Publication for HMGCS1 and NSDHL

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	3157			[link]
hsa	NSDHL	NAD(P) dependent steroid dehydrogenase-like	50814

Pubmed ID	Priority	Text
26548416	0.96	Hmgcs1, Sqle, Nsdhl, Cyp51 and Egr1) (Fig. 3).
	0.89	Hmgcs1, Nsdhl, Cyp51).
26938778	0.96	HMGCS1 (-32%), HMGCR (-51%), MVD (-48%), SQLE (-51%) and NSDHL (Entrez Gene: 18194) (-62%) relative to cells treated with the nontargeting control (Fig 7A).
29927962	0.96	HMGCS1, INSIG1, CYP51A1, PCSK9, DHCR24, HMGCR, LSS, ACAT2, SQLE, NSDHL, EBP, FAP, MVD, DHCR7, APOL1, LDLR, APOL3, FDFT1 and ABCG1).
26646011	0.95	HMGCS1, HMGCR, NSDHL, DHCR24, and SC5DL) have evolutionarily conserved predicted target sites for >=2 miRNAs that were upregulated more than 5-fold in at least one disease category and/or identified as master regulators of downregulated genes in at least one disease category (Fig. 7; see Fig. S3 in the supplemental material).
	0.59	HMGCS1, HMG-CoA synthase 1; HMGCR, HMG-CoA reductase; MVK, mevalonate kinase; PMVK, phosphomevalonate kinase; MVD, mevalonate decarboxylase; IDI1, isopentenyl-diphosphate delta isomerase 1; FDPS, farnesyl diphosphate synthase; FDFT1, farnesyl-diphosphate farnesyltransferase 1; SQLE, squalene epoxidase; LSS, lanosterol synthase; CYP51A1, cytochrome P450 family 41 subfamily A; TM7SF2, transmembrane 7 superfamily member 2; NSDHL, NAD(P)-dependent steroid dehydrogenase-like; HSD17B7, hydroxysteroid 17-beta dehydrogenase; DHCR24, 24-dehydrocholesterol reductase; SC5D, sterol-C5-desaturase; DHCR7, 7-dehydrocholesterol reductase.
28027290	0.94	HMGCS1, CYP51A1, DHCR24, DHCR7, STARD4, and NSDHL (S4 Fig);
29226804	0.91	HMGCS1, IDI1, LSS, NSDHL, and FDFT1), confirming that this is the main affected cellular pathway.
28962550	0.87	NSDHL, HMGCS1, IDI1, CNBP, APOL1, SREBF1), and a few from other pathways, like RHOU (Wnt signaling pathway) and EPDR1 (Cancer pathway).
26938916	0.76	HMGCS1, LDLR, NSDHL, CRABP2 and LASS4) (Fig 3G).
25672394	0.74	HMGCS1, MVD, IDI1, FDPS, FDFT1, CYP51, SC4MOL, NSDHL were simultaneously upregulated.
26306576	0.68	HMGCS1) and farnesyl pyrophosphate synthetase (FDPS) in both survivors and carriers, diphosphomevalonate decarboxylase (MVD) in survivors, and sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) only in carriers.
22265415	0.66	HMGCS1 (HR = 1.21, q = 0.007), HMGCR (HR = 1.17, q = 0.032), IDI1 (HR = 1.26, q < 0.001), FDPS (HR = 1.17, q = 0.012), SQLE (HR = 1.35, q < 0.001), LSS (HR = 1.16, q = 0.032), NSDHL (HR = 1.17, q = 0.032), DHCR7 (HR = 1.26, q < 0.001).