Orthologous genes in OrthoFinder**

Species Gene Description
 mmu-u.4   Hmgcr   3-hydroxy-3-methylglutaryl-Coenzyme A reductase 
 mmu-r.6   Hmgcr   3-hydroxy-3-methylglutaryl-Coenzyme A reductase 
 mmu-m.5   Hmgcr   3-hydroxy-3-methylglutaryl-Coenzyme A reductase 
 rno-u.3   Hmgcr   3-hydroxy-3-methylglutaryl-CoA reductase 
 hsa-u.4   HMGCR   3-hydroxy-3-methylglutaryl-CoA reductase 
 mcc-u.3   HMGCR   3-hydroxy-3-methylglutaryl-CoA reductase 
 cfa-u.3   HMGCR   3-hydroxy-3-methylglutaryl-CoA reductase 
 gga-u.3   HMGCR   3-hydroxy-3-methylglutaryl-CoA reductase 
 dre-u.3   hmgcra   3-hydroxy-3-methylglutaryl-CoA reductase a 
 dre-u.3   hmgcrb   3-hydroxy-3-methylglutaryl-CoA reductase b 
 dme-u.3   Hmgcr   HMG Coenzyme A reductase 
 cel-u.3   hmgr-1   3-hydroxy-3-methylglutaryl coenzyme A reductase 
 sce-u.3   HMG2   hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 
 sce-u.3   HMG1   hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 
 spo-u.3   isu1   Fe-sulfur cluster assembly protein Isu1 

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Top 50 coexpressed genes to Hmgcr (mmu-u.4 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 mmu100   Steroid biosynthesis  12 19 6.61
 mmu1212   Fatty acid metabolism  10 58 6.14
 mmu900   Terpenoid backbone biosynthesis  7 21 6.42
 mmu1040   Biosynthesis of unsaturated fatty acids  5 31 7.54
 mmu3320   PPAR signaling pathway  5 79 5.47

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mmu:Hmgcr (3-hydroxy-3-methylglutaryl-Coenzyme A reductase) External Links;


Show/Hide Columns:          
Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID CoexPub LINK Target Reference

mmu-u.4
for
Hmgcr
mmu-r.6
for
Hmgcr
mmu-m.5
for
Hmgcr
rno-u.3
for
Hmgcr
hsa-u.4
for
HMGCR
mcc-u.3
for
HMGCR
cfa-u.3
for
HMGCR
gga-u.3
for
HMGCR
dre-u.3
for
hmgcra
dre-u.3
for
hmgcrb
dme-u.3
for
Hmgcr
cel-u.3
for
hmgr-1
sce-u.3
for
HMG2
sce-u.3
for
HMG1
spo-u.3
for
isu1
1 Cyp51 cytochrome P450, family 51 13121 31 22.4 22.3
 9.7
 15.0
 13.3
 5.5
 12.5
15.6
 -0.7

0.8
 6.8
 -0.8
2 Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 208715 60 21.1 20.7
 9.3
 16.3
-1.5
 25.0
-0.0
 9.7
0.7
 17.1
1.3
 15.0
0.3
 12.2
 1.7
 5.7
 4.1
 0.4
 7.4
3 Msmo1 methylsterol monoxygenase 1 66234 9 19.7 18.4
 9.3
 16.6
 20.3
 8.3
 11.9
4.7
 19.1
 15.3
 -0.5

0.4
 5.5
4 Sqle squalene epoxidase 20775 52 19.6 20.6
 7.9
 18.6
 20.0
 6.4
 14.2
 16.2
 13.4
 -0.5

-0.3
 4.8
5 Ldlr low density lipoprotein receptor 16835 60 17.7 17.2
 8.0
 8.6
2.0
 14.6
4.1
 3.1
1.8
 11.0
3.5
 9.0
2.5
 6.3
5.6
 1.0
0.3
 1.0
0.3
 1.3
-0.2


