Publication for Hmgcr and Mvd

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	15357			[link]
mmu	Mvd	mevalonate (diphospho) decarboxylase	192156

Pubmed ID	Priority	Text
30954949	0.98	Hmgcr, Sqle, Mvd and Elovl6 were homogeneously upregulated, whereas Fasn expression was strongly downregulated, in Fasn(-) HCCs (online supplementary figure S8).
	0.98	Hmgcr, Sqle and Mvd (figure 2D), resulting in highest CE levels in Fasn(-) HCC (figures 2D and 4D).
	0.94	Hmgcr, squalene monooxygenase (Sqle) (padj=0.057), diphosphomevalonate decarboxylase (Mvd), which are involved in the mevalonate and cholesterol biosynthesis pathways, were highest in Fasn(-) HCCs and cytochrome P450 family 7 subfamily a member 1 (Cyp7a1) (padj=0.205) and cytochrome P450 family 7 subfamily b member 1 (Cyp7b1), two key enzymes responsible for cholesterol ester (CE) degradation, were lowest in the same tumours (figure 2B and D).
	0.81	Hmgcr, Mvd and Sqle in Fasn(+) and Fasn(-) HCCs from PIK3CA/c-Met and PIK3CA/Ras mice.
23299886	0.98	Hmgcr, Mvk, Pmvk, Mvd, Fdft1 and Sqle/Erg1 in the cholesterol biosynthetic pathway are decreased in SRSF3HKO liver.
	0.88	Hmgcr, Mvk, Pmvk, Dhcr7, Erg1, Fdft1 and Mvd is not seen in the Xbp1 liver knockout.
22252456	0.98	Hmgcr, Pmvk, Mvd, Fdps, Nsdhl, Idi1, Sc4mol, Cyp51, and Dhcr7).
26799318	0.98	HMG-CoA-reductase (Hmgcr) and mevalonate-5P-decarboxylase (Mvd), all gene sets revealed significantly increased (p<0.05) abundance of mRNA transcripts in DUhTP mice if compared to unselected controls (Fig 3).
26938273	0.98	Hmgcr, Mvd, Cyp51a1, and Srebf2), which were reported to facilitate structural remodeling of the small intestine, in the upper part of the small intestine (Fig 6C) but not in the lower part (Fig 6D).
27878435	0.98	MVD, HMGCR, HSD3B7, HMGCS1, LSS, FDFT1, DHCR7, HSD17B7, NSDHL, DHCR24, FDPS, SIGMAR1, SQLE, MVK, that are expressed in the lens.
30735525	0.98	HMG-CoA reductase (Hmgcr), mevalonate diphospho decarboxylase (Mvd), cytochrome P450 family 511 (Cyp51), 7-dehydrocholesterol reductase (Dhcr7), and cholestenol delta-isomerase (Ebp) were remarkably decreased by treatment with PD153035 (Fig 4C).
31327168	0.98	Hmgcr, Acss2, Pmvk, Mvd, Fdft1, Ldlr, and Sqle (Figure 2A).
31540279	0.98	hmgcr, mvd, srebp2, and fdps, was significantly increased in H-RasV12-expressing NIH3T3 cells (Figure 4A).
30008738	0.97	HMG-CoA reductase (Hmgcr), squalene epoxidase (Sqle), mevalonate (diphospho) decarboxylase (Mvd), and lanosterol synthase (Lss), were remarkably decreased in the HL group compared to the HU group (Figure 4(c)).
30069000	0.97	Hmgcr, Hmgcs1, Hsd17b7, Idi1, Lss, Mvd, Mvk, Msmo1, Nsdhl, Pmvk, Sc5d, Sqle, and Tm7sf2 were significantly decreased in HFD livers.
31296899	0.97	Hmgcr, Mvd, Hsd17b7, and Dhcr7) and steroid hormone synthesis (StAR, StARD3, and Hsd17b7), but downregulation of the genes driving TG synthesis from the lists of GSEA (Fig. 3E, Supplementary Fig. 5).
30483502	0.94	HMGCR), 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA), mevalonate kinase (MVK), phosphomevalonate kinase (PMVK), diphosphomevalonate decarboxylase (MVD), farnesyl diphosphate synthase (FDPS), farnesyl-diphosphate farnesyltransferase 1 (FDFT1), squalene epoxidase (SQLE), 7-dehydrocholesterol reductase (DHCR7), or related metabolites may be involved in modulating HSC biology.
22461453	0.91	Hmgcr, Mvd, Fdps, Sqle, and Dhcr7).
25799309	0.87	Mvd, Sc5d, Hmgcr, Sqle, Cnbp, Dhcr24, Nsdhl, Fdps, Sc4mol, Fdft1 and Tm7sf2), cholesterol transport and uptake (e.g., Cd36, Apoa4 and Ldlr), cholesterol homeostasis (e.g., Fabp4, Apoa4, Pcsk9 and Ldlr), triglyceride synthesis (Ces3, Ppap2a, Dgat2, Ppap2c and Pcsk9) and triacylglycerol catabolism (Lpl and Gk2) (Fig. 4A, Fig. 5E, F and S7-S8 Tables), indicating that the decreased expression of these hepatic genes involved in cholesterol and triglyceride metabolism might be responsible, or contribute to the decreased cholesterol and triglyceride levels observed in Rm155LG/Alb-Cre transgenic mice.