Publication for Ldlr and Insig1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Ldlr	low density lipoprotein receptor	16835			[link]
mmu	Insig1	insulin induced gene 1	231070

Pubmed ID	Priority	Text
22073164	0.98	ldlr, insig1, pgc1beta, lpin2, and acsl1 (Fig. 6A).
	0.95	ldlr, insig1, pgc1beta, and acsl1), confirming a CB1-dependent effect of IDFP (Supplemental Table S6).
21291556	0.98	Insig-1 and Ldlr, both being SREBP target genes, were up-regulated in the Lean mice.
24806461	0.98	Insig1/2Delta/Delta mice (Table S2), including Scd1, Scd2, Fasn, Ldlr, Hmgcs1, Sqle and Lss, demonstrating an inverse relationship between SREBP suppression and activation in ScapDelta/Delta and Insig1/2 Delta/Delta mice, respectively.
25147951	0.98	Ldlr, Insig-1, and Fdps, which are direct targets of SREBPs and involved in the cholesterol/lipid biosynthetic pathways, are down-regulated in S1Pcko cartilage (Table 2) mirroring that seen in the microarray.
26315393	0.98	LDLR, ABCA1, and INSIG1.
26968099	0.98	LDLR, as well as several other genes involved in lipid metabolism, including ABCA1, SIK1, PGC1a, AMPK and INSIG1.
28725049	0.98	insulin induced gene-1 (INSIG-1), lanosterol synthase (LSS), mevalonate pyrophosphate decarboxylase (MVD), the low density lipoprotein receptor (LDLR) and squalene epoxidase (SQLE) were all enhanced in the absence of calreticulin (Fig. 1D).
28808191	0.98	INSIG1 (lowering endogenous synthetic levels of cholesterol), stimulate the expression of IDOL to degrade LDLR, and stimulate the expression of ABCA1/ABCG1 to promote cholesterol removal from the cell, thereby acting as an effective foil to the SREBP2 pathway.
26311497	0.97	LDLR, FDPS, SS, ACC, FAS, SCD-1 and GPAT, but also ameliorated gene expression in SREBP pathway, including SREBP-1a, SREBP-1c, SREBP-2 and Insig-1,without change in Scap expression (Fig. 6b).
	0.90	LDLR, FDPS (farnesyl diphosphate synthase), SS, FAS (FA synthase), SCD-1 (stearoyl CoA desaturase-1), ACC (acetyl CoA carboxylase), ACLY (ATP citrate lyase), GPAT (glycerol-3-phosphate acyltransferase), SREBP-1c, SREBP-2, and Insig-1 were all lower in PAQR3-shRNA group than in the control mice.
27168937	0.97	insig1, ldlr, lss, mvk, sc4mol, sc5dl, sqle) that Schmidt et al. (2009) identified as differently expressed in response to conditional knockout of por in mice, a cytochrome P450 that is essential for steroidogenesis (Fluck et al. 2004), were coordinately upregulated in our study at 22-24 DPA.
	0.90	ldlr, lss, mvk, pmvk, insig1, sc4mol, sc5dl, sqle) (Fig. 12I-L).
22441164	0.97	LDL receptor (LDLR) and Insig-1 were all significantly increased 1.6- to 4.7-fold in P0 129 Pex2-/- versus control mouse liver.
26528138	0.97	Insig1 and Ldlr which are decreased in late-stage SOD1G93A astrocytes.
19260826	0.96	LDL receptor (Ldlr) and Insig1 were lower in 25HC-treated cells than in controls (Figure 4B).
	0.95	Ldlr and Insig1 mRNA levels (Figure 4B), although less potently than 25HC.
	0.95	Ldlr and Insig1 expression (Supplementary Figure S2).
22952870	0.96	low density lipoprotein receptor (LDLR), sterol regulatory element-binding protein-1 (SREBP-1), sterol regulatory element-binding protein-2 (SREBP-2), SREBP-cleavage activating protein (SCAP), insulin-induced gene-1 (INSIG-1), site-1 protease (S1P), and site-1 protease (S2P).
25361754	0.95	Ldlr, Hmgcs and Insig1 and upregulation of Cyp7A1 genes.
25799309	0.92	Insig1, Ppap2a, Dgat2, Ppap2c, Pcsk9, Lpl, Gk2, Apoa4, Cd36 and Ldlr) involved in lipogenesis, lipid transport, lipid storage, bile acid biosynthesis, fatty acid synthesis, fatty acid oxidation, fatty acid catabolism, cholesterol biosynthesis, cholesterol transport, cholesterol homeostasis and triglyceride synthesis, indicating that the decreased expression of hepatic genes involved in lipid metabolism might be responsible, or contribute to the altered hepatic and serum lipid profiles (Fig. 8).
24486573	0.79	LDLR (D), and also of the transcription factor SREBP2 (G) and multiple of its target genes including PCSK9 (F), HMGCS (H), CYP51 (I), and INSIG1 (J) with a trend towards such an effect for INSIG2A (K) also.
26501192	0.65	LDLR and ABCA1) and energy homeostasis (insulin receptor (InsR) precursor (Pre) and mature (Beta) forms, IRS1, INSIG1, SIRT1, AMPK-alpha1, AMPK-alpha2, SIK1, CPT1-alpha, PGC1-alpha).