Publication for Ldlr and Nsdhl

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Ldlr	low density lipoprotein receptor	16835			[link]
mmu	Nsdhl	NAD(P) dependent steroid dehydrogenase-like	18194

Pubmed ID	Priority	Text
26344763	0.98	NsdhlDelta5/Y keratinocytes showed reduced expression of LDLR (Fig. 3C, D).
	0.98	NSDHL in A431 cervical carcinoma cells (Fig. 4B), while LDLR expression was decreased (Fig. 4C).
	0.98	NSDHL activates canonical LXR targets such as ABCA1, ABCG1, and represses LDLR, which regulate cellular release and uptake of cholesterol, respectively.
	0.97	Nsdhl induced the expression of ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, reduced the expression of low-density lipoprotein receptor (LDLR), decreased intracellular cholesterol and was dependent on the liver X receptor (LXR) alpha.
	0.91	NSDHL (Bpa) show increased ABCA1 and loss of LDLR expression.
	0.61	LDLR in NSDHL-deficient A431 cells (numbers, normalized bands density).
26938916	0.97	LDLR, NSDHL, SC4MOL, SREBF2; S4F Table).
	0.95	LDLR, NSDHL, SREBF2, SC4MOL) mostly differ with those in Bahd1-KO murine placentas (e.g. Apoc3, Atp8b1, Cyp11A1, Insig2, Osbpl5, Pbx1, VldlR).
29073233	0.94	Ldlr, Cyp46a1, Akr1d1, and Cela3b) and 11 genes in the brain of male Cyp46a1-/- mice (Apoa2, Apoc3, Nr0b2, Npc1/1, Srebf2, Snx17, Cyp46a1, Nsdhl, Lipe, Il4, and Apoa4) showed more than a 2-fold change (an arbitrary cut off limit) in the expression level as compared to the expression of the genes in the brain of wild type animals (Fig 3).
25799309	0.87	Nsdhl, Fdps, Sc4mol, Fdft1 and Tm7sf2), cholesterol transport and uptake (e.g., Cd36, Apoa4 and Ldlr), cholesterol homeostasis (e.g., Fabp4, Apoa4, Pcsk9 and Ldlr), triglyceride synthesis (Ces3, Ppap2a, Dgat2, Ppap2c and Pcsk9) and triacylglycerol catabolism (Lpl and Gk2) (Fig. 4A, Fig. 5E, F and S7-S8 Tables), indicating that the decreased expression of these hepatic genes involved in cholesterol and triglyceride metabolism might be responsible, or contribute to the decreased cholesterol and triglyceride levels observed in Rm155LG/Alb-Cre transgenic mice.