[←][→] hsa  PDGFB Gene
functional annotation
Function   platelet derived growth factor subunit B  
GO BP
GO:0072255 [list] [network] metanephric glomerular mesangial cell development  (1 genes)  ISS  
GO:0010512 [list] [network] negative regulation of phosphatidylinositol biosynthetic process  (2 genes)  IDA  
GO:0071506 [list] [network] cellular response to mycophenolic acid  (2 genes)  ISS  
GO:0035793 [list] [network] positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (3 genes)  IDA  
GO:1905176 [list] [network] positive regulation of vascular associated smooth muscle cell dedifferentiation  (3 genes)  IDA  
GO:2000591 [list] [network] positive regulation of metanephric mesenchymal cell migration  (3 genes)  IDA  
GO:0003104 [list] [network] positive regulation of glomerular filtration  (4 genes)  ISS  
GO:1900127 [list] [network] positive regulation of hyaluronan biosynthetic process  (4 genes)  IDA  
GO:0072126 [list] [network] positive regulation of glomerular mesangial cell proliferation  (6 genes)  IDA  
GO:0035655 [list] [network] interleukin-18-mediated signaling pathway  (7 genes)  IDA  
GO:0038001 [list] [network] paracrine signaling  (7 genes)  ISS  
GO:1905064 [list] [network] negative regulation of vascular associated smooth muscle cell differentiation  (13 genes)  IDA  
GO:0070528 [list] [network] protein kinase C signaling  (15 genes)  IMP  
GO:1902894 [list] [network] negative regulation of pri-miRNA transcription by RNA polymerase II  (16 genes)  IDA  
GO:0010544 [list] [network] negative regulation of platelet activation  (19 genes)  IDA  
GO:0090280 [list] [network] positive regulation of calcium ion import  (22 genes)  IDA  
GO:1904754 [list] [network] positive regulation of vascular associated smooth muscle cell migration  (25 genes)  IDA  
GO:0031954 [list] [network] positive regulation of protein autophosphorylation  (27 genes)  IBA IDA  
GO:0045737 [list] [network] positive regulation of cyclin-dependent protein serine/threonine kinase activity  (32 genes)  IDA  
GO:0043552 [list] [network] positive regulation of phosphatidylinositol 3-kinase activity  (33 genes)  IDA  
GO:0048008 [list] [network] platelet-derived growth factor receptor signaling pathway  (35 genes)  IBA IDA  
GO:0032148 [list] [network] activation of protein kinase B activity  (36 genes)  IDA  
GO:1902895 [list] [network] positive regulation of pri-miRNA transcription by RNA polymerase II  (40 genes)  IDA  
GO:0045840 [list] [network] positive regulation of mitotic nuclear division  (43 genes)  IDA  
GO:0002548 [list] [network] monocyte chemotaxis  (45 genes)  IDA  
GO:0014911 [list] [network] positive regulation of smooth muscle cell migration  (46 genes)  IDA  
GO:0048146 [list] [network] positive regulation of fibroblast proliferation  (48 genes)  IDA  
GO:0050918 [list] [network] positive chemotaxis  (48 genes)  IEA  
GO:1904707 [list] [network] positive regulation of vascular associated smooth muscle cell proliferation  (49 genes)  IDA  
GO:0061098 [list] [network] positive regulation of protein tyrosine kinase activity  (58 genes)  IDA  
GO:2000573 [list] [network] positive regulation of DNA biosynthetic process  (66 genes)  IDA  
GO:2000379 [list] [network] positive regulation of reactive oxygen species metabolic process  (75 genes)  IDA  
GO:0043536 [list] [network] positive regulation of blood vessel endothelial cell migration  (77 genes)  IDA  
GO:0001892 [list] [network] embryonic placenta development  (82 genes)  ISS  
GO:0051781 [list] [network] positive regulation of cell division  (88 genes)  IEA  
GO:0043406 [list] [network] positive regulation of MAP kinase activity  (89 genes)  IBA IDA  
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling  (91 genes)  IBA IDA  
GO:0032091 [list] [network] negative regulation of protein binding  (95 genes)  IDA  
GO:0072593 [list] [network] reactive oxygen species metabolic process  (99 genes)  IMP  
GO:0048661 [list] [network] positive regulation of smooth muscle cell proliferation  (102 genes)  IDA  
GO:0001938 [list] [network] positive regulation of endothelial cell proliferation  (111 genes)  IDA  
GO:0010811 [list] [network] positive regulation of cell-substrate adhesion  (122 genes)  IDA  
GO:0002576 [list] [network] platelet degranulation  (129 genes)  TAS  
GO:0050921 [list] [network] positive regulation of chemotaxis  (141 genes)  IDA  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (149 genes)  IDA  
GO:0032147 [list] [network] activation of protein kinase activity  (156 genes)  IDA  
GO:0018105 [list] [network] peptidyl-serine phosphorylation  (184 genes)  IDA  
GO:0051897 [list] [network] positive regulation of protein kinase B signaling  (186 genes)  TAS  
GO:0050731 [list] [network] positive regulation of peptidyl-tyrosine phosphorylation  (198 genes)  IDA  
GO:0060326 [list] [network] cell chemotaxis  (205 genes)  IDA  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (217 genes)  IBA IDA  
GO:0000165 [list] [network] MAPK cascade  (376 genes)  TAS  
