Publication for DHCR24 and HMGCS1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	DHCR24	24-dehydrocholesterol reductase	1718			[link]
hsa	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	3157

Pubmed ID	Priority	Text
26646011	0.97	HMGCS1, HMG-CoA synthase 1; HMGCR, HMG-CoA reductase; FDPS, farnesyl diphosphate synthase; SQLE, squalene epoxidase; LSS, lanosterol synthase; NSDHL, NAD(P)-dependent steroid dehydrogenase-like; DHCR24, 24-dehydrocholesterol reductase; SC5D, sterol-C5-desaturase; DHCR7, 7-dehydrocholesterol reductase.
	0.94	HMGCS1, HMGCR, NSDHL, DHCR24, and SC5DL) have evolutionarily conserved predicted target sites for >=2 miRNAs that were upregulated more than 5-fold in at least one disease category and/or identified as master regulators of downregulated genes in at least one disease category (Fig. 7; see Fig. S3 in the supplemental material).
31261735	0.97	DHCR24, HMGCS1, IDI1, LSS, MVD, MVK, and SQLE, which were all downregulated.
26535009	0.95	HMGCS1, DHCR7, DHCR24, LDLR, FDFT1, FDPS, IDI1, MVD, SQLE, LSS, NSDHL, SC5DL, INSIG1, ACLY, and ACSS2 (see fig. S1 for full list).
31138790	0.94	DHCR24, HMGCS1 and HMGCR was lower in ccRCC cells than in adjacent tissues, and thus, we concluded that the cause of the higher cholesterol content in ccRCC is not cholesterol synthesis but exogenous uptake.
	0.84	HMGCS1, HMGCR and DHCR24 gene expression was low in ccRCC cells (Fig. 6c), which indicated that ccRCC cells do not acquire cholesterol through synthesis.
	0.60	HMGCS1, HMGCR and DHCR24 between ccRCC and adjacent tissues in the TCGA database.
26095650	0.92	HMGCS1 probe set 221750_at, FC = 1.1, P = 0.008), HMG-CoA reductase (HMGCR probe set 202539_s_at, FC = 4.5, P = 0.0008 and probe set 202540_s_at, FC = 1.2, P = 0.005), farnesyl diphosphate synthase (FDPS probe set 201275_at, FC = 1.1, P = 0.002), squalene synthase (FDFT1 probe set 210950_s_at, FC = 1.1, P = 0.012) and 24-dehydrocholesterol reductase (DHCR24 probe set 200862_at, FC = 1.2, P = 0.005).
20005986	0.90	HMGCS1, as well as IDI1 and DHCR24 increased with oligodendroglial differentiation (Fig. 3A), as did the nuclear-encoded mitochondrially-targeted transcripts SOD2, HADHSC, and PDK2 (Fig. 3B), at p < 0.05.
28027290	0.88	HMGCS1, CYP51A1, DHCR24, DHCR7, STARD4, and NSDHL (S4 Fig);
31540257	0.85	DHCR24 (30.3), FDFT1 (6.6), HMGCR (500.4), HMGCS1 (1952.9), HMGCS2 (82.1), LCAT (3.3), LSS (5.7), MSMO1 (996.6), SOAT1 (1710.2), SOAT2 (1.9), and SQLE (214.0).
29133782	0.83	DHCR24, LDR, HMGCS1, INSIG1, and SQLE), protein metabolism (SCL7A5), and lymphocyte differentiation (FGL2 and BHLHE40) (Fig. 1g, Supplementary Fig. 1e, and Supplementary Data 1).
23170111	0.65	HMGCS1, MSMO1, LDLR, DHCR7, SCD, ACAT2, LSS, FASN, MSMO1, SQLE, DHCR24, FDFT1, IDI1, FADS2, ACSS2, EBP, SC5DL, NSDHL and LPIN1), cell cycle regulation (14% of total gene expression changes: CDC2, CDCA8, CDKN3, PRC1, MCM4, CDC20, CDC45L, CCNA1, CCNB2, CCNA2, TOP2A and CDCA7), angiogenesis (5% of total gene expression changes: PGF, ANGPT2, ANGPTL4 and RGS4) and ubiquitin modifications (3% of total gene expression changes: UBE2T, UBE2C and UHRF1).
27746144	0.62	HMGCS1 that converts acetyl-CoA to HMG-CoA; HMGCR, the rate limiting step in the pathway that converts HMG-CoA to mevalonate, and DHCR24 which ultimately converts desmosterol to cholesterol.