Publication for Ldlr and Stard4

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Ldlr	low density lipoprotein receptor	16835			[link]
mmu	Stard4	StAR-related lipid transfer (START) domain containing 4	170459

Pubmed ID	Priority	Text
19597497	0.98	LDLR, StarD4, and Fads1 (cluster 1, P<0.01) that are involved in sterol transport and are transcriptionally regulated by sterol response element (SRE) transcription factors.
25147951	0.98	Stard4, Ldlr, Insig-1, and Fdps, which are direct targets of SREBPs and involved in the cholesterol/lipid biosynthetic pathways, are down-regulated in S1Pcko cartilage (Table 2) mirroring that seen in the microarray.
30805986	0.97	LDLR, which was involved in mediating the endocytosis of modified low-density lipoproteins (LDL)24 or cholesterol-rich LDL25 for the amplified uptake of fatty acid, as well as NPC1, which mediated intracellular cholesterol trafficking, STARD4, which linked to the movement of cholesterol to the endoplasmic reticulum (Figure 2E), while decreased in knockdown of TREM-1 by siTREM-1 (Figure 2E).
	0.94	LDLR, with cholesterol transporter NPC1 and STARD4, were downregulated in both Lv-shTREM-2/Lv-shTREM-3 and MK-2206 (Figure 5B), cholesterol and phospholipids exporters ABCA1 and ABCG1 with NPC2 were upregulated in both Lv-shTREM-2/Lv-shTREM-3 and MK-2206 (Figure 5B).
24324835	0.97	Stard4, Ldlr) and fatty acid and cholesterol synthesis (Hmgcs1, Hmgcr, Fdps, Fdft1, Acly, Fasn), and down regulates genes involved in lipoprotein secretion (ApoA4, ApoA5, Mttp), fatty acid uptake and elongation (Elovl3, Pnpla2), intracellular transport of cholesterol (Npc1), mitochondrial transfer of acyl CoA (Cpt2, Crot, Crat, Slc25a20) and beta oxidation (Acox1, Acox2, Acadm, Acadvl, Hadhb, Ech1, Acaa1) (Table S3).
30214638	0.96	Stard4 and Ldlr).
24440759	0.95	StarD4 was silenced using shRNA showed an increase in cellular free cholesterol as compared to control cells (Figure 2) and changes in NPC-1 and LDL-receptor levels, although more studies are needed to understand these effects.
26528138	0.94	Ldlr, Stard4, Hsd17b7, and Sqle (Brockington et al.,).
32027669	0.91	Ldlr, Pcsk9, Stard4) and retinoid synthesis (Aldh1a1, Rdh11).
	0.83	Ldlr, Pcsk9 and StARd4 share this pattern and have previously been linked to Srebp2 (Table 1).