Publication for Hmgcr and Hmgcs1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	15357			[link]
mmu	Hmgcs1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	208715

Pubmed ID	Priority	Text
25556834	0.99	HMG-CoA reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and HMGCS1 in both mutant and normal cell lines (Figures 3A, B).
	0.97	HMGCR gene expression is mild in N171-82Q mice (transgene expressed from prion promoter) reduced expression of HMGCR, HMGCS1, DHCR7, and CYP51 are observed in HD human and other mouse models.
	0.96	HMGCR levels, and also increased expression sterol biosynthesic enzymes: HMG-CoA synthase 1 (HMGCS1), lanosterol 14alpha-demethylase (CYP51), and 7-dehydrocholesterol reductase (DHCR7) (Figures 3C-F; Figures S3 C-F).
21715619	0.98	HMGCS1, HMGCR and MBP.
	0.98	HMGCS1 and HMGCR mRNA were significantly decreased in the PGC1alpha KO mice (Figure 2D), suggesting that a decrease in cholesterol, its precursors and metabolites was likely due to decreased expression of these enzymes that act upstream in the cholesterol biosynthesis pathway.
	0.98	HMGCS1 and HMGCR mRNA (Figure 3E), further suggesting that PGCalpha plays a role in the regulation of cholesterol genes.
	0.98	HMGCS1 and HMGCR.
	0.98	HMGCS1 and HMGCR (Figure 4A).
	0.98	HMGCS1 and HMGCR.
	0.97	HMGCS1 and HMGCR mRNAs.
	0.96	HMGCS1, HMGCR and MBP in OLs at least in part occurs via the regulation of PGCalpha.
	0.96	HMGCS1 and HMGCR, and MBP.
	0.93	HMG CoA synthase (HMGCS1) and HMG CoA reductase (HMGCR) were also reduced in PGC1alpha KO mice.
	0.93	HMGCS1) and HMG CoA reductase (HMGCR), the rate-limiting enzymes for cholesterol synthesis.
	0.79	HMGCS1 and HMGCR in primary OLs.
26838045	0.98	3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase 1 (Hmgcs1) and reductase (Hmgcr), rate-limiting enzymes in de novo cholesterol synthesis, in the wild-type mice, but not in the similarly treated Ppara-null mice (Fig. 5b).
	0.98	Hmgcs1 and Hmgcr mRNA levels, was also decreased (Fig. 5c).
	0.98	Hmgcs1/Hmgcr, rate-limiting enzymes in de novo cholesterol-synthesizing pathway.
	0.98	Hmgcs1 and Hmgcr, through PPARalpha activation.
	0.98	Hmgcs1/Hmgcr, rate-limiting enzymes of de novo cholesterogenesis, via PPARalpha signaling and reduces testicular cholesterol levels.
	0.96	Hmgcs1, Hmgcr, Acbd3, Cyp11a1, Hsd3b1, and Cyp17a1 mRNAs in Leydig cells of the control Ppara-null mice.
	0.93	Hmgcs1 and Hmgcr via PPARalpha in Leydig cells needs further investigation.
	0.88	HMG-CoA synthase 1 (Hmgcs1) and reductase (Hmgcr), involved in de novo cholesterol synthesis.
29237705	0.98	Hmgcs1, Hmgcr, Idi1, and Cyp51), as well as the known target gene Axin, were found to be up-regulated (Fig. 5 A).
	0.98	Hmgcs1, Hmgcr, Idi1, and Cyp51 (Fig. S3 D), whereas knocking down the expression of beta-catenin inhibited the expression of these enzymes (Fig. 5 B).
	0.98	HMGCR, IDI1, CYP51, and mouse Hmgcr (Fig. 5 C), suggesting that beta-catenin signaling directly regulates Hmgcs1, Hmgcr, Idi1, and Cyp51 transcription.
	0.98	Hmgcs1, Hmgcr, Idi1, and Cyp51 induced by disrupted ciliogenesis (Fig. 5 K).
	0.97	Hmgcs1, Hmgcr, Cyp51, and Idi1 after disrupted ciliogenesis.
	0.97	Hmgcs1, Hmgcr, Idi1, and Cyp51, and overexpression of beta-catenin significantly activated these promoters in luciferase assays (Fig. S3 E).
27211556	0.98	3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), 3-hydroxy-3-methylglutaryl-Coenzyme A synthase (Hmgcs) and the liver X receptor alpha (LXRalpha, Nr1h3)), which are all important in cholesterol synthesis, were significantly decreased by irisin treatment.
	0.98	Hmgcr, Hmgcs and Ldlr were decreased by irisin treatment in the presence or absence of OA in cultured hepatocytes (Fig. 4b).
	0.98	Hmgcr, Hmgcs and LXRalpha were decreased by treatment of hepatocytes with irisin in the presence or absence of OA (Fig. 4f).
