Publication for HMGCS1 and INSIG1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	3157			[link]
hsa	INSIG1	insulin induced gene 1	3638

Pubmed ID	Priority	Text
31651237	0.98	HMGCS1, INSIG1, LPIN1, HMGCR, and ACSS2 in group MBV2h vs. MBV6h (Additional file 7).
	0.97	INSIG1, HMGCR, HMGCS1, and LPIN1 were downregulated in the Mock vs. MBV group at 12 h, which was inconsistent with the transcriptome analysis.
	0.67	HMGCS1, INSIG1, LPIN1, HMGCR, and ACSS2 were found to be significantly upregulated in comparison groups Mock vs. MBV6h, Mock vs. MBV 12 h, and Mock vs. MBV24h groups.
28697173	0.97	HMGCS1, SQLE, IDI1) and homoeostasis (e.g., INSIG1) genes were 2-4-fold upregulated by the ASM inhibitors (Figure 1K).
	0.84	INSIG1, a cholesterol sensor in the endoplasmic reticulum (ER), was upregulated by all 20 compounds, and five cholesterol synthesis genes (HMGCR, HMGCS1, SQLE, MVD and SC4MOL) were among the 41 commonly deregulated genes (Supplementary Table 4).
23324130	0.97	INSIG1, HMGCS1 and HMGCR in moxLDL-SMC indicates the initiation of cholesterol synthesis in the 3h moxLDL-SMC cells.
26512780	0.97	3-hydroxy-3-methyl-glutaryl-CoA synthase 1 (HMGCS1), HMGCR, mevalonate kinase (MVK), mevalonate 5-pyrophosphate decarboxylase (MVD) and low-density lipoprotein receptor (LDLR) for cholesterogenesis; and two chaperones, insulin-induced gene 1 (INSIG1) and SREBP cleavage activating protein (SCAP) in PC-3 EV, PC-3 R248W and DU145 cells.
26519296	0.97	Hmgcs1 which has been shown to be positively associated with HDL-C levels; and c) Insig1 which is a gene that, when overexpressed in livers of Zucker diabetic fatty rats, attenuates hepatic steatosis.
28933554	0.97	INSIG1, HMGCS1, DHCR7, LSS, and MVD in SUDHL4 cells, with no upregulation seen when human HDL was administered (Figure 2a, Supplemental Figure S5).
31102995	0.97	INSIG1 (insulin induced gene 1), HMGCS1 (HMG-CoA synthase 1), FDFT1 (farnesyl-diphosphate farnesyltransferase 1), SQLE (squalene epoxidase), HMGCR, and LDLR (low-density lipoprotein receptor), were found to be recurrently regulated by many antipsychotics (Figure S6), supporting the lipid disturbance associated with antipsychotic medications.
27458152	0.96	HMGCS1, MVD and INSIG1) were verified in four cell lines with statistically significant higher average fold increases observed for three of these genes in the less sensitive cells (MCF7 and T47D) relative to the sensitive cells (SKBR3 and MDA-MB-231) after 48 hours exposure to atorvastatin (Figure 1B).
31023626	0.96	HMGCS1, INSIG1 and SCD expression by qRT-PCR.
22162773	0.95	HMGCS1, 2.7 fold increase in IDI1, 4.2 fold (p value = 0.04) increase in CYP27B1 (Cytochrome P450, family 27, subfamily B, polypeptide 1), and 3.0 fold increase in INSIG1 (Insulin induced gene 1) levels at 48 h post transfection of NCI-H460 cells with STAT6 specific siRNA in comparison to the untransfected NCI-H460 cells (Fig. 3c).
	0.87	HMGCS1, 1.56 fold increase in IDI1, 2.4 fold increase in CYP27B1, and 1.25 fold increase in INSIG1 levels at 48 h post transfection of A549 cells with STAT6 specific siRNA in comparison to the untransfected A549 cells.
