Publication for Hmgcr and Tm7sf2
| Species | Symbol | Function* | Entrez Gene ID* | Other ID | Gene coexpression |
CoexViewer |
|---|---|---|---|---|---|---|
| mmu | Hmgcr | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 15357 | [link] | ||
| mmu | Tm7sf2 | transmembrane 7 superfamily member 2 | 73166 |
| Pubmed ID | Priority | Text |
|---|---|---|
| 25804527 | 0.98 | Hmgcr, was found markedly increased at 4 h TPA exposure in the skin of Tm7sf2+/+ mice (Fig. 1F). |
| 0.98 | HMGCR expression (Fig. S2), increased the Inv mRNA expression independently of the genotype, confirming the pivotal role for Tm7sf2 in keratinocyte differentiation. | |
| 0.97 | Hmgcr) and cholesterol uptake (Ldlr), as well as increased expression of the transcription factor (Srebp-2) responsible for driving expression of these genes detected in wild type animals, were all lost in Tm7sf2-/- mice. | |
| 0.96 | Hmgcr and Ldlr only in the skin of Tm7sf2+/+ mice (Fig. 1C and D). | |
| 25739789 | 0.98 | Hmgcr, Sqle, Dhcr24, Tm7sf2), together with Srebf2 (Fig. 3a). |
| 27878435 | 0.98 | TM7SF2, MVD, HMGCR, HSD3B7, HMGCS1, LSS, FDFT1, DHCR7, HSD17B7, NSDHL, DHCR24, FDPS, SIGMAR1, SQLE, MVK, that are expressed in the lens. |
| 30069000 | 0.98 | Hmgcr, Hmgcs1, Hsd17b7, Idi1, Lss, Mvd, Mvk, Msmo1, Nsdhl, Pmvk, Sc5d, Sqle, and Tm7sf2 were significantly decreased in HFD livers. |
| 25799309 | 0.87 | Hmgcr, Sqle, Cnbp, Dhcr24, Nsdhl, Fdps, Sc4mol, Fdft1 and Tm7sf2), cholesterol transport and uptake (e.g., Cd36, Apoa4 and Ldlr), cholesterol homeostasis (e.g., Fabp4, Apoa4, Pcsk9 and Ldlr), triglyceride synthesis (Ces3, Ppap2a, Dgat2, Ppap2c and Pcsk9) and triacylglycerol catabolism (Lpl and Gk2) (Fig. 4A, Fig. 5E, F and S7-S8 Tables), indicating that the decreased expression of these hepatic genes involved in cholesterol and triglyceride metabolism might be responsible, or contribute to the decreased cholesterol and triglyceride levels observed in Rm155LG/Alb-Cre transgenic mice. |
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