Orthologous genes in OrthoFinder**

Species Gene Description
 hsa-u.4   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 hsa-r.6   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 hsa-m.7   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 hsa-m2.4   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 hsa-u.4   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 mcc-u.3   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 mcc-u.3   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 mmu-u.4   Hmgcs2   3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 
 mmu-u.4   Hmgcs1   3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 
 rno-u.3   Hmgcs2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 rno-u.3   Hmgcs1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 cfa-u.3   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 cfa-u.3   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 gga-u.3   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 gga-u.3   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 dre-u.3   hmgcs1   3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 
 dme-u.3   Hmgs   HMG Coenzyme A synthase 
 cel-u.3   hmgs-1   Hydroxymethylglutaryl-CoA synthase 
 sce-u.3   ERG13   hydroxymethylglutaryl-CoA synthase 

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Top 50 coexpressed genes to HMGCS1 (hsa-u.4 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 hsa100   Steroid biosynthesis  12 19 6.57
 hsa1212   Fatty acid metabolism  9 50 6.42
 hsa900   Terpenoid backbone biosynthesis  6 19 6.57
 hsa1040   Biosynthesis of unsaturated fatty acids  5 24 6.14
 hsa4152   AMPK signaling pathway  5 109 4.74

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hsa:HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID CoexPub LINK Target Reference

hsa-u.4
for
HMGCS1
hsa-r.6
for
HMGCS1
hsa-m.7
for
HMGCS1
hsa-m2.4
for
HMGCS1
hsa-u.4
for
HMGCS2
mcc-u.3
for
HMGCS1
mcc-u.3
for
HMGCS2
mmu-u.4
for
Hmgcs2
mmu-u.4
for
Hmgcs1
rno-u.3
for
Hmgcs2
rno-u.3
for
Hmgcs1
cfa-u.3
for
HMGCS2
cfa-u.3
for
HMGCS1
gga-u.3
for
HMGCS2
gga-u.3
for
HMGCS1
dre-u.3
for
hmgcs1
dme-u.3
for
Hmgs
cel-u.3
for
hmgs-1
sce-u.3
for
ERG13
1 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 3156 71 25.0 23.7
 10.6
 20.3
 -0.0
 9.7
 0.7
 -1.1
 21.1
 -1.5
 16.3
 1.3
 17.1
 0.3
 15.0
 12.2
1.7
 5.7
 4.1
 7.4
0.4
2 MSMO1 methylsterol monooxygenase 1 6307 19 22.6 21.9
 10.4
 17.8
 -0.0
 14.0
 1.3
 -1.2
 22.9
 -1.8
 22.8
 1.0
-1.2
 11.3
4.7
 0.9
 15.6
 14.9

5.1
3 SQLE squalene epoxidase 6713 44 21.9 20.8
 10.3
 17.8
 -0.7
 13.1
 -0.2
 -1.5
 22.0
 -2.1
 19.3
 0.8
 12.8
 0.2
 13.4
 13.0

5.5
4 IDI1 isopentenyl-diphosphate delta isomerase 1 3422 31 21.4 20.2
 9.2
 17.5
 0.4
 14.0
2.4
 -0.1
-0.7
 -1.4
 23.0
 -2.0
 19.6
 0.3
 14.1
 1.1
 16.8
 7.6
 2.7
 0.2
 5.2
5 INSIG1 insulin induced gene 1 3638 21 19.1 18.9
 9.1
 14.7
 0.2
-0.2
 6.4
0.3
 0.1
-1.1
 0.9
-1.5
 18.2
1.6
 -0.1
-1.4
 14.9
0.1
 0.3
 11.2
 1.4
1.3
 11.9
3.2
 8.1
-0.1


6 ACAT2 acetyl-CoA acetyltransferase 2 39 19 18.8 18.7
 8.3
 14.4
 0.0

1.5
-1.3
 16.0
1.5
 1.3
-2.3
 18.1
0.9
 0.4
 11.8
 1.3
 9.0
 8.4
 4.2

7 MVD mevalonate diphosphate decarboxylase 4597 22 18.0 18.1
 7.0
 13.5
 -0.3
 9.1
 -0.1
 -1.8
 17.9

0.5
 8.7
 0.9
 6.0
 11.9
 3.3
 1.0
 13.7
8 FDFT1 farnesyl-diphosphate farnesyltransferase 1 2222 39 17.3 17.1
 9.0
 13.3
 0.4
 9.5
 0.7
 -1.0
 19.8
 -1.0
 17.7
 0.9
 14.4
 0.9
 13.4
 9.2

