Orthologous genes in OrthoFinder**

Species Gene Description
 mmu-u.4   Ldlr   low density lipoprotein receptor 
 mmu-r.6   Ldlr   low density lipoprotein receptor 
 mmu-m.5   Ldlr   low density lipoprotein receptor 
 mmu-u.4   Lrp8   low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 
 rno-u.3   Lrp8   LDL receptor related protein 8 
 rno-u.3   Ldlr   low density lipoprotein receptor 
 hsa-u.4   LRP8   LDL receptor related protein 8 
 hsa-u.4   LDLR   low density lipoprotein receptor 
 mcc-u.3   LRP8   LDL receptor related protein 8 
 mcc-u.3   LDLR   low density lipoprotein receptor 
 cfa-u.3   LDLR   low density lipoprotein receptor 
 cfa-u.3   LRP8   LDL receptor related protein 8 
 gga-u.3   LRP8   LDL receptor related protein 8 
 gga-u.3   LDLR   low density lipoprotein receptor 
 dre-u.3   lrp2b   low density lipoprotein receptor-related protein 2b 
 dre-u.3   100536757   very low-density lipoprotein receptor-like 
 dme-u.3   LpR2   Lipophorin receptor 2 
 dme-u.3   LpR1   Lipophorin receptor 1 
 cel-u.3   T13C2.6   EGF-like domain-containing protein 
 cel-u.3   F14B4.1   Uncharacterized protein 

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Top 50 coexpressed genes to Ldlr (mmu-u.4 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 mmu100   Steroid biosynthesis  11 19 6.61
 mmu1212   Fatty acid metabolism  9 58 6.14
 mmu900   Terpenoid backbone biosynthesis  8 22 6.33
 mmu4152   AMPK signaling pathway  6 119 5.89
 mmu1040   Biosynthesis of unsaturated fatty acids  5 31 7.54

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mmu:Ldlr (low density lipoprotein receptor) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID CoexPub LINK Target Reference

mmu-u.4
for
Ldlr
mmu-r.6
for
Ldlr
mmu-m.5
for
Ldlr
mmu-u.4
for
Lrp8
rno-u.3
for
Lrp8
rno-u.3
for
Ldlr
hsa-u.4
for
LRP8
hsa-u.4
for
LDLR
mcc-u.3
for
LRP8
mcc-u.3
for
LDLR
cfa-u.3
for
LDLR
cfa-u.3
for
LRP8
gga-u.3
for
LRP8
gga-u.3
for
LDLR
dre-u.3
for
lrp2b
dre-u.3
for
100536757
dme-u.3
for
LpR2
dme-u.3
for
LpR1
cel-u.3
for
T13C2.6
cel-u.3
for
F14B4.1
1 Msmo1 methylsterol monoxygenase 1 66234 7 19.2 17.6
 9.2
 3.4
 2.1
 10.5
 4.6
 14.9
 1.3
 8.0
 6.9
3.3
 2.4
2.0
 1.8
 9.7
 1.4
 0.9



2 Sqle squalene epoxidase 20775 18 18.9 18.9
 8.2
 4.7
 2.2
 9.3
 4.9
 13.6
 3.3
 7.3
 11.3
 2.6
 2.0
 10.8
 1.0
 1.8



3 Cyp51 cytochrome P450, family 51 13121 6 18.3 17.8
 8.2
 4.4
 1.9
 9.1
 2.3
 10.4
 2.2
 8.1
 8.7
 3.5

0.2
 1.0



4 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 15357 60 17.7 17.2
 8.0
 5.1
 2.0
 8.6
 4.1
 14.6
 1.8
 3.1
 11.0
 3.5
 2.5
 9.0
 1.8
-0.5
 0.9
0.3
 0.3
 1.0
 1.3
 -0.2
5 Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 208715 22 16.8 15.8
 7.8
 3.0
-0.3
 1.1
-0.7
 8.6
-1.3
 4.6
-2.0
 15.3
-1.0
 1.3
-0.0
 8.6
-0.2
 8.9
0.3
 2.4
-0.3
 2.5
-0.4
 6.2
1.0
 -0.3
 2.3
 1.4
 0.4
 -0.0
 -0.7
6 Insig1 insulin induced gene 1 231070 18 16.7 17.5
 6.7
 2.4
-0.8
 1.2
-0.6
 7.6
-1.0
 4.2
-1.0
 16.6
-0.3
 1.5
-0.8
 5.5
-1.6
 8.6
 2.5
 1.4
-0.2
 6.9
-1.7
 0.5
-1.4
 0.1
-2.1



