Publication for HMGCS1 and SCD

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	3157			[link]
hsa	SCD	stearoyl-CoA desaturase	6319

Pubmed ID	Priority	Text
24493696	0.98	SCD-1 for lipogenesis, HMGCS1, HMGCR, MVK, MVD and LDLR for cholesterogenesis, two chaperones, INSIG1 and SCAP.
	0.97	SCD-1, HMGCS1, HMGCR, MVK, MVD and LDLR and two chaperones, INSIG-1 and SCAP in LNCaP and C4-2B cells examined by qRT-PCR.
	0.97	SCD-1, HMGCS1, HMGCR, MVK and MVD and two chaperones, INSIG-1 and SCAP compared to the control group.
	0.97	SCD-1, HMGCS1, HMGCR, MVK, MVD and LDLR, and further reduces the levels of intracellular fatty acid and cholesterol.
	0.95	SCD-1, HMGCS1, HMGCR, MVK, MVD, INSIG1 and SCAP (Fig. 5A).
26153245	0.98	SCD, FADS1, HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL), and efflux ( ABCA1, ABCG1), producing a molecular profile expected to increase intracellular cholesterol.
	0.98	SCD, FADS1, HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL), and cholesterol efflux ( ABCA1, ABCG1).
	0.98	3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1); farnesyl-diphosphate farnesyltransferase 1 (FDFT1); squalene epoxidase (SQLE); methylsterol monooxygenase 1 (SC4MOL); cytochrome P450, family 51, subfamily A, polypeptide 1 (CYP51A1); stearoyl-CoA desaturase (SCD); fatty acid desaturase 1 (FADS1); low density lipoprotein receptor (LDLR); myosin regulatory light chain interacting protein (MYLIP); ATP-binding cassette, subfamily G, member 1 (ABCG1); and ATP-binding cassette, subfamily A, member 1 (ABCA1).
	0.95	HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL, SCD, and FADS1), and 3 that were downregulated with increasing BMI (MYLIP, ABCG1, and ABCA1).
27811063	0.98	HMGCS1, LSS, and SCD encode key enzymes in the pathways for cholesterol and unsaturated fatty acid biosynthesis (Fig. 3A), and the results presented in Fig. 2 suggest that the reaction products of these pathways might be essential for CSLC enrichment and survival.
	0.98	HMGCS1, LSS, and SCD; Fig. 4).
	0.71	SCD, LSS, HMGCS1) critical for cholesterol and unsaturated fatty acid synthesis.
31932581	0.98	SCD1, HMGCS1 and HMGCR in A2780 and SKOV3 cells with treatment as indicated.
	0.97	SCD1) and cholesterol synthesis (HMGCS1, HMGCR).
	0.86	SCD1 and HMGCS1 were observed when SIK2 was knockdown or overexpressed in A2780 and SKOV3 cells.
28933554	0.98	3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (HMGCS1), 7-Dehydrocholesterol Reductase (DHCR7), Lanosterol Synthase (LSS), Stearoyl-CoA Desaturase (SCD), and Mevalonate Diphosphate Decarboxylase (MVD).
29869753	0.98	SCD, SCAP, SREBF1, SREBF2, MBTPS1, MBTPS2, LDLR, HMGCS1, LIMA1] in patient samples collected from metastatic vs. primary prostate cancer (a) and multiple myeloma vs. normal bone marrow (b).
31159817	0.98	HMGCS1, FDPS, LSS and SQLE) and lipogenic (e.g. ACACA, SCD, FASN, FADS1 and ELOVL6) pathways.
31592021	0.98	SCD increase expression by RT-qPCR in a time-dependent manner under sterol-depleted conditions supplemented with statin treatment (5% lipoprotein-deficient media with 5 microM simvastatin and 50 microM mavelonic acid) when compared to sterol-rich conditions (10% FBS) supplemented with DMSO vehicle control, similarly to SREBP2 and its downstream gene HMGCS1.
23919967	0.97	HMGCS*, CPT1A*, SCD1*, FASN*, CYP24A1*, SREBP1), thus reinforcing that a K-2/SXR mechanism is in effect.
