[←][→] rno  Pdgfb Gene
functional annotation
Function   platelet derived growth factor subunit B  
GO BP
GO:0072255 [list] [network] metanephric glomerular mesangial cell development  (1 genes)  ISO ISS  
GO:0072264 [list] [network] metanephric glomerular endothelium development  (1 genes)  ISO  
GO:1905176 [list] [network] positive regulation of vascular associated smooth muscle cell dedifferentiation  (1 genes)  IEA ISO  
GO:0010512 [list] [network] negative regulation of phosphatidylinositol biosynthetic process  (2 genes)  IEA ISO ISS  
GO:0045977 [list] [network] positive regulation of mitotic cell cycle, embryonic  (2 genes)  ISO  
GO:0071506 [list] [network] cellular response to mycophenolic acid  (2 genes)  IDA  
GO:0072262 [list] [network] metanephric glomerular mesangial cell proliferation involved in metanephros development  (2 genes)  ISO  
GO:1904899 [list] [network] positive regulation of hepatic stellate cell proliferation  (2 genes)  IMP  
GO:0035793 [list] [network] positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (3 genes)  IEA ISO ISS  
GO:2000591 [list] [network] positive regulation of metanephric mesenchymal cell migration  (3 genes)  IDA ISO  
GO:0003104 [list] [network] positive regulation of glomerular filtration  (4 genes)  ISO ISS  
GO:0035655 [list] [network] interleukin-18-mediated signaling pathway  (5 genes)  IEA ISO  
GO:1900127 [list] [network] positive regulation of hyaluronan biosynthetic process  (5 genes)  IEA ISO ISS  
GO:0038001 [list] [network] paracrine signaling  (7 genes)  ISO ISS  
GO:0060664 [list] [network] epithelial cell proliferation involved in salivary gland morphogenesis  (7 genes)  ISO  
GO:0072126 [list] [network] positive regulation of glomerular mesangial cell proliferation  (8 genes)  IEA ISO ISS  
GO:1905064 [list] [network] negative regulation of vascular associated smooth muscle cell differentiation  (8 genes)  IEA ISO  
GO:2000491 [list] [network] positive regulation of hepatic stellate cell activation  (8 genes)  IMP  
GO:0045743 [list] [network] positive regulation of fibroblast growth factor receptor signaling pathway  (9 genes)  ISO  
GO:0044752 [list] [network] response to human chorionic gonadotropin  (11 genes)  IEP  
GO:0016322 [list] [network] neuron remodeling  (15 genes)  ISO  
GO:0070528 [list] [network] protein kinase C signaling  (18 genes)  IEA ISO  
GO:0010544 [list] [network] negative regulation of platelet activation  (19 genes)  IEA ISO ISS  
GO:0060445 [list] [network] branching involved in salivary gland morphogenesis  (20 genes)  ISO  
GO:1902894 [list] [network] negative regulation of pri-miRNA transcription by RNA polymerase II  (20 genes)  IEA ISO  
GO:1904754 [list] [network] positive regulation of vascular associated smooth muscle cell migration  (21 genes)  IEA ISO  
GO:0061298 [list] [network] retina vasculature development in camera-type eye  (25 genes)  ISO  
GO:0031954 [list] [network] positive regulation of protein autophosphorylation  (26 genes)  IBA IEA ISO ISS  
GO:0006929 [list] [network] substrate-dependent cell migration  (27 genes)  ISO  
GO:0032148 [list] [network] activation of protein kinase B activity  (27 genes)  IEA ISO ISS  
GO:0090280 [list] [network] positive regulation of calcium ion import  (27 genes)  IEA ISO ISS  
GO:0002548 [list] [network] monocyte chemotaxis  (31 genes)  IEA ISO ISS  
GO:0043552 [list] [network] positive regulation of phosphatidylinositol 3-kinase activity  (31 genes)  IEA ISO ISS  
GO:0032967 [list] [network] positive regulation of collagen biosynthetic process  (33 genes)  IMP  
GO:0045737 [list] [network] positive regulation of cyclin-dependent protein serine/threonine kinase activity  (36 genes)  IEA ISO ISS  
GO:1904385 [list] [network] cellular response to angiotensin  (36 genes)  IEP  
GO:1904707 [list] [network] positive regulation of vascular associated smooth muscle cell proliferation  (38 genes)  IEA ISO  
GO:0048008 [list] [network] platelet-derived growth factor receptor signaling pathway  (39 genes)  IBA IMP ISO  
GO:1902895 [list] [network] positive regulation of pri-miRNA transcription by RNA polymerase II  (44 genes)  IEA ISO  
GO:0050918 [list] [network] positive chemotaxis  (47 genes)  IEA  
GO:0045840 [list] [network] positive regulation of mitotic nuclear division  (48 genes)  IEA ISO ISS  
GO:0042462 [list] [network] eye photoreceptor cell development  (49 genes)  ISO  