7 Fdps farnesyl diphosphate synthetase 110196 14 16.3 17.0
 6.7
 3.3
 1.3
 8.3
 4.5
 10.3
 1.6
 2.9
 8.3
 3.3
 1.7
 9.7
 -0.6
 1.5
 -0.0
 -1.3
 2.4
 0.1
8 Dhcr24 24-dehydrocholesterol reductase 74754 9 15.7 16.0
 6.6
 2.7
 1.6
 8.3
 5.3
 13.0
 2.2
 6.0
 9.0
 4.0
 1.7
 10.0
 -0.3
 1.7

-0.0
-0.3
 0.1
-0.7
9 Fdft1 farnesyl diphosphate farnesyl transferase 1 14137 18 15.7 14.9
 7.3
 2.5
 0.8
 8.2
 3.7
 12.0
 1.1
 4.6
 7.3
 2.6
 1.4
 9.3
 -0.0
 1.0



10 Idi1 isopentenyl-diphosphate delta isomerase 319554 5 15.4 13.5
 7.7
 3.3
 2.2
 8.5
 3.8
 13.0
 2.2
0.1
 6.9
3.0
 10.3
 3.4
 1.9
 8.6
 0.3
 1.3
 0.3
 0.9
 -0.3
 0.6
11 Srebf2 sterol regulatory element binding factor 2 20788 71 15.2 15.3
 6.5
 3.4
0.9
 1.0
-1.3
 7.4
4.4
 4.9
2.4
 14.1
6.8
 2.9
1.6
 6.5
4.2
 3.3
 3.1
 1.1
-0.5
 10.0
4.4
 0.5
-0.3
 -0.2
-0.8
 2.9
 3.0
 0.4
 -1.2
12 Lss lanosterol synthase 16987 5 14.8 13.9
 6.9
 3.7
 2.4
 8.3
 3.6
 11.8
 0.6
 2.5
 9.3
 2.8
 1.6
 11.1
 0.2
 1.0



13 Mvd mevalonate (diphospho) decarboxylase 192156 3 14.7 14.2
 6.6
 3.6

3.9
 12.7
 0.3
 5.7
 4.5
 2.3
 1.4
 7.4
 -0.8
 2.1
 0.9
 -0.1
 -0.8
 -0.5
14 Stard4 StAR-related lipid transfer (START) domain containing 4 170459 8 14.5 14.4
 6.3
 3.3
1.0
 0.5
-0.2
 6.8
3.1
 -0.8
 0.0
 4.8
-0.5
 5.0
0.1
 4.9
2.0
 2.1
0.1
 2.6
1.9
 7.2
2.8
 0.8
0.3
 1.1
-0.1

-2.0
 -0.2
15 Sc5d sterol-C5-desaturase 235293 2 14.2 14.4
 6.0
 3.4
 2.1
 7.8
 2.6
 8.1
 0.9
 3.8
 7.4
 3.6
 0.6
 7.8
 0.9
 1.3



16 Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 15490 1 14.0 12.1
 7.2
 3.6
 2.9
 9.2
 4.4
 9.7
 1.2
 5.1
 3.5
 3.2
 1.3
 8.7
 -0.6
 0.8



17 Nsdhl NAD(P) dependent steroid dehydrogenase-like 18194 4 13.6 13.2
 6.0
 2.7
 0.9
 8.1
 3.6
 10.1
 0.4
 4.3
 7.8
 3.0
 1.5
 8.9
 0.2
 1.5



