[←][→] mmu  Grb2 Gene
functional annotation
Function   growth factor receptor bound protein 2  
GO BP
GO:0060670 [list] [network] branching involved in labyrinthine layer morphogenesis  (14 genes)  IMP  
GO:0007173 [list] [network] epidermal growth factor receptor signaling pathway  (43 genes)  ISO  
GO:0008543 [list] [network] fibroblast growth factor receptor signaling pathway  (47 genes)  IGI  
GO:0008286 [list] [network] insulin receptor signaling pathway  (60 genes)  ISO  
GO:0031623 [list] [network] receptor internalization  (68 genes)  ISO  
GO:0071479 [list] [network] cellular response to ionizing radiation  (68 genes)  ISO  
GO:0031532 [list] [network] actin cytoskeleton reorganization  (72 genes)  ISO  
GO:2000379 [list] [network] positive regulation of reactive oxygen species metabolic process  (77 genes)  ISO  
GO:0030838 [list] [network] positive regulation of actin filament polymerization  (84 genes)  IGI  
GO:0042770 [list] [network] signal transduction in response to DNA damage  (126 genes)  ISO  
GO:0007265 [list] [network] Ras protein signal transduction  (150 genes)  TAS  
GO:0007568 [list] [network] aging  (216 genes)  ISO  
GO:0043408 [list] [network] regulation of MAPK cascade  (690 genes)  IGI  
GO:0048646 [list] [network] anatomical structure formation involved in morphogenesis  (957 genes)  IMP  
GO:0030154 [list] [network] cell differentiation  (3713 genes)  IMP  
GO CC
GO:0070436 [list] [network] Grb2-EGFR complex  (2 genes)  ISO  
GO:0008180 [list] [network] COP9 signalosome  (34 genes)  IDA ISO  
GO:0005911 [list] [network] cell-cell junction  (518 genes)  IDA  
GO:0012506 [list] [network] vesicle membrane  (611 genes)  IDA  
GO:0005730 [list] [network] nucleolus  (895 genes)  ISO  
GO:0005768 [list] [network] endosome  (951 genes)  ISO  
GO:0005794 [list] [network] Golgi apparatus  (1525 genes)  IEA  
GO:0005654 [list] [network] nucleoplasm  (3580 genes)  ISO  
GO:0005829 [list] [network] cytosol  (3785 genes)  TAS  
GO:0005886 [list] [network] plasma membrane  (5442 genes)  IDA  
GO:0032991 [list] [network] protein-containing complex  (5540 genes)  ISO  
GO:0005634 [list] [network] nucleus  (7226 genes)  ISO  
GO:0016020 [list] [network] membrane  (9571 genes)  IDA  
GO:0005737 [list] [network] cytoplasm  (11434 genes)  IDA ISO  
GO MF
GO:0005168 [list] [network] neurotrophin TRKA receptor binding  (6 genes)  ISO  
GO:0043560 [list] [network] insulin receptor substrate binding  (11 genes)  ISO  
GO:0046875 [list] [network] ephrin receptor binding  (32 genes)  IPI ISO  
GO:0005154 [list] [network] epidermal growth factor receptor binding  (38 genes)  ISO  
GO:0001784 [list] [network] phosphotyrosine residue binding  (47 genes)  ISO  
GO:0051219 [list] [network] phosphoprotein binding  (110 genes)  ISO  
GO:0017124 [list] [network] SH3 domain binding  (133 genes)  ISO  
GO:0019903 [list] [network] protein phosphatase binding  (182 genes)  IPI  
GO:0030674 [list] [network] protein-macromolecule adaptor activity  (267 genes)  IDA  
GO:0019901 [list] [network] protein kinase binding  (774 genes)  ISO  
GO:0019904 [list] [network] protein domain specific binding  (820 genes)  IPI ISO  
GO:0044877 [list] [network] protein-containing complex binding  (1549 genes)  ISO  
GO:0019899 [list] [network] enzyme binding  (2298 genes)  ISO  
GO:0042802 [list] [network] identical protein binding  (2357 genes)  ISO  
GO:0005515 [list] [network] protein binding  (9507 genes)  IPI  
KEGG mmu01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
mmu01522 [list] [network] Endocrine resistance (93 genes)
mmu04010 [list] [network] MAPK signaling pathway (294 genes)
mmu04012 [list] [network] ErbB signaling pathway (84 genes)
mmu04014 [list] [network] Ras signaling pathway (232 genes)
mmu04062 [list] [network] Chemokine signaling pathway (192 genes)
mmu04068 [list] [network] FoxO signaling pathway (131 genes)
mmu04072 [list] [network] Phospholipase D signaling pathway (149 genes)
mmu04150 [list] [network] mTOR signaling pathway (156 genes)
mmu04151 [list] [network] PI3K-Akt signaling pathway (359 genes)
