Publication for HMGCS1 and SQLE

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	3157			[link]
hsa	SQLE	squalene epoxidase	6713

Pubmed ID	Priority	Text
26938778	0.98	HMGCS1 (Entrez Gene: 208715), HMGCR (Entrez Gene: 15357), MVD (Entrez Gene: 192156), SQLE (Entrez Gene: 20775), and SREBF2 (Entrez Gene: 20788) in CH25H -/- cells treated with interferon gamma (IFN-gamma) (UniProt: P01580).
	0.86	SQLE and SREBF2) and 24 h (HMGCS1, HMGCR, MVD and SQLE) after addition of the cytokine.
	0.82	HMGCS1 (-32%), HMGCR (-51%), MVD (-48%), SQLE (-51%) and NSDHL (Entrez Gene: 18194) (-62%) relative to cells treated with the nontargeting control (Fig 7A).
31604910	0.98	HMGCS1, MVK, and SQLE (Fig. 3d, right panel).
	0.97	HMGCS1, MVK, SQLE, and DHCR24 in ChIP-seq and ChIP-qPCR analyses (Fig. 4f top, Supplementary Fig. 4c, d top).
19560108	0.98	3-hydroxy-methylglutaryl-CoA synthase 1 (HMGCS), emopamil sterol isomerase (EBP), squalene epoxidase (SQLE) and sterol 4 methyl oxidase (SCAMOL).
22265415	0.98	HMGCS1 (HR = 1.21, q = 0.007), HMGCR (HR = 1.17, q = 0.032), IDI1 (HR = 1.26, q < 0.001), FDPS (HR = 1.17, q = 0.012), SQLE (HR = 1.35, q < 0.001), LSS (HR = 1.16, q = 0.032), NSDHL (HR = 1.17, q = 0.032), DHCR7 (HR = 1.26, q < 0.001).
26646011	0.98	HMGCS1, HMG-CoA synthase 1; HMGCR, HMG-CoA reductase; MVK, mevalonate kinase; PMVK, phosphomevalonate kinase; MVD, mevalonate decarboxylase; IDI1, isopentenyl-diphosphate delta isomerase 1; FDPS, farnesyl diphosphate synthase; FDFT1, farnesyl-diphosphate farnesyltransferase 1; SQLE, squalene epoxidase; LSS, lanosterol synthase; CYP51A1, cytochrome P450 family 41 subfamily A; TM7SF2, transmembrane 7 superfamily member 2; NSDHL, NAD(P)-dependent steroid dehydrogenase-like; HSD17B7, hydroxysteroid 17-beta dehydrogenase; DHCR24, 24-dehydrocholesterol reductase; SC5D, sterol-C5-desaturase; DHCR7, 7-dehydrocholesterol reductase.
28118603	0.98	HMGCS1, and HMGCR) and downstream in the cholesterol biosynthetic pathway (FDPS, FDFT1, and SQLE), were all downregulated in dense NHAs but not dense glioma TS lines (Figure 1G and Supplementary Figure 1E).
30154400	0.98	HMGCS1 and HMGCR (m) and the sterol synthesis enzyme SQLE.
31058187	0.98	HMGCS1; (C) SQLE; (D) COL4A3; (E) DAG1; (F) LAMB2.
21408089	0.97	Hmgcs1, Hmgcr, Idi1, and Sqle gene expression changes were then analyzed by Q-RT-PCR (Figure 1E-H).
	0.96	HMGCS1, HMGCR, and SQLE protein levels in mCMV infected (24 hpi) or mock-treated BMDM.
	0.96	HMGCS1, 50% for HMGCR, and 85% for SQLE.
	0.93	Hmgcs1, Hmgcr, Idi1, and Sqle genes in BMDM after 24 h mock treatment, mCMV, or mCMVdie3 infection, respectively.
	0.54	HMGCS1, HMGCR, and SQLE (Figure 2A).
29703166	0.97	HMGCS1, HMGCR, IDI1, FDFT1, SQLE, CYP51A1, MSMO1, NSDHL, EBP and SC5D) ranked among the top 150 most differentially expressed genes in the balanced dataset (average rank of 76) (Additional file 2).
