Publication for HMGCS1 and MVK

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	3157			[link]
hsa	MVK	mevalonate kinase	4598

Pubmed ID	Priority	Text
23326422	0.98	HMGCS and MVK) and uptake (LDLR).
	0.97	HMGCS and MVK were described to be up-regulated by HDACi, along with ABCA1, although both studies were performed in non-neuronal cell lines.
	0.91	HMGCS, HMGCR and MVK, which were decreased to about 70%, 75% and 30% of control values, respectively (Fig. 1).
22211244	0.98	HMGCS1, IDI1, LSS, EBP and MVK).
26512780	0.98	3-hydroxy-3-methyl-glutaryl-CoA synthase 1 (HMGCS1), HMGCR, mevalonate kinase (MVK), mevalonate 5-pyrophosphate decarboxylase (MVD) and low-density lipoprotein receptor (LDLR) for cholesterogenesis; and two chaperones, insulin-induced gene 1 (INSIG1) and SREBP cleavage activating protein (SCAP) in PC-3 EV, PC-3 R248W and DU145 cells.
21559365	0.97	HMGCS1, MVK, and PCSK9.
	0.97	HMGCS, MVK, LDLR12, and PCSK9 are not due to splice variant specific differences in transcript stability.
	0.97	HMGCS1, HMGCR, MVK, LDLR and PCSK9 with cDNA derived the liver of an African Green monkey or HepG2 cell line (human control).
	0.97	HMGCS1, LDLR and MVK were reduced in the cells transfected with the non-targeting siRNA after sterol depletion, but not after PTBP1 knock-down.
	0.97	HMGCS1, MVK, and PCSK9 splice variants.
	0.96	HMGCS, MVK and LDLR12(+), but had no effect on LDLR4(+) (Figure S3).
	0.96	HMGCS1 and MVK.
	0.95	HMGCS1, MVK, LDLR and PCSK9 transcripts were quantified in liver biopsies obtained from monkeys with (n = 28) and without (n = 23) cholesterol supplementation.
	0.94	HMGCS1 and MVK, as well as another key gene involved in cholesterol uptake, PCSK9, are subject to similar regulation, suggestive of a pathway level effect.
	0.92	HMGCS1, MVK and LDLR12(+) transcriptional response to statin after PTBP1 knock-down suggests that these genes are also subject to transcriptional regulation by PTBP1, consistent with previous reports that PTBP1 can bind and activate promoters.
	0.76	HMGCS1, MVK, LDLR and PCSK9 in African Green monkeys.
24493696	0.97	HMGCS1, HMGCR, MVK, MVD and LDLR, and further reduces the levels of intracellular fatty acid and cholesterol.
	0.96	HMGCS1, HMGCR, MVK, MVD and LDLR and two chaperones, INSIG-1 and SCAP in LNCaP and C4-2B cells examined by qRT-PCR.
	0.95	HMGCS1, HMGCR, MVK, MVD and LDLR for cholesterogenesis, two chaperones, INSIG1 and SCAP.
	0.95	HMGCS1, HMGCR, MVK and MVD and two chaperones, INSIG-1 and SCAP compared to the control group.
	0.87	HMGCS1, HMGCR, MVK, MVD, INSIG1 and SCAP (Fig. 5A).
31604910	0.97	HMGCS1, HMGCR, MVK, and SQLE (Fig. 3e).
	0.93	HMGCS1, MVK, SQLE, and DHCR24 in ChIP-seq and ChIP-qPCR analyses (Fig. 4f top, Supplementary Fig. 4c, d top).
	0.90	HMGCS1, MVK, MVD, and SQLE was also significantly downregulated by XY018 or its combination with statin (Fig. 7c, Supplementary Fig. 7a).
	0.89	MVK and HMGCS1 and found that they were highly responsive to RORgamma-mediated transactivation.
21561152	0.97	mevalonate kinase, MVK; HMG-CoA reductase, HMGCR; ATP citrate lyase, ACL; insulin induced gene 1, INSIG1; mevalonate pyrophosphate decarboxylase, MVD; HMGCoA synthase 1, HMGCS; isopentenyl-diphosphate delta isomerase 1, IDI1; stearoyl-CoA desaturase, SCD1; LDL receptor, LDLR; ribosomal protein L13a, RPL13A; beta- 2 microglobulin, B2M; glyceraldehyde-3-phosphate dehydrogenase, GAPDH.
26109433	0.97	HMGCS1, MVK, LDHA).
26883200	0.97	HMGCS1), 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), mevalonate kinase (MVK), mevalomate 5-pyrophosphate decarboxylase (MVD) and low-density lipoprotein receptor (LDLR) in PCa cells with genetically manipulated SREBP-2.