6 Insig1 insulin induced gene 1 231070 22 17.0 17.0
 7.4
 12.4
-0.8
 15.6
1.2
 2.1
0.4
 11.5
 11.7
1.6
 8.9
0.3
 2.6
1.4




7 Idi1 isopentenyl-diphosphate delta isomerase 319554 18 16.9 15.3
 8.2
 14.7
 19.4
 4.1
2.4
 14.1
 15.6
 7.1
 -0.2
 1.8
 1.3
 -0.8
 5.1
 -1.3
8 Fdps farnesyl diphosphate synthetase 110196 44 16.1 17.3
 6.3
 12.7
 12.8
 4.0
 13.2
 12.4
 10.6
 0.1
 -0.9
 3.1
 -0.7
 4.1
9 Fdft1 farnesyl diphosphate farnesyl transferase 1 14137 41 16.1 16.4
 6.8
 13.0
 17.1
 2.5
 13.2
 14.8
 7.9
 -0.8

0.1
 4.7
10 Stard4 StAR-related lipid transfer (START) domain containing 4 170459 3 14.9 15.0
 6.4
 10.0
0.5
 0.4
 2.8
-1.0
 7.8
2.9
 17.7
3.5
 3.5
1.4
 -0.2
-1.3
-0.1


11 Mvd mevalonate (diphospho) decarboxylase 192156 15 14.3 14.1
 6.3
15.1
 2.9
 9.2
 7.9
 9.2
 0.9
 2.4
 0.1
 -0.7
 5.0
 0.3
12 Srebf2 sterol regulatory element binding factor 2 20788 79 13.9 14.9
 5.5
 9.7
1.6
 12.2
3.1
 2.3
1.4
 1.3
 11.1
4.0
 7.2
3.3
 0.4
0.4
 0.3
 -0.9
 -0.4
-0.8
 1.1
-1.0
 -0.5
13 Lss lanosterol synthase 16987 13 13.8 13.9
 5.9
 12.4
 10.3
 2.9
 10.1
 13.2
 15.8
 -0.9

-0.5
 5.0
 -1.0
14 Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 15490 7 13.8 12.0
 7.0
 12.3
 12.9
 2.0
 7.3
 12.1
 10.3
 -1.4

0.2
 3.6
15 Sc5d sterol-C5-desaturase 235293 6 13.8 14.4
 5.6
 10.5
 12.8
 4.3
 11.1
 8.2
 12.8
 -1.6

-0.4
 4.5
16 Nsdhl NAD(P) dependent steroid dehydrogenase-like 18194 8 13.8 14.5
 5.6
 10.4
 14.6
 2.0
 10.7
 14.4
 11.2
 0.3

0.0
 5.0
17 Dhcr24 24-dehydrocholesterol reductase 74754 18 13.1 13.4
 5.6
 10.6
 13.0
 4.7
 8.5
 13.1
 12.6
 -0.6
-0.4
-1.1


18 Aacs acetoacetyl-CoA synthetase 78894 4 12.0 11.8
 5.3
 11.1
 5.6
 3.8
 6.1
 14.3
 8.5
 -0.5
0.9


19 Rdh11 retinol dehydrogenase 11 17252 1 11.7 11.7
 5.0
 4.1
1.2
 8.6
0.7
 3.3
1.1
 8.6
2.0
 6.8
0.8
 6.7
2.7
 2.4
1.6
 3.3
0.9
 3.9
2.5
 -1.2
 -0.2
20 Acat2 acetyl-Coenzyme A acetyltransferase 2 110460 19 11.7 12.7
 4.5
 13.6
-0.2
 15.7
11.8
 6.8
 7.6
 0.9
 2.0



21 Dhcr7 7-dehydrocholesterol reductase 13360 31 11.1 12.0
 4.3
 10.6
8.6
 15.1
5.4
 4.7
2.9
 10.6
6.4
 15.0
4.5
 10.5
8.9
 0.6
0.3
 -0.6
 -0.6
 2.0
-0.8
 5.7
1.1
22 Pmvk phosphomevalonate kinase 68603 12 10.7 11.1
 4.4
 7.4
 0.2
 0.8
 0.6
 4.0
 5.6
 0.3
 2.7
 0.4


