Publication for CYP51A1 and HMGCS1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	CYP51A1	cytochrome P450 family 51 subfamily A member 1	1595			[link]
hsa	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	3157

Pubmed ID	Priority	Text
26548416	0.97	Hmgcs1, Nsdhl, Cyp51).
	0.92	HMGCS1, CYP51, NSDHL, SQLE and SREBP1) was significantly reduced upon treatment with metformin (Fig. 5).
	0.60	Hmgcs1, Sqle, Nsdhl, Cyp51 and Egr1) (Fig. 3).
31490950	0.97	hmgcs1, hmgcr, fdft1, sqle, cyp51 by qPCR analysis.
	0.63	hmgcs1, hmgcr, fdft1, cyp51, and sqle, are induced by T3 and quetiapine or quetiapine alone.
32034223	0.97	HMGCS1, HMGCR, CYP51A1, DHCR7) and transport (i.e. ABCA1, ABCG1, LDLR).
	0.89	HMGCS1, HMGCR, CYP51A1, 7-dehydrocholesterol reductase DHCR7) as well as cholesterol transport (low density lipoprotein receptor LDLR, ATP-binding cassette transporter ABCA1 and ABCG1) expressed in human muscle cells and significantly altered by different exposure to statins.
18959802	0.97	Hmgcs1), HMG CoA reductase (Hmgcr), sterol receptor binding factor-2 (Srebf2) and lanosterol 14 alpha-demethylase (Cyp51a1) (involved in cholesterol metabolism), and others including fatty acid synthase (Fasn), fatty acid binding protein (Fabp), farnesyl diphosphate synthase (Fdps), acetyl-coA carboxylase (Acaca), acetyl-coA dehydrogenase (Acadm), acetyl-coA acetyl transferase (Acat2), peroxisome proliferative activated receptor, gamma (Ppargamma) and a variety of apolipoproteins that are involved in fatty acid and triglyceride metabolism.
27648077	0.97	3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), HMG-CoA reductase (HMGCR), farnesyl diphosphate synthase (FDPS), Cytochrome P450 Family 51 Subfamily A Polypeptide 1 (CYP51A1), and 7-dehydrocholesterol reductase (DHCR7) mRNA levels (Figure 5(b)).
28027290	0.97	HMGCS1, CYP51A1, DHCR24, DHCR7, STARD4, and NSDHL (S4 Fig);
29849100	0.97	3-hydroxy-3-methylglutaryl-coa synthase 1 - HMGCS1, 3-hydroxy-3-methylglutaryl-coa reductase -HMGCR, Cytochrome P450, family 51, subfamily A, polypeptide 1 - CYP51A1, Fatty acid desaturase 1 - FADS1, Hydroxysteroid (17-beta) dehydrogenase 8 - HSD17B8, Isopentenyl-diphosphate delta isomerase 1 - IDI1, Aldolase C, fructose-bisphosphate - ALDOC, Acyl-coa synthetase short-chain family member 2 - ACSS2, ATP citrate lyase - ACLY, Hydroxysteroid (17-beta) dehydrogenase 7 - HSD17B7, Farnesyl diphosphate synthase - FDPS, Farnesyl-diphosphate farnesyltransferase 1 - FDFT1, Mevalonate kinase - MVK, NAD(P) dependent steroid dehydrogenase-like - NSDHL, FK506 binding protein 4 - FKBP4, Retinol dehydrogenase 11 - RDH11, Pantothenate kinase 3 - PANK3, Hydroxysteroid (17-beta) dehydrogenase 12 - HSD17B12, Atpase family, AAA domain containing 2 - ATAD2, Thymidylate synthetase - TYMS, Prenyl (decaprenyl) diphosphate synthase, subunit 1 - PDSS1, Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 - CHST6 and NADH dehydrogenase (ubiquinone) flavoprotein 2 -NDUFV2) and purmorphamine treatment group (NADPH oxidase 4 - NOX4, Cytochrome P450, family 26, subfamily B, polypeptide 1 - CYP26B1, Synapse differentiation inducing 1 - SYNDIG1, Transglutaminase 2 - TGM2, Dehydrogenase/reductase (SDR family) member 3 - DHRS3, Iduronate 2-sulfatase - IDS, Transketolase - TKT, Diazepam binding inhibitor - DBI, Phosphodiesterase 6 A - PDE6A, Carbonic anhydrase XI - CA11 and Paraoxonase 3 - PON3), respectively (Fig. 2D).
