Publication for Hmgcr and Mvk

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	15357			[link]
mmu	Mvk	mevalonate kinase	17855

Pubmed ID	Priority	Text
23299886	0.98	Hmgcr, Mvk, Pmvk, Mvd, Fdft1 and Sqle/Erg1 in the cholesterol biosynthetic pathway are decreased in SRSF3HKO liver.
	0.87	Hmgcr, Mvk, Pmvk, Dhcr7, Erg1, Fdft1 and Mvd is not seen in the Xbp1 liver knockout.
23260873	0.98	3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), 7-Dehydrocholesterol reductase (Dhcr7), mevalonate kinase (Mvk), 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (Hmgcs 1), farnesyl diphosphate synthase (Fdps) and squalene epoxidase (Sqle), were significantly down-regulated.
26973245	0.98	HMG CoA reductase and mevalonate kinase (MVK).
27270401	0.98	mevalonate kinase in HIDS or the pharmacological inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase results in the depletion of geranylgeranyl pyrophosphate, which has been reported to induce IL-1beta release in myeloid cells through an as-yet-unknown inflammasome.
27878435	0.98	HMGCR, HSD3B7, HMGCS1, LSS, FDFT1, DHCR7, HSD17B7, NSDHL, DHCR24, FDPS, SIGMAR1, SQLE, MVK, that are expressed in the lens.
29262627	0.97	mevalonate kinase (MVK), squalene synthase (SQS), and the 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR), among others significantly drive the tumorigenic process and increases the aggressiveness of the tumors.
	0.97	mevalonate kinase, HMGCR, and the master transcription factor SREBP 2, suggesting that cholesterol could be positioned as a key element in HCC progression.
24722244	0.97	Mvk, Hmgcr, were significantly reduced in the PTG KO mice (Fig. 8C and Supplementary Table 2), consistent with quantitative real-time PCR data.
28150810	0.97	Hmgcr, Mvk, Fdps, Sqle, Lss, Nsdhl, Sc5d, and Dhcr24.
30069000	0.97	Hmgcr, Hmgcs1, Hsd17b7, Idi1, Lss, Mvd, Mvk, Msmo1, Nsdhl, Pmvk, Sc5d, Sqle, and Tm7sf2 were significantly decreased in HFD livers.
30334382	0.97	HMGCR and upregulations of cholesterol synthesis enzymes mevalonate kinase (Mvk), phosphomevalonate kinase (Pmvk), farnesyl-diphosphate farnesyltransferase 1 (Fdft1/Sqs), and squalene epoxidase (Sqle).
21203578	0.96	HMG-CoA reducatase (Hmgcr) and numerous genes in this pathway such as mevalonate kinase (Mvk), squalene epoxidase (Sqle), isopentenyl-diphosphate delta isomerase 1 (Idi1), and farnesyl diphosphate farnesyl transferase 1 (Fdft1).
30483502	0.94	HMGCR), 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA), mevalonate kinase (MVK), phosphomevalonate kinase (PMVK), diphosphomevalonate decarboxylase (MVD), farnesyl diphosphate synthase (FDPS), farnesyl-diphosphate farnesyltransferase 1 (FDFT1), squalene epoxidase (SQLE), 7-dehydrocholesterol reductase (DHCR7), or related metabolites may be involved in modulating HSC biology.
25799309	0.87	Mvk, Mvd, Sc5d, Hmgcr, Sqle, Cnbp, Dhcr24, Nsdhl, Fdps, Sc4mol, Fdft1 and Tm7sf2), cholesterol transport and uptake (e.g., Cd36, Apoa4 and Ldlr), cholesterol homeostasis (e.g., Fabp4, Apoa4, Pcsk9 and Ldlr), triglyceride synthesis (Ces3, Ppap2a, Dgat2, Ppap2c and Pcsk9) and triacylglycerol catabolism (Lpl and Gk2) (Fig. 4A, Fig. 5E, F and S7-S8 Tables), indicating that the decreased expression of these hepatic genes involved in cholesterol and triglyceride metabolism might be responsible, or contribute to the decreased cholesterol and triglyceride levels observed in Rm155LG/Alb-Cre transgenic mice.