Publication for HMGCS1 and MSMO1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	3157			[link]
hsa	MSMO1	methylsterol monooxygenase 1	6307

Pubmed ID	Priority	Text
26153245	0.98	3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1); farnesyl-diphosphate farnesyltransferase 1 (FDFT1); squalene epoxidase (SQLE); methylsterol monooxygenase 1 (SC4MOL); cytochrome P450, family 51, subfamily A, polypeptide 1 (CYP51A1); stearoyl-CoA desaturase (SCD); fatty acid desaturase 1 (FADS1); low density lipoprotein receptor (LDLR); myosin regulatory light chain interacting protein (MYLIP); ATP-binding cassette, subfamily G, member 1 (ABCG1); and ATP-binding cassette, subfamily A, member 1 (ABCA1).
	0.93	HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL), and efflux ( ABCA1, ABCG1), producing a molecular profile expected to increase intracellular cholesterol.
	0.87	HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL, SCD, and FADS1), and 3 that were downregulated with increasing BMI (MYLIP, ABCG1, and ABCA1).
	0.75	HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL), and cholesterol efflux ( ABCA1, ABCG1).
20110263	0.98	HMGCS1, HMGCR, FDFT1, SC4MOL and LPIN1 genes.
	0.97	HMGCS1, HMGCR, FDFT1, SC4MOL, and LPIN1, expression of which was induced by GW7647, suggesting cross-talk between PPARalpha and SREBP signaling.
	0.97	HMGCS1, HMGCR, FDFT1, SC4MOL and LPIN1, while AGPAT9 is a candidate target gene based on its role in triacylglycerol synthesis.
31540257	0.98	HMGCS1 (16.8/16.5), HMGCS2 (9.8/10.4), LCAT (7.7/7.7), LSS (8.1/7.5), MSMO1 (16.6/16.2), SOAT1 (17.2/17.5), SOAT2 (5.1/4.9), and SQLE (13.5/12.9).
	0.97	HMGCS1 (1952.9), HMGCS2 (82.1), LCAT (3.3), LSS (5.7), MSMO1 (996.6), SOAT1 (1710.2), SOAT2 (1.9), and SQLE (214.0).
25763114	0.98	HMGCS1, (C) HMGCR, (D) IDI1, (E) SQLE, and (F) SC4MOL.
29703166	0.98	HMGCS1, HMGCR, IDI1, FDFT1, SQLE, CYP51A1, MSMO1, NSDHL, EBP and SC5D) ranked among the top 150 most differentially expressed genes in the balanced dataset (average rank of 76) (Additional file 2).
28933554	0.97	Methylsterol Monooxygenase 1 (MSMO1), INSIG1, 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (HMGCS1), 7-Dehydrocholesterol Reductase (DHCR7), Lanosterol Synthase (LSS), Stearoyl-CoA Desaturase (SCD), and Mevalonate Diphosphate Decarboxylase (MVD).
	0.97	MSMO1, INSIG1, HMGCS1, DHCR7, LSS, and MVD in SUDHL4 cells, with no upregulation seen when human HDL was administered (Figure 2a, Supplemental Figure S5).
	0.97	HMGCS1 and MSMO1 were elevated with 50nM HDL NP treatment in the HBL-1 but not the TMD8 cell line (Supplemental Figure S5).
30237397	0.97	HMGCS1, HSD17B7, INSIG1, LSS, MSMO1, SQLE, LDLR, and ACAT2) (Fig. 6a), which is consistent with the mechanism of action of melittin.
	0.94	HMGCS1, HSD17B7, INSIG1, LSS, MSMO1, SQLE, LDLR, and ACAT2) in response to overexpression of NONHSAT105177; b Protein levels of cholesterol biosynthesis pathway molecule CLU in response to overexpression of NONHSAT105177. (*P < 0.05, **P < 0.01, ***P < 0.001)
25672394	0.97	HMGCS1, MVD, IDI1, FDPS, FDFT1, CYP51, SC4MOL, NSDHL were simultaneously upregulated.
