Publication for Fasn and Ldlr

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Fasn	fatty acid synthase	14104			[link]
mmu	Ldlr	low density lipoprotein receptor	16835

Pubmed ID	Priority	Text
19509018	0.98	Ldlr-/- mice was associated with significant reduction in plasma adipose-derived FFA (Fig. 3A), glucose, and insulin (Fig. 4A and B), as well as with diminished expression of lipogenic master gene, sterol regulatory element-binding transcription factor 1 (Srebf1), and its key downstream target, fatty acid synthase mRNA and protein (Fig. 5B-D).
22197325	0.98	Ldlr-/-) mice showed increased expression of genes involved in FA synthesis, elongation, glycerolipid formation, and lipid storage, including Fasn, Acly, and Gpam (Figure 3B-C, Table S2).
25038053	0.98	FAS, ACC, HMGCR, and LDLR.
26619823	0.98	fatty acid synthase (Fasn), were significantly increased and stearoyl-CoA desaturase-1 (Scd1) showed a tendency to increase in the livers of LD-fed Elovl6-/-Ldlr-/- mice compared with LD-fed Elovl6+/+Ldlr-/- mice (Fig. 6A).
28720427	0.98	fatty acid synthase (FAS), and stearoyl coA-desaturase (SCD)1, as well as inducible degrader of the LDLR (IDOL).
29183708	0.98	LDLR (IDOL), SREBP-1c, fatty acid synthase (FASN), phospholipid transfer protein (PLTP) and ADP-ribosylation factor (ARF)-like 7 (ARL7).
30863480	0.98	low-density lipoprotein receptor (LDLR) gene, the acetyl-CoA carboxylase (ACC) gene, the fatty acid synthase (FAS) gene, and transcription and expression of glucokinase (GK) genes.
32111832	0.98	LDLR, SQLE, and FASN in response to sterol-depletion, in Hap1-SPRINGKO cells basal expression of these genes was reduced and the response to sterol-depletion was largely abrogated.
19556020	0.97	fatty acid synthase (FAS) and acetyl coenzyme-A carboxylase (ACC), whereas SREBP-2 activity has been more closely linked to regulation of genes involved in cholesterol synthesis and uptake, such as low-density lipoprotein receptor (LDLR) and 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR).
	0.96	FAS and ACC were detected, whereas those of LDLR and HMGCR were not, suggesting the activation of SREBP-1 but not SREBP-2 (Fig. 4A).
	0.79	FAS and ACC for SREBP-1 and LDLR and HMGCR for SREBP-2.
25402228	0.97	Fasn, Srebf1, Hmgcr, Hmgcs1, Prkce and Ldlr (Ldl Receptor), decreased Apoe expression, and unchanged expression of Apoa1 and Cyp4a10 in livers of ME1-Tg compared to WT controls (Figure 5A, H).
	0.96	Fasn, Srebf1, Pparg, Hmgcr, Hmgcs1, Ldlr, Apoa1, Apoe and Cyp4a10 genes, while Prkce transcript levels were decreased in livers of ME1-Tg compared to WT controls (Figure S2A-B).
31547031	0.97	low-density lipoprotein receptor, as well as fatty acid synthesis genes, such as SREBP-1c and fatty acid synthase.
	0.95	FAS, and LDL receptor.
24608444	0.97	FAS, HMGCR, HMGCS, and LDLR, were expressed at significantly lower levels in response to BF175 treatment.
25155036	0.97	FAS, LDLR, SCD-1, and DGAT-2 are all targets of SREBP-1c.
25352833	0.97	LDL receptor (LOX-1), carbohydrate-responsive element binding protein (ChREBP), fatty acid synthase (FAS), and acyl-CoA carboxylase (ACC) was detected, whereas expression of SREBP-1, SREBP-2, HMGCR, peroxisome proliferator-activated receptor alpha (PPAR-alpha), fatty acid binding protein (L-FABP), and carnitine palmitoyltransferase 1A (CPT1A) was decreased.
26042593	0.97	Fasn, Cpt1a, Fabp4, Hmgcr and Ppara expression, while in MCS diet-fed controls Ldlr expression was significantly attenuated.
27499577	0.96	FAS, LDLR, and CYP7alpha1 in the liver.
	0.96	FAS, HMGCR, LDLR, CYP7alpha1 and PPAR-alpha proteins in the liver; and the SREBP-1, SCD-1, FAS, PPAR-alpha and adiponectin proteins in adipose tissue were reversed by PGBR.
