Publication for ACAT2 and HMGCS1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	ACAT2	acetyl-CoA acetyltransferase 2	39			[link]
hsa	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	3157

Pubmed ID	Priority	Text
30348985	0.98	HMGCS1, ACSS2, TM7SF2, TMEM97, CP, CRP, SLPI, C2orf82, ACAT2, TM4SF5, MSMO1, LEPR).
17052361	0.97	ACAT2, HMGCR, HMGCS1, FDPS, SC5DL, DHCR7, LDLR, FASN and SCD1) in four CNS-relevant human cell lines.
	0.96	ACAT2, HMGCS1, HMGCR, FDPS, SC5DL and DHCR7; see legend to Fig. 1 for complete names), cholesterol transport (LDLR) and fatty acid biosynthesis (FASN and SCD1).
	0.78	3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) (5.6, p = 0.000009), fatty acid synthase (FASN) (5.4, p = 0.000008), 7-dehydrocholesterol reductase (DHCR7) (4.3, p = 0.000008), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) (3.1, p = 0.00001), sterol-C5-desaturase like (SC5DL) (3.1, p = 0.00001), acetyl-CoA acetyltransferase 2 (also termed acetoacetyl-CoA thiolase; ACAT2) (3.0, p = 0.00009), low density lipoprotein receptor (LDLR) (2.8, p = 0.00001) and farnesyl diphosphate synthase (FDPS) (2.8, p = 0.000009).
26535575	0.97	HMGCS1, FDPS, HMGCR, and ACAT2.
	0.96	HMGCS1, TMEM97, ACAT2, HMGCR, SC4MOL, FDPS, SQLE, CDK5RAP2, and INSIG1.
	0.94	HMGCS1, TMEM97, TM7SF2, FDFT1, ACAT2, EBP, FDPS, HMGCR, SQLE, DHCR7, C14orf1, and INSIG1.
29226804	0.97	ACAT2, HMGCS1, MVD, IDI1, and FPDS) (Figure 3B).
	0.76	ACAT2 and HMGCS1) were described by an additional node representing their activity.
	0.67	ACAT2, FDPS, ACLY, HMGCS1, IDI1, LSS, NSDHL, and FDFT1), confirming that this is the main affected cellular pathway.
22684502	0.97	Acat2, Aacs, Hmgcs1, Mvd, Idi1, Fdft1, Tm7sf2, Ebp, Nsdhl, Sc5d and Dhcr24) (Figure 7A).
28933554	0.97	Acetyl-CoA Acetyltransferase 2 (ACAT2), Squalene Epoxidase (SQLE), Methylsterol Monooxygenase 1 (MSMO1), INSIG1, 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (HMGCS1), 7-Dehydrocholesterol Reductase (DHCR7), Lanosterol Synthase (LSS), Stearoyl-CoA Desaturase (SCD), and Mevalonate Diphosphate Decarboxylase (MVD).
29927962	0.97	HMGCS1, INSIG1, CYP51A1, PCSK9, DHCR24, HMGCR, LSS, ACAT2, SQLE, NSDHL, EBP, FAP, MVD, DHCR7, APOL1, LDLR, APOL3, FDFT1 and ABCG1).
31058187	0.97	HMGCS1, SQLE, and ACAT2, which were involved in cholesterol biosynthesis process and also enriched in metabolism pathway.
21279722	0.96	ACAT2; 2.3.3.10 = HMGCS1 and HMGCS2; 2.8.3.5 = OXCT2.
22265415	0.96	ACAT2 (HR = 1.23, q = 0.0069), HMGCS1 (HR = 1.21, q = 0.007), HMGCR (HR = 1.17, q = 0.032), IDI1 (HR = 1.26, q < 0.001), FDPS (HR = 1.17, q = 0.012), SQLE (HR = 1.35, q < 0.001), LSS (HR = 1.16, q = 0.032), NSDHL (HR = 1.17, q = 0.032), DHCR7 (HR = 1.26, q < 0.001).