GO:0045740 [list] [network] positive regulation of DNA replication  (51 genes)  IMP  
GO:0061098 [list] [network] positive regulation of protein tyrosine kinase activity  (57 genes)  IEA ISO ISS  
GO:0043536 [list] [network] positive regulation of blood vessel endothelial cell migration  (59 genes)  IEA ISO ISS  
GO:0014911 [list] [network] positive regulation of smooth muscle cell migration  (68 genes)  IMP ISO  
GO:0048146 [list] [network] positive regulation of fibroblast proliferation  (75 genes)  IEA ISO ISS  
GO:0051781 [list] [network] positive regulation of cell division  (76 genes)  IEA  
GO:2000573 [list] [network] positive regulation of DNA biosynthetic process  (77 genes)  IEA ISO ISS  
GO:2000379 [list] [network] positive regulation of reactive oxygen species metabolic process  (80 genes)  IEA ISO ISS  
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling  (81 genes)  IBA IEA ISO ISS  
GO:0048678 [list] [network] response to axon injury  (86 genes)  IEP  
GO:0007416 [list] [network] synapse assembly  (88 genes)  ISO  
GO:0072593 [list] [network] reactive oxygen species metabolic process  (96 genes)  IEA ISO ISS  
GO:0001938 [list] [network] positive regulation of endothelial cell proliferation  (97 genes)  IEA ISO ISS  
GO:0032091 [list] [network] negative regulation of protein binding  (101 genes)  IEA ISO  
GO:0043406 [list] [network] positive regulation of MAP kinase activity  (101 genes)  IBA IDA IEA ISO  
GO:0001892 [list] [network] embryonic placenta development  (108 genes)  ISO ISS  
GO:0048661 [list] [network] positive regulation of smooth muscle cell proliferation  (115 genes)  IMP ISO  
GO:0021782 [list] [network] glial cell development  (132 genes)  ISO  
GO:0032147 [list] [network] activation of protein kinase activity  (133 genes)  ISO ISS  
GO:0071260 [list] [network] cellular response to mechanical stimulus  (134 genes)  IEP  
GO:0043627 [list] [network] response to estrogen  (137 genes)  IEP  
GO:0010811 [list] [network] positive regulation of cell-substrate adhesion  (144 genes)  IEA ISO  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (149 genes)  IEA ISO ISS  
GO:0050921 [list] [network] positive regulation of chemotaxis  (160 genes)  IEA ISO ISS  
GO:0018105 [list] [network] peptidyl-serine phosphorylation  (188 genes)  IEA ISO ISS  
GO:0008584 [list] [network] male gonad development  (194 genes)  IEP  
GO:0060326 [list] [network] cell chemotaxis  (200 genes)  ISO ISS  
GO:0050731 [list] [network] positive regulation of peptidyl-tyrosine phosphorylation  (204 genes)  ISO  
GO:0060041 [list] [network] retina development in camera-type eye  (205 genes)  ISO  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (232 genes)  IBA IEA ISO ISS  
GO:0032355 [list] [network] response to estradiol  (258 genes)  IEP  
GO:0050730 [list] [network] regulation of peptidyl-tyrosine phosphorylation  (273 genes)  ISO  
GO:0032868 [list] [network] response to insulin  (287 genes)  IEP  
GO:0030336 [list] [network] negative regulation of cell migration  (294 genes)  ISO  
GO:0042060 [list] [network] wound healing  (338 genes)  IEP  
GO:0048514 [list] [network] blood vessel morphogenesis  (401 genes)  ISO  
GO:0030031 [list] [network] cell projection assembly  (416 genes)  ISO  
GO:0001666 [list] [network] response to hypoxia  (420 genes)  IEP  
GO:0043410 [list] [network] positive regulation of MAPK cascade  (490 genes)  ISO ISS  
GO:0009611 [list] [network] response to wounding  (500 genes)  IEA ISO ISS  
GO:0001568 [list] [network] blood vessel development  (504 genes)  ISO  
GO:0030036 [list] [network] actin cytoskeleton organization  (519 genes)  ISO  
GO:0071363 [list] [network] cellular response to growth factor stimulus  (567 genes)  IEA ISO  
GO:0030335 [list] [network] positive regulation of cell migration  (586 genes)  IBA ISO  
GO:0007507 [list] [network] heart development  (631 genes)  ISO ISS  
GO:0042493 [list] [network] response to drug  (643 genes)  IEP  
GO:0006468 [list] [network] protein phosphorylation  (680 genes)  ISO ISS  
GO:0030097 [list] [network] hemopoiesis  (692 genes)  ISO ISS  
GO:0010629 [list] [network] negative regulation of gene expression  (1007 genes)  IEA ISO  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (1044 genes)  IBA ISO ISS  
GO:0010628 [list] [network] positive regulation of gene expression  (1232 genes)  IEA ISO  
