Publication for HMGCS1 and SC5D

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	3157			[link]
hsa	SC5D	sterol-C5-desaturase	6309

Pubmed ID	Priority	Text
27313533	0.98	SC5DL, and HMGCS1 were deregulated in this patient cohort.
29703166	0.98	HMGCS1, HMGCR, IDI1, FDFT1, SQLE, CYP51A1, MSMO1, NSDHL, EBP and SC5D) ranked among the top 150 most differentially expressed genes in the balanced dataset (average rank of 76) (Additional file 2).
26646011	0.97	HMGCS1, HMG-CoA synthase 1; HMGCR, HMG-CoA reductase; MVK, mevalonate kinase; PMVK, phosphomevalonate kinase; MVD, mevalonate decarboxylase; IDI1, isopentenyl-diphosphate delta isomerase 1; FDPS, farnesyl diphosphate synthase; FDFT1, farnesyl-diphosphate farnesyltransferase 1; SQLE, squalene epoxidase; LSS, lanosterol synthase; CYP51A1, cytochrome P450 family 41 subfamily A; TM7SF2, transmembrane 7 superfamily member 2; NSDHL, NAD(P)-dependent steroid dehydrogenase-like; HSD17B7, hydroxysteroid 17-beta dehydrogenase; DHCR24, 24-dehydrocholesterol reductase; SC5D, sterol-C5-desaturase; DHCR7, 7-dehydrocholesterol reductase.
	0.85	HMGCS1/HMGCR and HMGCR/SC5DL, respectively), and three genes (HMGCS1, HMGCR, and SC5DL) harbor putative target sites for miR-27.
	0.79	HMGCS1, HMGCR, NSDHL, DHCR24, and SC5DL) have evolutionarily conserved predicted target sites for >=2 miRNAs that were upregulated more than 5-fold in at least one disease category and/or identified as master regulators of downregulated genes in at least one disease category (Fig. 7; see Fig. S3 in the supplemental material).
	0.69	HMGCS1, HMG-CoA synthase 1; HMGCR, HMG-CoA reductase; FDPS, farnesyl diphosphate synthase; SQLE, squalene epoxidase; LSS, lanosterol synthase; NSDHL, NAD(P)-dependent steroid dehydrogenase-like; DHCR24, 24-dehydrocholesterol reductase; SC5D, sterol-C5-desaturase; DHCR7, 7-dehydrocholesterol reductase.
22684502	0.96	Hmgcs1, Mvd, Idi1, Fdft1, Tm7sf2, Ebp, Nsdhl, Sc5d and Dhcr24) (Figure 7A).
23170111	0.95	HMGCS1, MSMO1, LDLR, DHCR7, SCD, ACAT2, LSS, FASN, MSMO1, SQLE, DHCR24, FDFT1, IDI1, FADS2, ACSS2, EBP, SC5DL, NSDHL and LPIN1), cell cycle regulation (14% of total gene expression changes: CDC2, CDCA8, CDKN3, PRC1, MCM4, CDC20, CDC45L, CCNA1, CCNB2, CCNA2, TOP2A and CDCA7), angiogenesis (5% of total gene expression changes: PGF, ANGPT2, ANGPTL4 and RGS4) and ubiquitin modifications (3% of total gene expression changes: UBE2T, UBE2C and UHRF1).
28855511	0.95	HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL, SC5DL, SCD, and FADS1), as well as downregulation of cholesterol efflux genes (ABCG1 and ABCA1).
31406127	0.95	HMGCS1, FDFT1, DHCR7 and SC5D), de novo lipogenesis (FASN and ACSS2) and phospholipid dephosphorylation (PLPP3) were upregulated in the hepatic TM6SF2 E167K spheroids, while gluconeogenesis (FBP1) was upregulated in the spheroids and downregulated in humans carrying the E167K risk variant (Fig. 6).
17052361	0.93	HMGCS1, FDPS, SC5DL, DHCR7, LDLR, FASN and SCD1) in four CNS-relevant human cell lines.
	0.93	HMGCS1, HMGCR, SC5DL and LDLR) was measured after exposing GaMg cells to various concentrations (0.1, 1, 10 and 25 muM) of chlorpromazine, haloperidol, clozapine, olanzapine, risperidone or ziprasidone (Table 1).
	0.88	HMGCS1, HMGCR, FDPS, SC5DL and DHCR7; see legend to Fig. 1 for complete names), cholesterol transport (LDLR) and fatty acid biosynthesis (FASN and SCD1).
	0.69	3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) (5.6, p = 0.000009), fatty acid synthase (FASN) (5.4, p = 0.000008), 7-dehydrocholesterol reductase (DHCR7) (4.3, p = 0.000008), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) (3.1, p = 0.00001), sterol-C5-desaturase like (SC5DL) (3.1, p = 0.00001), acetyl-CoA acetyltransferase 2 (also termed acetoacetyl-CoA thiolase; ACAT2) (3.0, p = 0.00009), low density lipoprotein receptor (LDLR) (2.8, p = 0.00001) and farnesyl diphosphate synthase (FDPS) (2.8, p = 0.000009).
26535009	0.73	HMGCS1, DHCR7, DHCR24, LDLR, FDFT1, FDPS, IDI1, MVD, SQLE, LSS, NSDHL, SC5DL, INSIG1, ACLY, and ACSS2 (see fig. S1 for full list).
28827664	0.63	HMGCS1; HMGCR; IdI1; FDFT1; SQLE; CYP51A1; SC5D; DHCR; HSD17B7, see Fig. 4A) are down regulated, we experimentally determined if this influenced cholesterol accumulation (Fig. 4C).