Publication for Hmgcr and Aacs

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	15357			[link]
mmu	Aacs	acetoacetyl-CoA synthetase	78894

Pubmed ID	Priority	Text
27200103	0.98	AACS gene, which encodes the ketone body-utilizing enzyme, is transcriptionally regulated by SREBP-2 and the knockdown of SREBP-2 induced downregulation of AACS and HMGCR gene expression.
	0.97	AACS, and HMGCR mRNA levels were dramatically suppressed in the mice that were fed FAVA (Figures 5(b) and 5(c)).
	0.97	AACS, and HMGCR mRNA levels.
	0.95	AACS, and HMGCR RNA in the mouse liver were induced by FAVA.
19721697	0.98	AACS and HMGCR are key enzymes in cholesterol synthesis, and LDLR is responsible for the uptake of low-density lipoprotein (LDL)-cholesterol from the blood.
	0.97	Hmgcr, Low density lipoprotein receptor (Ldlr), and Acetoacetyl-CoA synthetase (Aacs) in Rev-KO and TgRev animals suggested that the activity of SREBP2 was affected in these animals as well (Figure 1D), in spite of the apparently normal Srebp2 mRNA accumulation (Figure S4A).
31139087	0.98	3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and fatty acid elongase family members (ELOVL), the low-density lipoprotein receptor (LDLr), and acetoacetyl-CoA synthetase (AACS) to modulate daily lipid metabolism in the liver.
27185526	0.97	Aacs (acetoacetyl-CoA synthetase), Hmgcr (3-hydroxy-3-methylglutaryl-Coenzyme A reductase), and Lss (Lanosterol synthase), were also increased (Figure 5D).