[←][→] mmu  Pdgfb Gene
functional annotation
Function   platelet derived growth factor, B polypeptide  
GO BP
GO:0072255 [list] [network] metanephric glomerular mesangial cell development  (1 genes)  IMP  
GO:0072264 [list] [network] metanephric glomerular endothelium development  (1 genes)  IEP  
GO:1904899 [list] [network] positive regulation of hepatic stellate cell proliferation  (1 genes)  ISO  
GO:1905176 [list] [network] positive regulation of vascular associated smooth muscle cell dedifferentiation  (1 genes)  ISO  
GO:0010512 [list] [network] negative regulation of phosphatidylinositol biosynthetic process  (2 genes)  ISO  
GO:0045977 [list] [network] positive regulation of mitotic cell cycle, embryonic  (2 genes)  IGI  
GO:0071506 [list] [network] cellular response to mycophenolic acid  (2 genes)  ISO  
GO:0072262 [list] [network] metanephric glomerular mesangial cell proliferation involved in metanephros development  (2 genes)  IMP  
GO:0035793 [list] [network] positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (3 genes)  ISO  
GO:2000591 [list] [network] positive regulation of metanephric mesenchymal cell migration  (3 genes)  ISO  
GO:0003104 [list] [network] positive regulation of glomerular filtration  (4 genes)  IMP  
GO:0035655 [list] [network] interleukin-18-mediated signaling pathway  (5 genes)  ISO  
GO:1900127 [list] [network] positive regulation of hyaluronan biosynthetic process  (5 genes)  ISO  
GO:0038001 [list] [network] paracrine signaling  (6 genes)  IMP  
GO:0038033 [list] [network] positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  (6 genes)  TAS  
GO:0060664 [list] [network] epithelial cell proliferation involved in salivary gland morphogenesis  (7 genes)  IMP  
GO:1905064 [list] [network] negative regulation of vascular associated smooth muscle cell differentiation  (7 genes)  ISO  
GO:2000491 [list] [network] positive regulation of hepatic stellate cell activation  (7 genes)  ISO  
GO:0072126 [list] [network] positive regulation of glomerular mesangial cell proliferation  (8 genes)  ISO  
GO:0045743 [list] [network] positive regulation of fibroblast growth factor receptor signaling pathway  (9 genes)  IDA  
GO:0016322 [list] [network] neuron remodeling  (15 genes)  IMP  
GO:0060947 [list] [network] cardiac vascular smooth muscle cell differentiation  (15 genes)  TAS  
GO:0070528 [list] [network] protein kinase C signaling  (17 genes)  ISO  
GO:0010544 [list] [network] negative regulation of platelet activation  (19 genes)  ISO  
GO:1904754 [list] [network] positive regulation of vascular associated smooth muscle cell migration  (19 genes)  ISO  
GO:0060445 [list] [network] branching involved in salivary gland morphogenesis  (20 genes)  IMP  
GO:1902894 [list] [network] negative regulation of pri-miRNA transcription by RNA polymerase II  (20 genes)  ISO  
GO:0006929 [list] [network] substrate-dependent cell migration  (26 genes)  IDA  
GO:0045737 [list] [network] positive regulation of cyclin-dependent protein serine/threonine kinase activity  (26 genes)  ISO  
GO:0031954 [list] [network] positive regulation of protein autophosphorylation  (27 genes)  IBA ISO  
GO:0061298 [list] [network] retina vasculature development in camera-type eye  (27 genes)  IMP  
GO:0032148 [list] [network] activation of protein kinase B activity  (28 genes)  ISO  
GO:0032967 [list] [network] positive regulation of collagen biosynthetic process  (29 genes)  ISO  
GO:0090280 [list] [network] positive regulation of calcium ion import  (29 genes)  ISO  
GO:0043552 [list] [network] positive regulation of phosphatidylinositol 3-kinase activity  (31 genes)  ISO  
GO:0002548 [list] [network] monocyte chemotaxis  (33 genes)  ISO  
GO:1904707 [list] [network] positive regulation of vascular associated smooth muscle cell proliferation  (34 genes)  ISO  
GO:0048008 [list] [network] platelet-derived growth factor receptor signaling pathway  (41 genes)  IBA ISO  
GO:0061098 [list] [network] positive regulation of protein tyrosine kinase activity  (44 genes)  ISO  
GO:0045840 [list] [network] positive regulation of mitotic nuclear division  (45 genes)  ISO  
GO:0045740 [list] [network] positive regulation of DNA replication  (47 genes)  ISO  