28855511	0.97	HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL, SC5DL, SCD, and FADS1), as well as downregulation of cholesterol efflux genes (ABCG1 and ABCA1).
30348985	0.96	HMGCS1, ACSS2, TM7SF2, TMEM97, CP, CRP, SLPI, C2orf82, ACAT2, TM4SF5, MSMO1, LEPR).
26778752	0.95	hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), and methylsterol monooxygenase 1 (SC4MOL), as well as enhances cholesterol efflux by promoting ABCA1.
29627388	0.95	MSMO1, DHCR24, CYP51A1, HMGCS1) are involved in the cholesterol biosynthesis pathway and 1 gene (INSIG1) encodes an endoplasmic reticulum protein that regulates cholesterol biosynthesis (REACTOME, http://reactome.org) (Table S5).
26535575	0.93	HMGCS1, TMEM97, ACAT2, HMGCR, SC4MOL, FDPS, SQLE, CDK5RAP2, and INSIG1.
	0.90	SC4MOL (2 probe sets), AACS, CDK5RAP2, FGFBP1, ANAPC7, ELOVL6, EML1, GINS3 and MVD as well as one out of three transcripts for HMGCS1 did not replicate.
28697173	0.93	HMGCS1, SQLE, MVD and SC4MOL) were among the 41 commonly deregulated genes (Supplementary Table 4).
23170111	0.92	HMGCS1, MSMO1, LDLR, DHCR7, SCD, ACAT2, LSS, FASN, MSMO1, SQLE, DHCR24, FDFT1, IDI1, FADS2, ACSS2, EBP, SC5DL, NSDHL and LPIN1), cell cycle regulation (14% of total gene expression changes: CDC2, CDCA8, CDKN3, PRC1, MCM4, CDC20, CDC45L, CCNA1, CCNB2, CCNA2, TOP2A and CDCA7), angiogenesis (5% of total gene expression changes: PGF, ANGPT2, ANGPTL4 and RGS4) and ubiquitin modifications (3% of total gene expression changes: UBE2T, UBE2C and UHRF1).
26918450	0.87	HMGCS, HMG-CoA synthase; IDH2, isocitrate dehydrogenase 2 (NADP+), mitochondrial; LDHA, lactate dehydrogenase A; LPL, lipoprotein lipase; MDH1, malate dehydrogenase 1, NAD (soluble); MDH2, malate dehydrogenase 2, NAD (mitochondrial); ME1, malic enzyme 1, NADP+-dependent, cytosolic; ME3, malic enzyme 3, NADP+-dependent, mitochondrial; MSMO1, methylsterol monooxygenase 1; PC, pyruvate carboxylase; PCCB, propionyl CoA carboxylase, beta polypeptide; PCK2, phophoenolpyruvate carboxykinase 2 (mitochondrial); PDH, pyruvate dehydrogenase complex; PGAM1, phosphoglycerate mutase 1 (brain); PGM1, phosphoglucomutase 1, PHGDH, phosphoglycerate dehydrogenase; PK, pyruvate kinase; PSAT1, phosphoserine aminotransferase 1; SPTLC3, serine palmitoyltransferase, long chain base subunit 3; TM7SF2, transmembrane 7 superfamily member 2.
27654507	0.82	HMGCS1, MVK, IDI1, FDPS, FDFT1, SQLE1, LSS1, TM7SF2, and MSMO1) increased in abundance when ARID1A was induced (Table I).
27693002	0.65	HMGCS1, and methylsterol monooxygenase 1(SC4MOL) for modulation of HDL-C uptake and cholesterol biosynthesis.
19438813	0.59	3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1); periplakin (PPL); sterol-C4-methyl oxidase-like (SC4MOL); SRY (sex determining region Y)-box 15 (SOX15); squalene epoxidase (SQLE) and Wnt inhibitory factor 1 (WIF1).