| functional annotation |
| Function |
platelet derived growth factor subunit A |
|
| GO BP |
|
GO:0060683 [list] [network] regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
|
(1 genes)
|
ISS
|
 |
|
GO:0010512 [list] [network] negative regulation of phosphatidylinositol biosynthetic process
|
(2 genes)
|
IDA
|
|
|
GO:1990401 [list] [network] embryonic lung development
|
(2 genes)
|
ISS
|
|
|
GO:0035793 [list] [network] positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
|
(3 genes)
|
IDA
|
|
|
GO:0072124 [list] [network] regulation of glomerular mesangial cell proliferation
|
(11 genes)
|
IDA
|
|
|
GO:0010544 [list] [network] negative regulation of platelet activation
|
(19 genes)
|
IDA
|
|
|
GO:0002053 [list] [network] positive regulation of mesenchymal cell proliferation
|
(22 genes)
|
ISS
|
|
|
GO:0031954 [list] [network] positive regulation of protein autophosphorylation
|
(27 genes)
|
IBA
IDA
|
|
|
GO:0048008 [list] [network] platelet-derived growth factor receptor signaling pathway
|
(35 genes)
|
IBA
IDA
|
|
|
GO:0048286 [list] [network] lung alveolus development
|
(41 genes)
|
ISS
|
|
|
GO:0050919 [list] [network] negative chemotaxis
|
(45 genes)
|
IDA
|
|
|
GO:0048146 [list] [network] positive regulation of fibroblast proliferation
|
(48 genes)
|
IDA
|
|
|
GO:0001942 [list] [network] hair follicle development
|
(69 genes)
|
ISS
|
|
|
GO:0014910 [list] [network] regulation of smooth muscle cell migration
|
(88 genes)
|
IDA
|
|
|
GO:0051781 [list] [network] positive regulation of cell division
|
(88 genes)
|
IEA
|
|
|
GO:0043406 [list] [network] positive regulation of MAP kinase activity
|
(89 genes)
|
IBA
IDA
|
|
|
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling
|
(91 genes)
|
IBA
IDA
|
|
|
GO:2000278 [list] [network] regulation of DNA biosynthetic process
|
(110 genes)
|
IDA
|
|
|
GO:0002576 [list] [network] platelet degranulation
|
(129 genes)
|
TAS
|
|
|
GO:0051897 [list] [network] positive regulation of protein kinase B signaling
|
(186 genes)
|
IDA
TAS
|
|
|
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade
|
(217 genes)
|
IBA
IDA
|
|
|
GO:0050730 [list] [network] regulation of peptidyl-tyrosine phosphorylation
|
(267 genes)
|
ISS
|
|
|
GO:0001525 [list] [network] angiogenesis
|
(316 genes)
|
ISS
|
|
|
GO:0032956 [list] [network] regulation of actin cytoskeleton organization
|
(357 genes)
|
TAS
|
|
|
GO:0000165 [list] [network] MAPK cascade
|
(376 genes)
|
TAS
|
|
|
GO:0043588 [list] [network] skin development
|
(378 genes)
|
ISS
|
|
|
GO:0030198 [list] [network] extracellular matrix organization
|
(379 genes)
|
TAS
|
|
|
GO:0043410 [list] [network] positive regulation of MAPK cascade
|
(431 genes)
|
IMP
|
|
|
GO:0042060 [list] [network] wound healing
|
(455 genes)
|
TAS
|
|
|
GO:0030031 [list] [network] cell projection assembly
|
(493 genes)
|
ISS
|
|
|
GO:0030036 [list] [network] actin cytoskeleton organization
|
(525 genes)
|
ISS
|
|
|
GO:0009611 [list] [network] response to wounding
|
(554 genes)
|
IDA
|
|
|
GO:0030335 [list] [network] positive regulation of cell migration
|
(554 genes)
|
IBA
IDA
|
|
|
GO:0009887 [list] [network] animal organ morphogenesis
|
(947 genes)
|
ISS
|
|
|
GO:0008284 [list] [network] positive regulation of cell population proliferation
|
(976 genes)
|
IBA
IDA
|
|
|
GO:0001775 [list] [network] cell activation
|
(1087 genes)
|
TAS
|
|
|
GO:0007267 [list] [network] cell-cell signaling
|
(1120 genes)
|
TAS
|
|
|
| GO CC |
|
GO:0031093 [list] [network] platelet alpha granule lumen
|
(67 genes)
|
TAS
|
|
|
GO:0005902 [list] [network] microvillus
|
(91 genes)
|
ISS
|
|
|
GO:0005796 [list] [network] Golgi lumen
|
(104 genes)
|
TAS
|
|
|
GO:0005788 [list] [network] endoplasmic reticulum lumen
|
(313 genes)
|
TAS
|
|
|
GO:0000139 [list] [network] Golgi membrane
|
(626 genes)
|
TAS
|
|
|
GO:0009986 [list] [network] cell surface
|
(898 genes)
|
IDA
|
|
|
