Publication for Ldlr and Hmgcs1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Ldlr	low density lipoprotein receptor	16835			[link]
mmu	Hmgcs1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	208715

Pubmed ID	Priority	Text
28395113	0.98	HMGCS, and LDLR) but also ameliorated SREBP-2 gene expression at low cholesterol levels (Fig. 8B).
	0.97	HMGCS, squalene synthase, and LDLR) and other lipid transport genes (adenosine triphosphate-binding cassette transporter A 1 and ACAT2) was reduced in CRTC2-/- mice (Fig. 5D).
22197325	0.98	Hmgcs1, Hmgcr, and Cyp51, were increased in WTD-fed L-FoxO1 and L-FoxO1:Ldlr-/- mice (Figure 3B,C, Table S2).
22855714	0.98	Hmgcs1, Srebf2, Hmgcr, Fdft1, Dhcr24, Sqle and Idi1) and in the uptake of extracellular cholesterol (Ldlr) (Fig. 5B).
23021221	0.98	Hmgcs1, Hmgcr, Lss and Dhcr24, were down-regulated by the HCHF diet, especially in LDLR KO mice (Figure 2B), with Dhcr24 being the most suppressed transcript among the entire set of transcripts evaluated.
24806461	0.98	Ldlr, Hmgcs1, Sqle and Lss, demonstrating an inverse relationship between SREBP suppression and activation in ScapDelta/Delta and Insig1/2 Delta/Delta mice, respectively.
26168293	0.98	Hmgcs1) and transport (Ldlr, Abca1, Abcg8) were significantly higher in the livers of HFD-fed compared with CD-fed mice and MNAM supplementation of HFD prevented these changes in a dose-dependent manner (Supplementary Fig. 6d,e).
26315393	0.98	HMGCS1, DHCR7, LDLR, ABCA1, and INSIG1.
26964834	0.98	low density lipoprotein receptor (LDLR), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1), and farnesyl diphosphate synthase (FDPS).
27211556	0.98	Hmgcs and Ldlr were decreased by irisin treatment in the presence or absence of OA in cultured hepatocytes (Fig. 4b).
27291420	0.98	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), and low density lipoprotein receptor (Ldlr).
29899496	0.98	Ldlr-/-Sort1-/- mouse jejunum had reduced LXR-related (Nr1h3, Nr1h2, Rxra, Apoe, Abca1, Abcg1, Srebf1, Ppara, Sp1, Hnf4a) and sterol-related (Hmgcr, Hmgcs1, Cyp27a1, Vldlr) mRNA levels (Fig. 5a and Supplementary Fig. S3c).
30580099	0.98	Ldlr, Pcsk9, Hmgcr, Hmgcs1, Pmvk and Acat2 (Fig. 3F).
26938916	0.97	HMGCS1, LDLR, NSDHL, SC4MOL, SREBF2; S4F Table).
	0.95	HMGCS1, LDLR, NSDHL, SREBF2, SC4MOL) mostly differ with those in Bahd1-KO murine placentas (e.g. Apoc3, Atp8b1, Cyp11A1, Insig2, Osbpl5, Pbx1, VldlR).
	0.81	HMGCS1, LDLR and SC4MOL correlated with obesity-related type 2 diabetes and cardiovascular diseases.
25402228	0.97	Hmgcs1, Prkce and Ldlr (Ldl Receptor), decreased Apoe expression, and unchanged expression of Apoa1 and Cyp4a10 in livers of ME1-Tg compared to WT controls (Figure 5A, H).
	0.96	Hmgcs1, Ldlr, Apoa1, Apoe and Cyp4a10 genes, while Prkce transcript levels were decreased in livers of ME1-Tg compared to WT controls (Figure S2A-B).
27168937	0.97	hmgcs1, insig1, ldlr, lss, mvk, sc4mol, sc5dl, sqle) that Schmidt et al. (2009) identified as differently expressed in response to conditional knockout of por in mice, a cytochrome P450 that is essential for steroidogenesis (Fluck et al. 2004), were coordinately upregulated in our study at 22-24 DPA.
	0.90	hmgcs1, ldlr, lss, mvk, pmvk, insig1, sc4mol, sc5dl, sqle) (Fig. 12I-L).
22441164	0.97	HMG-CoA synthase 1 (HMGCS1), HMGCR, FPPS, IDI1, SQS, squalene epoxidase (SQLE), lanosterol synthase (LSS), 7-dehydrocholesterol reductase (DHCR7), LDL receptor (LDLR) and Insig-1 were all significantly increased 1.6- to 4.7-fold in P0 129 Pex2-/- versus control mouse liver.
22673505	0.97	LDLR (LDL receptor) and HMGCS1 (HMG-CoA synthase) through a negative feedback loop.
23584088	0.97	Ldlr and Hmgcs1 was significantly decreased in Abcg4-/- relative to the WT MEPs but not in GMPs which do not express Abcg4 (Supplementary Fig. 8a,b).
24324835	0.97	Ldlr) and fatty acid and cholesterol synthesis (Hmgcs1, Hmgcr, Fdps, Fdft1, Acly, Fasn), and down regulates genes involved in lipoprotein secretion (ApoA4, ApoA5, Mttp), fatty acid uptake and elongation (Elovl3, Pnpla2), intracellular transport of cholesterol (Npc1), mitochondrial transfer of acyl CoA (Cpt2, Crot, Crat, Slc25a20) and beta oxidation (Acox1, Acox2, Acadm, Acadvl, Hadhb, Ech1, Acaa1) (Table S3).
27222860	0.97	Hmgcs1, Insig, Hmgcr, and Ldlr, was markedly diminished in the down-regulated genes, while the activation of a network containing stress-responsive Atf4-Atf3-Ddit3 (CHOP) axis was most prominently in the up-regulated genes.
31296736	0.93	Hmgcs1, and Gps1) and lipid uptake (e.g., Npc1l1, Ldlr, Slc27a2, and Slc27a4; Fig. 5 D); and (c) proteins involved in mitochondrial respiratory function and ROS generation (Atp5b, Atp5g1, Cox17, Cox5b, Cox8a, Cycs, Sdhb, Sdhc, Sdhd, Ndufa6, and Ndufb8; Fig. 5 E).
31543682	0.75	Hmgcs1) and transport (ApoCIII, Ldlr, Lrp1, Scarb1); impaired insulin (Akt, Irs1, Irs2) and FXR (Cyp7a1, Cyp8b1, Ostb) signaling; enhanced monocyte differentiation/recruitment (Ccr1, Ccr2, Cd14, Cd68, Cd86, Il1a, Il1a, Mac-2, Mcp-1), pro-inflammatory signaling (Nfkb, P38, Tgfbr, Tnfa); inflammasome (Ipaf, Nlrp1b, Nlrp3, Tlr4) and pro-apoptotic activity (Casp-8, Rip-1, Rip-3), and enhanced extracellular matrix (ECM) reorganization (a-Sma, Col1a1, Col1a2, Col3a1, Col5a1/2/3, Col6a1/2/3, Mmp2, Mmp13, Timp1/2/3).