Publication for Hmgcr and Elovl6

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	15357			[link]
mmu	Elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)	170439

Pubmed ID	Priority	Text
30954949	0.98	Hmgcr, Sqle, Mvd and Elovl6 were homogeneously upregulated, whereas Fasn expression was strongly downregulated, in Fasn(-) HCCs (online supplementary figure S8).
	0.94	Elovl6, an enzyme for very long FA elongation, Hmgcr, squalene monooxygenase (Sqle) (padj=0.057), diphosphomevalonate decarboxylase (Mvd), which are involved in the mevalonate and cholesterol biosynthesis pathways, were highest in Fasn(-) HCCs and cytochrome P450 family 7 subfamily a member 1 (Cyp7a1) (padj=0.205) and cytochrome P450 family 7 subfamily b member 1 (Cyp7b1), two key enzymes responsible for cholesterol ester (CE) degradation, were lowest in the same tumours (figure 2B and D).
31847305	0.98	Elovl6 and Hmgcr (Figure 5I) as well as protein level of SREBP1 (Figure 5J) and L-arabinose increased mRNA levels of Hmgcr and Acox1 (acyl-Coenzyme A oxidase 1) (Figure 5I), which catalyzes the desaturation of medium chain fatty acyl-CoAs.
	0.97	Elovl6 and Hmgcr (3-hydroxy-3-methylglutaryl-Coenzyme A reductase) (Figure 5G), which is the rate-limiting enzyme in cholesterol biosynthesis, suggesting L-arabinose suppresses elongation of long-chain fatty acid and cholesterol biosynthesis in heart of mice on HFD.
31749969	0.97	ELOVL6 and ACCalpha were significantly lower in IL-1alpha KO compared with Loxp mice (figure 6A), with similar levels of DGAT, LXR, Srebpf-1c, ChREBP, HMGCR, Cyp7a and LDLR (Fig. 6A and online supplementary fig. S1).
	0.83	ELOVL6), acetyl-CoA carboxylase alpha (ACCalpha), diacylglycerol acyltransferase (DGAT), the primary regulators of DNL including liver X receptors (LXR), sterol regulatory element-binding protein-1c (Srebpf-1c) and carbohydrate response element binding protein (ChREBP), and cholesterol metabolism related genes such as 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), cholesterol 7 alpha-hydroxylase (Cyp7a) and LDL receptor (LDLR).
29361464	0.88	Elovl6, Hmgcr, Mvk, Pltp, Me1, Dhcr7, and Acly, whereas Chchd6 forms a separate subnetwork surrounded by cell cycle genes as well as fatty acid related genes Cd36 and Pparg.
30287090	0.69	Elovl6; 3-hydroxy-3-methylglutaryl-CoA reductase, Hmgcr) in inguinal and visceral fats.