7.8
9 DHCR7 7-dehydrocholesterol reductase 1717 28 16.2 15.8
 7.6
 12.7
 0.7
0.0
 7.6
0.4
 0.6
0.3
 0.0
-0.9
 13.8
9.9
 0.5
-1.1
 13.7
10.8
 1.6
1.1
 10.1
6.4
 0.8
0.4
 11.6
2.8
 9.7
8.1
 -1.6
 -0.5
 4.7
1.0
10 NSDHL NAD(P) dependent steroid dehydrogenase-like 50814 11 15.4 14.8
 6.6
 12.2
 -0.6
 6.1
 -0.8
 -0.8
 18.7
 -0.8
 15.6
 1.0
 13.2
 0.6
 11.7
 13.8

5.8
11 LDLR low density lipoprotein receptor 3949 34 15.3 15.6
 7.0
 11.4
 -1.0
-2.0
 8.6
1.3
 -0.0
-0.2
 -0.3
-1.4
 16.8
3.0
 -0.7
-1.3
 8.6
1.1
 0.3
-0.3
 8.9
2.4
 1.0
-0.4
 6.2
2.5
 6.8
4.1
 1.4
0.4
 -0.0
-0.7
12 FDPS farnesyl diphosphate synthase 2224 40 14.9 16.6
 7.0
 9.7
 -0.4
 8.9
 0.1
 -1.2
 18.7
 -0.4
 16.9
 1.1
 13.4
 0.3
 11.0
 14.4
 0.8
 1.6
 7.0
13 CYP51A1 cytochrome P450 family 51 subfamily A member 1 1595 19 14.3 21.6
 10.1
 3.6
 -0.7
 16.7
 0.7
 -1.6
 25.3
 -1.9
 22.5
 1.0
 12.7

13.3

5.8
14 HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 51478 5 14.1 11.9
 6.0
 12.9
 -0.0
 6.6
 -0.6
 -0.2
 14.7
 -1.8
 14.6
 1.0
 9.3
 0.8
 9.3
 12.1

5.8
15 SREBF2 sterol regulatory element binding transcription factor 2 6721 40 14.1 13.7
 6.6
 11.1
 -0.7
-0.8
 8.2
1.2
 0.3
-0.6
 -0.7
-1.3
 14.9
3.5
 -0.9
-1.3
 11.2
2.5
 -0.3
 1.5
 0.7
-0.1
 8.9
2.1
 9.0
2.5
 2.4
 -0.3
 0.2
-0.5
16 MVK mevalonate kinase 4598 24 14.1 14.6
 6.6
 10.1
 0.9
 3.6
 0.8
 -2.1
 14.2
 -0.9
 11.1
 1.0
 7.3
 0.2
 5.4
 8.5
3.0
 8.1
17 SCD stearoyl-CoA desaturase 6319 24 13.8 14.4
 6.4
 9.8
 -0.7
-0.9
 5.2
-0.0
 -0.5
-0.6
 -0.7
-1.0
 8.1
6.2
 -0.6
-1.0
 7.1
5.6
 -0.5
-0.9
 8.3
-0.3
 0.3
0.2
 4.3
-0.5
 3.4
-1.0
 2.5
2.1
 0.5
0.0
 3.6
18 SC5D sterol-C5-desaturase 6309 10 13.8 13.8
 6.5
 10.4
 0.2
 5.3
 -0.2
 -1.0
 16.8
 -1.1
 14.3
 1.1
 11.7
 1.6
 9.7
 11.7

3.4
19 LSS lanosterol synthase 4047 15 12.9 12.6
 6.0
 10.0
 -0.2
 5.5
 0.4
 -1.2
 16.0
 -1.7
 14.3
 0.3
 9.1
 0.6
 10.2
 14.7

4.2
20 DHCR24 24-dehydrocholesterol reductase 1718 11 12.5 13.4
 5.8
 8.5
 0.4
 7.6
 0.2
 0.1
 14.0
 -1.2
 13.4
 0.8
 9.1
 0.3
 12.6
 11.1
1.0
0.1
21 ERG28 ergosterol biosynthesis 28 homolog 11161 0 12.0 12.1
 6.1
 9.0
 0.3
 2.8
 -0.7
 0.0
 8.2
 0.5
 8.8
 0.3
 5.7
 0.4
 5.5
 5.4

3.2
22 EBP EBP cholestenol delta-isomerase 10682 6 11.9 12.2
 5.3
 8.8
 0.7
 7.5
 -0.3
 -0.4
 4.3
 -0.5
 7.7
 1.0
 8.4
 1.2
 7.9
 12.5