18 Mvk mevalonate kinase 17855 4 13.0 13.0
 5.6
 2.3
 0.4
 7.0
 3.0
 11.6
 -0.2
 3.4
 4.7
 2.3
 2.3
 6.9
 -0.4
 2.7

2.1
 -0.3
19 Aacs acetoacetyl-CoA synthetase 78894 3 11.9 11.9
 5.2
 3.7
 2.6
 7.0
 2.2
 4.9
 3.3
 2.5
 4.4
 3.0
 2.9
 7.9
 -0.5
 1.3

1.5
 -1.4
20 Dhcr7 7-dehydrocholesterol reductase 13360 4 11.7 11.7
 5.1
 2.6
2.3
 1.8
1.5
 6.9
5.6
 5.4
0.9
 15.1
4.2
 1.8
-0.1
 6.2
0.6
 7.8
4.3
 2.6
0.9
 1.7
1.1
 8.6
1.5
 2.0
0.7
 1.5
0.8
 0.5
 -1.1
 -0.7
 0.5
21 Pcyt2 phosphate cytidylyltransferase 2, ethanolamine 68671 0 11.2 10.4
 5.4
 1.9
 1.0
 4.8
 3.2
 7.0
 0.5
 1.8
 3.6
 1.7
 -1.1
 1.4
 -1.2
 -1.0
 1.8
 1.5
 0.8
-2.3
 0.3
-0.2
22 Acat2 acetyl-Coenzyme A acetyltransferase 2 110460 10 10.4 10.9
 4.2
 2.7
0.6
 1.5
-0.5
 8.1
0.1
 3.8
 11.5

6.9
 2.6
 0.6
 3.8
 -1.1
 0.7
 1.3
 -0.6

23 Pmvk phosphomevalonate kinase 68603 2 10.0 9.7
 4.5
 2.8
 -1.1
 4.2
 -0.5
 0.2
 1.4
 0.8
 0.2
 -1.4
 1.2
 3.8
 -0.2
 3.1
 -0.8
 -1.3
 -1.1
 0.4
24 Acly ATP citrate lyase 104112 10 9.0 8.8
 4.0
 1.6
 0.3
 5.1
 4.3
 7.6
 3.7
 2.5
 9.0
 3.5
 1.9
 4.5
 1.0
1.0
 1.8
1.1
 0.7
 0.7
 3.8
2.9
 0.8
-0.3
25 Tm7sf2 transmembrane 7 superfamily member 2 73166 2 8.8 9.6
 3.4
 2.6
2.3
 1.8
1.5
 6.9
5.6
 5.4
0.9
 15.1
4.2
 1.8
-0.1
 6.2
0.6
 7.8
4.3
 2.6
0.9
 1.7
1.1
 8.6
1.5
 2.0
0.7
 1.5
0.8
 0.5
 -1.1
 -0.7
 0.5
26 Fasn fatty acid synthase 14104 28 8.7 9.1
 3.6
 2.2
 1.4
 5.0
 5.6
 11.6
 2.9
 3.2
 5.1
 3.1
 2.3
 5.2
 0.4
 1.3
 2.1
1.5
 2.1
0.8
 3.7
 -0.3
27 Fads2 fatty acid desaturase 2 56473 2 8.2 7.8
 3.8
 4.6
3.5
 0.8
0.1
 5.0
4.4
 4.7
3.7
 10.2
10.1
 5.0
2.0
 4.5
3.6
 5.9
5.6
 3.8
2.0
 0.6
0.4
 3.3
3.3
 1.8
 0.5

1.5
1.0
 -0.3
-0.4
28 Rdh11 retinol dehydrogenase 11 17252 1 8.1 7.9
 3.6
 3.6
2.4
 0.2
-0.0
 2.2
-0.2
 3.1
1.1
 6.5
0.9
 0.2
0.1
 2.7
0.6
 5.3
1.3
 3.0
2.0
 2.0
0.4
 4.9
1.9
 1.2
0.9
 1.7
1.5
 0.9
0.7
 0.4
0.4
 2.6
1.4
 0.4
-0.2
29 Mmab methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human) 77697 0 8.0 7.4
 3.9
 0.9
 -0.0
 4.8
 3.0
 9.2
 -0.8
 1.4
 1.5
 2.2
 1.5
 4.8
 -0.3
 1.7

