Publication for Hmgcr and Acat2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	15357			[link]
mmu	Acat2	acetyl-Coenzyme A acetyltransferase 2	110460

Pubmed ID	Priority	Text
21071704	0.98	Hmgcr, Hmgcs, Srebp-2), cholesterol catabolism (Cyp7a1, Cyp8b1), cholesterol esterification (Acat2, Lcat), and cholesterol uptake (Ldlr, SR-BI) were all significantly reduced in Hnf4alpha-deficient mice (Figure 2A).
	0.93	Hmgcr, Hmgcs, Cyp7a1, Abca1, Abcg5, Abcg8, Apoa1, Acat2, Lcat, or Srebp-1c (Figure 5A).
21631939	0.98	Acat2, Hmgcs, Hmgcr, Pmvk, Idi1, Fdps, and Lss, were all up-regulated between 1.3 to 3.0 fold at the transcript level.
24981838	0.98	HMGCR and ACAT2, was enhanced in Shp2hep-/- livers (Figure 5P).
26525535	0.98	3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase (Hmgcr), and HMG-CoA synthase (Hmgcs)] and enzymes responsible for the esterification of MUFA to cholesterol and TG via acyl CoA: cholesterol acyl transferase 2 (Acat2) and diacylglycerol acyl transferase 1 and 2 (Dgat1 & 2) were elevated in T5KO mice (Fig. 2A-D & F-J), including SCD1 at the protein level (Fig 2E).
29406859	0.98	acat2, hmgcr, cyp51, sqle, mvd, and dhcr24 (Online Figures 6C and 6D).
30580099	0.98	Hmgcr, Hmgcs1, Pmvk and Acat2 (Fig. 3F).
27536279	0.97	HMGCR, ACAT2, and ApoB and up-regulation of CYP7A1 levels, which inhibited the synthesis, absorption and transport of cholesterol, and enhanced its catabolism.
	0.97	HMGCR, HMGCS2, ACAT2, and ApoB and up-regulation of CYP7A1 expression levels of mRNA or proteins involved in cholesterol biosynthesis, absorption, catabolism.
	0.95	HMGCR, ACAT2, and ApoB mRNA expression by administering G. frondosa reduced the concentration of these enzymes and may have resulted in the decreased serum TC and LDL levels.
	0.70	HMGCR, ACAT2, ApoB, CYP7A1, and FAS enzymes reflected the expression of their respective mRNAs.
31993375	0.97	Acat2), hydroxymethylglutaryl-CoA synthase (Hmgcs1) and 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr).
	0.97	Acat2, Dgat1, Dgat2, Hmgcs, and Hmgcr) has been reported in TLR5-deficient mice (Singh et al.,).
	0.95	Acat2, Hmgcs1, and Hmgcr), di- and triglycerides (Plpp1, Plpp2, Plpp3, and Dgat2) and fatty acids (Fasn, Scd1, Fads1, Fads2, Elovl2, and Elovl5), and in the regulation of lipid metabolism (Srebp1c and Srebp2) was measured (Figure 7).
19557132	0.97	Hmgr) while expression of Acat1 and Acat2 was not affected (Figure 4A).
28395113	0.97	HMGCR, HMGCS, squalene synthase, and LDLR) and other lipid transport genes (adenosine triphosphate-binding cassette transporter A 1 and ACAT2) was reduced in CRTC2-/- mice (Fig. 5D).
25489402	0.96	ACAT-2), sterol regulatory element binding protein-2 (SREBP-2), and 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase was decreased, while expression of phosphorylated adenosine monophosphate activated protein kinase (p-AMPK)/AMPK ratio, cholesterol 7-alpha-hydroxylase (CYP7a1), and sterol 12-alpha-hydroxylase (CYP8b1) was increased in mice fed red rice.
	0.95	HMG-CoA reductase, ACAT-2 and SREBP-2 expression, and the increased degradation of cholesterol by the increased expression of CYP7a1 and CYP8b1.
28604676	0.96	ACAT2 and HMGCR.
	0.96	ACAT2 and HMGCR are gp78 substrates, their ubiquitination is regulated in opposite directions.
22132342	0.96	3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) within the enterocyte is esterified by acyl-CoA:cholesterol acyltransferase isoform 2 (ACAT2) to form cholesteryl esters.
23498953	0.96	HMGCR or ACAT2 in infected mouse liver.
25303682	0.96	Acat2 and Lxralpha, but not Hmgcr compared with control mice receiving no ezetimibe.
29659562	0.96	3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), and Acyl-CoA: cholesterol acyltranferase 2 (Acat2) (S5E Fig).
23744992	0.90	HMGCR, ACAT-2, Ldlr CYP7A1 and SR-BI was assessed.
28380440	0.72	HmgCoAr, Cyp7a1, Cyp27a1, Cyp8b1), and cholesterol esterification (Acat2).
23099119	0.66	Acat2, and Hmgcr (enzymes for cholesterol synthesis).