GO:0030198 [list] [network] extracellular matrix organization  (379 genes)  TAS  
GO:0043410 [list] [network] positive regulation of MAPK cascade  (431 genes)  IMP  
GO:0071363 [list] [network] cellular response to growth factor stimulus  (508 genes)  IDA  
GO:0007507 [list] [network] heart development  (537 genes)  ISS  
GO:0009611 [list] [network] response to wounding  (554 genes)  IDA NAS  
GO:0030335 [list] [network] positive regulation of cell migration  (554 genes)  IBA IDA  
GO:0030097 [list] [network] hemopoiesis  (574 genes)  IMP  
GO:0006468 [list] [network] protein phosphorylation  (682 genes)  IDA  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (976 genes)  IBA IDA  
GO:0010628 [list] [network] positive regulation of gene expression  (1188 genes)  IDA  
GO:0045892 [list] [network] negative regulation of transcription, DNA-templated  (1341 genes)  IDA  
GO:0010629 [list] [network] negative regulation of gene expression  (1587 genes)  IDA  
GO:0045893 [list] [network] positive regulation of transcription, DNA-templated  (1594 genes)  IDA  
GO CC
GO:0031093 [list] [network] platelet alpha granule lumen  (67 genes)  TAS  
GO:0005796 [list] [network] Golgi lumen  (104 genes)  TAS  
GO:0016323 [list] [network] basolateral plasma membrane  (228 genes)  ISS  
GO:0005788 [list] [network] endoplasmic reticulum lumen  (313 genes)  TAS  
GO:0062023 [list] [network] collagen-containing extracellular matrix  (426 genes)  HDA  
GO:0000139 [list] [network] Golgi membrane  (626 genes)  TAS  
GO:0009986 [list] [network] cell surface  (898 genes)  IDA  
GO:0005615 [list] [network] extracellular space  (3622 genes)  IBA  
GO:0005576 [list] [network] extracellular region  (4632 genes)  NAS TAS  
GO:0005737 [list] [network] cytoplasm  (11897 genes)  ISS  
GO MF
GO:0016176 [list] [network] superoxide-generating NADPH oxidase activator activity  (10 genes)  IDA  
GO:0048407 [list] [network] platelet-derived growth factor binding  (11 genes)  IPI  
GO:0005161 [list] [network] platelet-derived growth factor receptor binding  (15 genes)  IBA IDA IPI NAS  
GO:0042056 [list] [network] chemoattractant activity  (37 genes)  IDA  
GO:0005518 [list] [network] collagen binding  (69 genes)  IDA  
GO:0070851 [list] [network] growth factor receptor binding  (141 genes)  IBA  
GO:0008083 [list] [network] growth factor activity  (162 genes)  IDA  
GO:0046982 [list] [network] protein heterodimerization activity  (326 genes)  IPI  
GO:0042803 [list] [network] protein homodimerization activity  (680 genes)  IDA  
GO:0042802 [list] [network] identical protein binding  (1971 genes)  IPI  
GO:0005515 [list] [network] protein binding  (13898 genes)  IPI  
KEGG hsa01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
hsa04010 [list] [network] MAPK signaling pathway (294 genes)
hsa04014 [list] [network] Ras signaling pathway (232 genes)
hsa04015 [list] [network] Rap1 signaling pathway (210 genes)
hsa04020 [list] [network] Calcium signaling pathway (240 genes)
hsa04072 [list] [network] Phospholipase D signaling pathway (148 genes)
hsa04151 [list] [network] PI3K-Akt signaling pathway (354 genes)
hsa04510 [list] [network] Focal adhesion (201 genes)
hsa04540 [list] [network] Gap junction (88 genes)
hsa04630 [list] [network] JAK-STAT signaling pathway (162 genes)
hsa04810 [list] [network] Regulation of actin cytoskeleton (218 genes)
hsa05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (194 genes)
hsa05200 [list] [network] Pathways in cancer (531 genes)
hsa05206 [list] [network] MicroRNAs in cancer (310 genes)
hsa05211 [list] [network] Renal cell carcinoma (69 genes)
hsa05214 [list] [network] Glioma (75 genes)
hsa05215 [list] [network] Prostate cancer (97 genes)
hsa05218 [list] [network] Melanoma (72 genes)
hsa05231 [list] [network] Choline metabolism in cancer (98 genes)
hsa05418 [list] [network] Fluid shear stress and atherosclerosis (139 genes)
Protein NP_002599.1  NP_148937.1 
BLAST NP_002599.1  NP_148937.1 
Orthologous [Ortholog page] PDGFA (hsa)  Pdgfa (mmu)  Pdgfb (mmu)  Pdgfb (rno)  Pdgfa (rno)  Pvf1 (dme)  PDGFB (gga)  PDGFA (gga)  pdgfaa (dre)  PDGFB (cfa)  PDGFA (cfa)  PDGFB (mcc)  PDGFA (mcc)  pdgfab (dre)  pdgfbb (dre)  si:ch211-79m20.1 (dre)  PDGFB (fca)  PDGFA (fca) 
Subcellular
localization
wolf
extr 8,  mito 1,  cyto_mito 1  (predict for NP_002599.1)
cyto 5,  extr 3,  cyto_nucl 3  (predict for NP_148937.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04514 Cell adhesion molecules 4
hsa04151 PI3K-Akt signaling pathway 3
hsa05418 Fluid shear stress and atherosclerosis 3
hsa04670 Leukocyte transendothelial migration 3
hsa04510 Focal adhesion 2
Genes directly connected with PDGFB on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
5.8 CDH5 cadherin 5 [detail] 0 1003
5.5 ESAM endothelial cell adhesion molecule [detail] 0 90952
5.4 PCDH1 protocadherin 1 [detail] 0 5097
Coexpressed
gene list		 [Coexpressed gene list for PDGFB]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 5155      
Refseq ID (protein) NP_002599.1 
NP_148937.1 


The preparation time of this page was 0.3 [sec].