23 Mvk mevalonate kinase 17855 13 10.3 10.8
 4.2
 9.0
 12.6
 1.6
 6.2
 9.4
 6.7
 1.7
1.2
 -0.4
 4.7
 -1.0
24 Tm7sf2 transmembrane 7 superfamily member 2 73166 5 9.8 10.3
 3.9
 10.6
8.6
 15.1
5.4
 4.7
2.9
 10.6
6.4
 15.0
4.5
 10.5
8.9
 0.6
0.3
 -0.6
 -0.6
 2.0
-0.8
 5.7
1.1
25 Acly ATP citrate lyase 104112 13 8.8 9.0
 3.7
 8.4
 10.0
 2.1
 13.6
 7.0
 3.9
0.0
 2.0
-0.3
 1.3
 0.2
-0.1


26 Erg28 ergosterol biosynthesis 28 58520 0 8.7 7.5
 4.5
 7.3
 11.0
 0.5
 6.3
 6.6
 5.3
 -0.6

1.5
 5.4
27 Tmem97 transmembrane protein 97 69071 0 8.7 8.5
 3.9
 7.2
 9.8
 1.1
 4.1
 1.2
 8.3
 -1.6

-1.3
 1.8
28 Acsl3 acyl-CoA synthetase long-chain family member 3 74205 1 8.5 8.2
 3.8
 4.7
3.9
 10.0
4.9
 5.0
4.3
 4.8
3.9
 3.8
1.9
 2.0
1.2
 4.8
1.3
 1.0
 0.5
-1.1
 3.5
0.6
 1.8
1.6
29 Fads2 fatty acid desaturase 2 56473 1 8.1 8.3
 3.4
 5.5
4.2
 8.8
8.0
 2.5
-0.2
 5.8
3.6
 6.1
5.5
 10.9
 0.4
0.8
-0.1

-0.1
30 Pcyt2 phosphate cytidylyltransferase 2, ethanolamine 68671 1 8.0 8.2
 3.4
 4.9
 6.9
 0.6
 5.5
 -0.6
 1.8
 3.5
 2.6
 1.2
-0.8
 1.4
 -1.3
 0.1
31 Fasn fatty acid synthase 14104 52 7.8 8.6
 2.9
 7.0
 10.6
 1.7
 7.8
 9.0
 4.8
 0.6
 0.9
0.6
 -0.1

-2.2
32 Acsl4 acyl-CoA synthetase long-chain family member 4 50790 2 7.6 7.4
 3.4
 4.7
3.9
 10.0
4.9
 5.0
4.3
 4.8
3.9
 3.8
1.9
 2.0
1.2
 4.8
1.3
 1.0
 0.5
-1.1
 3.5
0.6
 1.8
1.6
33 Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast) 170439 5 7.3 7.8
 2.9
 7.9
 6.5
0.6
 1.1
0.7
 2.6
 6.0
 2.8
0.6
 1.3
0.7
 1.8
 0.8
0.5
 1.9
1.7
 0.6
0.4
 -1.0
34 Fads1 fatty acid desaturase 1 76267 1 7.2 7.2
 3.1
 5.5
4.2
 8.8
8.0
 2.5
-0.2
 5.8
3.6
 6.1
5.5
 10.9
 0.4
0.8
-0.1