mmu04380 [list] [network] Osteoclast differentiation (128 genes)
mmu04510 [list] [network] Focal adhesion (201 genes)
mmu04540 [list] [network] Gap junction (86 genes)
mmu04550 [list] [network] Signaling pathways regulating pluripotency of stem cells (140 genes)
mmu04630 [list] [network] JAK-STAT signaling pathway (168 genes)
mmu04650 [list] [network] Natural killer cell mediated cytotoxicity (121 genes)
mmu04660 [list] [network] T cell receptor signaling pathway (103 genes)
mmu04662 [list] [network] B cell receptor signaling pathway (81 genes)
mmu04664 [list] [network] Fc epsilon RI signaling pathway (66 genes)
mmu04714 [list] [network] Thermogenesis (231 genes)
mmu04722 [list] [network] Neurotrophin signaling pathway (121 genes)
mmu04910 [list] [network] Insulin signaling pathway (139 genes)
mmu04912 [list] [network] GnRH signaling pathway (90 genes)
mmu04915 [list] [network] Estrogen signaling pathway (134 genes)
mmu04917 [list] [network] Prolactin signaling pathway (74 genes)
mmu04926 [list] [network] Relaxin signaling pathway (129 genes)
mmu04935 [list] [network] Growth hormone synthesis, secretion and action (116 genes)
mmu05034 [list] [network] Alcoholism (205 genes)
mmu05160 [list] [network] Hepatitis C (165 genes)
mmu05161 [list] [network] Hepatitis B (163 genes)
mmu05163 [list] [network] Human cytomegalovirus infection (256 genes)
mmu05165 [list] [network] Human papillomavirus infection (362 genes)
mmu05200 [list] [network] Pathways in cancer (543 genes)
mmu05203 [list] [network] Viral carcinogenesis (229 genes)
mmu05205 [list] [network] Proteoglycans in cancer (205 genes)
mmu05206 [list] [network] MicroRNAs in cancer (303 genes)
mmu05207 [list] [network] Chemical carcinogenesis - receptor activation (225 genes)
mmu05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (222 genes)
mmu05210 [list] [network] Colorectal cancer (88 genes)
mmu05211 [list] [network] Renal cell carcinoma (68 genes)
mmu05213 [list] [network] Endometrial cancer (58 genes)
mmu05214 [list] [network] Glioma (74 genes)
mmu05215 [list] [network] Prostate cancer (99 genes)
mmu05220 [list] [network] Chronic myeloid leukemia (76 genes)
mmu05221 [list] [network] Acute myeloid leukemia (70 genes)
mmu05223 [list] [network] Non-small cell lung cancer (72 genes)
mmu05224 [list] [network] Breast cancer (147 genes)
mmu05225 [list] [network] Hepatocellular carcinoma (174 genes)
mmu05226 [list] [network] Gastric cancer (150 genes)
mmu05231 [list] [network] Choline metabolism in cancer (98 genes)
Protein NP_001300865.1  NP_001300866.1  NP_032189.1 
BLAST NP_001300865.1  NP_001300866.1  NP_032189.1 
Orthologous [Ortholog page] GRB2 (hsa)  GRAP2 (hsa)  GRAP (hsa)  Grap2 (mmu)  drk (dme)  Grap (mmu)  Grb2 (rno)  sem-5 (cel)  Grap (rno)  Grap2 (rno)  GRB2 (gga)  grap2b (dre)  GRAPL (hsa)  grb2b (dre)  GRAPL (gga)  GRAP2 (cfa)  GRB2 (cfa)  LOC489534 (cfa)  grb2a (dre)  grap2a (dre)  grapa (dre)  grapb (dre)  GRB2 (mcc)  GRAP (mcc)  GRAP2 (mcc)  GRAP2 (gga)  LSB1 (sce)  PIN3 (sce)  sla2a (dre)  GRAP2 (fca)  GRAP (fca)  GRB2 (fca) 
Subcellular
localization
wolf
cyto 9,  cyto_nucl 5  (predict for NP_001300865.1)
cyto 9,  cyto_nucl 5  (predict for NP_001300866.1)
cyto 9,  cyto_nucl 5  (predict for NP_032189.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04144 Endocytosis 6
mmu04062 Chemokine signaling pathway 3
mmu04070 Phosphatidylinositol signaling system 3
mmu05032 Morphine addiction 2
mmu04340 Hedgehog signaling pathway 2
Genes directly connected with Grb2 on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
6.8 Pitpna phosphatidylinositol transfer protein, alpha [detail] 0 18738
6.2 Ube2z ubiquitin-conjugating enzyme E2Z [detail] 0 268470
6.2 Grk2 G protein-coupled receptor kinase 2 [detail] 0 110355
6.1 Smap2 small ArfGAP 2 [detail] 0 69780
6.0 Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta [detail] 0 108083
Coexpressed
gene list		 [Coexpressed gene list for Grb2]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 14784      
Refseq ID (protein) NP_001300865.1 
NP_001300866.1 
NP_032189.1 


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