Publication for Ldlr and Lipg

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Ldlr	low density lipoprotein receptor	16835			[link]
mmu	Lipg	lipase, endothelial	16891

Pubmed ID	Priority	Text
20034506	0.97	lipase activity data indicate that plasma VLDL accumulation is likely a consequence of decreased VLDL clearance due to hepatic lipase and LDLR down-regulation more so than a consequence of increased lipid synthesis in part because several genes of cholesterol biosynthesis, including HMG-CoA reductase, also were down-regulated.
26619823	0.97	lipase activities of these genes might contribute to decreased hepatic lipid content in LD-fed Elovl6-/-Ldlr-/- mice.
19632679	0.96	lipase could function as ligand for VLDL uptake by the other hepatocyte receptor of the LDLR family, LRP.
	0.95	LDL receptor, the VLDL acted upon in the plasma by lipase is readily cleared from the plasma accounting for the reduction in plasma triglyceride and VLDL despite increased hepatic production.
	0.95	LDLR-/- mice fed a Western-type diet, the plasma triglyceride and VLDL was notably increased, even in the face of an increase in plasma lipase activity.
28970555	0.90	EL in atherosclerosis still remains inconclusive: in one study using apolipoprotein E (apoE)-deficient mice it has been shown that EL deficiency attenuates the progression of atherosclerosis, whereas in another study EL had no impact on atherosclerosis development in apoE- or LDL receptor-deficient mice.
24747115	0.83	Lipase, Macrophages and Atherosclerosis in LDLR-/- Mice
23723371	0.59	EL expression does not affect atherosclerosis in either ApoE-/- mice or LDLR-/- mice, even though plasma HDL-C levels are elevated.