	0.97	HMGCR and HMGCS was significantly blocked by inhibition of AMPK by AMPKalpha1 knockdown (Fig. 7c).
	0.93	Hmgcr and Hmgcs (Supplemental Fig. 3).
26467524	0.98	hmgcr (3-hydroxy-3-methylglutaryl-Co-A reductase:HMG-CoA reductase), and hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1:HMG-CoA synthase 1) (Fig. 3b).
	0.96	HMG-CoA synthase is converted to mevalonate by the action of HMG-CoA reductase.
	0.95	hmgcr, hmgcs1 and acly (enzymes involved in cholesterol synthesis) are downregulated, augmented serum cholesterol levels were found.
29899496	0.98	Hmgcr, Hmgcs1, Ch25h, Osbp2) (Fig. 5a and Supplementary Fig. S3b).
	0.98	Hmgcr, Hmgcs1, Cyp27a1, Vldlr) mRNA levels (Fig. 5a and Supplementary Fig. S3c).
	0.97	Hmgcr, Hmgcs1, Cyp27a1, Ch25h), and sterol trafficking genes (Lrp1, Vldlr, Osbp) in 15-week HF/HC-fed female mice WAT (Fig. 5a and Supplementary Fig. S3a).
23347841	0.98	HMG-CoA synthase, HMG-CoA reductase, and SREBP2) was downregulated by 25-HC.
	0.98	HMGCS1; responsible for the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA) and HMG-CoA reductase (HMGCR; catalyzing the rate-limiting step of cholesterol biosynthesis from HMG-CoA to mevalonate).
26109099	0.98	HMGCS1 and HMGCR were upregulated in cells treated with lovastatin, suggesting that tumor cells responded to mevalonate pathway blockage by transcriptionally upregulating genes in the same pathway to compensate for the reduced pools of pathway metabolites.
	0.98	HMGCS1 and HMGCR, which, as indicated above, encode enzymes in the mevalonate pathway, were significantly upregulated in lovastatin-treated tumors as compared to tumors from control-treated mice (Fig. 4D).
27111442	0.98	3-hydroxy-3-methylglutaryl-CoA synthase 1 (Hmgcs1) and 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr).
	0.97	Hmgcs1 and Hmgcr (Fig 4B and 4C).
28395113	0.98	HMGCR, HMGCS, and LDLR) but also ameliorated SREBP-2 gene expression at low cholesterol levels (Fig. 8B).
	0.97	HMGCR, HMGCS, squalene synthase, and LDLR) and other lipid transport genes (adenosine triphosphate-binding cassette transporter A 1 and ACAT2) was reduced in CRTC2-/- mice (Fig. 5D).
30054450	0.98	Hmgcs1 and Hmgcr (Fig. S2, G-I).
	0.96	Hmgcs1) and HMG-CoA reductase (Hmgcr) in LPS-primed cells, and the transcript levels were significantly down-regulated in Npc1-/- cells (Fig. S2, D-F).
31668396	0.98	Hmgcs1 and Hmgcr were significantly down-regulated by 2.2-fold and 1.6-fold respectively in PAR2-KO livers compared to WT.
	0.96	HMG-CoA reductase (Hmgcr) and synthase (Hmgcs1), with 50% drops in plasma cholesterol and total liver cholesterol content.
31775890	0.98	Hmgcs1 and HmgcoAr, encoding two key enzymes in cholesterol biosynthesis pathway, was not affected following intestinal microbiota depletion in the intestine (Additional file 5: Figure S3) but significantly increased by four- to sevenfold in the liver (Fig. 2d).
	0.94	HmgcoAr and Hmgcs1) were two times less expressed in the liver of HiChol recipients than in Norchol recipients (Fig. 5b).
23021221	0.98	Hmgcs1, Hmgcr, Lss and Dhcr24, were down-regulated by the HCHF diet, especially in LDLR KO mice (Figure 2B), with Dhcr24 being the most suppressed transcript among the entire set of transcripts evaluated.
23260873	0.98	3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), 7-Dehydrocholesterol reductase (Dhcr7), mevalonate kinase (Mvk), 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (Hmgcs 1), farnesyl diphosphate synthase (Fdps) and squalene epoxidase (Sqle), were significantly down-regulated.
24391516	0.98	HMGR our analysis identified circadian cycles of protein abundance in the mouse liver for several key enzymes involved in cholesterol and bile acid synthesis such as HMG-CoA synthase 1 (HMGCS1), isopentenyl-diphosphate delta-isomerase 1 (IDI1), CYP51, CYP7A1 and CYP8B1 (Figure 6 and S4F).
24958265	0.98	3-hydroxy-3-methylglutaryl-CoA synthase 1 (Hmgcs1), 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr) and 7-dehydrocholesterol reductase (Dhcr7).
25093715	0.98	3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1).