23 FASN fatty acid synthase 2194 25 11.6 11.8
 4.6
 8.5
 -0.4
 7.0
 -1.2
 -1.3
 8.8
 -1.2
 8.5
 1.4
 8.7
 -0.1
 6.3
 3.0
 2.4
2.4
 0.9
24 MMAB metabolism of cobalamin associated B 326625 0 10.7 11.6
 6.5
 7.2
 0.8
 1.5
 -0.2
 -0.9
 9.2
 -0.9
 5.2
 0.4
 2.0
 -0.1
 3.2
 0.1
1.1
25 FADS2 fatty acid desaturase 2 9415 2 10.6 11.2
 4.3
 7.4
 -0.8
-1.6
 4.5
3.8
 0.3
0.1
 1.4
0.7
 7.5
6.7
 2.1
1.2
 8.3
4.8
 -0.1
-0.5
 5.8
2.8
 1.3
0.3
 5.9
3.3
 6.9
1.7
-0.2
26 TMEM97 transmembrane protein 97 27346 1 10.6 10.5
 5.2
 8.0
 1.6
 2.8
 0.3
 0.2
 7.8
 -0.3
 7.9
 0.9
 4.7
 -0.0
 0.1
 8.0

3.5
27 FADS1 fatty acid desaturase 1 3992 9 9.8 10.2
 4.5
 7.1
 -0.8
-1.6
 4.5
3.8
 0.3
0.1
 1.4
0.7
 7.5
6.7
 2.1
1.2
 8.3
4.8
 -0.1
-0.5
 5.8
2.8
 1.3
0.3
 5.9
3.3
 6.9
1.7
-0.2
28 ACACA acetyl-CoA carboxylase alpha 31 7 9.5 8.7
 3.9
 8.0
 1.0
-1.0
 3.4
-0.3
 0.1
-0.4
 2.0
-1.2
 6.3
0.4
 0.8
-0.8
 5.5
0.2
 1.8
0.8
 6.4
0.4
 0.2
-0.3
 3.7
-0.7
 4.8
0.3
 1.7
 1.5
 2.9
0.5
29 PANK3 pantothenate kinase 3 79646 1 9.5 8.9
 4.1
 7.7
 2.6
0.6
 5.2
1.6
 0.7
0.5
 1.9
0.6
 8.3
4.4
 2.6
-0.2
 5.5
3.6
 1.3
0.3
 3.5
2.9
 2.2
0.3
 4.7
2.5
 3.1
1.2
 3.5

30 ACSL3 acyl-CoA synthetase long chain family member 3 2181 2 9.5 9.0
 3.1
 7.6
 -0.1
-0.9
 4.4
3.7
 0.2
-1.1
 -0.6
-0.8
 10.3
5.5
 0.1
-1.1
 8.1
3.7
 1.5
-1.0
 3.4
3.0
 0.9
-0.8
 3.7
3.2
 2.4
1.6
 2.8
 0.1
 2.3
2.0
31 HSD17B7P2 hydroxysteroid 17-beta dehydrogenase 7 pseudogene 2 158160 0 9.3 6.5
 1.7
 9.8














32 ACLY ATP citrate lyase 47 18 9.2 9.4
 3.7
 6.8
 -1.1
 4.0
 -1.0
 -1.8
 9.8
 -0.8
 9.0
 0.7
 13.0
 0.3
 6.1
 6.3
-1.0
 0.9
 0.4
-0.6
33 ACSS2 acyl-CoA synthetase short chain family member 2 55902 0 8.5 8.4
 3.9
 6.6
 0.8
0.7
 1.6
-0.8
 0.1
-0.4
 1.2
-0.6
 6.6
-0.1
 1.1
-1.9
 8.4
-0.9
 0.7
0.3
 5.3
0.0
 0.9
-0.1
 0.9
0.5
 2.8
-0.1
 2.8
 -0.3
 8.0
-1.0
34 RDH11 retinol dehydrogenase 11 51109 0 8.3 7.5
 3.5
 7.1
 0.6
0.2
 2.6
0.3
 0.7
0.3
 0.9
-0.2
 10.6
0.2
 0.2
0.1
 3.9
-0.1
 1.1
-0.1
 8.5
1.7
 2.6
1.5
 5.9
1.1
 5.5
2.2
 1.6
1.4
 1.3
1.1
 0.1
35 PCYT2 phosphate cytidylyltransferase 2, ethanolamine 5833 0 8.1 7.9
 3.1
 6.3
 0.5
 3.5
 0.2
 -0.2
 10.5
 -0.4
 6.8
 0.7
 6.0
 1.7
 0.1
 3.0
 0.6
 0.5
0.4
 0.1
36 SLC25A1 solute carrier family 25 member 1 6576 0 7.6 7.5
 3.6
 5.9
 0.2
 4.1
 -0.2
 -0.4
 7.2
 -0.4
 7.1
 0.6
 5.2
 3.2
 1.7
 1.2
0.6
1.8
0.4
 -0.0
-1.4
37 INSIG1-DT INSIG1 divergent transcript 105375591 0 7.6 7.7
















38 PNPLA3 patatin like phospholipase domain containing 3 80339 1 7.6 7.5
 3.4
 5.8
 -0.0
 2.2
 0.5
 -1.3
 2.0
 -2.0
 3.6
 3.0
 3.4