GO:0005615 [list] [network] extracellular space
|
(3622 genes)
|
IBA
IDA
|
|
|
GO:0005576 [list] [network] extracellular region
|
(4632 genes)
|
TAS
|
|
|
| GO MF |
|
GO:0048407 [list] [network] platelet-derived growth factor binding
|
(11 genes)
|
IPI
|
|
|
GO:0005161 [list] [network] platelet-derived growth factor receptor binding
|
(15 genes)
|
IBA
IDA
IPI
|
|
|
GO:0005518 [list] [network] collagen binding
|
(69 genes)
|
IDA
|
|
|
GO:0070851 [list] [network] growth factor receptor binding
|
(141 genes)
|
IBA
|
|
|
GO:0008083 [list] [network] growth factor activity
|
(162 genes)
|
IDA
|
|
|
GO:0046982 [list] [network] protein heterodimerization activity
|
(326 genes)
|
IPI
|
|
|
GO:0042803 [list] [network] protein homodimerization activity
|
(680 genes)
|
IDA
|
|
|
GO:0005515 [list] [network] protein binding
|
(13898 genes)
|
IPI
|
|
|
| KEGG |
hsa01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes) |
 |
| hsa04010 [list] [network] MAPK signaling pathway (294 genes) |
|
| hsa04014 [list] [network] Ras signaling pathway (232 genes) |
|
| hsa04015 [list] [network] Rap1 signaling pathway (210 genes) |
|
| hsa04020 [list] [network] Calcium signaling pathway (240 genes) |
|
| hsa04072 [list] [network] Phospholipase D signaling pathway (148 genes) |
|
| hsa04151 [list] [network] PI3K-Akt signaling pathway (354 genes) |
|
| hsa04510 [list] [network] Focal adhesion (201 genes) |
|
| hsa04540 [list] [network] Gap junction (88 genes) |
|
| hsa04630 [list] [network] JAK-STAT signaling pathway (162 genes) |
|
| hsa04810 [list] [network] Regulation of actin cytoskeleton (218 genes) |
|
| hsa05200 [list] [network] Pathways in cancer (531 genes) |
|
| hsa05202 [list] [network] Transcriptional misregulation in cancer (192 genes) |
|
| hsa05206 [list] [network] MicroRNAs in cancer (310 genes) |
|
| hsa05214 [list] [network] Glioma (75 genes) |
|
| hsa05215 [list] [network] Prostate cancer (97 genes) |
|
| hsa05218 [list] [network] Melanoma (72 genes) |
|
| hsa05231 [list] [network] Choline metabolism in cancer (98 genes) |
|
| hsa05418 [list] [network] Fluid shear stress and atherosclerosis (139 genes) |
|
| Protein |
NP_002598.4
NP_148983.1
XP_011513717.1
XP_011513718.1
XP_011513719.1
XP_011513720.1
XP_011513721.1
XP_016867778.1
|
| BLAST |
NP_002598.4
NP_148983.1
XP_011513717.1
XP_011513718.1
XP_011513719.1
XP_011513720.1
XP_011513721.1
XP_016867778.1
|
| Orthologous |
[Ortholog page]
PDGFB (hsa)
Pdgfa (mmu)
Pdgfb (mmu)
Pdgfb (rno)
Pdgfa (rno)
Pvf1 (dme)
PDGFB (gga)
PDGFA (gga)
pdgfaa (dre)
PDGFB (cfa)
PDGFA (cfa)
PDGFB (mcc)
PDGFA (mcc)
pdgfab (dre)
pdgfbb (dre)
si:ch211-79m20.1 (dre)
PDGFB (fca)
PDGFA (fca)
|
Subcellular
localization
wolf |
|
extr 10
|
(predict for NP_002598.4)
|
|
extr 10
|
(predict for NP_148983.1)
|
|
nucl 6,
cyto_nucl 4,
extr 3,
cyto 1
|
(predict for XP_011513717.1)
|
|
plas 4,
mito 3,
mito_pero 2,
extr 1,
E.R. 1
|
(predict for XP_011513718.1)
|
|
nucl 5,
cyto_nucl 4,
extr 3,
cyto 2
|
(predict for XP_011513719.1)
|
|
plas 4,
mito 3,
extr_plas 3,
extr 1,
mito_pero 1
|
(predict for XP_011513720.1)
|
|
nucl 5,
mito_nucl 4,
cyto_nucl 3,
mito 3,
extr 1,
cyto 1
|
(predict for XP_011513721.1)
|
|
nucl 5,
cyto_nucl 4,
cyto 2,
mito 1
|
(predict for XP_016867778.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| hsa04151 |
PI3K-Akt signaling pathway |
2 |
 |
| hsa04510 |
Focal adhesion |
2 |
 |
| hsa04810 |
Regulation of actin cytoskeleton |
2 |
 |
| hsa05205 |
Proteoglycans in cancer |
2 |
 |
Genes directly connected with PDGFA on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
CoexPub |
Entrez Gene ID* |
| 18.3 |
HRAT92 |
heart tissue-associated transcript 92 |
[detail] |
0 |
441307 |
| 5.4 |
ITGB5 |
integrin subunit beta 5 |
[detail] |
0 |
3693 |
| 5.3 |
PRKAR1B-AS1 |
PRKAR1B antisense RNA 1 |
[detail] |
0 |
101926963 |
|
Coexpressed
gene list |
[Coexpressed gene list for PDGFA]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
PDGFA Gene