26315393	0.98	HMGCR, HMGCS1, DHCR7, LDLR, ABCA1, and INSIG1.
26579440	0.98	3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and microsomal TG transfer protein (MTTP).
26964834	0.98	3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1), and farnesyl diphosphate synthase (FDPS).
27291420	0.98	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), and low density lipoprotein receptor (Ldlr).
27869139	0.98	HMG-CoA reductase (Hmgcr) and HMG-CoA synthase 1 (Hmgcs1), key enzymes involved in the biosynthesis of cholesterol, were significantly up-regulated (Fig. 3d).
27940000	0.98	Hmgcs1, Hmgcr) (Fig 4E,F).
28130274	0.98	HMG-CoA synthase 1 (Hmgcs1) and HMG-CoA reductase (Hmgcr), were downregulated in the liver of GF mice (Fig. 3A).
28725001	0.98	3-hydroxy-3-methylglutaryl-CoA synthase 1 (Hmgcs1), Hmgcr, farnesyl diphosphate synthetase (Fdps), and farnesyl diphosphate farnesyl transferase 1 (Fdft1), are transcriptionally regulated by sterol regulatory element-binding protein 2 (SREBP2) binding to sterol response elements (SREs).
29074585	0.98	HMG-CoA reductase (Hmgcr) and HMG-CoA synthase (Hmgcs1) were increased in both the basal and LXR-stimulated state (Figure 6I, 6J).
29307784	0.98	HMGCS1 (Fig. 6E) and HMGCR (Fig. 6F).
30069000	0.98	Hmgcr, Hmgcs1, Hsd17b7, Idi1, Lss, Mvd, Mvk, Msmo1, Nsdhl, Pmvk, Sc5d, Sqle, and Tm7sf2 were significantly decreased in HFD livers.
30620001	0.98	3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (Hmgcs1) and HMG CoA reductase (Hmgr), was elevated in BKO relative to DKO mice (Fig. 7C).
31993375	0.97	Hmgcs1) and 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr).
	0.96	Hmgcs1) and (B) 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr).
	0.95	Hmgcs1, and Hmgcr), di- and triglycerides (Plpp1, Plpp2, Plpp3, and Dgat2) and fatty acids (Fasn, Scd1, Fads1, Fads2, Elovl2, and Elovl5), and in the regulation of lipid metabolism (Srebp1c and Srebp2) was measured (Figure 7).
	0.82	Hmgcs1 gene, which encodes the hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase), the enzyme catalyzing the reaction in which acetyl-CoA condenses with acetoacetyl-CoA to form HMG-CoA, and Hmgcr gene, which encodes the HMG-CoA reductase, the enzyme responsible for converting HMG-CoA to mevalonate, a rate-limiting step in cholesterol synthesis (Zhang and Liu,).
25402228	0.97	HMG-CoA Reductase (Hmgcr), 3-hydroxy-3-methylglutaryl-CoA Synthase 1 (Hmgcs1), and Gardner-Rasheed Feline Sarcoma viral (Fgr) oncogene homolog were all up-regulated in jejunums of ME1-Tg mice.
	0.97	Hmgcr, Hmgcs1, Prkce and Ldlr (Ldl Receptor), decreased Apoe expression, and unchanged expression of Apoa1 and Cyp4a10 in livers of ME1-Tg compared to WT controls (Figure 5A, H).
	0.96	Hmgcr, Hmgcs1, Ldlr, Apoa1, Apoe and Cyp4a10 genes, while Prkce transcript levels were decreased in livers of ME1-Tg compared to WT controls (Figure S2A-B).
31729980	0.97	HMGCS1) and HMGC reductase (HMGCR), had a tendency to increase but only that of SREBP-2 had a significant difference (Additional file 3: Figure S3a).
	0.97	HMGCR, and HMGCS1), indicating a potential effect of FoxO3 on cholesterol homeostasis that is worthy of further investigation.
	0.96	HMGCS1 and HMGCR was upregulated significantly relative to that of the control (Additional file 3: Figure S3b).
22436747	0.97	3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (Hmgcs1), and 7-dehydrocholesterol reductase (Dhcr7).
22441164	0.97	HMG-CoA synthase 1 (HMGCS1), HMGCR, FPPS, IDI1, SQS, squalene epoxidase (SQLE), lanosterol synthase (LSS), 7-dehydrocholesterol reductase (DHCR7), LDL receptor (LDLR) and Insig-1 were all significantly increased 1.6- to 4.7-fold in P0 129 Pex2-/- versus control mouse liver.
25303682	0.97	3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), farnesyl diphosphate synthase (Fdps), lanosterol synthase (Lss), 3-hydroxy-3-methylglutaryl-coenzyme synthase 1 (Hmgcs1), and sterol regulatory element-binding protein 2 (Srebp2) were significantly increased by ezetimibe.