GO:0042462 [list] [network] eye photoreceptor cell development  (48 genes)  IMP  
GO:0045907 [list] [network] positive regulation of vasoconstriction  (53 genes)  TAS  
GO:0043536 [list] [network] positive regulation of blood vessel endothelial cell migration  (56 genes)  ISO  
GO:0014911 [list] [network] positive regulation of smooth muscle cell migration  (62 genes)  IMP ISO  
GO:1902895 [list] [network] positive regulation of pri-miRNA transcription by RNA polymerase II  (67 genes)  ISO  
GO:0048146 [list] [network] positive regulation of fibroblast proliferation  (70 genes)  ISO  
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling  (75 genes)  IBA IGI ISO  
GO:2000573 [list] [network] positive regulation of DNA biosynthetic process  (76 genes)  ISO  
GO:2000379 [list] [network] positive regulation of reactive oxygen species metabolic process  (77 genes)  ISO  
GO:0007416 [list] [network] synapse assembly  (86 genes)  IMP  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (89 genes)  ISO  
GO:0051781 [list] [network] positive regulation of cell division  (97 genes)  IEA  
GO:0001938 [list] [network] positive regulation of endothelial cell proliferation  (98 genes)  IGI ISO  
GO:0032091 [list] [network] negative regulation of protein binding  (98 genes)  ISO  
GO:0048661 [list] [network] positive regulation of smooth muscle cell proliferation  (103 genes)  IMP ISO  
GO:0072593 [list] [network] reactive oxygen species metabolic process  (103 genes)  ISO  
GO:0043406 [list] [network] positive regulation of MAP kinase activity  (109 genes)  IBA ISO  
GO:0032147 [list] [network] activation of protein kinase activity  (110 genes)  ISO  
GO:0001892 [list] [network] embryonic placenta development  (112 genes)  IMP  
GO:0021782 [list] [network] glial cell development  (116 genes)  IMP  
GO:0010811 [list] [network] positive regulation of cell-substrate adhesion  (137 genes)  ISO  
GO:0050921 [list] [network] positive regulation of chemotaxis  (150 genes)  ISO  
GO:0060041 [list] [network] retina development in camera-type eye  (173 genes)  IMP  
GO:0018105 [list] [network] peptidyl-serine phosphorylation  (187 genes)  ISO  
GO:0050731 [list] [network] positive regulation of peptidyl-tyrosine phosphorylation  (191 genes)  ISO  
GO:0060326 [list] [network] cell chemotaxis  (208 genes)  ISO  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (228 genes)  IBA ISO  
GO:0050730 [list] [network] regulation of peptidyl-tyrosine phosphorylation  (262 genes)  IDA  
GO:0030336 [list] [network] negative regulation of cell migration  (290 genes)  IGI  
GO:0009611 [list] [network] response to wounding  (368 genes)  ISO  
GO:0030031 [list] [network] cell projection assembly  (414 genes)  IDA  
GO:0071363 [list] [network] cellular response to growth factor stimulus  (426 genes)  ISO  
GO:0048514 [list] [network] blood vessel morphogenesis  (444 genes)  IDA IGI  
GO:0043410 [list] [network] positive regulation of MAPK cascade  (482 genes)  ISO  
GO:0030036 [list] [network] actin cytoskeleton organization  (527 genes)  IDA IGI  
GO:0001568 [list] [network] blood vessel development  (547 genes)  IEP  
GO:0030335 [list] [network] positive regulation of cell migration  (567 genes)  IBA IGI ISO  
GO:0007507 [list] [network] heart development  (585 genes)  IMP  
GO:0006468 [list] [network] protein phosphorylation  (665 genes)  ISO  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (1011 genes)  IBA ISO  
GO:0010629 [list] [network] negative regulation of gene expression  (1078 genes)  ISO  
GO:0010628 [list] [network] positive regulation of gene expression  (1244 genes)  ISO  
GO:0045892 [list] [network] negative regulation of transcription, DNA-templated  (1298 genes)  ISO  
GO:0045893 [list] [network] positive regulation of transcription, DNA-templated  (1550 genes)  ISO  
GO:0007275 [list] [network] multicellular organism development  (5017 genes)  IEA  
GO CC
GO:0016323 [list] [network] basolateral plasma membrane  (243 genes)  ISO  
GO:0043025 [list] [network] neuronal cell body  (722 genes)  ISO  
GO:0030425 [list] [network] dendrite  (740 genes)  ISO  
GO:0009986 [list] [network] cell surface  (1142 genes)  ISO  