-0.1
35 Scd2 stearoyl-Coenzyme A desaturase 2 20250 3 7.1 7.9
 2.6
 5.0
3.8
 12.1
0.2
 2.6
-0.4
 6.6
-0.5
 6.5
0.4
 4.2
-0.3
 1.8
1.2
 2.1
2.0
 -0.4
-0.8
 3.1
 2.8
36 Idh1 isocitrate dehydrogenase 1 (NADP+), soluble 15926 0 7.0 6.6
 3.3
 3.3
-0.9
 7.4
0.5
 0.3
0.3
 4.2
2.0
 1.5
-0.9
 2.3
-1.6
 -0.4
-2.3
 1.1
 0.2
-0.5
 -0.1
-0.4
 0.9
0.4
37 Cyb5b cytochrome b5 type B 66427 0 6.5 6.4
 2.9
 3.8
1.1
 6.0
0.7
 0.5
-0.9
 5.8
2.6
 2.3
2.0
 3.5
0.6
 1.2
-0.5
 0.1
-0.2
 -1.0
-1.5
 -0.8
 6.7
38 Tmem41b transmembrane protein 41B 233724 0 6.5 6.4
 2.9
 2.9
 5.0
 2.2
 5.2
 2.4
 1.1
 2.8
 1.5
 1.7


39 Pcsk9 proprotein convertase subtilisin/kexin type 9 100102 34 6.4 6.8
 2.6
 6.4
 5.6
 0.4
-0.1
 5.7
 -1.4

0.6
-0.5
 0.7
-0.1
 2.9
0.2
40 Mmab methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human) 77697 0 6.4 6.3
 2.9
 3.8
 8.7
 -0.0
 1.5
 4.9
 0.8
 0.1
1.8


41 Pank3 pantothenate kinase 3 211347 0 6.3 5.9
 2.9
 4.5
2.4
 9.5
3.8
 4.7
2.1
 3.1
1.4
 7.7
0.4
 2.0
0.7
 0.3
-0.1
 2.0



42 Mfsd14a major facilitator superfamily domain containing 14A 15247 0 5.9 5.3
 2.9
 4.4
0.8
 7.1
1.3
 3.5
2.4
 3.7
1.2
 5.5
0.2
 1.2
0.8
 3.9
3.0
 4.8
 0.5


43 LOC118568156 uncharacterized LOC118568156 118568156 0 5.8 5.8












44 Acaca acetyl-Coenzyme A carboxylase alpha 107476 0 5.5 6.6
 1.8
 5.7
0.3
 9.5
-1.6
 1.2
-1.4
 4.8
0.4
 5.6
-1.9
 3.7
-1.1
 1.3
-0.9
 0.7
 0.7
 3.1
-1.0
 2.4
2.1
 -1.3
45 Lbr lamin B receptor 98386 0 5.5 4.9
 2.8
 10.6
8.6
 15.1
5.4
 4.7
2.9
 10.6
6.4
 15.0
4.5
 10.5
8.9
 0.6
0.3
 -0.6
 -0.6
 2.0
-0.8
 5.7
1.1
46 Utp14b UTP14B small subunit processome component 195434 0 5.5 6.5
 1.8
 3.7
0.2
 -0.3
 3.6
1.4
 0.6
 -0.9
 1.0
 -0.6
 -0.1
 1.6
 -0.5
 0.7
47 Acss2 acyl-CoA synthetase short-chain family member 2 60525 0 5.5 5.3
 2.5
 6.3
-1.2
 8.8
-0.8
 -0.3
-1.1
 3.4
-0.9
 0.9
0.2
 3.3
-0.3
 1.5
1.5
 1.3
 2.4
 1.2
0.7
 6.5
-0.8
 2.0
0.7
48 Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 56348 0 5.4 5.9
 2.1
 2.3
 6.1
 0.9
 8.1
 6.6
 3.7
0.2
 1.0
0.6
 1.4
0.5
 2.2
0.2
 0.9
 1.2
 -0.1
-0.2
49 Clcn6 chloride channel, voltage-sensitive 6 26372 0 5.2 5.2
 2.3
 3.9
 6.8
 0.2
 0.5
 1.5
 -0.0
 -0.3




50 Mfsd2a major facilitator superfamily domain containing 2A 76574 0 5.2 5.1
 2.3











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