25319454	0.97	Hmgcs1 and Hmgcr, encoding the first and rate-limiting steps in cholesterol biosynthesis.
27013658	0.97	HMG-CoA synthase (HMGCS1) and HMG-CoA reductase (HMGCR) mRNA levels (Fig. 6A) but not in the mRNAs encoding other enzymes in the cholesterol biosynthetic pathway (Fig. 6B).
30959963	0.97	3-Hydroxy-3-methylglutaryl-Coenzyme A synthase (HMG-CoA synthase) executes HMG-CoA synthesis from acetoacetyl-CoA. The mRNA levels of HMG-CoA synthase were markedly suppressed in the MG-treated mice, whereas the levels of HMG-CoA reductase, a cholesterol biosynthetic enzyme from HMG-CoA, were significantly elevated (Figure 5C, bottom).
31480535	0.97	Hmgcs1 and Hmgcr genes, encoding HMG-CoA synthase and HMG-CoA reductase respectively, were reduced in the HF group but not recovered by NOB (Figure 3C).
27355629	0.96	HMG CoA synthase (Mcoln3) and HMG CoA reductase (Hmgcr), were downregulated.
	0.84	Hmgcs1), methylsterol monoxygenase 1 (Sc4mol), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr) and squalene epoxidase (Sqle) are in the list of the most significantly downregulated genes in this analysis (Table 2).
22912762	0.96	3-hydroxy-3-methylglutaryl-Coenzyme A synthethase 1 (Hmgcs1), isopentenyl-diphosphate-isomerase (Idi1) and NAD(P)H steroid dehydrogenase-like protein (Nsdhl)) were significantly decreased in the Mig-6d/d mice compared to Mig-6f/f mice while others (3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr)) were not.
27822554	0.96	3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), and 3-hydroxy-3-methylglutaryl-CoA synthase 1 (Hmgcs1) was also found in the livers of Gly-MCA-treated HFD-fed mice (see Fig. S6B).
30321984	0.96	3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and farnesyl pyrophosphate synthase (FDPS), has been reported in a high fat diet-induced obese mice model.
32160860	0.96	Hmgcs1 encode the enzyme HMG-CoA (the substrate of Hmgcr) and play an important role in cholesterol metabolism.
25688136	0.95	Hmgcr, Hmgcs1, Hmgcs2) and coenzyme Q synthesis pathways (coq2, coq3, coq5, coq7, pdss1, pdss2) were not affected in Mfn2 knockout hearts (Fig. 5 C).
26232687	0.95	Hmgcs1, Hmgcs2, Hmgcr, Fdps, Sqs, and Lss, which are involved in cholesterol synthesis, were significantly higher in OVX ERalpha (+/+) mice than in OVX ERalpha (-/-) mice.
28874658	0.95	Hmgcr, Sqs and Hmgcs1 transcripts in prostate of wild type (WT) and Pten pc -/- mice.
30914769	0.95	Hmgcs1), and octacosanol treatment significantly reduced 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr) expression.
32180899	0.95	HMGCS1 (3.5-fold), HMGCR (2.5-fold), SCD1 (2.5-fold), AGPS (1.9-fold), FABP4 (2.5-fold), DPT (2.2- fold), and PTEN (1.56-fold decline) in prostate tumors of LPB-Tag genotype when compared with the prostates of other genotypes.
23505564	0.94	3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (Hmgcr), the rate limiting enzyme in cholesterol synthesis, was similar in both 7 and 12 days old TK2-/- and TK2+/+ mice, but 3-hydroxy-3-methyl-glutaryl-coenzyme A synthase (Hmgcs) -1 displayed a trend towards decreasing expression levels with increasing age in the TK2-/- mice (Fig. 3B).
27484115	0.94	3-hydroxy-3-methylglutaryl coenzyme A synthase (HMGCS) and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the two key enzymes in hepatic cholesterol synthesis.
24447867	0.93	3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1).
25609476	0.93	HMGCR, HMGCS1, and SREBP-2 were markedly up-regulated, and the expression of GPAT was significantly down-regulated by dioscin in a dose-dependent manner compared with the model groups in the livers of ob/ob and HFD-induced mice (the results of statistical analysis are provided in Supplemental Figure 3C-D).
29234439	0.91	3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), and 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMGCS).
23299886	0.86	Hmgcs1, Hmgcr, Mvk, Pmvk, Dhcr7, Erg1, Fdft1 and Mvd is not seen in the Xbp1 liver knockout.
22745735	0.73	3-hydroxy-3-methylglutaryl-CoA synthase-1 (Hmgcs1) and 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr) (Fig. 4F).
20054815	0.66	Hmgcs1, Hmgcr, Pmvk, and Fdps.
24973215	0.61	HMG-CoA reductase (Hmgcr) and/or HMG-CoA synthase (Hmgcs1).