[←][→] hsa  SRC Gene
functional annotation
Function   SRC proto-oncogene, non-receptor tyrosine kinase  
GO BP
GO:0001545 [list] [network] primary ovarian follicle growth  (1 genes)  IEA  
GO:0086098 [list] [network] angiotensin-activated signaling pathway involved in heart process  (2 genes)  ISS  
GO:2000386 [list] [network] positive regulation of ovarian follicle development  (2 genes)  IEA  
GO:2000588 [list] [network] positive regulation of platelet-derived growth factor receptor-beta signaling pathway  (3 genes)  IEA  
GO:0071393 [list] [network] cellular response to progesterone stimulus  (4 genes)  ISS  
GO:0036035 [list] [network] osteoclast development  (6 genes)  IBA  
GO:0051902 [list] [network] negative regulation of mitochondrial depolarization  (6 genes)  IMP  
GO:1903997 [list] [network] positive regulation of non-membrane spanning protein tyrosine kinase activity  (7 genes)  NAS  
GO:2000394 [list] [network] positive regulation of lamellipodium morphogenesis  (7 genes)  IMP  
GO:2001286 [list] [network] regulation of caveolin-mediated endocytosis  (7 genes)  IMP  
GO:0007172 [list] [network] signal complex assembly  (8 genes)  TAS  
GO:0035635 [list] [network] entry of bacterium into host cell  (8 genes)  TAS  
GO:0050847 [list] [network] progesterone receptor signaling pathway  (9 genes)  IBA ISS  
GO:0033625 [list] [network] positive regulation of integrin activation  (11 genes)  TAS  
GO:0051974 [list] [network] negative regulation of telomerase activity  (11 genes)  IMP  
GO:0071803 [list] [network] positive regulation of podosome assembly  (11 genes)  IEA  
GO:0060576 [list] [network] intestinal epithelial cell development  (13 genes)  IDA  
GO:0038083 [list] [network] peptidyl-tyrosine autophosphorylation  (16 genes)  IEA  
GO:0098962 [list] [network] regulation of postsynaptic neurotransmitter receptor activity  (17 genes)  IEA  
GO:2000811 [list] [network] negative regulation of anoikis  (17 genes)  IMP  
GO:0043149 [list] [network] stress fiber assembly  (18 genes)  IMP  
GO:0051895 [list] [network] negative regulation of focal adhesion assembly  (18 genes)  ISS  
GO:2000641 [list] [network] regulation of early endosome to late endosome transport  (18 genes)  IMP  
GO:0060065 [list] [network] uterus development  (19 genes)  IEA  
GO:0070102 [list] [network] interleukin-6-mediated signaling pathway  (19 genes)  IDA  
GO:0032211 [list] [network] negative regulation of telomere maintenance via telomerase  (20 genes)  IMP  
GO:0048011 [list] [network] neurotrophin TRK receptor signaling pathway  (20 genes)  IEA  
GO:0071498 [list] [network] cellular response to fluid shear stress  (20 genes)  IEA  
GO:0036120 [list] [network] cellular response to platelet-derived growth factor stimulus  (21 genes)  IEA  
GO:0045056 [list] [network] transcytosis  (21 genes)  IEA  
GO:0046628 [list] [network] positive regulation of insulin receptor signaling pathway  (22 genes)  IEA  
GO:0060444 [list] [network] branching involved in mammary gland duct morphogenesis  (22 genes)  IEA  
GO:0045453 [list] [network] bone resorption  (23 genes)  IBA ISS  
GO:0010447 [list] [network] response to acidic pH  (25 genes)  IEA  
GO:0010954 [list] [network] positive regulation of protein processing  (25 genes)  IEA  
GO:0031954 [list] [network] positive regulation of protein autophosphorylation  (27 genes)  IEA  
GO:0048041 [list] [network] focal adhesion assembly  (28 genes)  IMP  
GO:0038128 [list] [network] ERBB2 signaling pathway  (32 genes)  TAS  
GO:0045737 [list] [network] positive regulation of cyclin-dependent protein serine/threonine kinase activity  (32 genes)  IEA  
GO:0043552 [list] [network] positive regulation of phosphatidylinositol 3-kinase activity  (33 genes)  IEA  
GO:0032148 [list] [network] activation of protein kinase B activity  (36 genes)  IEA  
GO:0051385 [list] [network] response to mineralocorticoid  (36 genes)  IEA  