GO:0005615 [list] [network] extracellular space  (2015 genes)  IBA ISO  
GO:0005576 [list] [network] extracellular region  (2754 genes)  IEA  
GO:0016020 [list] [network] membrane  (9571 genes)  IEA  
GO:0005737 [list] [network] cytoplasm  (11434 genes)  ISO  
GO MF
GO:0016176 [list] [network] superoxide-generating NADPH oxidase activator activity  (8 genes)  ISO  
GO:0048407 [list] [network] platelet-derived growth factor binding  (12 genes)  ISO  
GO:0005161 [list] [network] platelet-derived growth factor receptor binding  (14 genes)  IBA ISO  
GO:0042056 [list] [network] chemoattractant activity  (41 genes)  ISO  
GO:0005518 [list] [network] collagen binding  (80 genes)  ISO  
GO:0008083 [list] [network] growth factor activity  (148 genes)  ISO  
GO:0070851 [list] [network] growth factor receptor binding  (156 genes)  IBA  
GO:0046982 [list] [network] protein heterodimerization activity  (305 genes)  ISO  
GO:0042803 [list] [network] protein homodimerization activity  (780 genes)  ISO  
GO:0005102 [list] [network] signaling receptor binding  (1742 genes)  ISO  
GO:0042802 [list] [network] identical protein binding  (2357 genes)  ISO  
KEGG mmu01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
mmu04010 [list] [network] MAPK signaling pathway (294 genes)
mmu04014 [list] [network] Ras signaling pathway (232 genes)
mmu04015 [list] [network] Rap1 signaling pathway (214 genes)
mmu04020 [list] [network] Calcium signaling pathway (240 genes)
mmu04072 [list] [network] Phospholipase D signaling pathway (149 genes)
mmu04151 [list] [network] PI3K-Akt signaling pathway (359 genes)
mmu04510 [list] [network] Focal adhesion (201 genes)
mmu04540 [list] [network] Gap junction (86 genes)
mmu04630 [list] [network] JAK-STAT signaling pathway (168 genes)
mmu04810 [list] [network] Regulation of actin cytoskeleton (220 genes)
mmu05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (224 genes)
mmu05200 [list] [network] Pathways in cancer (543 genes)
mmu05206 [list] [network] MicroRNAs in cancer (303 genes)
mmu05211 [list] [network] Renal cell carcinoma (68 genes)
mmu05214 [list] [network] Glioma (74 genes)
mmu05215 [list] [network] Prostate cancer (99 genes)
mmu05218 [list] [network] Melanoma (72 genes)
mmu05231 [list] [network] Choline metabolism in cancer (98 genes)
mmu05418 [list] [network] Fluid shear stress and atherosclerosis (148 genes)
Protein NP_035187.2  XP_006520655.1  XP_030104269.1  XP_030104270.1  XP_030104271.1  XP_036015133.1  XP_036015134.1 
BLAST NP_035187.2  XP_006520655.1  XP_030104269.1  XP_030104270.1  XP_030104271.1  XP_036015133.1  XP_036015134.1 
Orthologous [Ortholog page] PDGFA (hsa)  PDGFB (hsa)  Pdgfa (mmu)  Pdgfb (rno)  Pdgfa (rno)  Pvf1 (dme)  PDGFB (gga)  PDGFA (gga)  pdgfaa (dre)  PDGFB (cfa)  PDGFA (cfa)  PDGFB (mcc)  PDGFA (mcc)  pdgfab (dre)  pdgfbb (dre)  si:ch211-79m20.1 (dre)  PDGFB (fca)  PDGFA (fca) 
Subcellular
localization
wolf
extr 8,  mito 1  (predict for NP_035187.2)
extr 4,  cyto 4,  cyto_nucl 3,  nucl 2,  extr_plas 2  (predict for XP_006520655.1)
nucl 4,  cyto_nucl 4,  cyto 3,  extr 3  (predict for XP_030104269.1)
nucl 4,  cyto_nucl 4,  cyto 3,  extr 3  (predict for XP_030104270.1)
extr 4,  cyto 4,  cyto_nucl 3,  nucl 2,  extr_plas 2  (predict for XP_030104271.1)
nucl 4,  cyto_nucl 4,  cyto 3,  extr 3  (predict for XP_036015133.1)
extr 4,  cyto 4,  cyto_nucl 3,  nucl 2,  extr_plas 2  (predict for XP_036015134.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04015 Rap1 signaling pathway 3
mmu04010 MAPK signaling pathway 2
mmu04014 Ras signaling pathway 2
mmu04151 PI3K-Akt signaling pathway 2
mmu05200 Pathways in cancer 2
Genes directly connected with Pdgfb on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
6.7 Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [detail] 0 106952
5.7 Sox18 SRY (sex determining region Y)-box 18 [detail] 2 20672
5.4 Podxl podocalyxin-like [detail] 0 27205
Coexpressed
gene list		 [Coexpressed gene list for Pdgfb]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 18591      
Refseq ID (protein) NP_035187.2 
XP_006520655.1 
XP_030104269.1 
XP_030104270.1 
XP_030104271.1 
XP_036015133.1 
XP_036015134.1 


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