39 CLCN6 chloride voltage-gated channel 6 1185 0 7.4 6.7
 2.8
 6.3
 -0.4
 1.2
 -0.7
 -1.2
 5.5
 -1.5
 3.0
 -0.6
 -0.1
 -0.2
 -0.5
 -1.7


40 DBI diazepam binding inhibitor, acyl-CoA binding protein 1622 0 7.2 7.3
 3.5
 5.3
 1.2
-0.4
 3.0
0.5
 0.7
-1.0
 2.0
0.2
 7.2
-0.6
 3.0
 6.1
 -0.1
 0.7
 1.6
1.5
 3.6
-0.4
 4.4
0.3
 1.0
0.8
 0.4
 3.0
41 IDH1 isocitrate dehydrogenase (NADP(+)) 1 3417 1 7.1 6.8
 3.2
 5.8
 0.9
0.5
 3.7
2.1
 0.5
-0.6
 1.0
0.2
 9.9
0.4
 0.2
0.0
 5.7
-0.7
 0.4
-0.2
 5.7
0.8
 1.3
0.6
 3.6
-0.2
 4.9
0.4
 3.6
 1.5
1.4
 0.3
0.2
42 LPIN1 lipin 1 23175 0 6.9 6.2
 3.4
 6.0
 1.2
-0.1
 1.8
1.5
 0.1
-1.5
 1.4
0.1
 2.6
0.4
 0.7
0.6
 1.8
0.2
 0.8
0.6
 5.8
0.3
 1.7
-0.5
 3.5
3.3
 1.7
1.2
 -0.3
 1.4
 0.7
43 ELOVL6 ELOVL fatty acid elongase 6 79071 3 6.8 7.2
 2.5
 4.7
 -0.5
-0.7
 1.5
1.1
 0.4
-2.2
 1.3
-1.2
 7.5
1.4
 -0.0
 8.0
 1.0
 3.6
 2.0
 5.9
 2.6
1.0
 2.5
 2.2
2.0
 1.4
1.4
44 ADIPOR2 adiponectin receptor 2 79602 0 6.5 5.8
 2.6
 5.6
 0.6
-0.9
 2.6
-0.9
 0.7
-0.1
 1.0
-1.2
 2.4
-0.8
 0.1
-0.4
 2.2
-1.3
 2.5
-0.3
 6.0
1.4
 0.3
0.2
 1.6
0.2
 3.0
1.6
 1.9
 3.8
-1.4
 0.5
-1.6
45 CYB5B cytochrome b5 type B 80777 0 6.3 6.4
 2.6
 4.6
 1.3
0.1
 4.2
0.7
 0.9
-0.3
 1.1
-0.7
 9.9
1.8
 0.5
-1.1
 4.3
1.3
 0.8
 5.8
3.4
 1.0
-0.3
 1.8
0.8
 2.8
1.3
 4.8
1.0
 1.9
0.6
 8.4
46 LIPG lipase G, endothelial type 9388 0 6.2 6.7
 2.8
 4.1
 1.0
 2.3
 1.9
 1.4
 3.2
 -1.2
 2.7
 -1.1
 4.5
 0.4
 5.2
 3.3


47 SELENOI selenoprotein I 85465 0 6.1 6.2
 2.6
 4.5
 -0.3
 2.4
 -0.7
 0.2
 3.6
 0.5
 3.4
 1.1
 5.1
 2.9
0.5
 7.6
-0.5
 4.3
 0.6
-0.8
 1.4
 1.8
1.6
48 TM7SF2 transmembrane 7 superfamily member 2 7108 0 5.9 6.0
 3.3
 4.4
 0.7
0.0
 7.6
0.4
 0.6
0.3
 0.0
-0.9
 13.8
9.9
 0.5
-1.1
 13.7
10.8
 1.6
1.1
 10.1
6.4
 0.8
0.4
 11.6
2.8
 9.7
8.1
 -1.6
 -0.5
 4.7
1.0
49 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 51144 0 5.9 5.4
 2.3
 4.9
 -0.6
 3.0
 -0.5
 -0.6
 7.0
 0.2
 4.2
 1.4
 7.8
 2.2
 5.8
 4.0
0.9
 2.9
2.3
 0.7
0.6
 2.1
50 MFSD14A major facilitator superfamily domain containing 14A 64645 0 5.8 5.6
 2.7
 4.6
 -0.7
-0.7
 2.0
0.5
 -0.2
-0.4
 -0.1
-1.1
 4.3
1.7
 -0.4
-1.1
 2.9
1.8
 0.3
-1.4
 2.7
1.2
 0.9
-0.4
 2.7
1.2
 2.3
1.8
 0.0
 0.7
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