GO:0071398 [list] [network] cellular response to fatty acid  (38 genes)  IEA  
GO:0010907 [list] [network] positive regulation of glucose metabolic process  (41 genes)  IEA  
GO:0033146 [list] [network] regulation of intracellular estrogen receptor signaling pathway  (41 genes)  IEA  
GO:0051602 [list] [network] response to electrical stimulus  (42 genes)  IEA  
GO:0045124 [list] [network] regulation of bone resorption  (44 genes)  TAS  
GO:0014911 [list] [network] positive regulation of smooth muscle cell migration  (46 genes)  IEA  
GO:0031648 [list] [network] protein destabilization  (46 genes)  IEA  
GO:0043114 [list] [network] regulation of vascular permeability  (46 genes)  TAS  
GO:0007173 [list] [network] epidermal growth factor receptor signaling pathway  (51 genes)  IBA TAS  
GO:0031295 [list] [network] T cell costimulation  (53 genes)  TAS  
GO:0034446 [list] [network] substrate adhesion-dependent cell spreading  (56 genes)  IEA  
GO:0045747 [list] [network] positive regulation of Notch signaling pathway  (57 genes)  IDA  
GO:0035306 [list] [network] positive regulation of dephosphorylation  (59 genes)  IDA  
GO:0034332 [list] [network] adherens junction organization  (61 genes)  IEA  
GO:2000573 [list] [network] positive regulation of DNA biosynthetic process  (66 genes)  IEA  
GO:0048010 [list] [network] vascular endothelial growth factor receptor signaling pathway  (69 genes)  TAS  
GO:0070301 [list] [network] cellular response to hydrogen peroxide  (75 genes)  IEA  
GO:0051057 [list] [network] positive regulation of small GTPase mediated signal transduction  (81 genes)  IMP  
GO:0043154 [list] [network] negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (82 genes)  IMP  
GO:0048477 [list] [network] oogenesis  (83 genes)  IEA  
GO:0048013 [list] [network] ephrin receptor signaling pathway  (86 genes)  TAS  
GO:1900182 [list] [network] positive regulation of protein localization to nucleus  (88 genes)  IEA  
GO:0043406 [list] [network] positive regulation of MAP kinase activity  (89 genes)  IEA  
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling  (91 genes)  TAS  
GO:0007229 [list] [network] integrin-mediated signaling pathway  (95 genes)  IMP  
GO:2001243 [list] [network] negative regulation of intrinsic apoptotic signaling pathway  (98 genes)  IBA IMP  
GO:2001237 [list] [network] negative regulation of extrinsic apoptotic signaling pathway  (106 genes)  IBA IMP  
GO:0007179 [list] [network] transforming growth factor beta receptor signaling pathway  (110 genes)  IMP  
GO:0002223 [list] [network] stimulatory C-type lectin receptor signaling pathway  (115 genes)  TAS  
GO:0042476 [list] [network] odontogenesis  (117 genes)  IEA  
GO:0038096 [list] [network] Fc-gamma receptor signaling pathway involved in phagocytosis  (132 genes)  TAS  
GO:0031333 [list] [network] negative regulation of protein-containing complex assembly  (135 genes)  IMP  
GO:0030168 [list] [network] platelet activation  (141 genes)  TAS  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (149 genes)  IDA IMP NAS  
GO:0090263 [list] [network] positive regulation of canonical Wnt signaling pathway  (151 genes)  IEA  
GO:0010634 [list] [network] positive regulation of epithelial cell migration  (176 genes)  IMP  
GO:0032869 [list] [network] cellular response to insulin stimulus  (177 genes)  IEA  
GO:0071902 [list] [network] positive regulation of protein serine/threonine kinase activity  (179 genes)  IDA  
GO:0018105 [list] [network] peptidyl-serine phosphorylation  (184 genes)  IEA  
GO:0051897 [list] [network] positive regulation of protein kinase B signaling  (186 genes)  IMP TAS  
GO:0046777 [list] [network] protein autophosphorylation  (187 genes)  IDA  
GO:0071222 [list] [network] cellular response to lipopolysaccharide  (191 genes)  IEA  
GO:0043393 [list] [network] regulation of protein binding  (195 genes)  IEA  