	0.85	HMGCS1 and IDI1 (cholesterol synthesis) and INSIG1, and CYP27B1 (cholesterol homeostasis) genes at both transcriptional (real time PCR) and translational levels (western blot analysis).
24246224	0.95	INSIG1, QPRT, HMGCR, HMGCS1, LDLR, FADS1, FADS2).
21561152	0.94	INSIG1; mevalonate pyrophosphate decarboxylase, MVD; HMGCoA synthase 1, HMGCS; isopentenyl-diphosphate delta isomerase 1, IDI1; stearoyl-CoA desaturase, SCD1; LDL receptor, LDLR; ribosomal protein L13a, RPL13A; beta- 2 microglobulin, B2M; glyceraldehyde-3-phosphate dehydrogenase, GAPDH.
21139994	0.93	INSIG1 and HMGCS1 increased at 6 h and decreased at 24 h [Figure 3c]; (2) the integrated stress response (ISR) genes ATF3, ATF4, PPP1R15A and DNAJB4 and HSF2 displayed different expression patterns after treatment with the three doses; at 0.1 mug/ml the expression of ATF3, ATF4 and DNAJB4 decreased from 6 to 24 h and the expression of HSF2 and PPP1R15A increased and then leveled off [Figure 3a], whereas after treatment with 1 mug/ml, they showed a progressive increase in mRNA expression; (3) expression of the apoptotic genes GDF15-A, CDKN1A and the Na+-K+-ATPase ATP1A1 progressively increased after treatment with digitoxin at all doses for 6 or 24 h [Figure 3b, Table 5a, b]; and (4) the expression of CDC16 decreased at 6 h and then leveled off [Figure 3c].
24493696	0.92	HMGCS1, HMGCR, MVK and MVD and two chaperones, INSIG-1 and SCAP compared to the control group.
	0.86	HMGCS1, HMGCR, MVK, MVD and LDLR and two chaperones, INSIG-1 and SCAP in LNCaP and C4-2B cells examined by qRT-PCR.
	0.73	HMGCS1, HMGCR, MVK, MVD and LDLR for cholesterogenesis, two chaperones, INSIG1 and SCAP.
26208975	0.90	HMGCS1, TRIB3, INHBA, INSIG1, and TMEM97 to examine their expression levels in the MI, MII, MIII, and MIV cells.
26535009	0.85	HMGCS1, and LDLR observed in cells grown in LPDS was reduced when cells were supplemented with exogenous cholesterol in the form of low-density lipoproteins (LDLs), which inhibit the processing of SREBPs by inducing the formation of a complex containing SCAP, SREBP, and INSIG1 that sequesters SREBPs in the ER (fig. S3A; compare LPDS to LPDS replenished with LDL).
	0.71	HMGCS1, DHCR7, DHCR24, LDLR, FDFT1, FDPS, IDI1, MVD, SQLE, LSS, NSDHL, SC5DL, INSIG1, ACLY, and ACSS2 (see fig. S1 for full list).
25788893	0.81	Hmgcs1, and Insig1 expression was upregulated by DEHP, suggesting an increase in cholesterol sources.
26535575	0.77	HMGCS1, TMEM97, ACAT2, HMGCR, SC4MOL, FDPS, SQLE, CDK5RAP2, and INSIG1.
30237397	0.77	HMGCS1, HSD17B7, INSIG1, LSS, MSMO1, SQLE, LDLR, and ACAT2) (Fig. 6a), which is consistent with the mechanism of action of melittin.
29927962	0.71	HMGCS1, INSIG1, CYP51A1, PCSK9, DHCR24, HMGCR, LSS, ACAT2, SQLE, NSDHL, EBP, FAP, MVD, DHCR7, APOL1, LDLR, APOL3, FDFT1 and ABCG1).
16305739	0.63	INSIG1, HMGCS1, IDI1, LSS or SREBF1) and could thus enhanced virion infectivity and viral replication.