29849100	0.96	Acetyl-coa acetyltransferase 2 - ACAT2, 3-hydroxy-3-methylglutaryl-coa synthase 1 - HMGCS1, 3-hydroxy-3-methylglutaryl-coa reductase -HMGCR, Cytochrome P450, family 51, subfamily A, polypeptide 1 - CYP51A1, Fatty acid desaturase 1 - FADS1, Hydroxysteroid (17-beta) dehydrogenase 8 - HSD17B8, Isopentenyl-diphosphate delta isomerase 1 - IDI1, Aldolase C, fructose-bisphosphate - ALDOC, Acyl-coa synthetase short-chain family member 2 - ACSS2, ATP citrate lyase - ACLY, Hydroxysteroid (17-beta) dehydrogenase 7 - HSD17B7, Farnesyl diphosphate synthase - FDPS, Farnesyl-diphosphate farnesyltransferase 1 - FDFT1, Mevalonate kinase - MVK, NAD(P) dependent steroid dehydrogenase-like - NSDHL, FK506 binding protein 4 - FKBP4, Retinol dehydrogenase 11 - RDH11, Pantothenate kinase 3 - PANK3, Hydroxysteroid (17-beta) dehydrogenase 12 - HSD17B12, Atpase family, AAA domain containing 2 - ATAD2, Thymidylate synthetase - TYMS, Prenyl (decaprenyl) diphosphate synthase, subunit 1 - PDSS1, Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 - CHST6 and NADH dehydrogenase (ubiquinone) flavoprotein 2 -NDUFV2) and purmorphamine treatment group (NADPH oxidase 4 - NOX4, Cytochrome P450, family 26, subfamily B, polypeptide 1 - CYP26B1, Synapse differentiation inducing 1 - SYNDIG1, Transglutaminase 2 - TGM2, Dehydrogenase/reductase (SDR family) member 3 - DHRS3, Iduronate 2-sulfatase - IDS, Transketolase - TKT, Diazepam binding inhibitor - DBI, Phosphodiesterase 6 A - PDE6A, Carbonic anhydrase XI - CA11 and Paraoxonase 3 - PON3), respectively (Fig. 2D).
31261735	0.96	ACAT2, CYP51A1, DHCR7, DHCR24, HMGCS1, IDI1, LSS, MVD, MVK, and SQLE, which were all downregulated.
28118603	0.94	ACAT2, HMGCS1, and HMGCR) and downstream in the cholesterol biosynthetic pathway (FDPS, FDFT1, and SQLE), were all downregulated in dense NHAs but not dense glioma TS lines (Figure 1G and Supplementary Figure 1E).
25153832	0.93	ACAT2, HMGCS, HMGCR, SQLE, LSS) were similar to our results.
18959802	0.92	Hmgcs1, Srebf2, Fabp Fasn, Fdps, Acaca, Acadm, Acat2, ApoA5, C1, E and L1 as well as Cyp27a1, Ldlr, Ppargamma and Tyms (Figure 4).
	0.87	Hmgcs1), HMG CoA reductase (Hmgcr), sterol receptor binding factor-2 (Srebf2) and lanosterol 14 alpha-demethylase (Cyp51a1) (involved in cholesterol metabolism), and others including fatty acid synthase (Fasn), fatty acid binding protein (Fabp), farnesyl diphosphate synthase (Fdps), acetyl-coA carboxylase (Acaca), acetyl-coA dehydrogenase (Acadm), acetyl-coA acetyl transferase (Acat2), peroxisome proliferative activated receptor, gamma (Ppargamma) and a variety of apolipoproteins that are involved in fatty acid and triglyceride metabolism.
27654507	0.91	(ACAT2, HMGCS1, MVK, MVD, IDI1, and FDPS) decreased in abundance in the ARID1A knockout (Table I).
	0.89	ACAT2, HMGCS1, MVK, IDI1, FDPS, FDFT1, SQLE1, LSS1, TM7SF2, and MSMO1) increased in abundance when ARID1A was induced (Table I).
25607805	0.89	HMGCS1, fatty acid desaturases (FADS1 and FADS2), and acyl-CoA synthesis genes (ACADVL, ACAT2, ACOX2, and ACSL3).
31540257	0.76	ACAT2 (521.5), DHCR7 (234.0), DHCR24 (30.3), FDFT1 (6.6), HMGCR (500.4), HMGCS1 (1952.9), HMGCS2 (82.1), LCAT (3.3), LSS (5.7), MSMO1 (996.6), SOAT1 (1710.2), SOAT2 (1.9), and SQLE (214.0).
29136510	0.53	ACAT2, HMGCS, HMGCR, IDI1, FDPS, SQLE, LSS, CYP51A1).