GO:0050731 [list] [network] positive regulation of peptidyl-tyrosine phosphorylation  (198 genes)  IC IMP  
GO:0071456 [list] [network] cellular response to hypoxia  (200 genes)  IEA  
GO:0016236 [list] [network] macroautophagy  (204 genes)  TAS  
GO:0070555 [list] [network] response to interleukin-1  (207 genes)  IMP  
GO:0002862 [list] [network] negative regulation of inflammatory response to antigenic stimulus  (208 genes)  TAS  
GO:0009612 [list] [network] response to mechanical stimulus  (214 genes)  IEA  
GO:0060491 [list] [network] regulation of cell projection assembly  (215 genes)  IEA  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (217 genes)  IEA  
GO:0007411 [list] [network] axon guidance  (270 genes)  TAS  
GO:0071375 [list] [network] cellular response to peptide hormone stimulus  (278 genes)  ISS  
GO:0010632 [list] [network] regulation of epithelial cell migration  (292 genes)  IMP  
GO:0009615 [list] [network] response to virus  (322 genes)  IEA  
GO:0051222 [list] [network] positive regulation of protein transport  (322 genes)  IEA  
GO:0050900 [list] [network] leukocyte migration  (375 genes)  TAS  
GO:0030900 [list] [network] forebrain development  (379 genes)  IEA  
GO:0042493 [list] [network] response to drug  (385 genes)  IEA  
GO:0022407 [list] [network] regulation of cell-cell adhesion  (458 genes)  IMP  
GO:0008283 [list] [network] cell population proliferation  (478 genes)  IEA  
GO:0001819 [list] [network] positive regulation of cytokine production  (491 genes)  IEA  
GO:0031667 [list] [network] response to nutrient levels  (496 genes)  IEA  
GO:0098609 [list] [network] cell-cell adhesion  (513 genes)  IEA  
GO:0007169 [list] [network] transmembrane receptor protein tyrosine kinase signaling pathway  (525 genes)  IBA  
GO:0043065 [list] [network] positive regulation of apoptotic process  (590 genes)  IEA  
GO:0045087 [list] [network] innate immune response  (835 genes)  IBA  
GO:0043066 [list] [network] negative regulation of apoptotic process  (905 genes)  IMP  
GO:0007155 [list] [network] cell adhesion  (942 genes)  IBA  
GO:0007186 [list] [network] G protein-coupled receptor signaling pathway  (1290 genes)  TAS  
GO:0007049 [list] [network] cell cycle  (1340 genes)  IEA  
GO:0045892 [list] [network] negative regulation of transcription, DNA-templated  (1341 genes)  IEA  
GO:0045893 [list] [network] positive regulation of transcription, DNA-templated  (1594 genes)  IEA  
GO:0035556 [list] [network] intracellular signal transduction  (1640 genes)  IDA  
GO:0030154 [list] [network] cell differentiation  (3566 genes)  IBA  
GO:0007165 [list] [network] signal transduction  (5169 genes)  TAS  
GO CC
GO:0099091 [list] [network] postsynaptic specialization, intracellular component  (19 genes)  IEA  
GO:0002102 [list] [network] podosome  (29 genes)  IEA  
GO:0005901 [list] [network] caveola  (83 genes)  IDA  
GO:0032587 [list] [network] ruffle membrane  (100 genes)  IEA  
GO:0031234 [list] [network] extrinsic component of cytoplasmic side of plasma membrane  (101 genes)  IBA  
GO:0005884 [list] [network] actin filament  (114 genes)  IEA  
GO:0005770 [list] [network] late endosome  (281 genes)  IDA  
GO:0014069 [list] [network] postsynaptic density  (329 genes)  IEA  
GO:0045121 [list] [network] membrane raft  (334 genes)  ISS  
GO:0098978 [list] [network] glutamatergic synapse  (338 genes)  IEA  
GO:0005925 [list] [network] focal adhesion  (421 genes)  ISS  
GO:0005743 [list] [network] mitochondrial inner membrane  (494 genes)  IDA  
GO:0005764 [list] [network] lysosome  (718 genes)  IDA  
GO:0048471 [list] [network] perinuclear region of cytoplasm  (733 genes)  IDA  
GO:0043005 [list] [network] neuron projection  (1374 genes)  IEA  
GO:0005739 [list] [network] mitochondrion  (1648 genes)  IDA  
GO:0030054 [list] [network] cell junction  (2092 genes)  IDA  
