fca)  GRAP (fca)  GRB2 (fca) 
Subcellular
localization
wolf
cyto 9,  cyto_nucl 5  (predict for NP_002077.1)
cyto 8,  cyto_nucl 5,  nucl 1  (predict for NP_987102.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04144 Endocytosis 4
hsa04145 Phagosome 4
hsa05152 Tuberculosis 3
hsa05132 Salmonella infection 3
hsa05165 Human papillomavirus infection 2
Genes directly connected with GRB2 on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
7.8 SNX11 sorting nexin 11 [detail] 0 29916
6.5 JPT1 Jupiter microtubule associated homolog 1 [detail] 0 51155
6.4 RAB5C RAB5C, member RAS oncogene family [detail] 0 5878
6.2 SMAP2 small ArfGAP2 [detail] 0 64744
Coexpressed
gene list		 [Coexpressed gene list for GRB2]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 2885      
Refseq ID (protein) NP_002077.1 
NP_987102.1 


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