0.6
 -1.6
30 Fads1 fatty acid desaturase 1 76267 4 7.8 7.7
 3.5
 4.6
3.5
 0.8
0.1
 5.0
4.4
 4.7
3.7
 10.2
10.1
 5.0
2.0
 4.5
3.6
 5.9
5.6
 3.8
2.0
 0.6
0.4
 3.3
3.3
 1.8
 0.5

1.5
1.0
 -0.3
-0.4
31 Tmem97 transmembrane protein 97 69071 0 7.8 7.8
 3.3
 2.3
 0.6
 4.3
 3.4
 7.2
 2.0
 1.8
 2.3
 1.0
 0.2
 -0.2
 0.1
 2.5



32 Scd2 stearoyl-Coenzyme A desaturase 2 20250 4 7.5 8.2
 2.9
 3.4
1.4
 2.0
1.6
 4.4
4.3
 4.7
1.1
 12.3
0.2
 2.8
0.1
 4.3
-0.6
 5.0
0.6
 2.5
1.5
 3.9
0.6
 3.9
-0.8
 -0.6
-0.9
 2.6
-0.4
 2.0
1.7
 1.6
0.4
 0.6
0.4
 0.4
-0.4
33 Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast) 170439 5 7.2 7.4
 3.0
 2.7
-0.5
 1.7
 5.1
 3.4
-0.5
 6.0
-0.1
 1.4
1.4
 0.9
0.0
 2.5
 2.2
 1.7
 3.7
 1.4
0.6
 0.2
-0.3
 2.7
 0.9
 0.8
0.4
 1.8
0.2
34 Acsl3 acyl-CoA synthetase long-chain family member 3 74205 1 7.2 7.3
 3.1
 1.8
1.6
 1.3
0.2
 3.7
3.1
 3.1
1.6
 7.4
3.1
 1.8
1.3
 4.6
3.1
 2.5
1.0
 1.8
1.2
 2.5
2.4
 1.6
1.0
 0.3
0.1
 1.2
1.1
 4.4
 2.0
 6.0
1.6
 0.1
-0.1
35 Acaca acetyl-Coenzyme A carboxylase alpha 107476 8 7.2 7.1
 3.2
 2.4
-1.0
 0.9
0.7
 5.6
2.3
 5.5
0.1
 8.7
0.5
 1.7
-0.0
 2.5
0.5
 2.9
-0.8
 3.1
0.3
 1.4
-1.3
 4.3
-0.1
 0.5
-0.2
 1.7
-1.1
 2.0
 1.7
 1.7
 -0.7
36 Cyb5b cytochrome b5 type B 66427 0 7.1 6.9
 3.2
 1.7
-0.2
 0.2
-1.7
 3.4
-0.1
 2.1
-0.5
 4.4
0.7
 0.6
-0.3
 1.8
-0.3
 3.2
1.6
 2.6
1.3
 -0.0
-1.6
 1.1
0.9
 0.6
-0.8
 0.5
0.2
 1.9
0.3
 1.7
-0.8
 0.4
0.4
 -0.4
-1.2
37 Srebf1 sterol regulatory element binding transcription factor 1 20787 40 6.7 7.5
 2.5
 3.4
0.9
 1.0
-1.3
 7.4
4.4
 4.9
2.4
 14.1
6.8
 2.9
1.6
 6.5
4.2
 3.3
 3.1
 1.1
-0.5
 10.0
4.4
 0.5
-0.3
 -0.2
-0.8
 2.9
 3.0
 0.4
 -1.2
38 Erg28 ergosterol biosynthesis 28 58520 0 6.7 6.0
 3.3
 1.9
 -0.5
 3.3
 2.8
 8.4
 0.9
 2.5
 4.9
 2.8
 1.8
 6.7
 -0.4
 -2.2