GO:0070062 [list] [network] extracellular exosome  (2212 genes)  HDA  
GO:0005654 [list] [network] nucleoplasm  (4086 genes)  IDA  
GO:0005829 [list] [network] cytosol  (5345 genes)  IDA TAS  
GO:0005886 [list] [network] plasma membrane  (5772 genes)  IDA TAS  
GO:0005737 [list] [network] cytoplasm  (11897 genes)  IDA  
GO MF
GO:0071253 [list] [network] connexin binding  (6 genes)  IEA  
GO:0070700 [list] [network] BMP receptor binding  (13 genes)  IPI  
GO:0016004 [list] [network] phospholipase activator activity  (16 genes)  IDA  
GO:0043274 [list] [network] phospholipase binding  (22 genes)  IPI  
GO:0005158 [list] [network] insulin receptor binding  (23 genes)  IEA  
GO:0046875 [list] [network] ephrin receptor binding  (28 genes)  IPI  
GO:0042169 [list] [network] SH2 domain binding  (40 genes)  IPI  
GO:0030331 [list] [network] estrogen receptor binding  (41 genes)  IEA  
GO:0004715 [list] [network] non-membrane spanning protein tyrosine kinase activity  (46 genes)  IBA IDA NAS TAS  
GO:0005080 [list] [network] protein kinase C binding  (55 genes)  IEA  
GO:0097110 [list] [network] scaffold protein binding  (60 genes)  IPI  
GO:0051117 [list] [network] ATPase binding  (88 genes)  ISS  
GO:0051219 [list] [network] phosphoprotein binding  (88 genes)  IPI  
GO:0004714 [list] [network] transmembrane receptor protein tyrosine kinase activity  (127 genes)  IEA  
GO:0044325 [list] [network] transmembrane transporter binding  (133 genes)  IPI  
GO:0020037 [list] [network] heme binding  (139 genes)  IDA  
GO:0004713 [list] [network] protein tyrosine kinase activity  (140 genes)  EXP IBA IDA IMP NAS  
GO:0070851 [list] [network] growth factor receptor binding  (141 genes)  IBA IPI  
GO:0005178 [list] [network] integrin binding  (144 genes)  IPI TAS  
GO:0008022 [list] [network] protein C-terminus binding  (189 genes)  IPI  
GO:0031625 [list] [network] ubiquitin protein ligase binding  (297 genes)  IEA  
GO:0045296 [list] [network] cadherin binding  (333 genes)  HDA  
GO:0004672 [list] [network] protein kinase activity  (577 genes)  IDA  
GO:0019900 [list] [network] kinase binding  (758 genes)  IPI  
GO:0005524 [list] [network] ATP binding  (1474 genes)  IEA  
GO:0005102 [list] [network] signaling receptor binding  (1550 genes)  IBA IPI  
GO:0019899 [list] [network] enzyme binding  (2058 genes)  IPI  
GO:0005515 [list] [network] protein binding  (13898 genes)  IPI  
KEGG hsa01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
hsa01522 [list] [network] Endocrine resistance (98 genes)
hsa04012 [list] [network] ErbB signaling pathway (85 genes)
hsa04015 [list] [network] Rap1 signaling pathway (210 genes)
hsa04062 [list] [network] Chemokine signaling pathway (192 genes)
hsa04137 [list] [network] Mitophagy - animal (72 genes)
hsa04144 [list] [network] Endocytosis (251 genes)
hsa04360 [list] [network] Axon guidance (182 genes)
hsa04370 [list] [network] VEGF signaling pathway (59 genes)
hsa04510 [list] [network] Focal adhesion (201 genes)
hsa04520 [list] [network] Adherens junction (71 genes)
hsa04530 [list] [network] Tight junction (169 genes)
hsa04540 [list] [network] Gap junction (88 genes)
hsa04611 [list] [network] Platelet activation (124 genes)
hsa04613 [list] [network] Neutrophil extracellular trap formation (190 genes)
hsa04625 [list] [network] C-type lectin receptor signaling pathway (104 genes)
hsa04727 [list] [network] GABAergic synapse (89 genes)
hsa04750 [list] [network] Inflammatory mediator regulation of TRP channels (98 genes)
hsa04810 [list] [network] Regulation of actin cytoskeleton (218 genes)
hsa04912 [list] [network] GnRH signaling pathway (93 genes)
hsa04915 [list] [network] Estrogen signaling pathway (138 genes)
hsa04917 [list] [network] Prolactin signaling pathway (70 genes)
hsa04919 [list] [network] Thyroid hormone signaling pathway (121 genes)
hsa04921 [list] [network] Oxytocin signaling pathway (154 genes)
