Publication for Ldlr and Sqle

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Ldlr	low density lipoprotein receptor	16835			[link]
mmu	Sqle	squalene epoxidase	20775

Pubmed ID	Priority	Text
23585733	0.98	Sqle, Fdps, Idi1, and Ldlr) were all markedly down-regulated by 70%-90% (Figure 2E).
	0.98	Sqle, Idi1, and Ldlr) by 10%-27% in the cerebral cortex and hypothalamus, as well as some decrease in Srebf2 mRNA (Figure 3E).
30532187	0.98	Sqle, and Ldlr, was reduced in the liver of fed obese animals compared to lean controls.
	0.96	Sqle, and Ldlr were not (Fig 7G and S8E Fig).
22441164	0.98	squalene epoxidase (SQLE), lanosterol synthase (LSS), 7-dehydrocholesterol reductase (DHCR7), LDL receptor (LDLR) and Insig-1 were all significantly increased 1.6- to 4.7-fold in P0 129 Pex2-/- versus control mouse liver.
22855714	0.98	Sqle and Idi1) and in the uptake of extracellular cholesterol (Ldlr) (Fig. 5B).
24806461	0.98	Ldlr, Hmgcs1, Sqle and Lss, demonstrating an inverse relationship between SREBP suppression and activation in ScapDelta/Delta and Insig1/2 Delta/Delta mice, respectively.
31327168	0.98	Ldlr, and Sqle (Figure 2A).
27168937	0.97	ldlr, lss, mvk, sc4mol, sc5dl, sqle) that Schmidt et al. (2009) identified as differently expressed in response to conditional knockout of por in mice, a cytochrome P450 that is essential for steroidogenesis (Fluck et al. 2004), were coordinately upregulated in our study at 22-24 DPA.
	0.90	ldlr, lss, mvk, pmvk, insig1, sc4mol, sc5dl, sqle) (Fig. 12I-L).
32111832	0.97	squalene epoxidase (SQLE), and the low-density lipoprotein receptor (LDLR).
	0.97	LDLR, SQLE, and FASN in response to sterol-depletion, in Hap1-SPRINGKO cells basal expression of these genes was reduced and the response to sterol-depletion was largely abrogated.
20045742	0.97	squalene epoxidase) and phospholipids (i.e. CTalpha and PSS1), as well as lipoprotein turnover (i.e. LDLr and ABCA1).
28459857	0.97	Sqle and Ldlr, while the expression of ApoE was reduced by more than six-fold (data not shown).
28725049	0.97	low density lipoprotein receptor (LDLR) and squalene epoxidase (SQLE) were all enhanced in the absence of calreticulin (Fig. 1D).
25144734	0.96	squalene epoxidase by downregulation of sterol regulatory element-binding protein (SREBP)-1 and an increase in LDLR expression.
30214638	0.96	Sqle) and cholesterol transport (Stard4 and Ldlr).
26528138	0.94	Ldlr, Stard4, Hsd17b7, and Sqle (Brockington et al.,).
31974378	0.91	Sqle (Fig. 1g), but showed no influence on genes controlling cholesterol efflux or uptake, including Abca1, Abcg1, Ldlr, and Ldol (Supplementary Fig. 7).
32027669	0.90	Sqle) and fatty acids (Fasn, Scd1), but also direct cholesterol transport (Ldlr, Pcsk9, Stard4) and retinoid synthesis (Aldh1a1, Rdh11).
25799309	0.87	Sqle, Cnbp, Dhcr24, Nsdhl, Fdps, Sc4mol, Fdft1 and Tm7sf2), cholesterol transport and uptake (e.g., Cd36, Apoa4 and Ldlr), cholesterol homeostasis (e.g., Fabp4, Apoa4, Pcsk9 and Ldlr), triglyceride synthesis (Ces3, Ppap2a, Dgat2, Ppap2c and Pcsk9) and triacylglycerol catabolism (Lpl and Gk2) (Fig. 4A, Fig. 5E, F and S7-S8 Tables), indicating that the decreased expression of these hepatic genes involved in cholesterol and triglyceride metabolism might be responsible, or contribute to the decreased cholesterol and triglyceride levels observed in Rm155LG/Alb-Cre transgenic mice.
29991744	0.85	Sqle, Nsdh1, GLrx, Marcks), the proliferation-related genes (Mybl2, Mcm3, Ppef1, Ldlr, Plin2) and the cell motility-related genes (Cdsn, Itga3, H19, Limd2).