39 Slc25a1 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 13358 0 6.5 6.9
 2.6
 1.2
 0.8
 4.5
 2.0
 6.2
 1.2
 2.9
 4.9
 1.1
 -0.4
 0.9
 0.4
-0.3
 2.1
-1.7

1.8
0.2
 0.4
-0.6
40 Pdp2 pyruvate dehyrogenase phosphatase catalytic subunit 2 382051 0 6.5 6.0
 3.2
 1.5
-0.2
 1.3
0.5
 4.7
-0.9
 3.9
0.0
 4.4
1.6
 1.4
0.4
 2.0
-1.0
 4.9
0.8
 3.2
1.8
 -0.9
-1.1
 1.6
0.8
 -0.6
-0.8
 0.6
0.4
 -1.8
 -1.0
 1.1
 -1.4
41 Pank3 pantothenate kinase 3 211347 0 6.3 6.3
 2.8
 1.2
0.7
 -0.1
-0.5
 4.8
1.4
 2.4
1.0
 6.5
0.8
 1.5
-0.9
 3.8
0.1
 1.3
0.7
 1.6
1.6
 1.2
-0.8
 5.4
0.7
 0.6
-0.6
 1.7
1.2
 1.7
 2.6

42 Ccdc25 coiled-coil domain containing 25 67179 0 6.1 0.9
 5.7
 0.9
 0.6
 -0.4
 0.3
 -0.8
 1.5
 -0.9
 0.2
 -0.9
 -0.1
 0.0
 0.2
 1.3
 -1.4
 -1.8
 -0.5
-0.8
 0.5
-0.8
43 LOC118568156 uncharacterized LOC118568156 118568156 0 6.1 6.1

















44 Lipg lipase, endothelial 16891 6 6.1 5.0
 3.3
 2.8
 0.8
 1.4
 2.8
 5.7
 2.3
 1.6
 6.2
 3.4
 1.7
 2.4
 -0.0
 0.7



45 Pcsk9 proprotein convertase subtilisin/kexin type 9 100102 91 6.0 6.0
 2.7
 1.6
 0.7
 4.8
 2.7
 6.1
 0.6
 1.3

-0.1
 0.8
 1.3
 0.2



46 Scd1 stearoyl-Coenzyme A desaturase 1 20249 21 5.9 6.4
 2.3
 3.4
1.4
 2.0
1.6
 4.4
4.3
 4.7
1.1
 12.3
0.2
 2.8
0.1
 4.3
-0.6
 5.0
0.6
 2.5
1.5
 3.9
0.6
 3.9
-0.8
 -0.6
-0.9
 2.6
-0.4
 2.0
1.7
 1.6
0.4
 0.6
0.4
 0.4
-0.4
47 Idh1 isocitrate dehydrogenase 1 (NADP+), soluble 15926 0 5.9 6.6
 2.2
 1.1
-0.6
 -0.1
-1.8
 1.9
-0.5
 2.5
0.2
 5.0
0.8
 1.3
0.7
 2.7
-0.1
 3.5
0.8
 1.5
-0.4
 0.1
-1.3
 1.3
0.7
 2.0
0.4
 0.5
0.2
 1.7
 2.9
 0.8
-0.7
 -0.6
-1.0
48 Clcn6 chloride channel, voltage-sensitive 6 26372 0 5.9 5.6
 2.8
 2.8
 1.5
 2.9
 3.5
 7.5
 1.6
 -0.2
 0.4
 1.7
 0.7
 1.4
 0.5
 -0.2



49 Tmem41b transmembrane protein 41B 233724 0 5.5 5.7
 2.3
 1.5
 -0.1
 2.9
 1.0
 4.3
 -1.5
 -0.6
 3.4
 1.0
 0.1
 1.1
 -0.6
 0.9
 1.7
 0.5
 1.4
 -0.1
50 Mid1ip1 Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish)) 68041 0 5.5 5.4
 2.5
 0.8
 -1.0
 4.7
 1.5
 2.8
 -1.3
 -0.4
 0.7
 1.6
 1.0
 2.9
 0.5
 -0.3



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