	0.95	FAS (320%), LDLR (31%) and CYP7alpha1 (74%) proteins, compared with the SRD group.
	0.95	FAS, LDLR and CYP7alpha1 were enhanced by HFD.
	0.94	FAS (57%), HMGCR (78%), and increase in LDLR (50%), CYP7alpha1 (66%) and PPARalpha (75%) protein levels compared with the HFD group (Fig. 1).
	0.92	FAS, HMGCR, increasing LDLR, CYP7alpha1 and recovering adiponectin through regulating PPARs.
	0.90	FAS, HMGCR, LDLR, CYP7alpha1 and PPARalpha protein expressions in liver of high-fat diet (HFD) fed mice.
	0.90	FAS, HMGCR, LDLR, CYP7alpha1, PPARalpha, and adiponectin in liver and adipose tissue were recovered by PGBR.
21810592	0.96	fatty acid synthase decreased significantly in E3LDLR-/- livers after STZ administration while remaining elevated in diabetic E4LDLR-/- livers (Fig. 4D).
	0.95	FASN gene expression in the E3LDLR-/- mice, as previously reported in wild-type mice.
	0.90	FASN-directed lipogenesis, on the other hand, tended to be higher in the diabetic E4LDLR-/- livers but did not reach significance.
	0.51	FASN in the livers of diabetic E3LDLR-/- and diabetic E4LDLR-/- mice.
24438079	0.96	fatty acid synthase (FAS, Fasn) was significantly lower in obese LDLR-/- mice on both high-fat diets compared to LF-fed group after 16 weeks of feeding (Figure 4F and Additional file 3: Figure S4).
	0.96	FAS (Fasn) and acetyl-CoA carboxylase (ACC; Acaca) but not stearoyl-CoA desaturase 1 (SCD1; Scd1) were elevated in HFSC- compared to HFC-fed LDLR-/- mice after 16 weeks of treatment (Figure 5A-C).
27834848	0.96	fatty acid synthase (FAS), peroxisome proliferator activated receptor-gamma (PPARgamma), SREBP2, low-density lipoprotein receptor (LDLR), and hydroxymethylglutaryl-coenzyme A reductase (HMGR) genes compared with OLZ alone.
	0.95	fatty acid synthetase (FAS) and PPARgamma) and cholesterogenesis (SREBP2, low-density lipoprotein receptor (LDLR) and hydroxymethylglutaryl coenzyme A reductase (HMGR)).
22078933	0.96	Fasn), acetyl-CoA carboxylase 2 (Acacb), diacylglycerol O-acyltransferase 2 (Dgat2) and stearoyl-coenzyme A desaturase 1 (Scd1), whereas the cholesterol synthesis regulator Srebp2 (Srebf2) (Figure 2L), and its target genes Ldlr and Pcsk9 (Figure S2H), were unchanged.
25766252	0.96	FAs including palmitic acid; and also increased the plasma total and VDLD/LDL cholesterol levels, reduced LDL receptor expression and increased HMG-CoA reductase activity.
26023080	0.96	Ldlr by greater than two-fold and fatty acid synthase by seven-fold; in parallel, insulin suppressed Pck1 by thirty-fold (Fig. 1D).
27050512	0.96	LDLR and other lipogenic enzymes (e.g., SCD1 and FASN) play an important role in tumorigenesis.
30943218	0.96	Ldlr-/- mice express low levels of Fasn.
26318157	0.95	FASN, two key enzymes in fatty acid synthesis, were significantly decreased, while expression levels of LDLR were not changed (Fig. 5A).
30863273	0.95	low-density lipoprotein receptor, adenosine triphosphate (ATP)-binding cassette A1, and ATP-binding cassette G1, while decreasing the protein expression of Niemann-Pick C1-like protein 1, SREBP-1, fatty acid synthase, and acetyl-coenzyme A carboxylase, which were involved in intestinal cholesterol metabolism.
23021221	0.91	Fasn expression in macrophages derived from LDLR KO animals, and diet-induced increases in expression of Acot1 and Scd2 in macrophages derived from both WT and LDLR KO mice.
19014463	0.76	Fatty acid synthase, Stearoyl CoA desaturase 1, cholesterol synthesis and uptake genes, HMG CoA reductase, LDL receptor and Egr-1 transcription factor gene, that are also activated by IGF-1 in this study.