22684502	0.96	Cyp51, Mvk, Pmvk and Hsd17b7), and identified additional genes of this pathway (Hmgcs1, Mvd and Fdft1) that were also activated but had escaped microarray detection (Figure 7C).
29703166	0.95	CYP51A1, HMGCS1 and SC5D.
	0.76	HMGCS1, HMGCR, IDI1, FDFT1, SQLE, CYP51A1, MSMO1, NSDHL, EBP and SC5D) ranked among the top 150 most differentially expressed genes in the balanced dataset (average rank of 76) (Additional file 2).
29927962	0.95	HMGCS1, INSIG1, CYP51A1, PCSK9, DHCR24, HMGCR, LSS, ACAT2, SQLE, NSDHL, EBP, FAP, MVD, DHCR7, APOL1, LDLR, APOL3, FDFT1 and ABCG1).
28962550	0.94	CYP51A1, ITGA2, DHCR7 or HMGCS1.
	0.92	CYP51A1 in HCT-116, VEGFA in HT-29, HMGCS1 in both cell lines).
	0.86	CYP51A1, NSDHL, HMGCS1, IDI1, CNBP, APOL1, SREBF1), and a few from other pathways, like RHOU (Wnt signaling pathway) and EPDR1 (Cancer pathway).
	0.51	HMGCS1, hubs as VEGFA, high clustering coefficient genes like CHECK2 and IL8 and connector's nodes i.e. genes showing edges between functional groups, like NME1, CYP51A1, CYP11A1 and DHCR7.
29627388	0.94	CYP51A1, HMGCS1) are involved in the cholesterol biosynthesis pathway and 1 gene (INSIG1) encodes an endoplasmic reticulum protein that regulates cholesterol biosynthesis (REACTOME, http://reactome.org) (Table S5).
25672394	0.93	HMGCS1, MVD, IDI1, FDPS, FDFT1, CYP51, SC4MOL, NSDHL were simultaneously upregulated.
32117236	0.92	HMGCS1, CYP51A1, and LCLAT1), while cluster 2 genes showed enrichment for the terms epidermal development (GRHL3, KRT17, SPRR1A, and SPRR1B) and tumor antigen (MAGEA2, MAGEA3, MAGEA6, and MAGEA9B) (Figure 6B), suggesting possible roles for these biological processes in the promotion of the T cell-cold phenotype.
31261735	0.91	CYP51A1, DHCR7, DHCR24, HMGCS1, IDI1, LSS, MVD, MVK, and SQLE, which were all downregulated.
26153245	0.88	HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL, SCD, and FADS1), and 3 that were downregulated with increasing BMI (MYLIP, ABCG1, and ABCA1).
	0.55	3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1); farnesyl-diphosphate farnesyltransferase 1 (FDFT1); squalene epoxidase (SQLE); methylsterol monooxygenase 1 (SC4MOL); cytochrome P450, family 51, subfamily A, polypeptide 1 (CYP51A1); stearoyl-CoA desaturase (SCD); fatty acid desaturase 1 (FADS1); low density lipoprotein receptor (LDLR); myosin regulatory light chain interacting protein (MYLIP); ATP-binding cassette, subfamily G, member 1 (ABCG1); and ATP-binding cassette, subfamily A, member 1 (ABCA1).
28855511	0.86	HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL, SC5DL, SCD, and FADS1), as well as downregulation of cholesterol efflux genes (ABCG1 and ABCA1).
23324130	0.85	HMGCS1, FDPS and LSS and the most strongly down-regulated genes were APOE, LEPR, INSIG2, CYP51A1 and TNSF4 (Figure 4B).
29133782	0.85	CYP51A1 and MTHFD2), lipid metabolism (DHCR24, LDR, HMGCS1, INSIG1, and SQLE), protein metabolism (SCL7A5), and lymphocyte differentiation (FGL2 and BHLHE40) (Fig. 1g, Supplementary Fig. 1e, and Supplementary Data 1).