	0.95	SQLE (rate limiting enzymes), FDFT1, LSS (catalyzes first step), DHCR7 (catalyzes last step) in addition to NSDHL, MDMO1, EBP, IDI1, CYP51A1, HMGCS1 and SC5D.
30344014	0.97	3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), squalene monooxygenase (SQLE), isopentenyl-diphosphate delta isomerase 1 (IDI1), carnitine palmitoyltransferase I (CPT-1), fatty acid synthase (FASN) and acetyl-CoA carboxylases 1 (ACC1).
	0.96	HMGCS1, SQLE, and IDI1), as well as fatty acid oxidation (CPT-1) and synthesis (ACC1 and FASN) in different T cell subsets.
31467399	0.97	HMGCS1 and SQLE in 100 mug protein extracts prepared form HBEK3-KT at day 7 post exposure to the indicated X-rays dose.
	0.95	HMGCS1 and SQLE in HBEC3-KT exposed to increasing X-rays doses of 2, 4, 6 and 8 Gy.
31490950	0.97	hmgcs1, hmgcr, fdft1, sqle, cyp51 by qPCR analysis.
	0.96	hmgcs1, hmgcr, fdft1, cyp51, and sqle, are induced by T3 and quetiapine or quetiapine alone.
23871755	0.97	3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), 7-dehydrocholesterol reductase (DHCR7), and squalene epoxidase (SQLE).
28697173	0.97	HMGCS1, SQLE, IDI1) and homoeostasis (e.g., INSIG1) genes were 2-4-fold upregulated by the ASM inhibitors (Figure 1K).
29712938	0.97	SQLE, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (HMGCS1), CETP, and PCSK9, which are regulated by SREBP-2, might be responsible for cholesterol lowering effects by sauchinone.
29876015	0.97	SQLE, PMVK, MVK) to 270% (HMGCS1).
31360108	0.97	HMG-CoA synthase 1 (HMGCS1), mevalonate kinase (MVK), or squalene epoxidase (SQLE) in choriocarcinoma cell lines.
30206152	0.96	HMGCS1, MVD, MVK, and SQLE (Fig. 2C).
	0.76	HMGCS1, MVD, MVK, and SQLE), ER/Golgi trafficking (AP1S3 and ASAP2), and cell survival (TNFRSF10D and KLF4) are all induced in ZIKV+ macrophages and, based on previous data, have the potential to increase ZIKV pathogenicity.
29927962	0.96	HMGCS1, INSIG1, CYP51A1, PCSK9, DHCR24, HMGCR, LSS, ACAT2, SQLE, NSDHL, EBP, FAP, MVD, DHCR7, APOL1, LDLR, APOL3, FDFT1 and ABCG1).
31261735	0.96	HMGCS1, IDI1, LSS, MVD, MVK, and SQLE, which were all downregulated.
26535575	0.95	HMGCS1, TM7SF2, FDFT1, EBP, FDPS, HMGCR, SQLE, and DHCR7.
	0.51	HMGCS1, TMEM97, TM7SF2, FDFT1, ACAT2, EBP, FDPS, HMGCR, SQLE, DHCR7, C14orf1, and INSIG1.
29136510	0.95	HMGCS, HMGCR, IDI1, FDPS, SQLE, LSS, CYP51A1).
23170111	0.94	HMGCS1, MSMO1, LDLR, DHCR7, SCD, ACAT2, LSS, FASN, MSMO1, SQLE, DHCR24, FDFT1, IDI1, FADS2, ACSS2, EBP, SC5DL, NSDHL and LPIN1), cell cycle regulation (14% of total gene expression changes: CDC2, CDCA8, CDKN3, PRC1, MCM4, CDC20, CDC45L, CCNA1, CCNB2, CCNA2, TOP2A and CDCA7), angiogenesis (5% of total gene expression changes: PGF, ANGPT2, ANGPTL4 and RGS4) and ubiquitin modifications (3% of total gene expression changes: UBE2T, UBE2C and UHRF1).
28701475	0.94	HMGCS1 and SQLE mRNAs, are far more highly induced after EZH1 inactivation in VHL-/- ccRCC cells than in their pVHL-proficient counterparts (Fig. 8, D and E).
28933554	0.94	SQLE, MSMO1, INSIG1, HMGCS1, DHCR7, LSS, and MVD in SUDHL4 cells, with no upregulation seen when human HDL was administered (Figure 2a, Supplemental Figure S5).