hsa04926 [list] [network] Relaxin signaling pathway (129 genes)
hsa05100 [list] [network] Bacterial invasion of epithelial cells (77 genes)
hsa05120 [list] [network] Epithelial cell signaling in Helicobacter pylori infection (70 genes)
hsa05130 [list] [network] Pathogenic Escherichia coli infection (197 genes)
hsa05131 [list] [network] Shigellosis (247 genes)
hsa05135 [list] [network] Yersinia infection (137 genes)
hsa05152 [list] [network] Tuberculosis (180 genes)
hsa05161 [list] [network] Hepatitis B (162 genes)
hsa05163 [list] [network] Human cytomegalovirus infection (225 genes)
hsa05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (194 genes)
hsa05168 [list] [network] Herpes simplex virus 1 infection (495 genes)
hsa05203 [list] [network] Viral carcinogenesis (204 genes)
hsa05205 [list] [network] Proteoglycans in cancer (205 genes)
hsa05207 [list] [network] Chemical carcinogenesis - receptor activation (212 genes)
hsa05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (223 genes)
hsa05219 [list] [network] Bladder cancer (41 genes)
hsa05417 [list] [network] Lipid and atherosclerosis (215 genes)
hsa05418 [list] [network] Fluid shear stress and atherosclerosis (139 genes)
Protein NP_005408.1  NP_938033.1  XP_011527315.1  XP_016883513.1  XP_016883514.1  XP_016883515.1  XP_016883516.1 
BLAST NP_005408.1  NP_938033.1  XP_011527315.1  XP_016883513.1  XP_016883514.1  XP_016883515.1  XP_016883516.1 
Orthologous [Ortholog page] BLK (hsa)  FGR (hsa)  FRK (hsa)  FYN (hsa)  HCK (hsa)  LCK (hsa)  LYN (hsa)  PTK6 (hsa)  SRMS (hsa)  YES1 (hsa)  Blk (mmu)  Fgr (mmu)  Frk (mmu)  Fyn (mmu)  Hck (mmu)  Lck (mmu)  Lyn (mmu)  Ptk6 (mmu)  Src (mmu)  Srms (mmu)  Yes1 (mmu)  Yes1 (rno)  Fyn (rno)  Hck (rno)  Src42A (dme)  Src64B (dme)  Fgr (rno)  Frk (rno)  Lyn (rno)  Src (rno)  src-1 (cel)  F26E4.5 (cel)  src-2 (cel)  T25B9.4 (cel)  W01B6.5 (cel)  Srms (rno)  Lck (rno)  src (dre)  yrk (dre)  Blk (rno)  Ptk6 (rno)  fyna (dre)  YES1 (gga)  FYN (gga)  SRC (gga)  LCK (gga)  YES1 (cfa)  yes1 (dre)  lck (dre)  PTK6 (gga)  HCK (gga)  LYN (gga)  FRK (gga)  BLK (gga)  lyn (dre)  FYN (cfa)  SRMS (cfa)  LYN (cfa)  LCK (cfa)  FRK (cfa)  HCK (cfa)  SRC (cfa)  BLK (cfa)  FGR (cfa)  ptk6a (dre)  frk (dre)  blk (dre)  FYN (mcc)  fynb (dre)  BLK (mcc)  YES1 (mcc)  LYN (mcc)  SRC (mcc)  HCK (mcc)  FRK (mcc)  FGR (mcc)  LCK (mcc)  SRMS (mcc)  PTK6 (mcc)  ptk6b (dre)  FGR (gga)  nda2 (spo)  atb2 (spo)  srms (dre)  FGR (fca)  BLK (fca)  FYN (fca)  FRK (fca)  YES1 (fca)  LYN (fca)  LCK (fca)  SRMS (fca)  PTK6 (fca)  SRC (fca)  HCK (fca)  hck (dre)  LOC102156300 (cfa)  LOC119865729 (cfa) 
Subcellular
localization
wolf
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for NP_005408.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for NP_938033.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_011527315.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_016883513.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_016883514.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_016883515.1)
cyto 6,  cyto_nucl 4,  nucl 2,  extr 1,  mito 1  (predict for XP_016883516.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04810 Regulation of actin cytoskeleton 3
hsa04360 Axon guidance 2
hsa05135 Yersinia infection 2
hsa00310 Lysine degradation 2
hsa05130 Pathogenic Escherichia coli infection 2
Genes directly connected with SRC on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
4.9 TTYH3 tweety family member 3 [detail] 0 80727
4.9 MANBAL mannosidase beta like [detail] 0 63905
4.8 SOGA1 suppressor of glucose, autophagy associated 1 [detail] 0 140710
Coexpressed
gene list		 [Coexpressed gene list for SRC]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 6714      
Refseq ID (protein) NP_005408.1 
NP_938033.1 
XP_011527315.1 
XP_016883513.1 
XP_016883514.1 
XP_016883515.1 
XP_016883516.1 


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