GO:0045892 [list] [network] negative regulation of transcription, DNA-templated  (1280 genes)  ISO ISS  
GO:0014070 [list] [network] response to organic cyclic compound  (1383 genes)  IEP  
GO:0045893 [list] [network] positive regulation of transcription, DNA-templated  (1618 genes)  IDA ISO  
GO:0042127 [list] [network] regulation of cell population proliferation  (1780 genes)  IEP  
GO:0010033 [list] [network] response to organic substance  (3490 genes)  IEP  
GO CC
GO:0016323 [list] [network] basolateral plasma membrane  (260 genes)  IDA  
GO:0043025 [list] [network] neuronal cell body  (756 genes)  IDA  
GO:0030425 [list] [network] dendrite  (800 genes)  IDA  
GO:0009986 [list] [network] cell surface  (937 genes)  IEA ISO ISS  
GO:0005615 [list] [network] extracellular space  (1510 genes)  IBA IDA  
GO:0005576 [list] [network] extracellular region  (2120 genes)  IEA  
GO:0016020 [list] [network] membrane  (9382 genes)  IEA  
GO:0005737 [list] [network] cytoplasm  (10463 genes)  IDA  
GO MF
GO:0016176 [list] [network] superoxide-generating NADPH oxidase activator activity  (8 genes)  IEA ISO ISS  
GO:0048407 [list] [network] platelet-derived growth factor binding  (11 genes)  IEA ISO  
GO:0005161 [list] [network] platelet-derived growth factor receptor binding  (14 genes)  IBA IEA ISO  
GO:0042056 [list] [network] chemoattractant activity  (35 genes)  IEA ISO  
GO:0005518 [list] [network] collagen binding  (74 genes)  ISO  
GO:0008083 [list] [network] growth factor activity  (145 genes)  IEA ISO ISS  
GO:0070851 [list] [network] growth factor receptor binding  (150 genes)  IBA  
GO:0046982 [list] [network] protein heterodimerization activity  (329 genes)  IEA ISO  
GO:0042803 [list] [network] protein homodimerization activity  (699 genes)  IEA ISO ISS  
GO:0005102 [list] [network] signaling receptor binding  (1488 genes)  IMP  
GO:0042802 [list] [network] identical protein binding  (2232 genes)  ISO  
KEGG rno01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (80 genes)
rno04010 [list] [network] MAPK signaling pathway (293 genes)
rno04014 [list] [network] Ras signaling pathway (231 genes)
rno04015 [list] [network] Rap1 signaling pathway (213 genes)
rno04020 [list] [network] Calcium signaling pathway (238 genes)
rno04072 [list] [network] Phospholipase D signaling pathway (150 genes)
rno04151 [list] [network] PI3K-Akt signaling pathway (345 genes)
rno04510 [list] [network] Focal adhesion (200 genes)
rno04540 [list] [network] Gap junction (87 genes)
rno04630 [list] [network] JAK-STAT signaling pathway (158 genes)
rno04810 [list] [network] Regulation of actin cytoskeleton (223 genes)
rno05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (216 genes)
rno05200 [list] [network] Pathways in cancer (538 genes)
rno05206 [list] [network] MicroRNAs in cancer (292 genes)
rno05211 [list] [network] Renal cell carcinoma (70 genes)
rno05214 [list] [network] Glioma (74 genes)
rno05215 [list] [network] Prostate cancer (99 genes)
rno05218 [list] [network] Melanoma (73 genes)
rno05231 [list] [network] Choline metabolism in cancer (98 genes)
rno05418 [list] [network] Fluid shear stress and atherosclerosis (151 genes)
Protein NP_113712.1  XP_038934348.1 
BLAST NP_113712.1  XP_038934348.1 
Orthologous [Ortholog page] PDGFA (hsa)  PDGFB (hsa)  Pdgfa (mmu)  Pdgfb (mmu)  Pdgfa (rno)  Pvf1 (dme)  PDGFB (gga)  PDGFA (gga)  pdgfaa (dre)  PDGFB (cfa)  PDGFA (cfa)  PDGFB (mcc)  PDGFA (mcc)  pdgfab (dre)  pdgfbb (dre)  si:ch211-79m20.1 (dre)  PDGFB (fca)  PDGFA (fca) 
Subcellular
localization
wolf
extr 8,  E.R. 1,  mito 1,  E.R._golg 1  (predict for NP_113712.1)
extr 3,  cyto 3,  cyto_nucl 3,  nucl 3  (predict for XP_038934348.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno05418 Fluid shear stress and atherosclerosis 3
rno04010 MAPK signaling pathway 3
rno04014 Ras signaling pathway 3
rno04015 Rap1 signaling pathway 3
rno04514 Cell adhesion molecules 2
Genes directly connected with Pdgfb on the network
coex z* Locus Function* Coexpression
detail		 Entrez Gene ID*
5.6 Acvrl1 activin A receptor like type 1 [detail] 25237
5.3 Spns2 sphingolipid transporter 2 [detail] 100270678
5.0 Afap1l1 actin filament associated protein 1-like 1 [detail] 291565
Coexpressed
gene list		 [Coexpressed gene list for Pdgfb]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity*
Link to other DBs
Entrez Gene ID 24628      
Refseq ID (protein) NP_113712.1 
XP_038934348.1 


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