26418040	0.93	HMGCS1: -4.31(p = 4.49e-11), HMGCR: -2.57(p = 2.9e-10), -2.77(p = 3.13e-10), DHCR7:-2.41(p = 4.82e-8), -2.63(p = 3.84e-9), and SQLE: -2.38(p = 2.09e-8), -2.62(p = 1.00e-6).).
32033570	0.93	HMGCR, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), mevalonate diphosphate decarboxylase (MVD), and SQLE, thereby facilitating the cholesterol synthesis and changing the invadopodia cell membrane fluidity (Fig. 7b).
28357032	0.92	HMGCS1, HMGCR, SQLE, CYP7A1 and LDLR.
29133782	0.92	HMGCS1, INSIG1, and SQLE), protein metabolism (SCL7A5), and lymphocyte differentiation (FGL2 and BHLHE40) (Fig. 1g, Supplementary Fig. 1e, and Supplementary Data 1).
19438813	0.91	3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1); periplakin (PPL); sterol-C4-methyl oxidase-like (SC4MOL); SRY (sex determining region Y)-box 15 (SOX15); squalene epoxidase (SQLE) and Wnt inhibitory factor 1 (WIF1).
27595929	0.91	HMGCS1, HMGCR, SQLE, and DHCR7) were found to be suppressed with miR-122 inhibition; however, these gene are likely indirect targets, and thus the exact mechanism by which miR-122 regulates lipid metabolism is still unclear.
30237397	0.90	HMGCS1, HSD17B7, INSIG1, LSS, MSMO1, SQLE, LDLR, and ACAT2) (Fig. 6a), which is consistent with the mechanism of action of melittin.
	0.87	HMGCS1, HSD17B7, INSIG1, LSS, MSMO1, SQLE, LDLR, and ACAT2) in response to overexpression of NONHSAT105177; b Protein levels of cholesterol biosynthesis pathway molecule CLU in response to overexpression of NONHSAT105177. (*P < 0.05, **P < 0.01, ***P < 0.001)
18959802	0.90	Hmgcs1), farnesyl-diphosphate farnesyltransferase 1 (Fdft1), squalene epoxidase (Sqle), sterol regulatory element binding transcription factor 2 (Srebf2) and 7-dehydrocholesterol reductase (Dhcr7).
26535009	0.90	HMGCS1, DHCR7, DHCR24, LDLR, FDFT1, FDPS, IDI1, MVD, SQLE, LSS, NSDHL, SC5DL, INSIG1, ACLY, and ACSS2 (see fig. S1 for full list).
31253778	0.89	Sqle, Mvd, and Hmgcs1), respectively (Fig. 2c and Supplementary Fig. 4b).
22919472	0.84	HMGCS1, DHCR7 and SQLE.
26153245	0.82	HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL), and cholesterol efflux ( ABCA1, ABCG1).
28855511	0.73	HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL, SC5DL, SCD, and FADS1), as well as downregulation of cholesterol efflux genes (ABCG1 and ABCA1).
27313533	0.72	SQLE, SREBF, SC5DL, and HMGCS1 were deregulated in this patient cohort.
27705805	0.70	HMGCS1 (catalyzing HMG-CoA synthesis), HMGCR (rate-limiting enzyme of the cholesterol pathway), SQLE (catalyzing the first cholesterol-specific step in the cholesterol pathway), PHGDH and PSAT1 (the first two enzymes in the serine-glycine pathway), and SHMT2 (linking glycine synthesis to one-carbon metabolism and nucleotide production).
30147442	0.65	HMGCS1, HMGCR), lanosterol synthesis (FDFT1, SQLE, and LSS) and cholesterol synthesis (CYP51, MSMO1, HSD17B7, and SC5D).
31540257	0.63	HMGCS1 (16.8/16.5), HMGCS2 (9.8/10.4), LCAT (7.7/7.7), LSS (8.1/7.5), MSMO1 (16.6/16.2), SOAT1 (17.2/17.5), SOAT2 (5.1/4.9), and SQLE (13.5/12.9).
29851839	0.60	HMGCS1, SQLE, ACAT2, AKR1C1, CYP1B1, AKR1B1, and PNPLA3.