	0.91	HMGCS*, CPT1A*, SCD1*, FASN*, CYP24A1*, and SREBP1).
26133667	0.97	SCD and HMGCS1 are regulators of inflammation and in lipid-related metabolism and pathology.
	0.95	steroyl CoA desaturase-1 (SCD), and hydroxymethylglutaryl CoA synthase-1 (HMGCS1).
19560108	0.97	SCD, HMGCS and HMGCR was activated 1.5 to 2.7-fold (p<0.001) by culture of freshly isolated trophoblast cells in the presence of 400 nMol/L oleate but not with 10 mMol/L glucose (Figure 4).
31138790	0.97	SCD1 and the HMGCS1, HMGCR and DHCR24 between ccRCC and adjacent tissues in the TCGA database.
31316083	0.96	SCD and ACLY mRNA expression is markedly elevated in SKCM versus healthy skin tissues (Supplementary Fig. 4b,c), while HMGCS1 is higher in the healthy tissues (Supplementary Fig. 4d).
	0.89	SCD, ACLY and HMGCS1 expression using normalized RNA-Seq data from the SKCM group in TCGA and the normal skin tissue group in GTEx.
29153836	0.96	SCD1, ACLY, ACSS2, HMGCS1, and MVD was markedly decreased by SRPK2 knockdown as well as by rapamycin treatment (Figure 5D).
29404478	0.96	SCD, HMGCR, or HMGCS1 mRNA was normalized by the level of ATP5F1 mRNA and assigned a value of 1 in the nontreated OR6Ac cells.
24203995	0.93	HMGCS, 3-hydroxy-3-methylglutaryl-CoA synthase; PPAP, phosphatidic acid phosphatase; SCD, stearoyl-CoA desaturase; SPHK, sphingosine-1-kinase.
25811180	0.92	HMGCS), fatty acid biosynthetic genes (FASN, SCD1) and genes involved in lipoprotein assembly (MTTP, APOC3) (Fig. 2B).
21561152	0.90	HMGCS; isopentenyl-diphosphate delta isomerase 1, IDI1; stearoyl-CoA desaturase, SCD1; LDL receptor, LDLR; ribosomal protein L13a, RPL13A; beta- 2 microglobulin, B2M; glyceraldehyde-3-phosphate dehydrogenase, GAPDH.
25358453	0.86	steroyl CoA desaturase-1, SCD, and hydroxymethylglutaryl CoA synthase 1, HMGCS1.
	0.83	SCD and HMGCS1 are implicated in regulation of inflammation and in lipid-related metabolism and pathology.
29474981	0.73	stearoyl CoA desaturase-1 (Scd1), LDL receptor (Ldlr), and HMG-CoA synthase (Hmgcs1), through a negative feedback loop.
28352810	0.72	3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and squalene epoxidase (SE) that are related with TC synthesis, acetyl-CoA carboxylase alpha (ACC), fatty acid synthase (FAS) and stearoyl-CoA desaturase that are related with FA synthesis.
32180899	0.71	HMGCS1, HMGCR, SCD1, FABP4, and SCD1are critical enzymes in the pathways of lipid synthesis as well cholesterol and steroid synthesis.
17052361	0.55	stearoyl-CoA desaturase (delta-9-desaturase; SCD1) (7.4, p = 0.000008), 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) (5.6, p = 0.000009), fatty acid synthase (FASN) (5.4, p = 0.000008), 7-dehydrocholesterol reductase (DHCR7) (4.3, p = 0.000008), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) (3.1, p = 0.00001), sterol-C5-desaturase like (SC5DL) (3.1, p = 0.00001), acetyl-CoA acetyltransferase 2 (also termed acetoacetyl-CoA thiolase; ACAT2) (3.0, p = 0.00009), low density lipoprotein receptor (LDLR) (2.8, p = 0.00001) and farnesyl diphosphate synthase (FDPS) (2.8, p = 0.000009).
	0.53	HMGCS1, FDPS, SC5DL, DHCR7, LDLR, FASN and SCD1) in four CNS-relevant human cell lines.
31467349	0.55	HMGCS1, LSS, PLOD1, and SCD) were found in cell communication and lipid metabolic process categories (blue in Fig. 3).