29849100	0.97	3-hydroxy-3-methylglutaryl-coa synthase 1 - HMGCS1, 3-hydroxy-3-methylglutaryl-coa reductase -HMGCR, Cytochrome P450, family 51, subfamily A, polypeptide 1 - CYP51A1, Fatty acid desaturase 1 - FADS1, Hydroxysteroid (17-beta) dehydrogenase 8 - HSD17B8, Isopentenyl-diphosphate delta isomerase 1 - IDI1, Aldolase C, fructose-bisphosphate - ALDOC, Acyl-coa synthetase short-chain family member 2 - ACSS2, ATP citrate lyase - ACLY, Hydroxysteroid (17-beta) dehydrogenase 7 - HSD17B7, Farnesyl diphosphate synthase - FDPS, Farnesyl-diphosphate farnesyltransferase 1 - FDFT1, Mevalonate kinase - MVK, NAD(P) dependent steroid dehydrogenase-like - NSDHL, FK506 binding protein 4 - FKBP4, Retinol dehydrogenase 11 - RDH11, Pantothenate kinase 3 - PANK3, Hydroxysteroid (17-beta) dehydrogenase 12 - HSD17B12, Atpase family, AAA domain containing 2 - ATAD2, Thymidylate synthetase - TYMS, Prenyl (decaprenyl) diphosphate synthase, subunit 1 - PDSS1, Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 - CHST6 and NADH dehydrogenase (ubiquinone) flavoprotein 2 -NDUFV2) and purmorphamine treatment group (NADPH oxidase 4 - NOX4, Cytochrome P450, family 26, subfamily B, polypeptide 1 - CYP26B1, Synapse differentiation inducing 1 - SYNDIG1, Transglutaminase 2 - TGM2, Dehydrogenase/reductase (SDR family) member 3 - DHRS3, Iduronate 2-sulfatase - IDS, Transketolase - TKT, Diazepam binding inhibitor - DBI, Phosphodiesterase 6 A - PDE6A, Carbonic anhydrase XI - CA11 and Paraoxonase 3 - PON3), respectively (Fig. 2D).
30127457	0.97	MVK and HMGCS1) or uptake (LDLR) in either simvastatin or control treated conditions, Supplementary Figure S4.
27654507	0.96	HMGCS1, MVK, MVD, IDI1, and FDPS) decreased in abundance in the ARID1A knockout (Table I).
	0.95	HMGCS1, MVK, IDI1, FDPS, FDFT1, SQLE1, LSS1, TM7SF2, and MSMO1) increased in abundance when ARID1A was induced (Table I).
27705805	0.96	Hmgcs1, Hmgcr, Mvk, Phgdh, Psat1, Psph, and Shmt2 (Figure 3E).
32041307	0.96	HMGCS1, HMGCR, PMVK, MVK, MVD and IDI) involved in the mevalonate synthesis pathway.
28680417	0.95	MVK, HMGCS1, and PSCK9.
29670091	0.94	HMGCS1, HMGCR, MVD, MVK, and FDPS, was consistently decreased after M1 virus infection in both HCT-116 and SW1990 cell lines (Fig. 1f, g).
30206152	0.89	HMGCS1, MVD, MVK, and SQLE (Fig. 2C).
	0.76	HMGCS1, MVD, MVK, and SQLE), ER/Golgi trafficking (AP1S3 and ASAP2), and cell survival (TNFRSF10D and KLF4) are all induced in ZIKV+ macrophages and, based on previous data, have the potential to increase ZIKV pathogenicity.
23766705	0.89	HMGCS1), and mevalonate kinase also reported to be involved in cholesterol biosynthesis and receptor-mediated uptake through alternative splicing.
29876015	0.89	MVK) to 270% (HMGCS1).
18812209	0.88	3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1), mevalonate kinase (MVK), CCAAT/enhancer-binding protein (C/EPB), and scavenger receptor class B, member 1 (SCARB1) are up-regulated.
22684502	0.82	Mvk, Pmvk and Hsd17b7), and identified additional genes of this pathway (Hmgcs1, Mvd and Fdft1) that were also activated but had escaped microarray detection (Figure 7C).
26202976	0.74	HMGCS1, HMGCS2, HMGCR, MVK, PMVK, MVD, IDI1, IDI2, FDPS, GGPS1) were subject to mutation screening.
31360108	0.73	HMG-CoA synthase 1 (HMGCS1), mevalonate kinase (MVK), or squalene epoxidase (SQLE) in choriocarcinoma cell lines.
23314925	0.72	MVK, HMGCS1 and PSCK9.