Publication for Hmgcr and Acly

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	15357			[link]
mmu	Acly	ATP citrate lyase	104112

Pubmed ID	Priority	Text
27892461	0.98	ATP-citrate lyase (ACL) is a cytosolic enzyme upstream of HMG-CoA reductase in the lipid biosynthesis pathway that catalyses the cleavage of mitochondrial-derived citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
	0.98	ACL is a cytosolic enzyme upstream from HMG-CoA reductase that catalyses the first committed step in the utilization of citrate derived from the mitochondrial oxidation of carbohydrates for lipid synthesis.
	0.98	HMG-CoA reductase (HMGR) by statins, inhibition of liver ACL by ETC-1002-CoA results in the suppression of cholesterol synthesis and compensatory LDLR upregulation and LDL particle clearance from the blood.
	0.97	ACL and HMG-CoA reductase activity is complementary (Fig. 5i).
30954949	0.98	ATP citrate lyase (Acly), Hmgcr, Sqle, Mvd and Elovl6 were homogeneously upregulated, whereas Fasn expression was strongly downregulated, in Fasn(-) HCCs (online supplementary figure S8).
	0.95	Acly and Acaca, which are related to FA biosynthesis, Elovl6, an enzyme for very long FA elongation, Hmgcr, squalene monooxygenase (Sqle) (padj=0.057), diphosphomevalonate decarboxylase (Mvd), which are involved in the mevalonate and cholesterol biosynthesis pathways, were highest in Fasn(-) HCCs and cytochrome P450 family 7 subfamily a member 1 (Cyp7a1) (padj=0.205) and cytochrome P450 family 7 subfamily b member 1 (Cyp7b1), two key enzymes responsible for cholesterol ester (CE) degradation, were lowest in the same tumours (figure 2B and D).
29262627	0.98	ATP citrate lyase (ACLY), Acetyl-CoA carboxylase (ACC), mevalonate kinase (MVK), squalene synthase (SQS), and the 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR), among others significantly drive the tumorigenic process and increases the aggressiveness of the tumors.
29710765	0.98	ATP citrate lyase (Acly), 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr) and farnesyl diphosphate synthase (Fdps), were expressed at similar or even lower levels in the livers of sedentary and of exercised control-fed mice (Figure 4B).
24324835	0.97	Hmgcr, Fdps, Fdft1, Acly, Fasn), and down regulates genes involved in lipoprotein secretion (ApoA4, ApoA5, Mttp), fatty acid uptake and elongation (Elovl3, Pnpla2), intracellular transport of cholesterol (Npc1), mitochondrial transfer of acyl CoA (Cpt2, Crot, Crat, Slc25a20) and beta oxidation (Acox1, Acox2, Acadm, Acadvl, Hadhb, Ech1, Acaa1) (Table S3).
26935028	0.97	ACLY, SCD1, FAS, HMGCR, PEPCK and G-6-pase were strongly reduced in the livers of si-MALAT1-treated ob/ob mice (Fig. 6D).
26467524	0.96	hmgcr, hmgcs1 and acly (enzymes involved in cholesterol synthesis) are downregulated, augmented serum cholesterol levels were found.
27317765	0.95	ACLY, evident lower levels of FASN and HMGCR expression were revealed by IHC staining after the anti-tumor treatment of miR-22 (Figures 6H and S5).
29201040	0.94	ATP citrate lyase, fatty acid synthase, tumor necrosis factor alpha, and 3-hydroxy-3-methylglutaryl-CoA reductase and the concentrations of interleukin 6 and reactive oxygen species decreased upon A. glehni.
	0.89	ACLY and HMGCR.
26311497	0.91	HMGCR, HMGCS, LDLR, FDPS (farnesyl diphosphate synthase), SS, FAS (FA synthase), SCD-1 (stearoyl CoA desaturase-1), ACC (acetyl CoA carboxylase), ACLY (ATP citrate lyase), GPAT (glycerol-3-phosphate acyltransferase), SREBP-1c, SREBP-2, and Insig-1 were all lower in PAQR3-shRNA group than in the control mice.
29038350	0.88	Hmgcr, Abcg5, Abcg8) and of triglyceride synthesis (Srebf1, Fasn, Dgat2, Acly, Acaca, Acacb, Scd1, Gpd1) would be differentially expressed over time, this was actually not the case.
19014463	0.79	ATP-citrate lyase, Fatty acid synthase, Stearoyl CoA desaturase 1, cholesterol synthesis and uptake genes, HMG CoA reductase, LDL receptor and Egr-1 transcription factor gene, that are also activated by IGF-1 in this study.
30287090	0.60	ATP citrate lyase, Acly; acetyl-CoA carboxylase alpha, Acaca; fatty acid synthase, Fasn; stearoyl-CoA desaturase 1, Scd1; elongation of very long chain fatty acids-like 6, Elovl6; 3-hydroxy-3-methylglutaryl-CoA reductase, Hmgcr) in inguinal and visceral fats.